• Journal of Korean Society of Water and Wastewater
• /
• v.29 no.6
• /
• pp.625-632
• /
• 2015

The study of water environment system using a multivariate analysis in Changnyeong-Haman weir section has been conducted. The purpose of this study is to establish better understanding related water qualities in the Changnyeong-Haman weir section which can provide useful information. The data were consisted of water quality data and algae data including WT(water temperature), pH, DO, EC, COD, SS, T-N, $NH_3-N$, T-P, $PO_4-P$, Chl-a, TOC, d-silica, t-silica, Cyanobacteria, Diatoms, and Green algae. Statistical analyses used in this study were correlation analysis, principal components, and factor analysis. According to correlation analysis on COD and TOC, it revealed that the each value of correlation coefficient was 0.843. On the other result, a negative correlation was observed between diatoms and d-silica. Furthermore, the results of principal component analysis to the overall water quality were classified into four main factors with contribution rate 81.071%.

• Journal of Korean Society of Environmental Engineers
• /
• v.38 no.2
• /
• pp.71-78
• /
• 2016

The study of water environment system in Changnyeong-Haman weir section using a statistical analysis has been conducted. Statistical analyses used in this study were the correlation analysis, the principal components, and the factor analysis. The purpose of the study is to establish better understanding of relationships between water quality factors in the Changnyeong-Haman weir section which can provide useful information to manage Nakdong river. According to correlation analyses on COD and TOC, it revealed that the value of correlation coefficient was 0.844. Furthermore, the results from the principal component analysis categorized the water quality factors into three factor groups, the first principal factor group included COD, TOC, BOD, pH, water temperature (WT). And, it was observed that the concentration of cyanobacteria in the water body decreased, while the concentrations of the diatoms and the green algae increased after the events of rainfall.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.11
• /
• pp.4691-4698
• /
• 2015

Background: The tumor suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling. However, available results for the prognostic value of PTEN expression in patients with cancer remain controversial. Therefore, a meta-analysis of published studies investigating this issue was performed. Materials and Methods: A literature search via PubMed and EMBASE databases was conducted. Statistical analysis was performed by using the STATA 12.0 (STATA Corp., College, TX). Data from eligible studies were extracted and included into the meta-analysis using a random effects model. Results: A total of 3,810 patients from 27 studies were included in the meta-analysis, 22 investigating the relationship between PTEN expression and overall survival (OS) using univariate analysis, and nine with multivariate analysis. The pooled hazard ratio (HR) for OS was 1.64 (95% confidence interval (CI): 1.32-2.05) by univariate analysis and 1.56 (95% CI: 1.20-2.03) by multivariate analysis. In addition, eight papers including two disease-free-survival analyses (DFSs), four relapse-free-survival analyses (RFSs), three progression-free-survival analyses (PFSs) and one metastasis-free-survival analysis (MFS) reported the effect of PTEN on survival. The results showed that loss of PTEN expression was significant correlated with poor prognosis, with a combined HR of 1.74 (95% CI: 1.24-2.44). Furthermore, in the stratified analysis by the year of publication, ethnicity, cancer type, method, cut-off value, median follow-up time and neoadjuvant therapy in which the study was conducted, we found that the ethnicity, cancer type, method, median follow-up time and neoadjuvant therapy are associated with prognosis. Conclusions: Our study shows that negative or loss of expression of PTEN is associated with worse prognosis in patients with cancer. However, adequately designed prospective studies need to be performed for confirmation.

• Journal of Ecology and Environment
• /
• v.32 no.4
• /
• pp.229-236
• /
• 2009

A habitat model was developed to delineate potential habitat of the leopard cat (Prionailurus bengalensis) in a mountainous region of Kangwon Province, Korea. Between 1997 and 2005, 224 leopard cat presence sites were recorded in the province in the Nationwide Survey on Natural Environments. Fifty percent of the sites were used to develop a habitat model, and the remaining sites were used to test the model. Fourteen environmental variables related to topographic features, water resources, vegetation and human disturbance were quantified for 112 of the leopard cat presence sites and an equal number of randomly selected sites. Statistical analyses (e.g., t-tests, and Pearson correlation analysis) showed that elevation, ridges, plains, % water cover, distance to water source, vegetated area, deciduous forest, coniferous forest, and distance to paved road differed significantly (P < 0.01) between presence and random sites. Stepwise logistic regression was used to develop a habitat model. Landform type (e.g., ridges vs. plains) is the major topographic factor affecting leopard cat presence. The species also appears to prefer deciduous forests and areas far from paved roads. The habitat map derived from the model correctly classified 93.75% of data from an independent sample of leopard cat presence sites, and the map at a regional scale showed that the cat's habitats are highly fragmented. Protection and restoration of connectivity of critical habitats should be implemented to preserve the leopard cat in mountainous regions of Korea.

• Journal of Korean Neurosurgical Society
• /
• v.61 no.6
• /
• pp.761-766
• /
• 2018

Objective : Chronic subdural hematoma (CSDH) is a rare complication of unruptured intracranial aneurysm (UIA) clipping surgery. To prevent postoperative CSDH by reducing subdural fluid collection, we applied the modified arachnoid plasty (MAP) during the UIA clipping surgery to seal the dissected arachnoid plane. Methods : This retrospective study included 286 patients enrolled from July 2012 to May 2015. We performed arachnoid plasty in all patients, with MAP used after June 17, 2014. Patients were divided into two groups (non-MAP vs. MAP), and by using uni- and multivariate analyses, baseline characteristics, and relationships with postoperative CSDH between the two groups were analyzed. The degree of preoperative brain atrophy was estimated using the bicaudate ratio (BCR) index. Results : Ten patients (3.5%) among 286 patients had postoperative CSDH after clipping. Nine (3.1%) were in the non-MAP group, and one (0.9%) was in the MAP group. The higher BCR index showed statistical significance with occurrence of postoperative CSDH in both uni- (p=0.018) and multivariate (p=0.012; odds ratio [OR], 8.547; 95% confidence interval [CI], 1.616-45.455) analyses. MAP was associated with a lower risk of postoperative CSDH (p=0.022; OR, 0.068; 95% CI, 0.007-0.683). Conclusion : This study shows that the degree of preoperative brain atrophy is associated with an increased occurrence of CSDH after clipping and that MAP could help reduce the risk of postoperative CSDH after unruptured aneurysm clipping via a lateral supraorbital approach.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.47 no.3
• /
• pp.197-208
• /
• 2021

Objectives: The purpose of this retrospective study was to evaluate the variables associated with length of stay (LOS), hospital costs, intensive care unit (ICU) use, and treatment outcomes in patients hospitalized for maxillofacial infections at a tertiary medical center in South Korea. Materials and Methods: A retrospective chart review was conducted for patients admitted for treatment of maxillofacial infections at Dankook University Hospital from January 1, 2011 through September 30, 2020. A total of 390 patient charts were reviewed and included in the final statistical analyses. Results: Average LOS and hospital bill per patient of this study was 11.47 days, and ₩4,710,017.25 ($4,216.67), respectively. Of the 390 subjects, 97.3% were discharged routinely following complete recovery, 1.0% expired following treatment, and 0.8% were transferred to another hospital. In multivariate linear regression analyses to determine variables associated with LOS, admission year, infection side, Flynn score, deep neck infection, cardiovascular disease, admission C-reactive protein (CRP) and glucose levels, number and length of surgical interventions, tracheostomy, time elapsed from admission to first surgery, and length of ICU stay accounted for 85.8% of the variation. With regard to the total hospital bill, significantly associated variables were age, type of insurance, Flynn score, number of comorbidities, admission CRP, white blood cell, and glucose levels, admission temperature, peak temperature, surgical intervention, the length, type, and location of surgery, tracheostomy, time elapsed from admission to first surgery, and length of ICU use, which accounted for 90.4% of the variation. Age and ICU use were the only variables significantly associated with unfavorable discharge outcomes in multivariate logistic regression analysis. Conclusion: For successful and cost-effective management of maxillofacial infections, clinicians to be vigilant about the decision to admit patients with maxillofacial infections, perform appropriate surgery at an adequate time, and admit them to the ICU.

• Nuclear Engineering and Technology
• /
• v.54 no.11
• /
• pp.4253-4264
• /
• 2022

Since the implementation of the phosphate project in Bled El-Hadba (BEH) deposit, western region of Tébessa, no detailed study has been conducted to assess the natural radioactivity distribution and the associated radiological risk parameter for this open-pit mine. For the sake of determining a credible premining reference database for the region of interest, 21 samples were collected from different geological layers of the above-mentioned deposit. Gamma Spectrometry was applied for measuring radioactivity using a high resolution HPGe semiconductor detector. The obtained activity results have shown a significant broad variation in the radioactive contents for the different phosphate samples. The total average concentrations (in Bq·kg^-1) for ²²⁶Ra, ²³⁸U, ²³⁵U, ²³²Th and ⁴⁰K computed for the different type of phosphate layers were found to be 570 ± 169, 788 ± 280, 52 ± 18, 66 ± 6 and 81 ± 18 respectively. The mean activity concentrations of the measured radionuclides were compared to other regional and worldwide deposits. The ratios between the detected radioisotopes have been calculated for spatial distribution of natural radionuclides in the study area. Based on the aforementioned activity concentrations, the corresponding radiation hazard parameters were assessed. Correlations between the obtained parameters were drawn and a multivariate statistical analysis (Pearson Correlation, Cluster and Factor analysis) was carried out in order to identify the existing relationships.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
• /
• v.12 no.4
• /
• pp.275-286
• /
• 2014

This study evaluated the evolution stage and origin of chemical components of 12 boreholes at crystalline bedrock using multivariate statistical and groundwater quality analyses. Groundwater types are mostly belonged to Na(Ca)-$HCO_3$ and Ca-$HCO_3$ types, indicating that directly reaction of cation exchange ($Ca^{2+}{\rightarrow}Na^+$) prevailed. The degree of groundwater evolution is included the range from low to intermediate stage based on field and laboratory analytical conditions. As a result of multivariate statistical analysis, a typical indicator of groundwater contamination, $NO_3$-, has the positive correlation with $Na^+$ and $Cl^-$. The origin of sea spary ($Cl^-$) has the positive correlation with $Na^+$, $SO{_4}^{2-}$, $Mg^{2+}$, and $K^+$, while not correlation with $Ca^{2+}$, $Fe^{2+}$, $HCO_3{^-}$, $F^-$, and $SiO_2$. The concentration of $Cl^-$ and $NO_3{^-}$ belongs to general quality of groundwater and not exceeds over the Korean standard for drinking water. And the negative values of saturation index of minerals are calculated with chemical components in groundwater. Therefore, most of chemical components of groundwater in the study area are originated from natural process between rock and groundwater, whereas some of components are derived from sea spary and anthropogenic sources related to agricultural activities.

• Natural Product Sciences
• /
• v.17 no.2
• /
• pp.147-159
• /
• 2011

A high-performance liquid chromatography-electrospray ionization-tandem mass spectrometric method was developed to determine simultaneously eight marker constituents of Forsythiae fructus, and subsequently applied it to classify its two botanical origins. The marker compounds of Forsythia suspensa were phillyrin, pinoresinol, phillygenin, lariciresinol and forsythiaside; those of F.viridissima were arctiin, arctigenin and matairesinol. Separation of the eight analytes was achieved on a phenyl-hexyl column (150${\times}$2.0 mm i.d., 3 ${\mu}M$) using gradient elution with the mobile phase: (A) 10% acetonitrile in 0.5% acetic acid, (B) 40% aqueous acetonitrile. A few fragment ions specific to the types of lignans, among the product ions generated by collisonally induced dissociation (CID) of molecular ion clusters, such as [M-H]$^-$ or [M+OAc]$^-$ were used not only for fingerprinting analysis but for the quantification of each epimer by using multiple-reaction monitoring mode. It was shown good linearity ($r^2{\geq}$ 0.9998) over the wide range of all analytes; intra- and inter-day precisions (RSD, %) were within 9.14% and the accuracy ranged from 84.3 to 115.1%. The analytical results of 40 drug samples, combined with multivariate statistical analyses - principal component analysis (PCA) and hierarchical cluster analysis (HCA) - clearly demonstrated the classification of the test samples according to their botanical origins. This method would provide a practical strategy for assessing the authenticity or quality of the herbal drug.

• International Journal of Reliability and Applications
• /
• v.2 no.3
• /
• pp.209-240
• /
• 2001

Computer-based simulation and analysis is used extensively in engineering for a variety of tasks. Despite the steady and continuing growth of computing power and speed, the computational cost of complex high-fidelity engineering analyses and simulations limit their use in important areas like design optimization and reliability analysis. Statistical approximation techniques such as design of experiments and response surface methodology are becoming widely used in engineering to minimize the computational expense of running such computer analyses and circumvent many of these limitations. In this paper, we compare and contrast five experimental design types and four approximation model types in terms of their capability to generate accurate approximations for two engineering applications with typical engineering behaviors and a wide range of nonlinearity. The first example involves the analysis of a two-member frame that has three input variables and three responses of interest. The second example simulates the roll-over potential of a semi-tractor-trailer for different combinations of input variables and braking and steering levels. Detailed error analysis reveals that uniform designs provide good sampling for generating accurate approximations using different sample sizes while kriging models provide accurate approximations that are robust for use with a variety of experimental designs and sample sizes.