• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1995년도 제3회 추계심포지움
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• pp.9-15
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• 1995

When quiescent cells ate stimulated to enter the cell cycle, the thymidine kinase(TK) gene is transcriptionally activated at the border of Gl and 5. In this report we show that the human TK promoter contains multiple protein-binding sites. By site-directed mutagenesis, we identified a protein-binding site on the human TK promoter requited for conferring Gl-S-regulated transcription to a heterologous promoter and dissociated it functionally from an adjacent protein-binding domain containing an inverted CCAAT motif requited for high basal level expression. Substitution-mutation of this site results in constitutive expression of the neo reporter gene in serum-stimulated fibroblasts, as well as in cells arrested in mid-Gl by a temperature-sensitive mutation. The regulatory domains for the human TK promoter exhibit interesting symmetrical features, including a set of CCAAT motifs and sites similar to the novel Yi protein-binding site recently discovered in the mouse TK promoter. Thus, components of the hTK complex is important for hTK gene regulation.

• Imaging Science in Dentistry
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• 제42권2호
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• pp.105-109
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• 2012

Radicular cyst is the most common odontogenic cyst occurring in the jaws. The cyst is commonly found in relation to the maxillary anterior teeth in the third and fifth decade of life. Although multiple radicular cysts are not uncommon in the jaws, bilaterally symmetrical representation of these cysts is rare. Radiographs prior to extraction help in diagnosis of these cysts and thereby prevent further morbidities. We report a case of 16-year-old male patient who presented bilateral radicular cysts symmetrically in the mandible.

• 전자공학회논문지A
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• 제31A권8호
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• pp.16-25
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• 1994

The prediction of crosstalk in one of important problems in estimating the EMC of a system for high speed digital signal transmission. Crosstalk curves are shown in terms of characteristic impedance of lines spacing between lines and rise time of pulse by using general multiple coupled transmission line equation and harmonic-balance method. The coupled symmetrical two-line on dielectric material epoxy-glass FR 4(${\varepsilon}_r$), is fabricated to measure crosstalk occuring at the near end and far end of the passive line. The inter-line is inserted to reduce crosstalk between two microstrip lines. The simulation results and the measurement results are shown and found to be very close.

• Journal of Periodontal and Implant Science
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• 제51권2호
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• pp.77-87
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• 2021

Purpose: The aim of this study was to compare the efficacy of the tunnel technique for root coverage using a new xenogeneic acellular dermal matrix vs. connective tissue grafting (CTG) for the treatment of multiple maxillary adjacent recessions (recession type 1) at 12 months postoperatively. Methods: This study enrolled 12 patients with at least 3 contiguous, bilateral, symmetrical maxillary gingival recessions (i.e., at least 6 recessions per patient). In total, 74 recessions were treated using the modified coronally advanced tunnel (MCAT) technique combined with a novel porcine-derived acellular dermal matrix (PADM) at 37 test sites or CTG at 37 control sites. The following clinical parameters were measured: recession height, clinical attachment level, width of keratinized tissue, probing depth, recession width, gingival thickness, mean root coverage (MRC), and complete root coverage (CRC). Comparisons between test and control groups were made for pain visual analog scale scores at 14 days. Results: At 12 months, the MCAT with PADM (test) yielded a statistically significant improvement in all clinical parameters studied. MRC was significantly higher on the control sides (80.6%±23.7%) than on the test sides (68.8%±23.4%). Similarly, CRC was 48.7%±6.8% on the control sides (CTG), in contrast to 24.3%±8.2% on the test sides (PADM). Statistically significant differences were observed in favor of the control sides for all clinical parameters studied. Nevertheless, the MCAT in adjunction with PADM was clearly superior at reducing mean and maximum patient-reported postoperative pain intensity and pain duration in the first week after surgery. Conclusions: The use of PADM to treat multiple recessions improved clinical parameters at 12 months, but these outcomes were nevertheless poorer than those observed for CTG. However, PADM reduced morbidity, particularly the pain experienced by patients.

• Parasites, Hosts and Diseases
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• 제51권6호
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• pp.739-742
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• 2013

A 52-year-old woman presented with lower back pain, progressive symmetrical paraparesis with sensory impairment, and sphincter disturbance. Magnetic resonance imaging (MRI) of the whole spine revealed multiple intradural extramedullary serpiginous-mass lesions in the subarachnoid space continuously from the prepontine to the anterior part of the medulla oblongata levels, C7, T2-T8, and T12 vertebral levels distally until the end of the theca sac and filling-in the right S1 neural foramen. Sparganosis was diagnosed by demonstration of the sparganum in histopathological sections of surgically resected tissues and also by the presence of serum IgG antibodies by ELISA. DNA was extracted from unstained tissue sections, and a partial fragment of mitochondrial cytochrome c oxidase subunit 1 (cox1) gene was amplified using a primer set specific for Spirometra spp. cox1. After sequencing of the PCR-amplicon and alignment of the nucleotide sequence data, the causative agent was identified as the larva of Spirometra erinaceieuropaei.

• 대한한의학회지
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• 제24권4호
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• pp.139-148
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• 2003

Objectives : Polyneuropathies are diseases of multiple peripheral nerves. They are usually characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. It is generally regarded that the natural courses are poor, so we wanted to study the effects of Oriental medical treatment on a patient with polyneuropathy. Methods : We treated by conservative Oriental medical treatment a woman of 68 years who was diagnosed as a polyneuropathy and was hospitalized at Seoul Oriental Hospital, Kyungwon University, from 12th Mar. to 31st May, 2003. Changes of functional disability were checked by Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS), muscle atrophy was checked by measuring circumference of the thighs, calves, arms, and sensory impairment was checked by a sensory test. Results : 1. Functional disability caused by motor impairment was reduced after the Oriental medical treatment 2. Muscle atrophy was reduced after the Oriental medical treatment 3. Sensory impairment was reduced after the Oriental medical treatment Conclusion : We treated a patient who was diagnosed with polyneuropathy for over 80 days and recorded good effects of Oriental medical treatment on polyneuropathy.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제6권5호
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• pp.1354-1372
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• 2012

Route establishment in Mobile Ad Hoc Network (MANET) is the key mechanism to a successful connection between a pair of source and destination nodes. An efficient routing protocol constructs routing path with minimal time, less routing overhead and capable of utilizing all possible link connectivity. In general, most on-demand MANET routing protocols operates over symmetrical and bidirectional routing path, which is infeasible due to the inherent heterogeneous properties of wireless devices. Simulation results show that the presence of unidirectional links on a network severely affect the performance of a routing protocol. In this paper, a robust protocol independent scheme is proposed, which enable immediate rediscovery of alternative route for a path blocked by a unidirectional link. The proposed scheme is efficient; route rediscovery is locally computed, which results in significant minimization of multiple route packets flooding. Nodes may exploit route information of immediate neighbors using the local reply broadcast technique, which then redirect the control packets around the unidirectional links, therefore maintaining the end-to-end bidirectional connection. The proposed scheme along with Ad Hoc On-demand Distance Vector (AODV) and AODV-Blacklist routing protocol is investigated over three types of mobility models. Simulation results show that the proposed scheme is extremely reliable under poor network conditions and the route connectivity can be improved by as much as 75%.

• Journal of Yeungnam Medical Science
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• 제40권4호
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• pp.423-425
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• 2023

Porokeratosis ptychotropica is an uncommon form of porokeratosis, which was initially described in 1995. It is clinically characterized by symmetrical reddish to brown-colored hyperkeratotic, verrucous, or psoriasiform plaques on the perianal and gluteal regions. The lesions tend to integrate and expand centrally, with small peripheral satellite lesions. Early skin biopsy and appropriate diagnosis are essential because malignant change occurs in 7.5% of porokeratotic lesions. Conventional treatment options include topical steroid, retinoid, imiquimod, 5-fluorouracil, isotretinoin, excimer laser, photodynamic therapy, intralesional steroid or bleomycin injection, cryotherapy, carbon dioxide (CO₂) laser, and dermatome and excision, but none seem to achieve complete clearance. A 68-year-old woman presented with diffuse hyperkeratotic scaly lichenoid plaques on the buttocks that had persisted for several years. A skin biopsy of the buttocks revealed multiple cornoid lamellae and intense hyperkeratosis. There were some dyskeratotic cells beneath the cornoid lamellae and the granular layer was absent. Porokeratosis ptychotropica was diagnosed based on the characteristic clinical appearance and typical histopathological manifestations. She was treated with a CO₂ laser in one session and topical application of urea and imiquimod cream for 1 month. The lesions slightly improved at the 1-month follow-up. We herein present a rare case of porokeratosis ptychotropica.

• 대한수의학회지
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• 제32권4호
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• pp.543-553
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• 1992

Properties of unitary ATP-sensitive $K^+$ channels were studied using planar lipid bilayer technique. Vesicles were prepared from bullfrog (Rana catesbeiana) skeletal muscle. ATP-sensitive $K^+$ (K (ATP)) channels were identified by their unitary conductance and sensitivity to ATP. In the symmetrical solution containing 200mM KCI, 10mM Hepes, 1mM EGTA and pH 7.2, single K (ATP) channels showed a linear current-voltage relations with slight inward rectification. Slope conductance at reversal potential was $60.1{\pm}0.43$ pS(n=3)). Micromolar ATP reversibly inhibited the channel activity when applied to the cytoplasmic side. In the range of -50~＋50 mV, the channel activity was not voltage-dependent, but the channel gating within a burst was more frequent at negative voltage range. Varying the concentrations of external/internal KCl(mM) to 40/200, 200/200, 200/100 and 200/40 shifted reversal potentials to $-30.8{\pm}2.9$(n=3), $-1.1{\pm}2.7$(n=3), 10.5 and 30.6(mV), respecrivety. These reversal potentials were close to the expected values by the Nernst equation, indicating nearly ideal selectivity for $K^+$ over $Cl^-$. Under bi-ionic conditions of 200mM external test ions and 200mM internal $K^+$, the reversal potentials for each test ion/K pair were measured. The measured reversal potentials were used for the calculation of the releative permeability of alkali cations to $K^+$ ions using the Goldman-Hodgkin-Katz equation. The permeability sequence of 5 cations relative to $K^+$ was $K^+$(1), $Rb^+$(0.49), $Cs^+$(0.27), $Na^+$(0.027) and $Li^+$(0.021). This sequence was recognized as Eisenman's selectivity sequence IV. In addition, modelling the permeation of $K^+$ ion through ATP-sensitive $K^+$ channel revealed that a 3-barrier 2-site multiple occupancy model can reasonably predict the observed current-voltage relations.

• 한국인터넷방송통신학회논문지
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• 제13권4호
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• pp.193-200
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• 2013

최근 이동통신 뿐 만 아니라 TV방송 등에서도 릴레이를 이용한 양방향 무선채널의 전송효율을 높이기 위한 네트워크 코딩에 관한 연구가 활발히 진행되고 있다. 본 논문에서는 동시에 여러 개의 릴레이가 전송하는 대신 최선의 릴레이를 이용하여 양방향 데이터를 전송하는 네트워크 코딩 시스템의 평균 전송용량 및 오수신율을 유도하였다. 일반적으로 양방향 통신 시스템의 경우 순방향 및 역방향 링크의 데이터 비대칭성이 존재하므로, 데이터 대칭 링크와 비대칭 링크도 포함하여 성능을 유도하였다. 유도한 결과 병렬 릴레이의 수가 증가할수록 공간 다이버시티에 의한 신호 대 잡음비(SNR) 이득이 증가함을 알 수 있었고, 대칭 링크의 경우 주어진 조건하에서 단일 릴레이를 사용하였을 때보다 9개의 릴레이가 존재하는 경우 11.4 dB의 SNR 이득을 얻을 수 있었다. 또한 비대칭 링크의 경우, 오수신율은 데이터 비대칭성보다는 릴레이의 수에 민감하다는 결과를 얻었다.