• 대한간호
• /
• 제28권3호
• /
• pp.68-82
• /
• 1989

This study was a quasi-experimental research study to test the characteristics of temperature regulation according to sponge bath methods of cold application. Thirteen volunteers were selected from among nursing college students according to an established criteria using a purposive sampling technique. Four different cold application methods were used: $\circled1$ tepid water sponge bath at $28^{\circ}C$, $\circled2$ 20% alcohol sponge bath at $28^{\circ}C$, $\circled3$ 40% alcohol sponge bath at $28^{\circ}C$ and $\circled4$ tepid water sponge bath at 28$^{\circ}$C plus an ice bag to the head. Changes in rectal temperature, mean skin temperature, mean body temperature, heat content change and thermal discomfort during the cold application were measured at 5 minute intervals over a 120 minute period. The data collection period was from Dec. 20, 1988 to Feb. 3, 1989. The data were analyzed using descriptive statistics, simple regression, ANOVA, Duncan's multiple range test and Pearson correlation coefficient using the SPSS-X Program. The results of the study are summarized as follows. Five general hypothesis were tested. Hypothesis 1 that "Change in heat content will be decreased for each cold application method according to the cold application time" was rejected. (tepid water sponge bath: after 10 minutes of cold application, 20% alcohol sponge bath: after 25 minutes of cold application: 40% alcohol sponge bath: after 45 minutes of cold application, tepid water sponge bath plus an ice bag to the head: after 80 minutes of cold application) Hypothesis 2 that "Thermal discomfort will be changed for each cold application method according to the cold application time" was rejected after 5minutes of cold application. Hypothesis 3 that "Change in heat content will differ among the cold application methods" was accepted except 0~5, 0~10, 0~65, 0~105 and 0~120 minute. This difference showed significance only between sponge bath methods and tepid water sponge bath plus an ice bag to the head. Hypothesis 4 that "Thermal discomfort will differ among the cold application methods" was accepted at 15, 20, 35, 45, 75, 80, 90, 95, 100, 105, 110, 115 and 120 minute of cold application time. This difference showed significance only between sponge bath methods and tepid water sponge bath plus an ice bag to the head. Hypothesis 5 that "The higher the change in heat content, the higher the thermal discomfort during the cold application time" was accepted for between 10~60 and 75 minute of cold application. In conclusion, this study showed that in sponge bath at $28^{\circ}C$, 10~80 minute was a effective cold application time in the view of heat loss through the skin. Concerning the effects of evaporation and thermal discomfort, it was found that there was no difference with regard to the solutions; tepid water sponge bath; 20% alcohol sponge bath or 40% alcohol sponge bath at a $28^{\circ}C$ controlled solution temperature. So it was thought that the type of solution itself did not have a big influence on the heat loss through skin. The combined effect of sponge bath with an ice bag to the head showed a significant difference and also showed a slight increase in thermal discomfort. On the basis of this research it can be concluded that cold application, for example, an ice bag to the head during a tepid water sponge bath is a good method as it increase heat loss through conduction, although fit can also cause a slight increase in thermal discomfort. The correlation between changes in heat content and thermal discomfort were not high. So factors other than change in heat content are considered to have an effect on the cognition of thermal discomfort.

• 한국정보전자통신기술학회논문지
• /
• 제11권3호
• /
• pp.221-228
• /
• 2018

본 연구는 대학생들의 전공선택동기가 진로의사결정에 미치는 영향에 대하여 진로자기효능감을 매개효과로 분석하여 대학생의 진로지도 관련 자료로 활용하고자 한다. 연구대상은 G도에 소재한 4년제 일반대학 5개교 대학생 2, 3, 4학년 1,300명을 비무선적으로 편의표집 하여, 2017년 11월 1일부터 11월 30일까지 설문조사를 실시하였다. 분석방법은 빈도분석, 다중회귀분석, 3단계 매개효과 분석을 하였다. 연구결과 첫째, 전공선택동기는 진로의사결정에 영향을 미치는 것으로 나타났다. 둘째, 전공선택동기가 진로의사결정에 미치는 영향에 대한 진로자기효능감은 부분매개효과를 보이는 것으로 나타났다. 본 연구는 대학생들의 진로지도를 위한 교육의 기초자료가 될 것이다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권3호
• /
• pp.1191-1196
• /
• 2015

Background: Epidermal growth factor-like domain multiple 7 (EGFL7), recently identified as a secreted protein regulated by oxygen exposure, plays a critical role in promoting metastasis of hepatocellular carcinoma (HCC). Transcatheter arterial embolization (TAE) is widely used for treatment of HCC, resulting in hypoxia in tumors and surrounding liver tissues. Accordingly, we proposed the hypothesis that there could be a relationship between expression of EGFL7 and response to TAE. Materials and Methods: We established a rabbit VX2 liver tumor model using percutaneous puncture technique guided by computed tomography. TAE and sham embolization were performed and the results were confirmed by MRI 3 weeks after inoculation. We investigated the EGFL7 expression of the two groups at 6h and 3 days after intervention by means of immunohistochemistry and Western blotting. Results: Immunohistochemical staining demonstrated that the levels of EGFL7 protein significantly increased in the TAE-treated tumors compared with the control group at 6 hours (P=0.031) and 3 days (P=0.020) after intervention. Meanwhile, the relative EGFL7 protein detected in TAE group also up-regulated compared with the control group at 6 hours (P=0.020) and 3 days (P=0.024) after intervention. Conclusions: This study reveals an increase of EGFL7 expression in rabbit VX2 liver tumors after TAE. The role of EGFL7 in HCC, especially its biological behavior after TAE, needs further investigation.

• Asia pacific journal of information systems
• /
• 제18권1호
• /
• pp.53-77
• /
• 2008

In recent years, although numbers of corporations are bringing in PMO, they seem to be indifferent to PMO performance measurement. This demonstrates that there are also other reasons beside performance measurement of information systems (IS) project being ambiguous by introducing PMO; the lack of acknowledging the concrete function of PMO, and the scarcity of empirical study about the effect of PMO on the project members and project performance. In this sense, this study is aimed at proposing a new research model in which project success factors (i.e., standardization, management advocacy, and staff expertise) affect PMO capability (i.e., knowledge management, resources management, and problem solving competency) positively, leading to project performance (i.e., task outcomes, psychological outcomes, and organizational outcomes) eventually. To empirically test the research model, data are surveyed from PMO department and IS department. To prove the validity of the proposed research model, PLS analysis is applied with valid 132 questionnaires. By employing PLS technique, the measurement reliability and validity of research variables are tested and the path analysis is conducted to do the hypothesis testing. The path analysis results can be organized into 7 ways in large scale. First, standardization of project success factors has a positive association with knowledge management, resources management, and problem solving competency of PMO capabilities. The findings of this result indicate that the multiple or single project management should satisfy standardization in order to operate an effective PMO. Second, management advocacy of project success factors has a positive association with knowledge management, resources management, and problem solving competency. Management advocacy refers to the willingness of management to provide the required resources and authority for project success. There is agreement among researchers regarding the importance of management advocacy for favorable PMO capability. Third, staff expertise of project success factors has a positive association with knowledge management, resources management, and problem solving competency. The findings of this result indicate that the formation of an exceptional consultant or members with a proficient knowledge for staff expertise of project member is the key factor to elevate the PMO capability. Past research suggests that experience and knowledge and the resultant familiarity with the problem faced can be an important determinant of PMO capability. A capable project with appropriate staff expertise means that it enjoys a diversity of abilities and experiences. Fourth, knowledge management competency of PMO capabilities has a positive impact on psychological outcomes but has no direct effect on task outcomes and organizational outcomes. In domestic case of S. Korea, PMO was finally introduced to many other corporations in 2005 though it started bringing in 2000. Therefore, it had neither a significant impact on the task outcomes nor organizational outcomes by lacking the contents and the infrastructure of the knowledge management because the knowledge consolidation and management period of PMO is comparatively shorter by terms than other foreign nations. Fifth, resources management competency of PMO capabilities has a positive association with task outcomes, psychological outcomes, and organizational outcomes. In addition, problem solving competency of PMO capabilities has a positive association with task outcomes, psychological outcomes, and organizational outcomes. Therefore, the findings of this results stress that PMO capabilities has a positive impact on project performance. Sixth, according to the path analysis of the hypothesis, which suggested in this research, problem solving competency is the PMO capability which is the key success factor for task, psychological, and organizational outcomes as an integrated performance model. Further, the analysis reveals that problem solving competency is an important factor for integrated performance model. The finding is in line with past IS research, which affirms that the work of IS projects is essentially a problem solving endeavor. Seventh, in the path analysis of the hypothesis in this research, the path of the management advocacy $\rightarrow$ problem solving competency $\rightarrow$ organizational outcomes appears to be the most important and strongest path. In brief, the finding of this study suggests that project success factors influence PMO capability positively, and project performance as well. From the results, it can be concluded that PMO helped great improve the project success rate and project performance. This study advances research on PMO capability in three important aspects. First, the findings of our study have implications for IS theory and future research. Our study contributes to IS theory by synthesizing concepts from PMO research and project management research with those in IS research. We proposed and tested PMO capability of IS projects and the findings of our investigation provided some preliminary answers to some of the questions raised. Secondly, this thesis does not only help depicting the concept of IT governance but also approaches empirically. It makes a gradual approach to the main content, step by step, in contrary of simple standard, scholastic way of thinking. Finally, we argued that this task-oriented(technical) view is not sufficient to adequately conceptualize IS project performance. Hence, we applied that the research on organization teams, which provides a flip viewpoint to that of project management research in that it gives more weight for psychological outcomes of organizational work groups, can be very helpful in reconceptualizing the IS project performance construct. The limitations of this study are also discussed to provide research directions for future research.

• 벤처창업연구
• /
• 제16권4호
• /
• pp.153-165
• /
• 2021

온라인과 오프라인의 경계가 사라지면서 O2O(온라인에서 오프라인으로) 서비스가 급속히 증가하고 있다. 일반 제품과 달리 농식품은 신선도가 중요한 의사결정 요인이며, 다름 품목에 비해 환불 및 교환이 어려운 특성과 새로운 거래 방식으로 인해 O2O의 플랫폼 중 오픈 마켓으로 성장하는데 제한적인 요소가 많다. 이러한 장애를 극복하기 위해서는 소비자의 혁신성이 고려되어야 한다. 본 연구는 O2O(online to offline) 특성 중 빠르게 성장하고 있는 오픈 마켓을 중심으로 쇼핑몰 특성이 농식품 재구매 의도에 미치는 영향을 파악하는데 목적이 있다. 그리고 농식품 쇼핑몰 특성과 재구매 의도에 미치는 영향력에서 혁신성의 조절 효과를 분석하고자 한다. 이를 위해 편의표본추출기법을 이용하여 2021년 3월 1일부터 3월 30일까지 구글 설문을 통해 온라인 설문을 실시하였다. 농식품 오픈 마켓에서 구매경험자 총 270개의 분석 자료를 수집하였다. 분석방법은 spss 프로그램을 사용하였으며, 가설검증을 위해 다중회귀분석을 사용하였다. 분석결과 O2O(online to offline) 쇼핑몰 특성인 경제성, 상호작용성, 유희성은 농식품 재구매 의도에 유의한 정(+)의 영향을 미치는 것으로 나타났다. 상호작용성×혁신성, 유희성×혁신성은 재구매 의도에 유의한 정(+)의 영향을 미치는 것으로 나타났다. 본 연구결과 혁신성은 새로운 시스템이나 모바일 거래에 대하여 소비자의 부담을 줄여주고 있음을 알 수 있다. 본 연구의 결과를 통해서 농식품의 O2O 거래 활성화를 위해서는 혁신성이 낮은 소비자들의 거래를 활성화하기 위한 편리한 인터페이스 설계가 중요하다고 할 수 있다. 더불어 농업인들의 IT 역량강화를 위한 교육과 지원이 필요하다. 본 연구의 결과는 농식품 오픈마켓 쇼핑몰의 인프라 구축 등에 기여할 수 있을 것이다.

• 한국유통학회지:유통연구
• /
• 제17권1호
• /
• pp.37-63
• /
• 2012

가맹사업에 있어 배타적 영업지역보호정책의 문제는 경제학 및 경영학 분야뿐만 아니라 사회 정치적으로 매우 중요한 쟁점이다. 본 연구는 배타적 영업지역과 관련한 기존 문헌을 토대로 가맹사업에서의 효율성 관점에서 배타적 영업지역보호에 영향을 미치는 변수와 배타적 영업지역 보호가 가맹본부 및 가맹점의 성과에 미치는 영향을 분석하고 있다. 가맹점의 대부분이 중소상인들이란 점을 감안하면 유통정책적으로도 중요한 의미가 있다고 할 수 있다. 본연구는 사회적으로도 잇슈가 될 수 있는 기업의 전략을 타당성과 당위성, 그리고 논리성으로만 평가하는 것이 아니라 실제 자료를 근거로 분석하였다. 또, 정책연구들이 가지고 있는 자료와 이론의 한계를 감안한 탐색적 방법론을 활용하여 보다 실질적이고 현실적용성이 뛰어난 분석을 제안하였다. 분석 결과, 배타적 영업지역보호는 긍정적인 효과가 있기는 하지만 통계적으로 유의하지 못하였으며, 가맹점과 가맹본부간의 로얄티가 많아서 위험공유성향이 클때에는 배타적 영업지역보호를 하지 않는 것이 효과적이었고, 가맹점을 모집하기 위해 배타적 영업지역보호를 해주거나 배타적 영업지역보호를 통해서 가맹사업본부내의 효율성을 키우기 위한 경우에는 긍정적인 효과가 유의하게 나타나는 것으로 밝혀졌다. 하지만 외부경쟁으로부터 직영점을 보호하기 위하거나 시장성장을 활용하기 위한 배타적 영업지역보호는 좋은 성과를 내지 못하였다. 또한 쉽게 배타적 영업지역보호를 할 수 있기에 이런 제도를 도입하는 것도 역시 좋은 성과를 내지 못한 것으로 나타났다. 결과적으로 배타적 영업지역보호가 기업의 운영효율을 증대시키기 위하여 하는 경우는 성과가 좋으나 다른 목적을 위하여 배타적 영업지역보호를 활용하는 것은 바람직한 결과를 못내는 것으로 나타났다. 본 연구는 분석결과를 토대로 영업지역 보호를 획일적으로 활용하거나 법으로 강제하기 보다는 가맹사업본부와 가맹점의 관계 및 상황, 또 동기에 맞추어 탄력적으로 적용하는 것이 바람직하다는 제안을 하고 있으며, 이를 근거로 몇 가지 정책적 시사점을 제시하였다.

• 유통과학연구
• /
• 제14권8호
• /
• pp.123-128
• /
• 2016

Purpose - Korean Wave that overspreads around Asia and America, especially the Korean beauty wave, has reached Mongolia and Mongolian consumers. Mongolia consumers usually prefer foreign cosmetic brands to local brands, because the local brands cannot satisfy fast changing needs and wants of local consumers. Research design, data, and methodology - Based on previous studies about life style of Mongolian consumers, advertisement properties and consumer behaviors, we propose a research model and related hypothesis. In order to test hypotheses, we analyzed 366 survey data out of 376 by eliminating improper 10 responses. Factor analysis and reliability analysis was conducted by SPSS 22.0. We used multiple regression analysis and parameter analysis to test the relation between variables. Results - As exploring the Mongolian consumers' current usage of cosmetic products, we found that the customers' focus is how the products fit with their skin. Mongolian consumers often get the information about cosmetic products through TV and internet. Mongolian consumers show positive attitudes on the appearance of Korean celebrities in responsibility, while there is no significant effect on attractiveness. Mongolian consumer's behaviors toward brand have positive effect on both responsibility and attractiveness of Korean commercial celebrities. Responsibility and attractiveness of Korean commercial celebrities have positive effect on the behaviors toward advertisements of cosmetic products. Conclusions - Behaviors toward advertisements of cosmetic products have positive effect on both purchase intention and loyalty of customer. Responsibility and attractiveness of Korean commercial celebrities have positive effect on mediating variable of behavior toward advertisement and independent variable of purchase intention. Responsibility and attractiveness of Korean commercial celebrities have positive effect on mediating variable of behavior toward advertisement and independent variable of loyalty of customer. In order to improve the effect of advertisements, firms need to consider not only the technique of the model but also the image of model in regard to trust and professionalism appealing to consumers. In addition, firms need to choose the model who fits in with the image of the firms and the products and service of the firms. Finally, Mongolian consumers tend to acquire the shopping information through TV advertisements, especially featuring Korean popular stars, thus, TV advertisements can be a wise option in Mongolian cosmetic market.

• Asia pacific journal of information systems
• /
• 제17권2호
• /
• pp.1-28
• /
• 2007

The success of new product development is a key factor for getting competitive advantages. Marketing research has been investigating marketing capability, manufacturing technical capability, cross-functional integration, market knowledge competence, market orientation, and competitive environment as the key success factors of new product development. Recently, the role of IT infrastructure in enhancing new product advantage is assumed in the literature. However, the empirical studies on the role of IT infrastructure are lacking. The purpose of this study is to empirically exam the impacts of IT infrastructure on new product competitive advantage. In this study, IT infrastructure is conceptualized as the flexibility of IT infrastructure. Based on previous research, a conceptual model is established by incorporating the direct impact of IT infrastructure flexibility and its indirect impact through the key success factors on new product development. To empirically test the research model, data are surveyed from a pair of IS department and Marketing department of 92 consumer goods manufacturers. By employing PLS technique, the measurement reliability and reliability of research variables are tested and the path analysis is conducted to do the hypothesis testing. The path analysis shows that IT infrastructure flexibility has no direct effect on new product advantage, However, the indirect effect of IT infrastructure is found, which is mediated by marketing capability, manufacturing technical capability, cross-functional integration, and market orientation respectively. Hence, The flexible IT infrastructure increases cross-functional integration (H1), market orientation (H3), marketing capability (H5), and manufacturing technical capability (H6). All success factors of new product development excepts for competitive environment have a positive association with new product competitive advantages (from H10 to H14). Finally, the path from IT infrastructure flexibility to cross-functional integration, to market orientation, to market knowledge capability, and to new product advantage is found as the strongest path. These results indicate that the flexible IT infrastructure enhances information sharing with multiple departments and collaboration within a distributed innovation environment. The collaboration among departments positively affects the level of customer and competitor intelligence. The ability to obtain knowledge about customers and competitors makes firms to adapt to a changing environment quickly and to respond to customers' demands adequately. The flexible IT infrastructure also enhances the capability of organization to more rapidly respond to the changes in product design resulting in faster product development and reduced costs. In addition to, it enhances marketing capability by the two-way communications with customers and the analyses of various kinds of customer data. In brief, the finding of this study suggests that the flexible IT infrastructure allows many firms to pursue sustained new product competitive advantages. This study advances research on IT infrastructure in two important aspects. First, by Integrating marketing research and IS research, this study develops a conceptual model on the role of IT infrastructure in enhancing new product advantage. Second, it empirically finds the indirect impacts of IT infrastructure on new product advantage, which confirms the potential for the IS field to contribute to new product development research. The limitations of this study are also discussed to provide research directions for future research.

• Clinical and Experimental Reproductive Medicine
• /
• 제23권3호
• /
• pp.247-268
• /
• 1996

여포와 난포의 성숙, 배란과 착상, 임신의 유지와 태아의 성장 발달, 분만 및 유선발육과 비유 등 일련의 생식현상에서 있어서 성선자극호르몬과 스테로이드 호르몬의 작용이 중추적인 역할을 한다는 사실은 오래 전부터 알려져왔다. 그러나 이러한 일련의 현상에 고전적인 호르몬 외에도 다수의 성장인자가 관여되고 있음이 최근의 연구 결과 밝혀지고 있다. 생식기관에서 성장인자들은 대부분 autocrine/paracrine mode로 작용하여, 성선자극호르몬과 스테로이드 호르몬의 작용을 매개하거나 이들 호르몬 등과 교호적인 작용(synergy)을 한다. 생식기관 내 insulin-like growth factor(IGF) system은 최근 가장 활발히 연구된 분야 중의 하나로 생식현상의 전반에 걸쳐 중요한 역할을 하고 있음이 밝혀졌다. 본 지면에서는 IGF system에 관한 개괄적인 정보를 소개하고 현재까지 보고된 intrauterine IGF system에 관한 연구를 요약하고자 한다. IGF family는 IGF-I과 IGF-II ligands, 두종류의 IGF receptors(수용체), 그리고 지금까지 발견된 6종류의 IGF-binding proteins(IGFBPs)로 이루어져 있다. IGF-I과 IGF-II는 proinsulin과 상동한 구조를 가진 peptide로서 포도당과 아미노산 운반을 자극하는 등 insulin과 유사한 작용을 한다. 이 외에도 IGFs는 세포분열촉진제(mitogens)로서 여러 형태의 세포에 걸쳐 세포증식을 자극하고, 세포의 분화(differentiation)과 세포기능의 발현에 관여한다. IGFs는 간과 주로 messenchymal cells에서 발현되어 endocrine mode는 물론 autocrine/paracrine mode로 거의 모든 조직에 작용한다. IGF 수용체는 두종류가 알려져 있는데 type I IGF receptor는 tyrosine kinase로서 IGF-I과 IGF-II에 공히 high-affinity를 나타내고, 상기한 대부분의 IGFs의 작용을 매개한다. Type II IGF receptor 혹은 IGF-II/mannose-6-phosphate receptor는 두개의 서로 다른 binding sites를 가지고 있는데 IGF-II binding site는 IGF-II에만 high-affinity를 나타낸다. Type II IGF receptor의 주요 역할은 IGF-II를 lysosomal targeting하여 ligand를 파괴하는데 있다. 체액 속의 IGFs는 대부분 IGFBP에 결합되어 있다. IGFBPs는 IGF의 저장/운반체 혹은 IGF 작용을 조절하는 역할을 하는 것으로 알려져 있으나 개개 IGFBP의 역할에 대해서는 지극히 제한된 정보만이 알려져 있다. IGFBPs의 IGF ligands에의 affinity는 IGF receptors의 IGFs에의 affinity보다 크기 때문에 대부분의 in vitro 상황 하에서 IGFBPs는 IGF 작용을 억제한다. IGFBP에 결합되어 있는 IGF가 어떤 기작에 의해 IGFBP로부터 분리되어 IGF receptor에 도달하는지는 알려지지 않고 있으나, 혈액과 조직액에 들어있는 불특정 IGFBP protease activity는 IGF의 방출과정에서 일역을 하는 것으로 믿어지고 있다. 최근 연구보고에 의하면 특정 in vitro 상황 하에서 IGFBP-1, -3, -5 등은 IGF와 무관한 작용도 있다는 증빙이 있어 IGF system의 또 다른 차원을 예고하고 있다. IGF family members의 mRNAs & proteins는 영장류, 설치류 및 가축의 자궁조직과 수태물(conceptus)에서 발현되어 자궁과 태아의 성장 발달에 중요한 역할을 한다. 자궁조직의 IGF system의 발현은 성선호르몬, 국소 생리조절인자 등에 의해 발현시기와 장소의 특이성이 결정되며, 발현된 IGFs와 IGFBPs는 autocrine/paracrine mode로 자궁조직에 작용하기도 하고, 자궁강에 분비되어 수태물의 성장 발달에 관여한다. 착상을 전후하여 수태물에서도 IGF system이 발현되는데 개개 IGF family member의 발현 시기는 모체로부터 유래된 mRNA의 유무, 수태물 자체의 genetic programming, 모체와의 상호작용 등에 의해 결정되고, IGFs의 작용 부위 역시 시간(생리적 상태)과 장소의 특이성이 있다. 이와같이 conceptus IGF system의 발현이 시간적, 공간적으로 조절되고있다는 사실은 IGFs가 수태물의 성장 발달에 일역을 한다는 가설을 간접적으로 지지해 준다. 자궁조직과 수태물에서 발현된 IGFs는 세포의 증식과 분화, 포도당과 아미노산의 운반과 단백질합성, placental lactogen과 prolactin 등과 같은 유선자극호르몬의 생성을 자극하고 스테로이드 호르몬의 합성에도 관여한다. 태아의 성장 발달에 있어서 IGFs의 역할은 embryo의 IGF-I, IGF-II, 혹은 IGF receptor gene을 homologous recombination technique에 의해 파괴(gene targeting)하여을 때의 결과로써 입증되었다. 생쥐의 IGF and/or IGF-II gene 혹은 IGF receptor gene을 파괴했을 때 출생 전후 모두 성장 발달이 지연되며 출생시 무게는 정상치의 30-60% 수준에 머물고, 특히 type I IGF receptor gene 혹은 IGF-I과 IGF-II genes를 모두 파괴했을 경우에는 출생 후 곧 치사한다. 자궁 내의 IGFBPs는 IGF ligands를 자궁 내에 제한시키거나 IGFs의 receptor binding을 억제하는 negative regulators 역할을 하는 것으로 믿어지고 있다. 그러나 영장류의 자궁에서 IGFBP-I과 같은 특정 IGFBP는 IGFs보다 월등히 많은 양이 발현 분비되고 있는 것으로 추산되고 있으며, 또한 이 단백질은 모체탈락막세포에서 분비되는 주요 단백질 중의 하나라는 점을 감안할 때 IGFBP-I이 IGF과 무관한 작용이 있을 가능성도 배제할 수 없다. 따라서 IGFBPs의 역할 규명은 IGF system을 이해하는데 중요한 부분을 차지하고 있어 향후 이 분야의 연구에 많은 기대와 촛점이 모여지고 있다.