• 한국자기공명학회논문지
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• 제25권3호
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• pp.33-38
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• 2021

Type 1 diabetes mellitus (T1DM) is caused by insufficient production of insulin, which is involved in carbohydrate metabolism. Type 2 diabetes mellitus (T2DM) has insulin resistance in which cells do not respond adequately to insulin. The purpose of this study was to estimate the characteristics of type 1 diabetes using streptozotocin-treated mice (STZ-mouse). The sera samples were collected from the models of hyperglycemic mouse and healthy mouse. Based on the pair-wise comparison, five metabolites were found to be noticeable: glucose, malonic acid, 3-hyroxybutyrate, methanol, and tryptophan. It was very natural glucose was upregulated in STZ-mouse. 3-hyroxybutyrate was also increased in the model. However, malonic acid, tryptophan, and methanol was downregulated in STZ-mouse. Several metabolites acetoacetate, acetone, alanine, arginine, asparagine, histidine, lysine, malate, methionine, ornithine, proline, propylene glycol, threonine, tyrosine, and urea tended to be varied in STZ-mouse while the statistical significance was not stratified for the variation. The multivariate model of PCA clearly showed the group separation between healthy control and STZ-mouse. The most significant metabolites that contributed the group separation included glucose, citrate, ascorbate, and lactate. Lactate did not show the statistical significance of change in t-test while it tends to down-regulated both in DNP and Diabetes.

• Genomics & Informatics
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• 제17권1호
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• pp.8.1-8.10
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• 2019

Alveolar type II cells constitute a small fraction of the total lung cell mass. However, they play an important role in many cellular processes including trans-differentiation into type I cells as well as repair of lung injury in response to toxic chemicals and respiratory pathogens. Transcription factors are the regulatory proteins dynamically modulating DNA structure and gene expression. Transcription factor profiling in microarray datasets revealed that several members of AP1, ATF, $NF-{\kappa}B$, and C/EBP families involved in diverse responses were expressed in mouse lung type II cells. A transcriptional factor signature consisting of Cebpa, Srebf1, Stat3, Klf5, and Elf3 was identified in lung type II cells, Sox9+ pluripotent lung stem cells as well as in mouse lung development. Identification of the transcription factor profile in mouse lung type II cells will serve as a useful resource and facilitate the integrated analysis of signal transduction pathways and specific gene targets in a variety of physiological conditions.

• 한국동물학회지
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• 제39권2호
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• pp.215-222
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• 1996

In the previous studies, we have demonstrated that prorenin converting enzyme (PRECE) was identical to the epidermal grouch factor-binding protein (EGF-BP) type B, which was a member of the mouse glandular kallikrein family, To examine whether or not EGF-BP type A and C are involved in the processing of prorenin, we have cloned the CDNAS of the EGF-BP type h and C from a library of male ICR mouse submandibular gland (SMGI. And then CHO cells were transfected with the EGF-BP expression plasmids. and stable cell lines expressing a high level of the EGF-BPS precursor were obtained. The conditioned medium was then treated with trypsin, which has been knotvn to effectively convert the EGF-BP type A and C precursor to the active forms. 수ubsequentlv, the prorenin converting activity of the trypsin-treated or untreated medium was examined. PRECE converted exactly prorenin to renin, but the prorenin converting activities of EGF-BP type A and C were not detected. From these results, it seems that only type B of these EGF-BPs is involved in processing Ren 2 prorenin in mouse SMG.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2009년도 학술대회
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• pp.741-744
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• 2009

본 논문에서는 Pin-type Viboratctile Display Device와 Gyroscope 및 가속도 센서, USB HID을 이용한 글러브 마우스를 제시한다. 이 장치는 장갑 안에 위치한 Gyroscope와 가속도 센서를 통해 사용자의 손목의 움직임을 인식하고 Bluetooth를 통해 본 논문에서 사용하기 위해 제작된 마우스 인식이 가능한 USB 동글에 데이터를 전달한다. 그리고 특정 어플리케이션을 통해 PC상의 정보를 사용자에게 Pin-type Vibrotactile Display 장치를 통해 촉감을 전달한다. 이 마우스는 USB 장치를 제외한 시스템에 필요한 모든 장치들을 글러브 안에 위치하여 Wearable 형태의 시스템을 구현한다. 사용자가 일반적인 공간 마우스를 사용하고 싶으면 다른 어플리케이션 없이 USB 동글만으로 인식이 가능하고 진동촉각을 느끼고자 하면 PC의 시리얼 통신 포트를 USB 동글에 연결하여 사용할 수 있다.

• 한국정보통신학회논문지
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• 제13권8호
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• pp.1721-1728
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• 2009

미래형 컴퓨터 인터페이스는 기존의 마우스에서 사람의 손 또는 눈 등으로 대체되고 있다. 본 연구에서는 자이로센서를 이용하여 장갑형 무선 마우스를 개발하였다. 이는 사람의 손동작이 마우스 커서 움직임을 대신한다. 그리고 블루투스 기반의 무선센서 네트워크 기술을 도입하여 마우스와 시스템간의 연결을 무선화하여 유선마우스가 갖는 활동의 제약성을 극복하였다. 또한 USB 포트 인터페이스를 사용하여 설치 및 사용이 용이하도록 하였다. 개발한 장갑형 무선마우스는 프리젠테이션이나 게임 등의 다양한 사용자 인터렉션을 필요로 하는 분야에 포인팅 입력장치로 활용될 수 있는 가능성을 확인할 수 있었다.

• 한국동물학회지
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• 제34권3호
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• pp.389-393
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• 1991

To obtain monozygotic multiplets from 8-cell mouse embryos, we artificially constructed chimeric embryos by introducing one blastomere (donor) of 8-cell embryos of Fl hybrid (C57BL/6 X CBA) mice into 4-cell ICR mouse embryos (carrier) of which one blastomere had been previously removed with a micromanipulator. After 42 h of culture, the developmental frequency of chimeric embryos to normal morula and blastocyst was 95% (310/328). When chimeric embryos at morula or blastocvst stage were transferred to pseudopregnant mice,39%, (70/180) of them were born. Most of the offspring (56/70) were the carrier type in coat color, whereas only three of them were the donor type, of which ho were assumed to be derived from single 8-cell donor embryo. Because the two donor type mice Ivere the same sex and produced only the donor type offspring from a testcross, they are probably monozvgotic multiplets of 8-cell mouse embryos. However, since their internal chimerism was not able to be examined, it remains to be determined if their genetic constitutions are identical.

• 대한산업공학회지
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• 제37권3호
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• pp.209-215
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• 2011

The objective of this study was to determine whether there are differences in hand muscle activities (APB : abductor pollicis brevis, ED : extensor digitorum, ECU : extensor carpi ulnaris, and EI : extensor indicis) and subjective discomfort according to the three mouse sizes (small, medium, large) and two task types (pointing and scrolling). The mouse size and task type showed significant interaction effects on the total NEMG (p = 0.004) and on the NEMG of the abductor pollicis brevis muscle (p = 0.001). The total NEMG and the NEMG of APB showed the highest value in the 'scrolling' task using the 'small' mouse. However, the NEMG of the EI was different according to the mouse size, and the 'small' mouse showed the lowest value. The subjective discomfort was the lowest in the 'medium' mouse, and all nine subjects preferred the 'medium' size. The hand-size related anthropometric variables showed different correlations according to the task type and mouse size with the NEMGs and subjective discomfort. The results of this study could be used as a basic information for the determination of the proper mouse size according to the hand size.

• International Journal of Advanced Culture Technology
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• 제11권2호
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• pp.298-309
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• 2023

The mouse as an input device has undoubtedly brought convenience to users due to its intuitiveness and simplicity, but it also brought unprecedented issues such as carpal tunnel syndrome (CTS). As a result, the necessity of alternative input devices that put less strain on the wrist, while still providing the convenience of a conventional mouse, has emerged. Unfortunately, there have been several research about alternative devices to replace a mouse, however, they showed inconsistent results. This study suggests that those inconsistent results may stem from the type and the difficulty of tasks used in previous studies. Therefore, we designed this study to compare the performance and perceived workload of three input devices (Mouse/Trackball/Touchpad) in each condition in terms of task type (Targeting/Tracking) and difficulty level (Easy/Hard). The results indicated that there were significant performance differences and no significant workload differences among the three devices, and the interactions were observed in some conditions. These results can provide users with practical guidelines to choose the optimal input device according to their needs or purpose.

• Toxicological Research
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• 제13권4호
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• pp.417-421
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• 1997

Synaptobrevin is a kind of vesicle associated membrane proteins (VAMPs) which plays a secretary role in the neuronal synapse and was recently known as the biochemical target of botulinum neurotoxin type B. The structural gene of the synaptobrevin was cloned from mouse brain using RT-PCR technique and was seqrtenced. The deduced amino acid sequence showed that the synaptobrevin protein from mouse brain is exactly the same with that of the rat brain in the amino acid level. The synaptobrevin gene was subcloned into pET3a vector and expressed in E. coli. The molecular weight of the recombinant protein was 19 kDa as expected. Moreover, when the recombinant synaptobrevin protein was incubated with the native neurotoxin of Clostridium botulinum type B, it was cleaved by the toxin in a time dependent manner. This implies that the recombinant synaptobrevin protein and the native toxin are reacted in the same way as the native synaptobrevin did in the neuronal cells.

• 대한한의학회지
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• 제34권1호
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• pp.1-14
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• 2013

Objectives: This study was designed to investigate the anti-obesity, anti-diabetic and anti-inflammatory effects of Platycodi radix on obese type 2 diabetes mouse model. Methods: Obese type 2 diabetes mouse model was induced by Surwit's high fat, high sucrose diet for 8 weeks. Models were divided into 4 groups of normal diet (ND, n=10), high fat and high sucrose diet (HFD, n=10), high fat and high sucrose diet with Platycodi radix (PR, n=10), and high fat and high sucrose diet with Metformin (Met, n=10). Body weights were measured every week. After 7 weeks fasting, blood sugar and oral glucose tolerance tests were conducted. After 8 weeks blood samples were taken from mouse hearts and analyzed biochemically. Lipid profile, fructosamine, leptin and weight of epididymal fat pad and liver were measured. Adipose tissue macrophage percentage was analyzed by fluorescence-activated cell sorting (FACS). Results: Compared with the HFD group, body weight, glucose level, fructosamine, weight of epididymal fat pad and adipose tissue macrophage percentage decreased in the PR group. Conclusions: These results suggest that Platycodi Radix has anti-obesity, anti-diabetic, and anti-inflammatory effects on obese type 2 diabetes mouse model.