• Title/Summary/Keyword: Multifunctional particle

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Development of New Biochip Using Magnetic Force (자기력에 의한 신규 바이오칩의 개발)

  • Choi, Yong-Sung;Moon, Jong-Dae;Lee, Kyung-Sup
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2006.05a
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    • pp.105-108
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    • 2006
  • This paper describes a new constructing method of multifunctional biosensor using many kinds of biomaterials. A metal particle and an array was fabricated by photolithographic. Biomaterials were immobilized on the metal particle. The array and the particles were mixed in a buffer solution, and were arranged by magnetic force interaction and random fluidic self-assembly. A quarter of total Ni dots were covered by the particles. The binding direction of the particles was controllable, and condition of particles was almost with Au surface on top. The particles were successfully arranged on the array. The biomaterial activities were detected by chemiluminescence and electrochemical methods.

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Development of New Biochip using Magnetic Interaction and Random Fluidic Self-assembly (자기력과 Random Fluidic Self-assembly에 의한 신규 바이오칩의 개발)

  • Choi, Yong-Sung;Kwon, Young-Soo;Park, Dae-Hee
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.17 no.6
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    • pp.615-621
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    • 2004
  • This paper describes a new constructing method of multifunctional biosensor using many kinds of biomaterials. A metal particle and an array was fabricated by photolithographic. Biomaterials were immobilized on the metal particle. The array and the particles were mixed in a buffer solution, and were arranged by magnetic force interaction and random fluidic self-assembly. A quarter of total Ni dots were covered by the particles. The binding direction of the particles was controllable, and condition of particles was almost with Au surface on top. The particles were successfully arranged on the array. The biomaterial activities were detected by chemiluminescence and electrochemical methods.

Protein Chip Using Magnetic Force (자기력에 의한 단백질칩)

  • Choi, Yong-Sung;Moon, Jong-Dae;Lee, Kyung-Sup
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2006.06a
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    • pp.386-387
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    • 2006
  • This research describes a new constructing method of multifunctional biosensor using many kinds of biomaterials. A metal particle and an array was fabricated by photolithographic. Biomaterials were immobilized on the metal particle. The array and the particles were mixed in a buffer solution, and were arranged by magnetic force interaction and self-assembly. A quarter of total Ni dots were covered by the particles. The binding direction of the particles was controllable, and condition of particles was almost with Au surface on top. The particles were successfully arranged on the array. The biomaterial activities were detected by chemiluminescence and electrochemical methods.

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Qualitative Properties of Sulgidduk with the Different Density of Rice Powder Made by Multifunctional Grinder (가정용 믹서류를 이용하여 제조한 설기떡의 품질특성)

  • Lee, Yu-Na;Lee, Jong-Hyun;Kim, Young-Soon
    • The Korean Journal of Food And Nutrition
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    • v.25 no.4
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    • pp.1008-1015
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    • 2012
  • Sulgidduk is a kind of basic steamed rice cake in Korea. Multifunctional portable grinder was used for making sulgidduk and investigated the characteristic changes of rice powder for deciding the proper particle size of rice powder. Operation times for grinding the water absorbed swelled rice were 10, 20, 30 and 40 seconds. Moisture contents of rice powder and sulgidduk showed an increasing tendency with an increase of operation times for grinding. Springiness showed significant differences according to the operation times. Cohesiveness was decreased severely after 40 seconds grinding. Chewiness showed high after 20 seconds grinding in all groups; however, decreased after 40 seconds grinding and showed similar chewiness of the control group. Fracturability also showed severe increased tendency after 20 seconds grinding and decreased after 30 seconds grinding. Strength and hardness showed significant differences; they were increased until 30 seconds and severely decreased after 40 seconds grinding. L values showed significant differences in all the groups ($p{\leq}0.05$). The a and b values did not show any differences in all groups. Overall sensory evaluations, such as colors, flavors and texture, were increased with operation times for grinding and showed significant differences among the groups (p<0.05). As a result of this study, 40 seconds grinding times were the best condition for making sulgidduk, using by multifunctional grinder.

Glass-alumina Composites Prepared by Melt-infiltration: Ⅰ. Effect of Alumina Particle Size (용융침투법으로 제조한 유리-알루미나 복합체: Ⅰ. 알루미나 입도 효과)

  • Lee, Deuk-Yong;Jang, Ju-Woong;Kim, Dae-Joon;Park, Il-Seok;Lee, Jun-Kwang;Lee, Myung-Hyun;Kim, Bae-Yeon
    • Journal of the Korean Ceramic Society
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    • v.38 no.9
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    • pp.799-805
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    • 2001
  • Two commercial alumina powders having different particle size of $0.5{\mu}m$ and 3${\mu}$m were presintered at 1120$^{\circ}$C for 2h and then lanthanum aluminosilicate glass was infiltrated at 1100$^{\circ}$C for up to 4h to obtain the densified glass-alumina composites. The effect of alumina particle size on packing factor, microstructure, wetting, porosity and pore size, and mechanical properties of the composite was investigated. The optimum mechanical properties and compaction behavior were observed for the 3${\mu}$m alumina particle dispersed composite. The 3${\mu}$m alumina particle size and distribution for he preform were within 0.1 to 48${\mu}$m and bimodal and random orientation. The strength and the fracture toughness of the composite having 3${\mu}$m alumina particles were 519MPa and $4.5MPa{\cdot}m^{1/2}$, respectively.

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Glass-alumina Composites Prepared by Melt-infiltration: II. Kinetic Studies (용융침투법으로 제조한 유리-알루미나 복합체: II. Kinetic 연구)

  • Lee, Deuk-Yong;Jang, Joo-Wung;Lee, Myung-Hyun;Lee, Jun-Kwang;Kim, Dae-Joon;Park, Il-Seok
    • Journal of the Korean Ceramic Society
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    • v.39 no.2
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    • pp.145-152
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    • 2002
  • Four commercial alumina powders having different particle size of $0.5{\mu}m,\;2.8{\mu}m,\;12{\mu}m,\;and\;45{\mu}m$ were presintered at 1120$^{\circ}C$ for 2h and then lanthanum aluminosilicate glass was infiltrated at 1100$^{\circ}C$ for 2h in the interval of 0.1h to investigate the penetration kinetic of the glass into the alumina preforms. The infiltration distance is parabolic with respect to time as described by the Washburn equation and the penetration rate constant, K, increases with raising the alumina particle size. The strength of glass-alumina composites increases as the alumina particle size reaches to 2.8${\mu}m$ due to the increase in packing, however, decreases with further increasing the alumina particle size. The fracture toughness of the composites rises with increasing the alumina particle size due to the crack bowing and the interaction between crack and alumina particles.

Fabrication of Luminescent Hydroxyapatite Microspheres for Drug Loading and Release

  • Park, So Yeon;Kwon, Seung Lee;Baek, Mi Yeon;Yoo, Jin Sun;Kim, Min-Cheol;Jung, Hyun Suk
    • Proceedings of the Korean Vacuum Society Conference
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    • 2016.02a
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    • pp.360.1-360.1
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    • 2016
  • Hydroxyapatite (Ca10(PO4)6(OH)2, HAP) particles have attracted a great deal of attention in biomedical fields due to their good biocompatibility, bioactivity and fairly broad applications as drug delivery, dental implant, bone cement, and etc. Thus, many researchers have made an effort to add new functionalities such as luminescence, drug delivery, and bone regeneration properties up to HAP powders by controlling their nanostructure as well as composition. In this research, the mesoporous strontium substituted HAP (Sr-HAP) microspheres were synthesized using a hydrothermal method. In this synthesis, aspartic acid monomers were utilized to form microsphere by controlling surface energy of HAP particles and Sr ions were substituted into Ca ion sites, which induced luminescence property in HAP powders. Moreover, the change in the amount of Sr substitution was found to influence the particle size, morphology, and concurrently surface area, which led to changing drug loading as well as drug release property. The amount of Sr influences the morphology, luminescent properties, particle size, surface area cell viability and drug loading property, which are investigated by SEM, TEM, XRD, FTIR, BET, XPS and in vitro test such as MTT assay and drug release test. In particular, the multifunctional Sr-HAP with molar ratios of 0.25 (Sr/(Ca+Sr)) possessed the strongest luminescent property as well as the superior drug loading and sustained release properties that were correspondent with large surface area and pore size. Our study indicates that the fabricated multifunctional Sr-HAP microspheres are quite useful for bone regeneration and drug delivery.

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Highly Integrated DNA Chip Microarrays by Hydrophobic Interaction

  • Park, Yong-Sung;Kim, Do-Kyin;Kwon, Young-Soo
    • KIEE International Transactions on Electrophysics and Applications
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    • v.11C no.2
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    • pp.23-27
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    • 2001
  • Microarray-based DNA chips provide an architecture for multi-analyte sensing. In this paper, we report a new approach for DNA chip microarray fabrication. Multifunctional DNA chip microarrays were made by immobilizing many kinds if DNAs on transducers (particles). DNA chip microarrays were prepared by randomly distributing a mixture of the particles on a chip pattern containing thousands of micro meter-scale sites. The particles occupied different sites from array to array. Each particle cam be distinguished by a tag that is established on the particle. The particles were arranged on the chip pattern by the random fluidic self-assembly (RFSA) method, using hydrophobic interaction.

Protein Chip by Magnetic Array (자성체 어레이를 이용한 단백질칩)

  • Choi, Yong-Sung;Lee, Kyung-Sup;Park, Dae-Hee
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2005.07a
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    • pp.426-427
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    • 2005
  • This research describes a new constructing method of multifunctional biosensor using many kinds of biomaterials. A metal particle and an array was fabricated by photolithographic. Biomaterials were immobilized on the metal particle. The array and the particles were mixed in a buffer solution, and were arranged by magnetic force interaction and self-assembly. A quarter of total Ni dots were covered by the particles. The binding direction of the particles was controllable, and condition of particles was almost with Au surface on top. The particles were successfully arranged on the array. The biomaterial activities were detected by chemiluminescence and electrochemical methods.

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Magnetic withdrawal of particles for multiple purposes in nuclear power plants

  • Kam, Dong Hoon;Jeong, Yong Hoon;Choi, Sung-Min;Yun, Jong-Il
    • Nuclear Engineering and Technology
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    • v.53 no.12
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    • pp.3979-3989
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    • 2021
  • Several parametric effects on the magnetic collection have been evaluated considering dimension, strength of external magnetic field, injected velocity and particle concentration in the working fluid. Besides, accidental environments, expected in the containment of nuclear power plants, have also been addressed for the capture efficiency. The capture efficiency is especially enhanced with magnetic particle size and magnetic field strength through increased magnetic force; the non-magnetic coating thickness and fluid velocity hinder the magnetic collection. Based on the assessment, the magnetic withdrawal system can effectively capture magnetic particles even under accidental environments. Withdrawal of multifunctional magnetic particles or filtering of magnetic impurities can be effectively realized through the system.