• Bulletin of the Korean Chemical Society
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• 제35권5호
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• pp.1294-1298
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• 2014

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer representing 85% of lung cancer patients. Despite several EGFR-targeted drugs have been developed in the treatment of NSCLC, the clinical efficacy of these EGFR-targeted therapies is being challenged by the occurrence of drug resistance. In this regard, Hsp90 represents great promise as a therapeutic target of cancerous diseases due to its role in modulating and stabilizing numerous oncogenic proteins. Accordingly, inhibition of single Hsp90 protein simultaneously disables multiple signaling networks so as to overcome drug resistance in cancer. In this study, we synthesized a series of 11 butein analogues and evaluated their biological activities against gefitinibresistant NSCLC cells (H1975). Our study indicated that analogue 1h inhibited the proliferation of H1975 cells, down-regulated the expression of Hsp90 client proteins, including EGFR, Met, Her2, Akt and Cdk4, and upregulated the expression of Hsp70. The result suggested that compound 1h disrupted Hsp90 chaperoning function and could serve a potential lead compound to overcome the drug resistance in cancer chemotherapy.

• International journal of advanced smart convergence
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• 제8권4호
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• pp.58-67
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• 2019

The purpose of this study was to examine the relationship between sleep disorders, job satisfaction, health promotion behavior, quality of life, turnover intention. And also to find the predicting factors on turnover intention of shift and non-shift nurses. A descriptive study design was used. Study subjects were 239 nurses worked as a shift (167) and non-shift (72) in two general hospitals in P city. Turnover Intent, Sleep disorders, Job satisfaction, practicing health promotion profile and quality of life scales were used to collect the data. Data were analyzed by descriptive statistics and Pearson's correlation coefficient for find the relationship between study variables. Stepwise multiple regressions used to find predicting factors of turnover intention with other variables. The shift group showed lower Job satisfaction, practice of health promotion behavior and intention of turnover than non-shift nurses. The most important predictive factors of turnover intention in of shift group was job satisfaction (β =-. 477, p <.001) and non-shift group was health promotion behavior (β =-. 295, p = .040) than other factors. Findings showed that turnover intention highly influenced by job satisfaction than health promoting behavior and quality of life. This study suggests organizational efforts to provide sufficient staffing and nurse managersshould make more concentration to allot work schedule in order to avoid over load shift nurses and promote quality of client care.

• 정보처리학회논문지D
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• 제8D권4호
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• pp.439-450
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• 2001

Mobile agent is one of the promising ways of overcoming network load and latency. It is also a new software paradigm including those concepts of client/server, applet/servelet, and code-on-demand. In this paper, a new mobile agent concept with flexible replay scheme is proposed, which can deal with embarrassing situation when replying results should be accomplished in various distributed applications. For example, they are 1) a burden of bulky result, 2) a need of different replay scheme dependent on work type, 3) connection failure to the target node, and 4) a need of fast migration to next node to keep the itinerary. Regarding the source node, there may be another situation that it wants to be aware of whether its wi가 is completed or not. Three kinds of reply schemes are proposed for dealing flexibly with such situations. They are based on priority reply list where nodes to be replied are stored according to their priorities. An experimental supply chain management model using the proposed reply schemes is designed and implemented. It is one of good distributed applications appropriate for our reply schemes, because it requires different reply schemes according to work types and it is important to gather required information in time.

• 감성과학
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• 제23권1호
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• pp.57-68
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• 2020

This research investigates how digital design agencies and client companies incorporate design thinking-a human-centered approach to solving difficult problems-into their website development processes. Based on a literature review on the design-thinking-driven web development process, multiple case studies of award-winning website projects were performed by in-depth interviews with key practitioners. Through analyses of these cases, their user-centered approaches for website innovation were identified according to the following four phases: web planning (discovery and defining phases) and web design and development (development and delivery phases). Moreover, distinct approaches of design thinking practices were identified according to two website types: a brand promotion website with a killer brand storytelling approach; and a service channel website with a strategic UI/UX-driven approach. Next, the key success drivers of these website projects were suggested in light of the typical themes of design thinking (i.e., human centeredness, research based, context awareness, and collaboration). Some practical limitations were also found in adopting the design-thinking-driven web development process, such as limited research methods and tools, and insufficient prototyping and experimentation. Along with these limitations, it was also discovered that current digital design agencies still face the following challenges in adopting the design-thinking-driven web development process: building a long-term, playful partnership with clients; leveraging decision-makers' design thinking awareness; and coping with limited resources (design thinking practitioners, budgets, and schedules).

• Wind and Structures
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• 제26권2호
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• pp.69-74
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• 2018

Nowadays, using math logic in great civil projects is considered by the clients to achieve the goals of project including quality optimization, costs, avoiding individual, emotional and political decision making, long-term and short-term goals and they are the main requirements of each project and should be considered by the decision makers to avoid the illogical decision making applied on the majority of civil projects and this imposes great financial and spiritual costs on our country. The present study attempts to present one of the civil projects (Ghasre Shirin storage dam) whose client was not ministry of energy for the first time and the short-term and long-term goals of the private sector were applied based on the triangle of quality, cost and time. Also, the math logic and model (multi-criteria decision making method and decision making matrix) is used in one of the most important sections of project, sealing element, policies and new materials (Geosynthetics) are considered and this leads to suitable decision making in this regard. It is worth to mention that this method is used for other sections of a dam including body, water diversion system, diaphragm and other sectors or in other civil projects of building, road construction, etc.

• 성인간호학회지
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• 제20권2호
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• pp.341-352
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• 2008

Purpose: The purpose of this study was to identify relatively important predictors of quality of life (QOL) of HSCT recipients among client's characteristics(age, gender, family income, religiosity), HSCT-related characteristics(time since HSCT, type of HSCT, decision maker of HSCT) and social support. Methods: Eighty two participants who had a HSCT were recruited for the study. Data were analyzed by descriptive analysis, pearson's correlation, ANOVA and stepwise multiple regression using SPSS for Window(version 12.0) program to answer the research questions. Results: Family income, time since HSCT and religiosity explained 23.8% of the variance in the QOL of HSCT recipients. HSCT recipients who had higher family income, longer time past since HSCT, and more religious tend to have higher quality of life. Conclusion: Based on the findings of this study, we could know that the HSCT recipients need certain amount of time to recover their QOL after HSCT. Opportunities of reemployment and religious support should be considered when we develop intervention program for HSCT recipients.

• 한국콘텐츠학회논문지
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• 제5권2호
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• pp.79-85
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• 2005

웹 서버 클러스터 환경에서 다중의 서버들이 원활하게 상호연동을 수행하여 클라이언트의 요청을 처리 하기 위해서는 TCP 정보나 요청되는 대상의 컨텐트(content)정보를 이용하여 라우팅을 수행하는 라우터의 구현이 필수적이다. 본 논문의 구현 패키지 S/W에 의해 데이터 생성기, 가상서버, 서버1,2,3 에서 발생하는 패킷의 량을 측정한 것으로 서버1,2,3에게 트래픽을 분산시키는지 파악할 수 있었으며, 실험결과와 같이 들어오는 데이터의 크기가 많이 차이나지 않는 이상 라운드 로빈 알고리즘은 확실한 형태의 트래픽 분산을 가능하게 해주었다. 그리고 일부분에서 오차가 심한 경우도 있지만 횟수를 거듭하고 테스트가 장기화 될수록 오차는 줄어들었다.

• 한국건축시공학회지
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• 제2권1호
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• pp.147-154
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• 2002

In the Past, The selection of individual method of construction was done by head of construction site or an experienced person very frequently. By doing this, The wrong selection of construction method without exact adjudication of construction site situation lead to increasing of cost and extension of construction term. Finally it will effect all over the construction process. Especially, In case of underground construction in the beginning, there are a lot of a variable factor and it also effect on the entire construction process and it need very careful process. The purpose of this study is to present the best suitable methodology for selection of construction method by considering potential risk of construction method and variables together with external condition for underground construction. The purpose of this study Is to select the most suitable construction method by analysing potential conditions(construction site situation and client request in designing ) To do this, We prepared arrangement rule to arrange the conditions for construction method. And thin make checklist of the analyzing construction method. Though above process, To expect the risk of individual construction method using above risk checklist and using Analytic Hierarchy process among Multiple-Criteria Decision making, the professional opinions is to be adapted. By doing this, it can lead and select the most suitable construction method considering the data which get from risk density test.

• 한국통신학회논문지
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• 제29권2C호
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• pp.283-290
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• 2004

웹(Web)이 급속히 발전함에 따라 웹상에서 단순한 텍스트 파일 뿐 아니라 이미지, 오디오, 비디오 등의 멀티미디어 서비스에 대한 사용자의 요구도 기하급수적으로 증가하고 네트워크 대여폭의 수요도 급격히 증가하고 있다. 이러한 상황에서 콘텐츠의 빠른 전송과 적은 트래픽 발생을 위하여 Caching, P2P, CDN 등의 기술이 대두되었다. 본 연구에서는 콘텐츠가 여러 복제 웹 서버에 분산 배치되어 있는 환경에서 클라이언트의 요청에 가장 적절한 서비스를 해 줄 수 있는 웹 서버를 선택하기 위한 리다이렉션 시스템을 설계하고 구현하였다. 본 리다이렉션 시스템은 클라이언트의 요청을 토폴로지 상 가깝고 부하가 적은 복제 웹 서버로 리다이렉트 함으로써 클라이언트가 기대하는 응답시간을 단축시켰다. 이러한 연구는 지속적으로 증가하고 있는 대규모 멀티미디어 콘텐츠의 안정적이고 빠른 전송에 기여할 것이다.

• 정보과학회 컴퓨팅의 실제 논문지
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• 제22권1호
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• pp.26-31
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• 2016

Migrim(Migration enhanced Grid Middleware)은 임베디드 단말과 다중 서버들 간의 통신 미들웨어이다. 기존의 통신 미들웨어는 단말이 서버의 자원 상태를 알지 못하기 때문에, 특정 서버에 부하가 집중될 경우에도 그 서버로 계속 요청을 보내는 문제가 있다. 또한 단말은 서버가 가진 정보를 알 수 없기 때문에, 트랜잭션 처리 결과에 대한 정확도를 보장하기 어렵다. 병목현상과 응답 정확도 문제 해결을 위해, 본 논문에서는 Migrim에 적용한 커넥션 이전과 트랜잭션 이전 기법을 제안한다. 커넥션을 다른 서버로 위임하는 과정인 커넥션 이전을 통해 전체 서버에 부하를 균등하게 분산시킬 수 있고, 트랜잭션 처리를 다른 서버로 위임하는 과정인 트랜잭션 이전을 통해 응답의 정확도를 높일 수 있다.