• BMB Reports
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• 제51권4호
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• pp.174-181
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• 2018

A number of genes have been therapeutically targeted to relieve cancer, but cancer relapse is still a growing issue. The concept that the surrounding tumor environment is critical for the progression of cancer may foster an answer to the issue of cancer malignancy. Runt domain transcription factors (RUNX1, 2, and 3) are evolutionarily conserved and have been intensively studied for their roles in normal development and pathological conditions. During tumor growth, a hypoxic microenvironment and infiltration of the tumor by immune cells are common phenomena. In this review, we briefly introduce the consequences of hypoxia and immune cell infiltration into the tumor microenvironment with a focus on RUNX3 as a critical regulator. Furthermore, based on our current knowledge of the functional role of RUNX3 in hypoxia and immune cell maintenance, a probable therapeutic intervention is suggested for the effective management of tumor growth and malignancy.

• Smart Structures and Systems
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• 제22권4호
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• pp.383-397
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• 2018

Traditional base isolation systems focus on isolating the seismic response of a structure in the horizontal direction. However, in regions where the vertical earthquake excitation is significant (such as near-fault region), a traditional base-isolated building exhibits a significant vertical vibration. To eliminate this shortcoming, a rocking-isolated system named Telescopic Column (TC) is proposed in this paper. Detailed rocking and isolation mechanism of the TC system is presented. The seismic performance of the TC is compared with the traditional elastomeric bearing (EB) and friction pendulum (FP) base-isolated systems. A 4-storey reinforced concrete moment-resisting frame (RC-MRF) is selected as the reference superstructure. The seismic response of the reference superstructure in terms of column axial forces, base shears, floor accelerations, inter-storey drift ratios (IDR) and collapse margin ratios (CMRs) are evaluated using OpenSees. The results of the nonlinear dynamic analysis subjected to multi-directional earthquake excitations show that the superstructure equipped with the newly proposed TC is more resilient and exhibits a superior response with higher margin of safety against collapse when compared with the same superstructure with the traditional base-isolation (BI) system.

• 한국주거학회:학술대회논문집
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• 한국주거학회 2002년도 추계학술발표대회
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• pp.109-113
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• 2002

The purpose of this study was to investigate the trend of the room where activities of daily living and family events(activities of non-daily living) were performed with time. Research data was collected in 1992 and 2002 from households living in Seoul that have university student by using questionnaire surveys. Data was analyzed using the SPSS package program. The major findings of this study were as follows: 1) Living room was a multi-purpose space for various activities: receiving guests, family communication, ironing, sewing and dining as well as a kitchen. Anbang(master bed room) is the place where the couple sleeps. The room's purpose has changed from a multi-purpose space to a private space. 2) Most of the families performed the majority of the family events in the living room and Anbang. In the past, traditional events and birthday parties were performed in Anbang, but currently the trend has changed. This would mean that with time the majority of the family events were held in the living room. 3) Space planning is required to meet the dwellers' use of living room and Anbang.

• Tuberculosis and Respiratory Diseases
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• 제70권1호
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• pp.10-20
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• 2011

Various diseases can diffusely involve central airways, including the trachea and main stem bronchi. Central airway abnormalities are frequently not apparent or are overlooked on chest radiographs, even though the patient may have significant symptoms. Recent advances in spiral and multi-detector computed tomography (CT) with multi-planar reconstruction and three-dimensional demonstration, including virtual bronchoscopy, allow for excellent display of central airway anatomy and abnormalities with visualization of accurate locations of lesions. Early detection and proper diagnosis of airway diseases based on various radiographic findings will help determine appropriate treatment, including surgical planning and evaluation of treatment response. Herein we describe and illustrate the imaging findings of a wide spectra of diffuse central airway diseases.

• Journal of Communications and Networks
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• 제9권2호
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• pp.112-117
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• 2007

In this paper, we focus on the total transmission power minimization problem for downlink beamforming multiple-input multiple-output (MIMO) orthogonal frequency division multiplexing (OFDM) systems while ensuring each user's QoS requirement. Although the linear integer programming (LIP) solution we formulate provides the performance upper bound of the margin adaptive (MA) optimization problem, it is hard to be implemented in practice due to its high computational complexity. By regarding each user's equivalent channel gain as approximate independent values and using iterative descent method, we present a heuristic MA resource allocation algorithm. Simulation results show that the proposed algorithm efficiently converges to the local optimum, which is very close to the performance of the optimal LIP solution. Compared with existing space division multiple access (SDMA) OFDM systems with or without adaptive resource allocation, the proposed algorithm achieves significant performance improvement by exploiting the frequency diversity and multi-user diversity in downlink multiple-input single-output (MISO) OFDM systems.

• Journal of Communications and Networks
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• 제11권3호
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• pp.271-278
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• 2009

A new modulation scheme called multicoded-pulse position modulation (MC-PPM) is proposed for an ultrawideband (UWB) impulse radio communication system. The multicoded signal is generated by using several orthogonal codes for transmitting data simultaneously. Then, each multi-level value of the multicoded signal is converted to pulse position which results in not only an improved data rate, but also a processing gain in reception, delivering the power-efficient benefit of PPM and guaranteeing the low pulse energy for UWB systems. We notice that the modulation of multi-level values of the multicoded signal to pulse position is more efficient in terms of achievable data rate than the modulation of transmitting data based on other PPM schemes within given bandwidth and pulse energy. Therefore, as a performance measure, we focus on the achievable data rate (link capacity) of the proposed scheme and analyze it theoretically. Through simulation, we compare the link capacity of the MC-PPM scheme and other PPM schemes, such as M -ary PPM and multiple PPM. With the fixed bandwidth and same pulse energy condition, the UWB system based on the proposed MC-PPM scheme shows good link capacity and an increased data rate as L increases, which is contrary to other PPM schemes.

• International Journal of Quality Innovation
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• 제3권2호
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• pp.113-131
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• 2002

The relationships among multi-dimensional data (such as medical examination data) with ambiguity and variation are difficult to explore. The traditional approach to building a data classification system requires the formulation of rules by which the input data can be analyzed. The formulation of such rules is very difficult with large sets of input data. This paper first describes two classification approaches using back-propagation (BP) neural network and Mahalanobis distance (MD) classifier, and then proposes two classification approaches for multi-dimensional feature selection. The first one proposed is a feature selection procedure from the trained back-propagation (BP) neural network. The basic idea of this procedure is to compare the multiplication weights between input and hidden layer and hidden and output layer. In order to simplify the structure, only the multiplication weights of large absolute values are used. The second approach is Mahalanobis-Taguchi system (MTS) originally suggested by Dr. Taguchi. The MTS performs Taguchi's fractional factorial design based on the Mahalanobis distance as a performance metric. We combine the automatic thresholding with MD: it can deal with a reduced model, which is the focus of this paper In this work, two case studies will be used as examples to compare and discuss the complete and reduced models employing BP neural network and MD classifier. The implementation results show that proposed approaches are effective and powerful for the classification.

• 소성∙가공
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• 제13권5호
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• pp.429-434
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• 2004

Manufacturing process for milli components has recently gained researcher's focus with the increasing tendency toward highly integrated and micro-scaled parts for electronic devices. The milli-components need more precise manufacturing process than the conventional manufacturing process since the parts require higher dimensional accuracy than the conventional ones. In order to enhance the forming accuracy and productivity, various forming procedures proposed and studied by many researchers. In this paper, forming analysis of milli-components has been studied with a new micro-former. In modeling of progressive dies, multi-stage forming sequence has been analyzed with finite element analysis by LS-DYNA3D. The analysis proposes the sequential die and part shapes with the corresponding punch force and dimensional accuracy. The analysis also considers the effect of elastic dies on the dimensional accuracy of the formed parts. The analysis result demonstrates that the elastic analysis in the milli-forming process is indispensable for accurate forming analysis. The analysis procedure in the paper will provide good information in design of a new micro-former and milli-component

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제13권4호
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• pp.2223-2242
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• 2019

Distance Vector-Hop (DV-Hop) algorithm is widely used in node localization. It often suffers the wormhole attack. The current researches focus on Double-Wormhole-Node-Link (DWNL) and have limited attention to Multi-Wormhole-Node-Link (MWNL). In this paper, we propose a security DV-Hop algorithm (AMLDV-Hop) to resist MWNL. Firstly, the algorithm establishes the Neighbor List (NL) in initialization phase. It uses the NL to find the suspect beacon nodes and then find the actually attacked beacon nodes by calculating the distances to other beacon nodes. The attacked beacon nodes generate and broadcast the conflict sets to distinguish the different wormhole areas. The unknown nodes take the marked beacon nodes as references and mark themselves with different numbers in the first-round marking. If the unknown nodes fail to mark themselves, they will take the marked unknown nodes as references to mark themselves in the second-round marking. The unknown nodes that still fail to be marked are semi-isolated. The results indicate that the localization error of proposed AMLDV-Hop algorithm has 112.3%, 10.2%, 41.7%, 6.9% reduction compared to the attacked DV-Hop algorithm, the Label-based DV-Hop (LBDV-Hop), the Secure Neighbor Discovery Based DV-Hop (NDDV-Hop), and the Against Wormhole DV-Hop (AWDV-Hop) algorithm.

• 한국산업융합학회 논문집
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• 제22권2호
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• pp.209-218
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• 2019

This study proposes a new approach to Control the Orientation and position based on obstacle avoidance technology by multi sensors fusion and autonomous travelling control of mobile robot system for implimentation of Smart FA. The important focus is to control mobile robot based on by the multiple sensor module for autonomous travelling and obstacle avoidance of proposed mobile robot system, and the multiple sensor module is consit with sonar sensors, psd sensors, color recognition sensors, and position recognition sensors. Especially, it is proposed two points for the real time implementation of autonomous travelling control of mobile robot in limited manufacturing environments. One is on the development of the travelling trajectory control algorithm which obtain accurate and fast in considering any constraints. such as uncertain nonlinear dynamic effects. The other is on the real time implementation of obstacle avoidance and autonomous travelling control of mobile robot based on multiple sensors. The reliability of this study has been illustrated by the computer simulation and experiments for autonomous travelling control and obstacle avoidance.