• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.10
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• pp.7061-7070
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• 2015

Multi-Response Surface Optimization aims at finding the optimal setting of input variables considering multiple responses simultaneously. The Weighted Mean Squared Error (WMSE) minimization approach, which imposes a different weight on the two components of mean squared error, squared bias and variance, first obtains WMSE for each response and then minimizes all the WMSEs at once. Most of the methods proposed for the WMSE minimization approach to date are classified into the prior preference articulation approach, which requires that a decision maker (DM) provides his/her preference information a priori. However, it is quite difficult for the DM to provide such information in advance, because he/she cannot experience the relationships or conflicts among the responses. To overcome this limitation, this paper proposes a posterior preference articulation method to the WMSE minimization approach. The proposed method first generates all (or most) of the nondominated solutions without the DM's preference information. Then, the DM selects the best one from the set of nondominated solutions a posteriori. Its advantage is that it provides an opportunity for the DM to understand the tradeoffs in the entire set of nondominated solutions and effectively obtains the most preferred solution suitable for his/her preference structure.

• Proceedings of the Microbiological Society of Korea Conference
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• 2000.10a
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• pp.78-82
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• 2000

The AIDS epidemic continues unabated in many part of the world. After near two decades, no vaccine is available to combat the spread of this deadly disease. Much of the HIV -1 vaccine effort during the past decade has focused on the viral envelope glycoprotein, largely because it is the only protein that can elicit neutralizing antibodies (Nabs). Eliciting broadly cross-reactive Nabs has been a primary goal. The intrinsic genetic diversity of the viral envelope, however, has been one of the major impediments in vaccine development. We have recently completed a comprehensive study examining whether it is possible to elicit broadly acting Nabs by immunizing monkeys with mixtures of envelope proteins from multiple HIV -1 isolates. We compared the humoral immune responses elicited by vaccination with either single or multiple envelope proteins and evaluated the importance of humoral and non-humoral immune response in protection against a challenge virus with a homologous or heterologous envelope protein. Our results show that (1) Nab is the correlate of sterilizing immunity, (2) Nabs against primary HIV -1 isolates can be elicited by the live vector-prime/protein boost approach, and (3) polyvalent envelope vaccines elicit broader Nab response than monovalent vaccines. Nonetheless, our findings clearly indicate that the increased breadth of Nab response is by and large limited to strains included in the vaccine mixture and does not extend to heterologous non-vaccine strains. Our study strongly demonstrates how difficult it may be to elicit broadly reactive Nabs using envelope proteins and sadly predicts a similar fate for many of the vaccine candidates currently being evaluated in clinical trials. We have started to evaluate other vaccine candidates (e.g. genetically modified envelope proteins) that might elicit broadly reactive Nabs. We are also exploring other vaccine strategies to elicit potent cytotoxic T lymphocyte responses. Preliminary results from some of these experiments will be discussed.

• PNF and Movement
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• v.12 no.2
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• pp.71-80
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• 2014

Purpose: The purpose of this study was to provide basic data to establish effective clinical training programs by identifying various factors that influence the satisfaction of physical therapy students with those programs. Methods: The study subjects were 205 students from six colleges (two 4-year and four 3-year colleges) who participated in clinical training programs. The colleges have physical therapy departments and are located in Busan, Ulsan, and Gyeognam. A survey consisting of 75 questions was conducted between March and December, 2003. Survey responses were analyzed through a frequency analysis, descriptive statistics, and the multiple responses approach, and correlations among the questions were analyzed using a chi-square test. Results: The level of satisfaction with clinical training programs did not differ according to the school system or the size of the clinical training institution. However, several factors led to a higher level of satisfaction, including more active participation of students in the clinical training, more intensive instruction from school professors, a larger number of subjects to complete before the clinical training, and a higher level of student perception that their institution's clinical training program was systematic Conclusion: This study surveyed physical therapy students located in Busan, Ulsan, and Gyeongnam who attended selected schools and training institutions that have their own individual characteristics; therefore, this study may have limitations for comparative analysis. However, if more extensive studies are per formed regionally in the future using the approach taken here, clinical training programs could be developed that can satisfy both schools and the industry.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.1
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• pp.97-105
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• 2015

Multiresponse optimization (MRO) seeks to find the setting of input variables, which optimizes the multiple responses simultaneously. The approach of weighted mean squared error (WMSE) minimization for MRO imposes a different weight on the squared bias and variance, which are the two components of the mean squared error (MSE). To date, a weighted sum-based method has been proposed for WMSE minimization. On the other hand, this method has a limitation in that it cannot find the most preferred solution located in a nonconvex region in objective function space. This paper proposes a Tchebycheff metric-based method to overcome the limitations of the weighted sum-based method.

• Journal of Korean Society for Quality Management
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• v.43 no.3
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• pp.341-358
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• 2015

Purpose: This paper presents graphic methods and desirability function approach to determine best vibration reducing configuration for Surion helicopter. Many flight tests were executed and nine vibration levels in cockpit, cabin, and engine room were measured in each test and analyzed to find optimal configuration. Methods: Graphic analysis methods such as matrix, scatter, and box plots are used to identify better vibration-reducing flight test conditions. As an integrated measure of the performance of 9 vibration levels desirability function approach is adopted. Results: Three vibration reducing configurations are found to be proper and one configuration is recommended. Conclusion: It is expected to be helpful to adopt graphic and desirability function methods presented in this paper in developing new products or systems like helicopters. For efficient and effective flight testing of helicopters, it will be necessary to have consistently homogeneous environment for flight testing and applying design of experiments techniques and analyzing test data.

• Smart Structures and Systems
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• v.30 no.3
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• pp.303-315
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• 2022

The degradation of wheel tread may result in serious hazards in the railway operation system. Therefore, timely wheel defect diagnosis of in-service trains to avoid tragic events is of particular importance. The focus of this study is to develop a novel wheel defect detection approach based on the relevance vector machine (RVM) which enables online detection of potentially defective wheels with trackside monitoring data acquired under different running-speed conditions. With the dynamic strain responses collected by a trackside monitoring system, the cumulative Fourier amplitudes (CFA) characterizing the effect of individual wheels are extracted to formulate multiple probabilistic regression models (MPRMs) in terms of multi-kernel RVM, which accommodate both variables of vibration frequency and running speed. Compared with the general single-kernel RVM-based model, the proposed multi-kernel MPRM approach bears better local and global representation ability and generalization performance, which are prerequisite for reliable wheel defect detection by means of data acquired under different running-speed conditions. After formulating the MPRMs, we adopt a Bayesian null hypothesis indicator for wheel defect identification and quantification, and the proposed method is demonstrated by utilizing real-world monitoring data acquired by an FBG-based trackside monitoring system deployed on a high-speed trial railway. The results testify the validity of the proposed method for wheel defect detection under different running-speed conditions.

• Journal of KSNVE
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• v.9 no.2
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• pp.377-386
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• 1999

This paper is a study on model method for estimating system inputs from vibration responses, which is one of indirect input identification methods in frequency domain. The method has advantages over direct inverse method especially when points of operational inputs are inaccessible so that artificial excitation forces cannot be applied to obtain frequency response functions of the complete system. Procedures of extended modal model method are proposed and checked by numerical experiment. Mechanisms of error propagation, i.e., how errors in modal parameters such as poles nad mode shape vectors affect estimation of the input forces, are illustrated. Then, in order to counteract the error propagation, discrete modal filter approach is taken in this paper to compute the inversion of modal matrix in which the most serious errors seem to be generated. Further, a Reduced form of Modified Reciprocal Modal Vector(RMRMV) is proposed for estimating multiple inputs. It is shown to have smaller orthogonality error than MRMV.

• Structural Engineering and Mechanics
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• v.34 no.1
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• pp.97-107
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• 2010

Nonlinear thermoelastic static response characteristics of laminated composite conical panels are studied employing finite element approach based on first-order shear deformation theory and field consistency principle. The nonlinear governing equations, considering moderately large deformation, are solved using Newton-Raphson iterative technique coupled with the adaptive displacement control method to efficiently trace the equilibrium path. The validation of the formulation for mechanical and thermal loading cases is carried out. The present results are found to be in good agreement with those available in the literature. The adaptive displacement control method is found to be capable of handling problems with multiple snapping responses. Detailed parametric study is carried out to highlight the influence of semicone angle, boundary conditions, radius-to-thickness ratio and lamination scheme on the nonlinear thremoelastic response of laminated cylindrical and conical panels.

• IMMUNE NETWORK
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• v.20 no.1
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• pp.4.1-4.17
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• 2020

Tregs have a role in immunological tolerance and immune homeostasis by suppressing immune reactions, and its therapeutic potential is critical in autoimmune diseases and cancers. There have been multiple studies conducted on Tregs because of their roles in immune suppression and therapeutic potential. In tumor immunity, Tregs can promote the development and progression of tumors by preventing effective anti-tumor immune responses in tumor-bearing hosts. High infiltration of Tregs into tumor tissue results in poor survival in various types of cancer patients. Identifying factors specifically expressed in Tregs that affect the maintenance of stability and function of Tregs is important for understanding cancer pathogenesis and identifying therapeutic targets. Thus, manipulation of Tregs is a promising anticancer strategy, but finding markers for Treg-specific depletion and controlling these cells require fine-tuning and further research. Here, we discuss the role of Tregs in cancer and the development of Treg-targeted therapies to promote cancer immunotherapy.

• Journal of Digital Convergence
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• v.14 no.5
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• pp.227-236
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• 2016

Co-creation is an important approach to innovation that uses internal and external sources for value creation. This study identified the effects of intrinsic motivation, extrinsic motivation, and the moderating effects of activation factors using multiple regression and moderated multiple regression. To this end, 181 usable questionnaires were collected and analyzed. The result of analysis showed that intrinsic motivation had the significant meaning and the moderating effects of activation factors on the relationship between extrinsic motivation and co-creation participation exist. Companies may use this result to activate the co-creation participation of the customer. The future study analyzed by survey responses in multiple layers will improve the generalization of the study.