• 대한세포병리학회지
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• 제16권2호
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• pp.102-105
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• 2005

Chronic sclerosing sialadenitis, also known as Kuttner tumor, is a benign chronic inflammatory lesion of the salivary gland. Here, we describe a case of chronic sclerosing sialadenitis with mucinous ductal metaplasia in a parotid gland, which was confused with low-grade mucoepidermoid carcinoma on aspiration cytology.

• Clinical and Experimental Pediatrics
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• 제61권1호
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• pp.30-34
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• 2018

Congenital pulmonary airway malformation (CPAM), previously known as congenital cystic adenomatoid malformation, is a rare developmental lung abnormality associated with rhabdomyosarcoma, pleuropulmonary blastoma, and mucinous adenocarcinoma of the lung. We report an unusual case of a 10-day-old male newborn with a left lower lobe pulmonary cyst who underwent lobectomy, which revealed type II CPAM complicated by multifocal mucinous adenocarcinoma. KRAS sequencing revealed a somatic mutation in Codon12 ($GGT{\rightarrow}GAT$), suggesting the development of a mucinous adenocarcinoma in the background of mucinous metaplasia. Mucinous adenocarcinoma is the most common lung tumor associated with CPAM, but it generally occurs in older children and adults. Further, all cases in the literature are of type I CPAM. This case in a neonate indicates that malignant transformation can occur very early in type II CPAM.

• 한국수의병리학회지
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• 제5권2호
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• pp.67-70
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• 2001

Spontaneous subcutaneous cysts were detected from three dogs, being a 4-year-old male shih tzu, an 11-month-old female britany spaniel and a 9-month-old male mongrel. All the cysts were occurred around the joints (one elbow's and two shoulderes', respectively). After surgical removal, the lesions did not recur for 6 months follow-up. Neither cyst communicated with the joint cavity. Grossly, the subcutaneous ovoid cysts had moderate to abundant mucinous fluid. Histologically, the cyst wall consisted of inner myxomatous and outer immature connective tissue. Some parts of the cyst wall had various stages of myxoid metaplasia of collagen tissue leading to new cyst formation. The true lining cells of the inner cyst wall were not observed in all the cysts. From these results, these cases were diagnosed as subcutaneous ganglion cysts. This is the first report of canine subcutaneous ganglion cysts in Korea.

• Parasites, Hosts and Diseases
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• 제31권1호
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• pp.21-30
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• 1993

간흡충은 담관암 발생의 원인적 요소로 알려졌다. 그러나 간흡충이 담관암을 일으키는 병리 기전은 자세하게 알려져 있지 않다. 본 연구는 15 ppm의 dimethylnitrosamine(DMN)을 먹는 물로 투여한 햄스터에 간흡충을 감염시켜 담관암의 발생여부를 알아보고 담관암의 병리조직학적 변화를 관찰하고자 하였다. DMN을 투여하고 간흡충을 감염시킨 챔스터에서 11주 후에 8마리 중 6마리가 육안적 혹은 조직학적으로 담관암(cholangiocarcinoma)의 소견을 보였으며 나머지 2마리는 담관종(cholangiofibroma)으로 진단할 수 있었으나 부분적으로 악성적인 모습도 관찰 할 수 있었다. 담관암의 병리조직학적 소견은 담관상피세포가 선종상 혹은 유두상의 증식을 나타내고 높은 이형성을 보였으며 점액세포화생과 괴사소를 보이고 있었다. DMN 만을, 혹은 간흡충만을 투여하거나 감염시킨 햄스터들에서는 담관암이 전혀 발생되지 않았다. 본 .실험은 DMN을 투여한 햄스터에 간흡충감염으로 담관암이 발생하는 과정에서 DMN과 간흡충의 협동작용(synergism)을 보여준 것으로 추정한다.