• Title/Summary/Keyword: MsrA

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An Analysis of ISO 30300 Principles and ISO 30301 Requirements (ISO 30300 원리와 ISO 30301 요구사항 분석)

  • Ryu, Ga Hyun;Kim, Heesop
    • Journal of Korean Society of Archives and Records Management
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    • v.12 no.1
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    • pp.95-115
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    • 2012
  • The purpose of this study is to analyze the 7 principles of ISO 30300 and the requirements of ISO 30301 to provide the conceptual frame of MSR for various organizations providing a comprehensive understanding of the standard series. To achieve the aim of this study, we analyzed the relationship between 'ISO/FDIS 30300 MSR-Fundamentals and Vocabulary' and 'ISO/FDIS 30301 MSR- Requirements' using the Matrix Diagram approach. The results show that there exist some level of relationships between principles and requirement either directly or indirectly, however, 'Process approach' principle seems the closest relationship among them.

Dimethyl sulfoxide elevates hydrogen peroxide-mediated cell death in Saccharomyces cerevisiae by inhibiting the antioxidant function of methionine sulfoxide reductase A

  • Kwak, Geun-Hee;Choi, Seung-Hee;Kim, Hwa-Young
    • BMB Reports
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    • v.43 no.9
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    • pp.622-628
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    • 2010
  • Dimethyl sulfoxide (DMSO) can be reduced to dimethyl sulfide by MsrA, which stereospecifically catalyzes the reduction of methionine-S-sulfoxide to methionine. Our previous study showed that DMSO can competitively inhibit methionine sulfoxide reduction ability of yeast and mammalian MsrA in both in vitro and in vivo, and also act as a non-competitive inhibitor for mammalian MsrB2, specific for the reduction of methionine-R-sulfoxide, with lower inhibition effects. The present study investigated the effects of DMSO on the physiological antioxidant functions of methionine sulfoxide reductases. DMSO elevated hydrogen peroxide-mediated Saccharomyces cerevisiae cell death, whereas it protected human SK-Hep1 cells against oxidative stress. DMSO reduced the protein-carbonyl content in yeast cells in normal conditions, but markedly increased protein-carbonyl accumulation under oxidative stress. Using Msr deletion mutant yeast cells, we demonstrated the DMSO's selective inhibition of the antioxidant function of MsrA in S. cerevisiae, resulting in an increase in oxidative stress-induced cytotoxicity.

A Fast MSRCR Algorithm Using Hierarchical Discrete Correlation (HDC를 이용한 고속 MSRCR 알고리즘)

  • Han, Kyu-Phil
    • Journal of Korea Multimedia Society
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    • v.13 no.11
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    • pp.1621-1629
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    • 2010
  • This paper presents an improved fast MSRCR algorithm that MSRs are commonly adopted at tone mapping in color vision. Conventional MSRs consist of three SSRs, which use three Gaussian functions with different scales as those surround ones. This convolution processes require much computation load. Therefore, the proposed algorithm adopts a hierarchical discrete correlation which is equivalent to Gaussian function and the Retinex process is only applied to the luminance channel in order to get a fast processing. A simple color preservation scheme is applied to the Retinex output from the luminance channel in the proposed MSRCR algorithm. Experimental results show that the proposed algorithm required less number of oprations and computation time about 1/9.5 and 1/3.5 times, respectively, than those of the simplest MSR and was equivalent to conventional MSRs.

Contrast Enhancement Algorithm for Backlight Images using by Linear MSR (선형 MSR을 이용한 역광 영상의 명암비 향상 알고리즘)

  • Kim, Beom-Yong;Hwang, Bo-Hyun;Choi, Myung-Ryul
    • The Transactions of the Korean Institute of Electrical Engineers P
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    • v.62 no.2
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    • pp.90-94
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    • 2013
  • In this paper, we propose a new algorithm to improve the contrast ratio, to preserve information of bright regions and to maintain the color of backlight image that appears with a great relative contrast. Backlight images of the natural environment have characteristics for difference of local brightness; the overall image contrast improvement is not easy. To improve the contrast of the backlight images, MSR (Multi-Scale Retinex) algorithm using the existing multi-scale Gaussian filter is applied. However, existing multi-scale Gaussian filter involves color distortion and information loss of bright regions due to excessive contrast enhancement and noise because of the brightness improvement of dark regions. Moreover, it also increases computational complexity due to the use of multi-scale Gaussian filter. In order to solve these problems, a linear MSR is performed that reduces the amount of computation from the HSV color space preventing the color distortion and information loss due to excessive contrast enhancement. It can also remove the noise of the dark regions which is occurred due to the improved contrast through edge preserving filter. Through experimental evaluation of the average color difference comparison of CIELAB color space and the visual assessment, we have confirmed excellent performance of the proposed algorithm compared to conventional MSR algorithm.

Media Optimization and Comparison of Fermentation Type for Overproduction of Staphylodinase in Bacillus subtilis WB700 (Bacillus Subtilis W700에서의 Staphylpkinase 대량생산을 위한 배지 최적화 및 배양방법의 비교)

  • 박인석;김병기
    • KSBB Journal
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    • v.16 no.4
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    • pp.415-419
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    • 2001
  • To produce staphylokinase (SAK) in B. subtilis WB700, media optimization was carried out and the operation of batch and fed-batch fermentation were compared. Tryptone is a good nitrogen source and its optimum concentration in modified super rich(MSR) media is 15 g/L. When glucose is used as a limiting carbon source in the MSR media, 5 g/L of an optimum glucose concentration was identified for the SAK production under the control of P43 promoter. As the expression of P43 promoter is controlled by the limitation of oxygen, the SAK production was controlled at the 30% DO level in the fed-batch fermentation. Unexpectedly, batch fermentation using MSR media showed 1.5 times higher yield of SAK than that of the fed-batch fermentation. The main cause of the results comes from not achieving higher cell concentration in the fed-batch fermentation and the optimum expression level of P43 promoter under oxygen or nutrient limitations. We could not achieve the increase in cell concentration by any means in batch culture as well as fed-batch culture. The highest yield in the batch culture was 2880 units of SAK activity and 455 mg/L of secreted SAK.

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Optimum Combination of Pickup Coil Type and Magnetically Shielded Room for Maximum SNR to Measure Biomagnetism (생체신호 측정을 위한 최대의 신호 대 잡음비를 가지는 검출코일의 형태 와 자기차폐실의 최적 조합)

  • Yu, K.K.;Lee, Y.H.;Kang, C.S.;Kim, J.M.;Park, Y.K.
    • Progress in Superconductivity
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    • v.9 no.1
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    • pp.45-49
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    • 2007
  • We have investigated the optimum combination of the environmental noise condition and type of SQUID pickup coil in order to obtain maximum signal-to-noise ratio (SNR). The measurement probe consists of 1st order gradiometer with pickup coils of 100 mm, 70 mm, and 50 mm baseline length, a 2nd order gradiometer with 50 mm baseline, and a magnetometer. The pickup coils are fabricated by winding Nb wire on a bobbin with 200 mm diameter. Noise and heart signal of a healthy male were measured by various SQUID sensors with different types of pickup coils in various magnetically shielded rooms (MSR), and compared to each other. The shielding factors were found to be 43 dB, 35 dB and 25 dB at 0.1 Hz for MSR-AS, MSR-BS, MSR-CS, respectively. White noises were $3.5\;fT/Hz^{1/2}$, $4.5\;fT/Hz^{1/2}$ and $3\;fT/Hz^{1/2}$ for the 1st order gradiometers, the 2nd order gradiometers, and magnetometer for all MSRs. SNR of the magnetometer was up to 56 dB in MSR-AS, while the 1st order axial gradiometer with 70 mm baseline length was up to 54 dB in MSR-BS. The 2nd order axial gradiometer with 50 mm baseline length of pickup coil was found to be up to 40 dB in MSR-CS.

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GEANT4-based Monte Carlo Simulation of Beam Quality Correction Factors for the Leksell Gamma Knife® PerfexionTM

  • Schaarschmidt, Thomas;Kim, Tae Hoon;Kim, Yong Kyun;Yang, Hye Jeong;Chung, Hyun-Tai
    • Journal of the Korean Physical Society
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    • v.73 no.12
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    • pp.1814-1820
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    • 2018
  • With the publication of TRS-483 in late 2017 the IAEA has established an international code of practice for reference dosimetry in small and non-standard fields based on a formalism first suggested by Alfonso et al. in 2008. However, data on beam quality correction factors ($k^{f_{msr},f_{ref}}_{Q_{msr},Q_0}$) for the Leksell Gamma $Knife^{(R)}$ $Perfexion^{TM}$ is scarce and what little data is available was obtained under conditions not necessarily in accordance with the IAEA's recommendations. This study constitutes the first systematic attempt to calculate those correction factors by applying the new code of practice to Monte Carlo simulation using the GEANT4 toolkit. $k^{f_{msr},f_{ref}}_{Q_{msr},Q_0}$ values were determined for three common ionization chamber detectors and five different phantom materials, with results indicating that in most phantom materials, all chambers were well suited for reference dosimetry with the Gamma $Knife^{(R)}$. Similarities and differences between the results of this study and previous ones were also analyzed and it was found that the results obtained herein were generally in good agreement with earlier PENELOPE and EGSnrc studies.

Design and neutronic analysis of the intermediate heat exchanger of a fast-spectrum molten salt reactor

  • Terbish, Jamiyansuren;van Rooijen, W.F.G.
    • Nuclear Engineering and Technology
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    • v.53 no.7
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    • pp.2126-2132
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    • 2021
  • Various research groups and private interprises are pursuing the design of a Molten Salt Reactor (MSR) as one of the Generation-IV concepts. In the current work a fast neutron MSR using chloride fuel is analyzed, specially analyzing the power production and neutron flux level in the Intermediate Heat Exchanger (IHX). The neutronic analysis in this work is based on a chloride-fuel MSR with 600 MW thermal power. The core power density was set to 100 MW m-3 with a core H/D [[EQUATION]] 1.0 amd four Intermediate Heat Exchanger (IHX). This leads to a power of 150 MW per IHX; this power is also comparable to the IHX proposed in the SAMOFAR framework. In this work, a preliminary design of a 150 MW helical-coil IHX for a chloride-fueled MSR is prepared and the fission rate, capture rate, and inelastic scatter rate are evaluated.

Magnetocardiography System in Open-door Magnetically-shielded Room (열린 자기차폐실의 심자도 시스템)

  • Kim, J.M.;Lee, Y.H.;Kwon, H.;Yu, K.K.;Kim, K.;Park, Y.K.;Sasada, Ichiro
    • Progress in Superconductivity
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    • v.9 no.1
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    • pp.50-55
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    • 2007
  • We have installed a 61-channel magnetocardiography (MCG) system inside a magnetically shielded room (MSR) with a size of $2.4\;m\;{\times}2.4\;m\;{\times}2.4\;m$. The MCG system consists of 1st-order axial gradiometers containing double relaxation oscillation SQUIDs (DROSs) with pick-up coils of a base line of 70 mm. The MSR holds a shielding factor of 50 at 0.1 Hz and 10000 at 100 Hz, when its door in the middle on a front wall is closed. On opening the MSR door, we have obtained the characteristics of the MCG system with a 2.9 Hz noise generated from an air conditioning unit at 13 m distance off the MSR. In an open-door MSR ($140^{\circ}$ opening), a noise at the center channel increases up to $700\;fT/Hz^{l/2}$ at 2.9 Hz and $1.7\;pT/Hz^{1/2}$ at 60 Hz. MCG signals for a healthy human do not show distortion until the door opens to $45^{\circ}$, but show the effect of noise when the door opens further at $90^{\circ}$ and $140^{\circ}$. With the door opens to $45^{\circ}$, MCG measurement can be performed with ease of door operation and without creating claustrophobia for the patient.

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Vibration Reduction Method for Discharge Line of Moisture Separator Reheater (습분분리재열기 배수관 진동저감방안)

  • 이준신;손석만;김태룡
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2001.05a
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    • pp.688-694
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    • 2001
  • The 84m discharge line of moisture separator reheater(MSR) in Kori-2 had been suffered by excessive vibration from the beginning of power generation. In 1993, a complementary measure was taken to reduce the vibration level by adding several supports in the MSR pipeline. However, the piping vibration was beyond the allowable limit and an appropriate countermeasure was required to prevent the fatigue failure of the pipeline from the abnormal vibration. In this study, the vibrational characteristics of MSR pipeline and the countermeasure for abnormal vibration was investigated. Among the several vibration reduction methods, piping layout change by smoothing the pipeline was applied to the MSR pipeline in Kori-2. Applying the countermeasure, the vibration level was found to dramatically reduce from 17cm/sec to l.0cm/sec at the full-power operation condition.

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