• Korean Journal of Mathematics
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• 제27권1호
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• pp.1-8
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• 2019

We will deal with an n locus model in which mutation and gene conversion are taken into consideration. Also random partitions of the number n determined by chromosomes with n loci should be investigated. The diffusion process describes the time evolution of distributions of the random partitions. In this paper, we find the probability of distribution of the diffusion process with special diffusion operator $L_1$ and we show that the average probability of genes at different loci on one chromosome can be described by the rate of gene frequency of mutation and gene conversion.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제15권8호
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• pp.2805-2826
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• 2021

In most cases, the routing policy of networks shows a preference for a static one-to-one mapping of communication pairs to routing paths, which offers adversaries a great advantage to conduct thorough reconnaissance and organize an effective attack in a stress-free manner. With the evolution of network intelligence, some flexible and adaptive routing policies have already proposed to intensify the network defender to turn the situation. Routing mutation is an effective strategy that can invalidate the unvarying nature of routing information that attackers have collected from exploiting the static configuration of the network. However, three constraints execute press on routing mutation deployment in practical: insufficient route mutation space, expensive control costs, and incompatibility. To enhance the availability of route mutation, we propose an OpenFlow-based route mutation technique called Polymorphic Path Transferring (PPT), which adopts a physical and virtual path segment mixed construction technique to enlarge the routing path space for elevating the security of communication. Based on the Markov Decision Process, with considering flows distribution in the network, the PPT adopts an evolution routing path scheduling algorithm with a segment path update strategy, which relieves the press on the overhead of control and incompatibility. Our analysis demonstrates that PPT can secure data delivery in the worst network environment while countering sophisticated attacks in an evasion-free manner (e.g., advanced persistent threat). Case study and experiment results show its effectiveness in proactively defending against targeted attacks and its advantage compared with previous route mutation methods.

• 한국미생물·생명공학회지
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• 제19권3호
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• pp.248-252
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• 1991

Trichoderma viride의 변이주인 QM9123, QM9414, TK041 및 MCG77은 면역학적으로 동일한 cellobiohydrolase을 분비하는 결과로서 변이균주간은 구조 유전자는 동일하나 조절유전자가 변이했음을 알 수 있었고 탄소원의 cellobiohydrolase의 유도효과는 고분자 섬유소인 Alpha-cellulose와 Solk Floc의 가장 좋은 유도체였고, 저분자 유도체인 cellobiose와 CMC에 의해서 유도되는 형식이 다름을 알았다.

• 한국콘텐츠학회논문지
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• 제7권11호
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• pp.94-101
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• 2007

본 논문에서는 알려지지 않은 변형 웜을 탐지하기 위한 방법을 제안한다. 그 방법으로, 페이로드 영역에서 시그니쳐 생성 방안들을 패턴인식 알고리즘으로 연구되었던 Suffix Tree중에서 Longest Common Subsequence(LCSeq) 기법을 이용하여 새로운 시그니쳐를 자동적으로 생성할 수 있는 프로그램을 설계하여 구현하였다. 테스트를 통해 코드레드 웜과 님다 웜의 변종을 검출하는 과정을 보여주고 기존 snort의 시그니쳐와 LCSeq를 이용해 생성된 시그니쳐를 비교 평가하였다.

• 대한기계학회논문집A
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• 제27권11호
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• pp.1809-1814
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• 2003

Differential evolution (DE) algorithm is presented and applied to global optimization in this research. DE suggested initially fur the solution to Chebychev polynomial fitting problem is similar to genetic algorithm(GA) including crossover, mutation and selection process. However, differential evolution algorithm is simpler than GA because it uses a vector concept in populating process. And DE turns out to be converged faster than CA, since it employs the difference information as pseudo-sensitivity In this paper, a trial vector and its control parameters of DE are examined and unconstrained optimization problems of highly nonlinear multimodal functions are demonstrated. To illustrate the efficiency of DE, convergence rates and robustness of global optimization algorithms are compared with those of simple GA.

• 대한의생명과학회지
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• 제24권2호
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• pp.64-75
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• 2018

CCN3 (also known as NOV, Nephroblastoma overexpressed) proteins are involved in various pathologies during different developmental stages. We have previously shown that intracellular levels and normal extracellular secretion of CCN3 are important for neuronal differentiation. Furthermore, we demonstrated that a single amino acid in the CCN3 TSP-1 domain is important for extracellular secretion and that palmitoylation of CCN3 is required in this process. However, the effect of abnormal CCN3 accumulation on cells remains to be studied. Here, we found mutations in the TSP-1 domain of CCN3 that led to intracellular accumulation and abnormal aggregation of CCN3. It was observed that this mutation resulted in a phenomenon similar to neurodegeneration when overexpressed in the developing mouse cortex. This mutation also confirmed the activation of apoptotic gene expression in Neuro2a cells. In addition, we confirmed the in vivo transcriptional changes induced by this mutation using microarray analysis. We observed a significant increase in the expression of Anp32a, an apoptosis-related gene. Collectively, these results indicate that a single mutation in CCN3 can lead to abnormal cell death if it shows intracellular accumulation and abnormal aggregation.

• The Journal of Asian Finance, Economics and Business
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• 제7권8호
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• pp.419-424
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• 2020

This study analyzes the new GMCF method applied by the company with the aim to find out how the production of Accounting Information Systems (AIS) implemented by the company can be managed properly. The study also seeks to find out whether the company needs new system support facilities to facilitate the production performance reporting process of each division and evaluate the performance of GMCF systems in the company. The methods used are descriptive analysis techniques and statistical tests of Paired Sample T-Test comparison; this study uses production data of each unit of a product with random sampling to determine the level of product damage and compare production with the GMCF system and prior to using it. The results of the analysis found that the application of goods mutation control forms (GMCF) greatly influenced the smooth production reporting process, which resulted in an increase in achieving production targets and reducing the risk of product damage during the production process. The company also benefits from the efficiency of production costs when using the GMCF system and can quickly design policies for products that are damaged during the production process. In addition, the company can have damaged products repaired faster than before.

• 대한전기학회논문지:시스템및제어부문D
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• 제53권4호
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• pp.265-276
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• 2004

Genetic Algorithm(GA), that is shown stable performance to find an optimal solution, has been used as a method of solving large-scaled optimization problems with complex constraints in various applications. Since it takes so much time to execute a long computation process for iterative evolution and adaptation. In this paper, a hardware-based adaptive GA was proposed to reduce the serious computation time of the evolutionary process and to improve the accuracy of convergence to optimal solution. The proposed GA, based on steady-state model among continuos generation model, performs an adaptive mutation process with consideration of the evolution flow and the population diversity. The drawback of the GA, premature convergence, was solved by the proposed adaptation. The Performance improvement of convergence accuracy for some kinds of problem and condition reached to 5-100% with equivalent convergence speed to high-speed algorithm. The proposed adaptive GAP(Genetic Algorithm Processor) was implemented on FPGA device Xilinx XCV2000E of EHW board for face recognition.

• 한국공간구조학회논문집
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• 제1권1호
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• pp.125-134
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• 2001

The objective of this study is the development of size discrete optimum design algorithm which is based on the GAs(genetic algorithms). The algorithm can perform size discrete optimum designs of space trusses. The developed algorithm was implemented in a computer program. For the optimum design, the objective function is the weight of space trusses and the constraints are limite state design codes(1998) and displacements. The basic search method for the optimum design is the GAs. The algorithm is known to be very efficient for the discrete optimization. This study solves the problem by introducing the GAs. The GAs consists of genetic process and evolutionary process. The genetic process selects the next design points based on the survivability of the current design points. The evolutionary process evaluates the survivability of the design points selected from the genetic process. In the genetic process of the simple GAs, there are three basic operators: reproduction, cross-over, and mutation operators. The efficiency and validity of the developed discrete optimum design algorithm was verified by applying GAs to optimum design examples.

• Environmental Analysis Health and Toxicology
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• 제14권1_2호
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• pp.1-12
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• 1999

Recently, several new methods for the detection of genetic damages in vitro and in vivo based on molecular biological techniques were introduced according to the rapid progress in toxicology combined with cellular and molecular biology. Among these methods, mouse lymphoma thymidine kanase (tk) gene forward mutation assay, single cell gel electrophoresis (comet assay) and transgenic animal and cell line model as a target gene of lac I (Big Blue) and lac Z (Muta Mouse) gene mutation are newly introduced based on molecular toxicological approaches. The mouse lymphoma tk$\^$+/-/ gene assay (MOLY) using L5178Y tk$\^$+/-/ mouse lymphoma cell line is one of the mammalian forward mutation assays, and has many advantages and more sensitive than hprt assay. The target gene of MOLY is a heterozygous tk$\^$+/-/ gene located in 11 chromosome, so it is able to detect the wide range of genetic changes like point mutation, deletion, rearrangement, and mitotic recombination within tk gene or deletion of entire chromosome 11. The comet assay is a rapid, simple, visual and sensitive technique for measuring and analysing DNA breakages in mammalian cells, Also, transgenic animal and cell line models, which have exogenous DNA incorporated into their genome, carry recoverable shuttle vector containing reporter genes to assess endogenous effects or alteration in specific genes related to disease process, are powerful tools to study the mechanism of mutation in vivo and in vitro, respectively. Also in vivo acridine orange supravital staining micronucleus assay by using mouse peripheral reticulocytes was introduced as an alternative of bone marrow micronucleus assay. In this respect, there was an International workshop on genotoxicity procedure (IWGTP) supported by OECD and EMS (Environmental Mutagen Society) at Washington D. C. in March 25-26, 1999. The objective of IWGTP is to harmonize the testing procedures internationally, and to extend to finalization of OECD guideline, and to the agreement of new guidelines under the International Conference of Harmonization (ICH) for these methods mentioned above. Therefore, we introduce and review the principle, detailed procedure, and application of MOLY, comet assay, transgenic mutagenesis assay and supravital staining micronucleus assay.