• Journal of the Korea Convergence Society
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• v.11 no.7
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• pp.137-144
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• 2020

Based on the basic concepts and roles of the Science Museum, the research and development of the "Sound Light" interaction exhibition contents and experience exhibition space aimed at providing the exhibition, education and experience of scientific principle directly related to daily life will be implemented in the "Sound Light" exhibition space of the Gwangju National Science Museum. The scope of the research is to define the conditions and elements of the museum's hands-on exhibition by examining the case and status of the existing science museum's experience-type content prior research, and research and development of experience-type exhibition scenarios and contents for children based on them. The results of this research and development content are firstly developed with the theme of light and sound as interactive hologram experience content. Second, by multi-faceted media facade through projection mapping by multiple projectors, visual wide and spectacular screen composition and animation are realized. Third, visitors-oriented exhibitions and experiences that can interact with visitors by moving various colors and sounds together. Finally, interactive content is provided through hologram interfaces through hologram screens to encourage active participation of many visitors in viewing rather than simply delivering exhibition information and to promote revisiting the exhibition. Through a series of studies, it was possible to research and develop contents and experience exhibition spaces with theme park characteristics, which are the trend of science museums.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6155-6157
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• 2012

Background: Mutations in the MAPK (Mitogen Activated Protein Kinase) signaling pathway - EGFR/Ras/RAF/MEK have been associated with the development of several carcinomas. ERK2, a downstream target of the MAPK pathway and a founding member of the MAPK family is activated by cellular signals emanating at the cell membrane. Activated ERK2 translocates into the nucleus to transactivate genes that promote cell proliferation. MKP - a dual specific phosphatase - interacts with activated ERK2 via the common docking (CD) domain of the later to inactivate (dephosphorylate) and effectively terminate further cell proliferation. A constitutively active form of ERK2 carrying a single point mutation - E322K in its CD domain, was earlier reported by our laboratory. In the present study, we investigated the prevalence of this CD domain E322K mutation in 88 well differentiated OSCC tissue samples. Materials and Method: Genomic DNA specimens isolated from 88 oral squamous cell carcinoma tissue samples were amplified with primers flanking the CD domain of the ERK2 gene. Subsequently, PCR amplicons were gel purified and subjected to direct sequencing to screen for mutations. Results: Direct sequencing of eighty eight OSCC samples identified an E322K CD domain mutation in only one (1.1%) OSCC sample. Conclusions: Our result indicates that mutation in the CD domain of ERK2 is rare in OSCC patients, which suggests the role of genetic alterations in other mitogenic genes in the development of carcinoma in the rest of the patients. Nevertheless, the finding is clinically significant, as the relatively rare prevalence of the E322K mutation in OSCC suggests that ERK2, being a common end point signal in the multi-hierarchical mitogen activated signaling pathway may be explored as a viable drug target in the treatment of OSCC.

• Horticultural Science & Technology
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• v.32 no.4
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• pp.473-483
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• 2014

In this work, the effects of shade combination, shade height and wind regime on greenhouse climate were quantified. A two-dimensional (2-D) computational fluid dynamics (CFD) model was developed based on an 11-span plastic greenhouse in eastern China for wind almost normal to the greenhouse orientation. The model was first validated with air temperature profiles measured in a compartmentalized greenhouse cultivated with mature lettuce (Lactuca sativa L., 'Yang Shan'). Next, the model was employed to investigate the effect of shade combinations on greenhouse microclimate patterns. Simulations showed similar airflow patterns in the greenhouse under different shade combinations. The temperature pattern was a consequence of convection and radiation transfer and was not significantly influenced by shade combination. The use of shade screens reduced air velocity by $0.02-0.20m{\cdot}s^{-1}$, lowered air temperature by $0.2-0.8^{\circ}C$ and raised the humidity level by 0.9-2.0% in the greenhouse. Moreover, it improved the interior climate homogeneity. The assessment of shade performance revealed that the external shade had good cooling and homogeneity performance and thus can be recommended. Furthermore, the effects of external shade height and wind regime on greenhouse climate parameters showed that external shade screens are suitable for installation within 1 m above roof level. They also demonstrated that, under external shade conditions, greenhouse temperature was reduced relative to unshaded conditions by $1.3^{\circ}C$ under a wind speed of $0.5m{\cdot}s^{-1}$, whereas it was reduced by merely $0.5^{\circ}C$ under a wind speed of $2.0m{\cdot}s^{-1}$. Therefore, external shading is more useful during periods of low wind speed.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.9
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• pp.107-115
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• 2013

Smart appliances with multi-media and telecommunication equipments provide users complicated convenience functions. On the contrary, 8-bit controller-based low performance electronics still cannot afford such multimedia and telecommunication. If we find a way to have low-end electronics connected and provide complicated functions, they can be also made "smart". Fortunately, 8-bit controllers used in low-end appliances have UART, which can be connected to any of BlueTooth, Wi-Fi and ZigBee communication modules which can, in turn, communicate with smart devices. Any communication module can be attached to the low-end electronics due to the variety of smart devices' connectivity at the other side. Although the convenience functions seem complicated, they are actually macros in a script form composed of micro commands which implement the base functions of appliances. Since the kinds of the base functions are not that many, the low-end electronic appliances will become "smart" if their control program can be extended to execute sequentially the micro commands in any combination. Such simple innovation has not seen the world, until now due to the overhead of the additionally required hardware such as display devices and buttons. The high-quality display and touch screen functionalities of smart devices can replace the required hardware, and remove the overhead completely. In fact, the low-end appliances become smart as if an "evolution kit" is newly equipped.

• Journal of Biosystems Engineering
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• v.28 no.6
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• pp.517-524
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• 2003

There have been worldwide research and development efforts to automate various processes of bio-production and those efforts will be expanded with priority given to tasks which require high intensive labor or produce high value-added product and tasks under hostile environment. In the field of bio-production capabilities of the versatility and robustness of automated system have been major bottlenecks along with economical efficiency. This paper introduces a new concept of automation based on tole-operation, which can provide solutions to overcome inherent difficulties in automating bio-production processes. Operator(farmer), computer, and automatic machinery share their roles utilizing their maximum merits to accomplish given tasks successfully. Among processes of greenhouse watermelon cultivation tasks such as pruning, watering, pesticide application, and harvest with loading were chosen based on the required labor intensiveness and functional similarities to realize the proposed concept. The developed system was composed of 5 major hardware modules such as wireless remote monitoring and task control module, wireless remote image acquisition and data transmission module, gantry system equipped with 4 d.o.f. Cartesian type robotic manipulator, exchangeable modular type end-effectors, and guided watermelon loading and storage module. The system was operated through the graphic user interface using touch screen monitor and wireless data communication among operator, computer, and machine. The proposed system showed practical and feasible way of automation in the field of volatile bio-production process.

• Journal of Internet Computing and Services
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• v.20 no.6
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• pp.143-156
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• 2019

Discussion on OTT regulation has become fiercer, as OTT services' impacts on the global and domestic media market have been exponentially growing. In South Korea, it is argued that, on the basis of the similarity between television program and OTT's video content, OTT needs to be regulated in order to protect fair competition and to control sociocultural effects. In many of the discussions, developed countries' cases have been used for supporting OTT regulation. In this paper, we first analyzed the global OTT market trends based on our own categorization of OTT services. then we assessed the validity of the application of the foreign cases in the current OTT regulation debates in Korea. We proposed six OTT types (aggregation, mediation, mediation-aggregation, multi-screen, outlet, and outlet-linear) simultaneously considering service operator' origin, business model, content format, and content delivery. These services have been consistently evolving, and the OTT market has been increasingly competitive especially around content differentiation. Regulators must be wary of hastily introducing competition regulation to the dynamically innovating OTT market. The foreign cases, including the US, EU, the UK, and Japan, hardly seem to be appropriate bases for strengthening OTT regulation. Rather, they were focused more on promoting competition in the domestic media market and enriching the content ecosystem. Therefore, we need to consider revision of the outdated media regulation frameworks instead of fitting OTT under them, and to recognize the priority of securing practical jurisdiction on global service providers before capturing local players into the conventional regulation systems.

• Journal of Korean Society of Environmental Engineers
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• v.39 no.12
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• pp.741-749
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• 2017

This study aims to provide the technical considerations and implications for the development of soil vulnerability assesment tool based on the review of existing tools and case studies applied both domestically and internationally. For this study, we specifically investigated the basic theories and major features implemented in the screening models abroad. In contrast, one case study of prioritizing the vulnerable districts was presented to identify the research trends in Korea. Our literature review suggested that the characteristic of target areas and contaminants needed to be properly incorporated into soil vulnerability assessment because the current tools in Korea neglected these properties which prevented this tool from being used as a correct measure of soil management and prevention. We also reached the conclusion that in terms of technical aspect, the soil vulnerability assessment tool should be developed based on the physical theory and environmental data that were varied over space and time so that the end-users were able to readily and effectively screen soil vulnerability over large areas. In parallel with technical improvement, great effort needed to be devoted to develop an integrated environmental information system that increased the availability of data and shared various types of environmental data through enhanced multi-agency collaboration.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.3
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• pp.572-579
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• 2009

A monitoring system needs many parameters to increase devices for monitoring data and to support various services. In particular, monitoring the status of a device in a wireless mobile environment has a difficulty in displaying multi data in a limited screen size, and transfer of the status data of a device into a network is largely related with network traffic. The research aims at designing a control board that collects data in order to effectively manage a greenhouse environment system. Also, the research tries to appropriately operate devices, environment data monitoring, and the control of each device by realizing a multiplexed interface based on a web. Thus, in the case in which a distributed client was a computer, monitoring and control were obtained with a web browser through the Lab VIEW web server of a server or local control module in order to effectively monitor and control according to the status of a user. In the case in which a client was a PDA, application of a wireless mobile considering the scale and data processing capacity of a displayer was connected. As a result of the research, we could confirm a satisfactory outcome from the viewpoint of a human-centered design by supplying adaptability and mobility according to the environment of a user.

• Journal of the Korea Convergence Society
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• v.10 no.9
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• pp.237-247
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• 2019

The purpose of this study was to evaluate the level and intensity of emotional labor of physical therapists and occupational therapists, and to identify the factors affecting them. Cross-sectional study was conducted on physical therapists and occupational therapists across the country using self-populated questionnaire. A total of 2,000 questionnaires were distributed to retrieve 1,500 questionnaires(75%), of which 1,374 questionnaires(68.7%) were finally analyzed, excluding 126 that answered duplicates or were missing answers. Multi-linear regression was performed to identify factors on the strength of emotional labor. According to the analysis results, high-risk groups in the areas under 'Emotional demand and regulation' and 'Overload and conflict in customer service' and 'Emotional disharmony and hurt' were 29.4%, 19.0% and 22.0% respectively, especially in 'Emotional demand and regulation', 'Overload and conflict in customer service', 'Emotional disharmony and hurt' for women working days, and 49% of daily work hours. Accordingly, we will be able to regularly screen physical therapists and occupational therapists for dangerous groups, and manage the intensity of emotional labor through the creation of a therapist's working environment, such as limiting overtime hours and assigning appropriate number of patients. Through this study, the grounds and methods for mitigating the negative effects of emotional labor and mediating emotional labor should be provided.

• BMB Reports
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• v.55 no.6
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• pp.275-280
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• 2022

The treatment of atopic dermatitis (AD) is challenging due to its complex etiology. From epidermal disruption to chronic inflammation, various cells and inflammatory pathways contribute to the progression of AD. As with immunosuppressants, general inhibition of inflammatory pathways can be effective, but this approach is not suitable for long-term treatment due to its side effects. This study aimed to identify a plant extract (PE) with anti-inflammatory effects on multiple cell types involved in AD development and provide relevant mechanistic evidence. Degranulation was measured in RBL-2H3 cells to screen 30 PEs native to South Korea. To investigate the anti-inflammatory effects of Parasenecio auriculatus var. matsumurana Nakai extract (PAE) in AD, production of cytokines and nitric oxide, activation status of FcεRI and TLR4 signaling, cell-cell junction, and cell viability were evaluated using qRT-PCR, western blotting, confocal microscopy, Griess system, and an MTT assay in RBL-2H3, HEK293, RAW264.7, and HaCaT cells. For in vivo experiments, a DNCBinduced AD mouse model was constructed, and hematoxylin and eosin, periodic acid-Schiff, toluidine blue, and F4/80-staining were performed. The chemical constituents of PAE were analyzed by HPLC-MS. By measuring the anti-degranulation effects of 30 PEs in RBL-2H3 cells, we found that Paeonia lactiflora Pall., PA, and Rehmannia glutinosa (Gaertn.) Libosch. ex Steud. show an inhibitory activity of more than 50%. Of these, PAE most dramatically and consistently suppressed cytokine expression, including IL-4, IL-9, IL-13, and TNF-α. PAE potently inhibited FcεRI signaling, which mechanistically supports its basophil-stabilizing effects, and PAE downregulated cytokines and NO production in macrophages via perturbation of toll-like receptor signaling. Moreover, PAE suppressed cytokine production in keratinocytes and upregulated the expression of tight junction molecules ZO-1 and occludin. In a DNCB-induced AD mouse model, the topical application of PAE significantly improved atopic index scores, immune cell infiltration, cytokine expression, abnormal activation of signaling molecules in FcεRI and TLR signaling, and damaged skin structure compared with dexamethasone. The anti-inflammatory effect of PAE was mainly due to integerrimine. Our findings suggest that PAE could potently inhibit multi-inflammatory cells involved in AD development, synergistically block the propagation of inflammatory responses, and thus alleviate AD symptoms.