• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5325-5330
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• 2014

Background: Chronic myelocytic leukemia is a disease that threatens both adults and children. Great progress has been achieved in treatment but protein-protein interaction networks underlining chronic myelocytic leukemia are less known. Objective: To develop a protein-protein interaction network for chronic myelocytic leukemia based on gene expression and to predict biological pathways underlying molecular complexes in the network. Materials and Methods: Genes involved in chronic myelocytic leukemia were selected from OMIM database. Literature mining was performed by Agilent Literature Search plugin and a protein-protein interaction network of chronic myelocytic leukemia was established by Cytoscape. The molecular complexes in the network were detected by Clusterviz plugin and pathway enrichment of molecular complexes were performed by DAVID online. Results and Discussion: There are seventy-nine chronic myelocytic leukemia genes in the Mendelian Inheritance In Man Database. The protein-protein interaction network of chronic myelocytic leukemia contained 638 nodes, 1830 edges and perhaps 5 molecular complexes. Among them, complex 1 is involved in pathways that are related to cytokine secretion, cytokine-receptor binding, cytokine receptor signaling, while complex 3 is related to biological behavior of tumors which can provide the bioinformatic foundation for further understanding the mechanisms of chronic myelocytic leukemia.

• 대한간호
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• 제25권3호통권136호
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• pp.42-45
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• 1986

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.167.2-168
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• 2003

Anticancer drug resistance occasionally occurs in malignant hematologic diseases such as acute myelocytic leukemia (AML) treated with chemotherapy and is a major problem to complete remission. Malignant cells primarily induce intrinsic resistance to treatment of anticancer drug, but gradually obtain acquired resistance to cytotoxic activities of chemotherapy. In this study, we monitored the expression profiles of doxorubicin resistance-related genes in AML-2/DX100, a doxorubicin-resistant human acute myelocytic leukemia cell line. (omitted)

• 대한간호
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• 제23권2호통권125호
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• pp.29-36
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• 1984

Bone marrow transplantation has been recognized as one of the best methods in the treatment of patients with severe aplastic anemia, acute leukemia, chronic myelocytic leukemia, congenital immune deficiency syndrome and radiation exposure. While there are

• 한국동물학회지
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• 제32권2호
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• pp.142-152
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• 1989

CALLA 항원에 대한 단일클론 항체는 백혈병의 진단이나 치료에 대한 활용가능성을 잠재하고 있기 때문에 구미, 일본 등지에서는 이에 대한 연구가 활발하다. 이 점에 유의하여 본 연구자들은 CALLA에대한 새로운 단일클론항체 KP-22를 개발하고, 이 단일클론항체를 이용 CALLA의 분포를 여러 세포주에 대하여 조사한 결과 common ALL, Burkitt's lymphoma, T-ALL 세포주는 현저한 CALLA양성 반응을 보였으나 사람의 섬유아세포 계역을 제외한 모든 비백혈병성 암세포주 및 myelocytic leukemia 세포주들은 음성이었다. 막 단백질을 125I 방사능 표지한 후 KP-22를 이용, 면역 침전법으로 백혈병세포주와 사람의 정상 섬유아세포에서 CALLA를 정제하여 전기영동한 결과 각각 분자량이 약 95Kd 및 100Kd인 단일 band로 확인되었으나 이들의 peptide mapping 양상은 같았으므로 분자량에서의 미세한 차이는 posttranslational modification 과정에서 첨가되는 sialic acid에 기인 하는 것으로 사료된다.

• 대한치과의사협회지
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• 제17권4호통권119호
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• pp.291-296
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• 1979

This patient, 30 year-old korean male, was admitted with complaints of the gingival enlargement and spontaneous bleeding of the gingival tissue with acute leukemia. In reviewing this case, the following points should have been understood; 1. This is a case of the gingivitis, gingival enlargement, gingival bleeding, so the patient showed the masticatory disturbances. 2. The generalized weakness, petechia in skin, anemia, and hepatomegaly on palpation were seen. 3. With the histopathological examination by means of microscopic views, numerous myelocytic cells, of which their shapes were in irregular, were appeared. 4. The prognosis was poor in spite of any other internal treatments.

• Archives of Pharmacal Research
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• 제29권1호
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• pp.80-87
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• 2006

Leukemias are common worldwide. Wilms'tumor1 (WT1) protein is highly expressed in leukemic blast cells of myeloid and lymphoid origin. Thus, WT1 mRNA serves as a tumor marker for leukemias detection and monitoring disease progression. Curcumin is well known for its anticancer property. The objective of this study was to investigate the effect of curcumin on WT1 gene expression in patient leukemic cells. The leukemic cells were collected from 70 childhood leukemia patients admitted at Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, Thailand, in the period July 2003 to February 2005. There were 58 cases of acute lymphoblastic leukemia (ALL), 10 cases of acute myeloblastic leukemia (AML), and 2 cases of chronic myelocytic leukemia (CML). There were 41 males and 29 females ranging from 1 to 15 years old. Leukemic cells were cultured in the presence or absence of 10 mM curcumin for 48 h. WT1 mRNA levels were determined by RT-PCR. The result showed that curcumin reduced WT1 gene expression in the cells from 35 patients (50%). It affected the WT1 gene expression in 4 of 8 relapsed cases (50%), 12 of 24 cases of drug maintenance (50%), 7 of 16 cases of completed treatment (44%), and 12 of 22 cases of new patients (54%). The basal expression levels of WT1 gene in leukemic patient cells as compared to that of K562 cells were classified as low level (1-20%) in 6 of 20 cases (30%), medium level (21-60%) in 12 of 21 cases (57%), and high level (61-100%) in 17 of 23 cases (74%). In summary, curcumin decreased WT1 mRNA in patient leukemic cells. Thus, curcumin treatment may provide a lead for clinical treatment in leukemic patients in the future.

• Archives of Pharmacal Research
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• 제25권4호
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• pp.475-479
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• 2002

Capsaicin, a major pungent constituent of red pepper (Capsicum annuum L.) possesses a vast variety of pharmacologic and physiologic activities. Despite its irritant properties, the compound exerts anti-inflammatory and anti-nociceptive effects. Previous studies from this laboratory revealed that capsaicin, when topically applied onto dorsal skin of female ICR mice, strongly attenuated activation of NF-kB and AP-1 induced by the typical tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), which may account for its anti-tumor promoting activity in mouse skin. In the present work, we have found that capsaicin suppresses TPA-stimulated activation of NF-kB through inhibition of $IkB{\alpha}$ degradation and blockade of subsequent nuclear translocation of p65 in human pro myelocytic leukemia HL-60 cells. Methylation of the phenolic hydroxyl group of capsaicin abolished its inhibitory effect on NF-kB DNA binding. Likewise, TPA-induced activation of AP-1 was mitigated by capsaicin treatment.

• 대한후두음성언어의학회지
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• 제33권1호
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• pp.42-44
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• 2022

Chronic invasive aspergillosis is a life-threatening disease, especially in immunocompromised patients. The diagnosis and treatment of tracheal aspergillosis (TA) are challenging because of its rarity and nonspecific clinical presentations. The treatment standard of TA has been medical treatment like other forms of invasive aspergillosis, but patients with medically resistant TA require surgical intervention. We demonstrated a successful surgical outcome of chronic invasive TA in a 16-year-old patient with immunocompromised status related to acute myelocytic leukemia.

• 한국의학물리학회지:의학물리
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• 제20권3호
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• pp.152-158
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• 2009

선형 가속기의 Total Skin Electron Beam Therapy (TSEBT)는 유용하게 사용 되어왔으며, 2에서 9 MeV 에너지 영역의 전자는 mycosis fungoides와 cutaneous lymphomas와 같은 신체의 큰 부분을 덮는 표면상의 병변 치료에 사용 되어져 왔다. 본 연구에서는 Stanford technique로 환자를 치료 하였으며, Stanford technique는 선형 가속기로 전자 빔을 수평 방향으로 조사하여 서 있는 환자의 주위에 $60^{\circ}$로 위치한 6개의 조사면(anterior, posterior, 그리고 4개의 obliques)으로 치료하는 TSEBT의 표준이 되는 방법이다. 각 조사면은 수평으로 하고 적절한 각도에 점을 맞춘 두 개 성분의 빔으로 이루어져있다. 치료시간을 짧게 하기 위해 환자는 하루에 세 개의 이중 조사면으로 치료한다. 첫째 날에는 anterior로 하나의 이중 조사면, posterior에서 두 개의 이중 조사면 그리고 그 다음날에 posterior에서 하나의 이중 조사면 그리고 anterior 경사에서 두 개의 이중 조사면으로 치료한다. 따라서 6개의 이중 조사면의 완전한 주기는 2일로 완성된다. 환자를 치료하기 전 먼저 선량 측정을 하기 위해 원통형 아크릴 팬텀을 제작하여 그 사이 선량계 필름을 삽입하고 환자가 치료 받는 6개 조사면 방향으로 조사를 한 후 선량 분포를 알아보았다. 그런 후 Rando 팬텀을 사용하여 열형광선량계(thermoluminescent dosimetry : TLD)를 앞 가슴, 좌우 옆구리, 등에 부착한 후 6개 조사면 방향으로 방사선을 조사한 후 선량을 측정 하였다.