• 분석과학
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• 제34권5호
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• pp.193-201
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• 2021

We have demonstrated a sensitive analytical method of measuring oleracone D in mouse plasma using a liquid chromatography-tandem mass spectrometry (LC-MS/MS). Oleracone D and oleracone F (internal standard) in mouse plasma samples were processed using a liquid-liquid extraction method with methyl tertbutyl ether, resulting in high and reproducible extraction recovery (80.19-82.49 %). No interfering peaks around the peak elution time of oleracone D and oleracone F were observed. The standard calibration curves for oleracone D ranged from 0.5 to 100 ng/mL and were linear with r² of 0.992. The inter- and intra-day accuracy and precision and the stability fell within the acceptance criteria. The pharmacokinetics of oleracone D following intravenous and oral administration of oleracone D at doses of 5 mg/kg and 30 mg/kg, respectively, were investigated. When oleracone D was intravenously injected, it had first-order elimination kinetics with high clearance and volume of distribution values. The absolute oral bioavailability of this compound was calculated as 0.95 %, with multi-exponential kinetics. The low aqueous solubility and a high oral dose of oleracone D may explain the different elimination kinetics of oleracone D between intravenous and oral administration. Collectively, this newly developed sensitive LC-MS/MS method of oleracone D could be successfully utilized for investigating the pharmacokinetic properties of this compound and could be used in future studies for the lead optimization and biopharmaceutic investigation of oleracone D.

• 대한토목학회논문집
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• 제41권4호
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• pp.405-416
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• 2021

최근 전국적으로 시행을 추진하고 있는 안전속도 5030 정책은 이동성의 저하 및 통행 불편 등으로 인해 일부 시민들의 불만이 증가하는 경향을 보여 정책을 성공적으로 추진하기 위해서는 교통사고, 통행속도 등 정량적인 정책평가 기준에서 벗어나 도로를 이용하는 시민들의 다양한 의견을 수렴하는 것이 중요하다. 따라서 본 연구에서는 도로를 이용하는 시민을 운전자 집단과 비운전자 집단으로 분류하고 이를 대상으로 안전속도 5030 정책 시행에 따른 제한속도의 적정성 평가와 도로서비스 질의 만족도 평가(MDS), 중요도-만족도 분석(IPA) 등 시민의식 분석을 실시하였다. 시민의식 분석결과, 도로서비스 질 중에 특히, 이동성, 경제성, 환경성에 대한 만족도가 낮게 나타났는데, 이에 만족도가 낮은 도로를 대상으로 제한속도와 도로서비스 질의 개선방안을 제시하여 안전속도 5030 정책의 성공적 추진을 도모하고자 하였다.

• 한국수자원학회논문집
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• 제52권3호
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• pp.195-206
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• 2019

본 연구에서는 주 단위 지하수자원 관리 취약시기 평가 방법을 개발하였다. 강수의 지하수위에 대한 영향을 고려하기 위하여 한계 침투량을 고려한 강우이동평균 방법을 통해 지하수위와의 상관계수를 산정하였다. 취약 시기 평가 기준을 개발하고 평가 기준에 대한 가중치를 엔트로피 방법을 이용하여 산정하였다. 강수와의 상관계수와 산정된 가중치를 이용한 주 단위 지하수자원 관리 취약시기 평가 방법을 개발하였으며, 개발한 방법을 통하여 소규모 행정구역을 대상으로 취약시기를 평가하였다. 본 연구에서 개발된 방법은 지역적일뿐만 아니라 계절적인 지하수자원의 효율적 관리 대책 수립의 근거가 될 수 있을 것이다.

• 대한통합의학회지
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• 제7권1호
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• pp.27-36
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• 2019

Purpose : The purpose of this study figures out how the biofeedback exercise combined with a Shaker exercise and a jaw-opening exercise affects the suprahyoid muscle activation of stroke with a swallowing disorder. Methods : The study period was from June, 2018 to September, 2018, to 45 patients who were suitable for selection criteria. Participants were divided into three groups: a visuoauditory biofeedback group (VABG), and a visual biofeedback group (VBG), and a self-exercise group (SG). The three groups were divided into the Shaker exercise and the jaw-opening exercise, and the biofeedback training by themselves. Three groups performed an intervention three times a day, five times a week, and four weeks long. Also, suprahyoid muscle activity was measured with a pre-test, a post-test and a follow-up test. Results : To know the suprahyoid muscle activity after the intervention, there were statistically significant differences between the pre-test and the post-intervention (p< .01). All three groups showed the improvement with the mean comparing followed by VABG, VBG and SG. Comparing between the post- test and the follow-up test, all three groups showed the reduction of suprahyoid muscle activity with the mean comparing, followed VABG, VBG and SG. Conclusion : It found that it was more effective when providing a double-sensory biofeedback than when training with a single-sensory biofeedback. Therefore, it is necessary to provide a multi-sensory input when applying the biofeedback in rehabilitation of the swallowing disorder.

• 디지털융복합연구
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• 제17권2호
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• pp.135-144
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• 2019

대형마트보다 저렴하고 편의성도 높은 창고형 매장에 대한 물류 중요성이 증대되고 있다. 하지만 창고형 매장의 통합 Depot 위치선정에 관한 연구는 부족한 실정이다. 이러한 측면에서 본 연구에서는 통합 Depot 위치선정을 위한 요인도출 및 가중치 산출, 대상지의 위치 우선순위 산정을 다기준 의사결정 방법인 AHP(Analytic Hierarchy Process)방법을 도입하여 계산하는 것을 연구의 목적으로 한다. 분석결과, 선정 요인별 중요도에서는 수배송 비용절감(0.198)이 가장 높게 나왔으며, 수배송 거리절감(0.168), 수배송 시간절감(0.149) 순으로 도출 되었다. 본 연구 결과는 Depot를 통합 운영 시 비용 절감과 효율성 증가를 수치화하여 실제 실무자들에게 보다 현실적인 기초자료를 제시할 수 있을 것으로 판단된다. 향후연구에서는 분석에 사용되는 요인의 추가작업을 통하여 분석모형을 정교화 할 필요가 있다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제13권1호
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• pp.406-434
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• 2019

In general, an information security approach estimates the risk, where the risk is to occur due to an unusual event, and the associated consequences for cloud organization. Information Security and Risk Management (ISRA) practices vary among cloud organizations and disciplines. There are several approaches to compare existing risk management methods for cloud organizations but their scope is limited considering stereo type criteria, rather than developing an agent based task that considers all aspects of the associated risk. It is the lack of considering all existing renowned risk management frameworks, their proper comparison, and agent techniques that motivates this research. This paper proposes Agent Based Information Security Framework for Hybrid Cloud Computing as an all-inclusive method including cloud related methods to review and compare existing different renowned methods for cloud computing risk issues and by adding new tasks from surveyed methods. The concepts of software agent and intelligent agent have been introduced that fetch/collect accurate information used in framework and to develop a decision system that facilitates the organization to take decision against threat agent on the basis of information provided by the security agents. The scope of this research primarily considers risk assessment methods that focus on assets, potential threats, vulnerabilities and their associated measures to calculate consequences. After in-depth comparison of renowned ISRA methods with ABISF, we have found that ISO/IEC 27005:2011 is the most appropriate approach among existing ISRA methods. The proposed framework was implemented using fuzzy inference system based upon fuzzy set theory, and MATLAB(R) fuzzy logic rules were used to test the framework. The fuzzy results confirm that proposed framework could be used for information security in cloud computing environment.

• Asian-Australasian Journal of Animal Sciences
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• 제32권8호
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• pp.1077-1083
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• 2019

Objective: Sow longevity is important for efficient and profitable pig farming. Recently, there has been an increasing interest in social genetic effect (SGE) of pigs on stress-tolerance and behavior. The present study aimed to estimate genetic correlations among average daily gain (ADG), stayability (STAY), and number of piglets born alive at the first parity (NBA1) in Korean Yorkshire pigs, using a model including SGE. Methods: The phenotypic records of ADG and reproductive traits of 33,120 and 11,654 pigs, respectively, were evaluated. The variances and (co) variances of the studied traits were estimated by a multi-trait animal model applying the Bayesian with linear-threshold models using Gibbs sampling. Results: The direct and SGEs on ADG had a significantly negative (-0.30) and neutral (0.04) genetic relationship with STAY, respectively. In addition, the genetic correlation between the social effects on ADG and NBA1 tended to be positive (0.27), unlike the direct effects (-0.04). The genetic correlation of the total effect on ADG with that of STAY was negative (-0.23) but non-significant, owing to the social effect. Conclusion: These results suggested that total genetic effect on growth in the SGE model might reduce the negative effect on sow longevity because of the growth potential of pigs. We recommend including social effects as selection criteria in breeding programs to obtain satisfactory genetic changes in both growth and longevity.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제13권3호
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• pp.1260-1283
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• 2019

Low earth orbit (LEO) satellite broadband network is a crucial part of the space information network. LEO satellite constellation design is a top-level design, which plays a decisive role in the overall performance of the LEO satellite network. However, the existing works on constellation design mainly focus on the coverage criterion and rarely take network performance into the design process. In this article, we develop a unified framework for constellation optimization design in LEO satellite broadband networks. Several design criteria including network performance and coverage capability are combined into the design process. Firstly, the quality of service (QoS) metrics is presented to evaluate the performance of the LEO satellite broadband network. Also, we propose a network stability model for the rapid change of the satellite network topology. Besides, a mathematical model of constellation optimization design is formulated by considering the network cost-efficiency and stability. Then, an optimization algorithm based on non-dominated sorting genetic algorithm-II (NSGA-II) is provided for the problem of constellation design. Finally, the proposed method is further evaluated through numerical simulations. Simulation results validate the proposed method and show that it is an efficient and effective approach for solving the problem of constellation design in LEO satellite broadband networks.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2015년도 학술발표회
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• pp.264-264
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• 2015

최근 기후변화는 우리 삶에 다양한 영향을 미치고 있으며, 이에 따른 수문순환 변화 역시 자명하게 받아들이고 있다. 이에 따라 수자원 취약성 평가 및 대책에 관한 연구는 다양하게 진행되고 있는 실정이다. 하지만 국내의 경우 전체 유역에 대한 수자원 취약성 평가 연구는 부족한 실정이다. 따라서 본 연구에서는 국내 총 12 수계인 한강, 안성천, 금강, 삽교천, 영산강, 섬진강, 탐진강, 만경강, 동진강, 낙동강, 태화강, 형산강 유역에 대한 수자원 취약성 평가를 실시하였다. 평가 방법으로는 장기간에 걸친 다양한 토양의 특징, 토지이용, 관리상태의 변화에 따른 크고 복잡한 유역의 유출량을 추정하기 위해 개발된 SWAT(Soil and Water Assessment Tool) 모형을 이용하여 수문 모형을 구축하였고, 유출 관련 매개변수 최적화 작업은 SWAT-CUP 모형을 이용하였다. 최적화된 매개변수의 적용을 통해 각 유역별 유출량을 산정하였다. 그 결과 2009년과 2011년은 한강, 낙동강, 금강, 영산강순 이였으며, 2010년은 낙동강, 한강, 금강, 영산강순 이였다. 면적별 유출량인 비유량(specific discharge)을 산정한 결과, 2009년에는 영산강, 낙동강, 금강, 한강순 이며, 2010년에는 영산강, 금강, 낙동강, 한강순 이였으며, 2011년에는 금강, 한강, 영산강, 낙동강 순을 보였다. 또한, 인구당 유출량 산정 결과 2009년에는 영산강, 금강, 낙동강, 한강순 이며, 2010년에는 영산강, 금강, 낙동강, 한강순 이며, 2011년에는 영산강, 금강, 낙동강, 한강순 이었다. 이를 바탕으로 국내 총 12 수계에 대한 수자원 취약성을 산정해보았다. 대응변수는 이수의 수요 및 공급적인 측면에서 구분하였으며, 사회/경제, 물 이용, 환경, SWAT으로 구성하였습니다. 수자원 취약성 평가를 위해 다기준의사결정기법(MCDM, Multi-Criteria Decision Making) 중 하나인 TOPSIS(Technique for Order of Preference by Similarity to Ideal Solution)기법을 사용하였다. 산정 결과 삽교천, 동진강, 형산강, 안성천, 섬진강, 만경강, 낙동강, 영산강, 태화강, 금강, 한강, 탐진강 순 이였다. 본 연구 결과는 향후 다중 공간에 구축한 고해상도 모형을 통해 국내 수문상황 진단 및 고해상도 미래 수문 시나리오 생산을 통한 수자원 관리에도 활용될 전망이며, 기후변화 취약성 평가를 위한 지표 개발에 이용될 예정이다.

• Geomechanics and Engineering
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• 제24권5호
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• pp.407-418
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• 2021

Due to the complexity of the causes of the sliding mass instabilities, landslide susceptibility and hazard evaluation are difficult, but they can be more carefully considered and regionally evaluated by using new programming technologies to minimize the hazard. This study aims to evaluate the landslide hazard zonation in the Tabriz region, Iran. A fuzzy logic-based multi-criteria decision-making method was proposed for susceptibility analysis and preparing the hazard zonation maps implemented in MATLAB programming language and Geographic Information System (GIS) environment. In this study, five main factors have been identified as triggering including climate (i.e., precipitation, temperature), geomorphology (i.e., slope gradient, slope aspect, land cover), tectonic and seismic parameters (i.e., tectonic lineament congestion, distribution of earthquakes, the unsafe radius of main faults, seismicity), geological and hydrological conditions (i.e., drainage patterns, hydraulic gradient, groundwater table depth, weathered geo-materials), and human activities (i.e., distance to roads, distance to the municipal areas) in the study area. The results of analyses are presented as a landslide hazard map which is classified into 5 different sensitive categories (i.e., insignificant to very high potential). Then, landslide susceptibility maps were prepared for the Tabriz region, which is categorized in a high-sensitive area located in the northern parts of the area. Based on these maps, the Bozgoosh-Sahand mountainous belt, Misho-Miro Mountains and western highlands of Jolfa have been delineated as risk-able zones.