• Journal of Microbiology and Biotechnology
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• 제32권12호
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• pp.1632-1632
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• 2022

• 대한골관절종양학회지
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• 제10권1호
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• pp.39-44
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• 2004

거대 세포종은 일반적으로 양성 골종양이지만 드물게 폐로 전이하는 특성이 있다. 임상적으로 거대 세포종의 폐 전이는 지속적으로 진행하기도 하지만 종종 스스로 성장이 정지하거나 또는 자연 소실되는 경우도 있는 것으로 알려져 있다. 저자들은 거대 세포종의 광범위한 폐전이가 자연 소실된 예를 경험하여 보고하고자 한다.

• 대한골관절종양학회지
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• 제13권2호
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• pp.119-123
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• 2007

거대 세포 육아종(Giant cell reparative granuloma)는 흔하지 않는 양성 종양으로 상악골이나 하악골에서 흔하다. 그러나 수지에서는 매우 드물다. 저자들는 21세된 남자 환자로 인지에서 발생한 거대 세포 육아종을 보고하고자 한다. 조직학적으로 거대 세포 육아종이었다.

• 대한의용생체공학회:의공학회지
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• 제26권2호
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• pp.101-110
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• 2005

Periosteum and periosteum-derived progenitor cells have demonstrated the potential for stimulative applications in repairs of various musculoskeletal tissues. It has been found that the periosteum contains mesenchymal progenitor cells capable of differentiating into either osteoblasts or chondrocytes depending on the culture conditions. Anatomically, the periosteum is a heterogeneous multi-layered membrane, consisting of an inner cambium and an outer fibrous layer. The present study was designed to elucidate the cellular phenotypic characteristics of cambium and fibrous layer cells in vitro, and to assess whether structural integrity of the tendon in the bone tunnel can be improved by periosteal augmentation of the tendon­bone interface. It was found the cells from each layer showed distinct phenotypic characteristics in a primary monolayer culture system. Specifically, the cambium cells demonstrated higher osteogenic characteristics (higher alkaline phosphatase and osteocalcin levels), as compared to the fibrous cells. Also in vivo animal model showed that a periosteal augmentation of a tendon graft could enhance the structural integrity of the tendon-bone interface, when the periosteum is placed between the tendon and bone interface with the cambium layer facing toward the bone. These findings suggest that extra care needs to be taken in order to identify and maintain the intrinsic phenotypes of the heterogeneous cell types within the periosteum. This will improve our understanding of periosteum in applications for musculoskeletal tissue repairs and tissue engineering.

• 대한약침학회지
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• 제11권4호
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• pp.5-14
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• 2008

Objective This study was undertaken to determine the effect of Whallak-tang on expression of CD/cytokine Genes. Methods The expression of CD/Cytokine Genes were examined by cDNA microarray using the human mast cell line(HMC-1). Results The expression of ATP5F1, FLJ20671, unknown, KIAA0342, OAS2, unknown genes were increased in $200{\sim}300%$ range. The expression of unknown, MDS006, IFITM1, MRPL3, ZNF207, FTH1, FBP1, NRGN, NR1H2, KIAA0747 genes were decreased in $0{\sim}33%$ range. Conclusion These results would provide important basic data on the possibility of the clinical treatment of Whallak-tang in musculoskeletal disease.

• 대한골관절종양학회지
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• 제5권1호
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• pp.23-28
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• 1999

Between Sep. 1986 and Mar. 1996, twenty four patients with recurrent giant cell tumor of their long bones were treated and followed up for more than two years. We applied three different modalities for treatment: curettage with bone graft, curettage and packing with polymethylmethacrylate, wide excision with or without reconstruction. During the average 51.5 months after operation(24-97 months), two of three patients who underwent curettage with bone graft showed recurrence. Patients who underwent wide excision showed no recurrence. Five of fifteen patients who underwent curettage and packing with polymethylmethacrylate showed recurrence. Four of seven who showed recurrence were treated with reapplication of curettage and packing with polymethylmethacrylate. All four patients showed no recurrence, and two of them have been followed up for more than two years. We suggest that the curettage and packing with polymethylmethacrylate is an effective treatment modality of the recurrent giant cell tumor.

• 대한골관절종양학회지
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• 제7권2호
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• pp.73-79
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• 2001

슬관절을 중심으로 대퇴골 원위부, 경골 근위부에 호발하는 거대세포종은 양성 종양임에도 불구하고 그 생물학적 양상이 때로는 매우 공격적이어서 심한 골파괴를 초래하여 치료적 측면에서 관절의 연골면을 보존하는 문제에 봉착하게 된다. 또한, 소파술과 단순한 골이식술을 시행한 경우 재발 가능성이 매우 높으며, 간혹 폐전이에 대한 보고도 있는바 양성으로서의 거대세포종이 항상 관심의 대상이 되고 있다. 본 교실에서는 25세 남자 환자에서 대퇴골 원위부에 발생한 양성의 거대세포종을 골소파술과 methylmethacrylate 충전을 시행하였으나, 수술 후 2년 후에 재발과 더불어 폐 전이를 일으킨 예에 대해서 문헌 고찰과 함께 증례 보고하는 바이다.

• 대한골관절종양학회지
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• 제4권2호
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• pp.103-106
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• 1998

Giant cell tumor was described by Sir Astley Cooper in 1818. This tumor is considered to be a benign tumor but has problems of recurrence and metastatic change after treatment. Methods of operative treatment of this tumor have included currettage, currettage and bone graft, excision, resection, excision and graft and amputation. We experienced a case of giant cell tumor which involved the distal part of right radius and treated by wide excision and fibular graft. The postoperative courses have been satisfactory because of no recurrence or malignant change. After 6 years and 1 month follow up, the patient was able to return to daily life without any problem.

• 대한골관절종양학회지
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• 제15권1호
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• pp.75-80
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• 2009

골수외 형질세포종은 아주 드물게 발생하는 종양으로, 전체 형질 세포 종양의 3~5 %를 차지하며 상부 호흡기관에서 주로 발생한다. 그 외 드물게 위장관, 방광, 중추 신경계, 유방, 갑상선, 고환, 타액선, 임파선, 피부 등에서 발생한 증례보고가 있다. 저자들은 49세 남자의 대둔근에서 발생한 골수외 형질세포종 1예를 경험하였기에 이를 문헌 고찰과 함께 보고하는 바이다.

• Journal of Acupuncture Research
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• 제23권4호
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• pp.135-148
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• 2006

Objectives : Juglandis Semen herbal acupuncture solution(JSS) has a broad array of clinical applications in oriental medicine, including treatment of chronic musculoskeletal diseases such as arthritis. This study was performed to investigate the global gene expression profiles using microarray assay in RAW 264.7 cell line treated with JSS and to advance our understanding of the pharmacologic effect of Jss. Methods : Change of the gene expression profile in RAW cell line following treatment with JSS alone, with lipopolysaccharide(LPS) alone, or with LPS plus JSS was investigated with a cut-off level of 2 fold change in the expression. Results : Of the 8170 genes profiled in this study, 95 were upragulated and 42 downregulated following JSS treatment, 51 were upragulated and 21 downregulated following LPS treatment, and 88 were upregulated and 69 downregulated following costimulation of JSS and LPS. Conclusion : JSS treatment induced upregulation of some genes including IL-10 with its possible implication in an antiinflammatory action of JSS. However, further research on expression profile changes induced by JSS treatment is expected.