• 대한한의진단학회지
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• 제15권3호
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• pp.245-260
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• 2011

Objectives: The aim of this experiment is to know the effect of Mountain Cultivated Ginseng Pharmacopuncture on Heart Rate Variability (HRV), Pulse wave velocity (PWV) in Middle Aged Women. Methods: We investigated on 40 women of breast cancer patients. First, we measured their Heart Rate Variability(HRV), Pulse wave velocity (PWV) and then Mountain Cultivated Ginseng Pharmacopuncture $20m{\ell}$ were injected on them. After 30 minutes, we measured Heart Rate Variability(HRV), Pulse wave velocity(PWV) again. As a result, method of non-equivalent control group non-synchronized design were used for evaluation. Results: In HRV, Mean HRV is significantly decreased from 69.15 to 63.34 after injection. Mean RR is significantly increased from 877.20 to 962.10 after injection. SDNN is significantly increased from 32.56 to 41.34 after injection. PNN50 is significantly decreased after injection. RNSSD, SDSD, TP, VLF is significantly increased after injection. Stress Resistance ability is significantly increased from 37.55 to 44.60 after injection. And In PWV, E-R, E-L, H-R, H-L is significantly decreased after injection. Conclusions: Effect of Mountain Cultivated Ginseng Pharmacopuncture on Heart Rate Variability (HRV) increased adaptability of autonomic nervous system and on Pulse wave velocity (PWV) decreased arterial stiffness.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2004년도 하계학술대회 논문집 Vol.5 No.1
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• pp.425-428
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• 2004

65% of the Korean peninsula is composed of mountainous area, 97% of which is composed of forest. Therefore, there is high possibility of mountain fire because a lot of potential inflammables such as fallen leaves are stacked on the ground. Moreover, most of the overhead transmission lines in Korea are operated on the mountain. However, there has been very little study for the effect of mountain fire on polymeric insulator for transmission line, though the study is significantly required Therefore, in this study the authors observed the deformation of the housing of the insulator under fire with respect to the ignition time, using artificial ignition testing equipment, and investigated electrical and mechanical characteristics of the insulator by dry withstand voltage test, impulse flashover test and tensile load test.

• Journal of Ginseng Research
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• 제44권5호
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• pp.704-716
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• 2020

Background: Ginsenoside Rh2 (GRh2) is a characterized component in red ginseng widely used in Korea and China. GRh2 exhibits a wide range of pharmacological activities, such as anti-inflammatory, antioxidant, and anticancer properties. However, its effects on Toxoplasma gondii (T. gondii) infection have not been clarified yet. Methods: The effect of GRh2 against T. gondii was assessed under in vitro and in vivo experiments. The BV2 cells were infected with tachyzoites of T. gondii RH strain, and the effects of GRh2 were evaluated by MTT assay, morphological observations, immunofluorescence staining, a trypan blue exclusion assay, reverse transcription PCR, and Western blot analyses. The in vivo experiment was conducted with BALB/c mice inoculated with lethal amounts of tachyzoites with or without GRh2 treatment. Results and conclusion: The GRh2 treatment significantly inhibited the proliferation of T. gondii under in vitro and in vivo studies. Furthermore, GRh2 blocked the activation of microglia and specifically decreased the release of inflammatory mediators in response to T. gondii infection through TLR4/NF-κB signaling pathway. In mice, GRh2 conferred modest protection from a lethal dose of T. gondii. After the treatment, the proliferation of tachyzoites in the peritoneal cavity of infected mice markedly decreased. Moreover, GRh2 also significantly decreased the T. gondii burden in mouse brain tissues. These findings indicate that GRh2 exhibits an antieT. gondii effect and inhibits the microglial activation through TLR4/NF-κB signaling pathway, providing the basic pharmacological basis for the development of new drugs to treat toxoplasmic encephalitis.

• Smart Structures and Systems
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• 제31권3호
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• pp.213-227
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• 2023

A passive prismatic-shaped isolation platform (PIP) is proposed to realize enhanced quasi-zero stiffness (QZS) effect. The design concept uses a horizontal spring to produce a tunable negative stiffness and installs oblique springs inside the cells of the prismatic structure to provide a tunable positive stiffness. Therefore, the QZS effect can be achieved by combining the negative stiffness and the positive stiffness. To this aim, firstly, the mathematical modeling and the static analysis are conducted to demonstrate this idea and provide the design basis. Further, with the parametric study and the optimal design of the PIP, the enhanced QZS effect is achieved with widened QZS range and stable property. Moreover, the dynamic analysis is conducted to investigate the vibration isolation performance of the proposed PIP. The analysis results show that the widened QZS property can be achieved with the optimal designed structural parameters, and the proposed PIP has an excellent vibration isolation performance in the ultra-low frequency due to the enlarged QZS range. Compared with the traditional QZS isolator, the PIP shows better performance with a broader isolation frequency range and stable property under the large excitation amplitude.

• Applied Microscopy
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• 제40권3호
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• pp.133-138
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• 2010

인체 자궁암 세포 HeLa에 항암제 cisplatin (CDDP)과 산삼배양근 추출물(ETCMG)을 투여하여 세포 성장률, 형태, 전기영동에 의한 DNA fragmentation, 세포주기 분석을 통하여 apoptosis 유도를 확인하였다. ETCMG 2, 4, 6mg/mL, CDDP $4{\mu}g/mL$의 농도로 24시간 투여한 후 세포의 성장에 미치는 영향을 분석하고, ETCMG를 항암제로서 효과가 입증되어있는 CDDP와 복합투여하여 비교한 결과 apoptosis비율은 대조군에 비하여 ETCMG의 농도가 증가할수록 농도에 비례하여 현저히 증가하였고 (p<0.05), CDDP와 ETCMG를 복합투여한 경우에 ETCMG를 단독으로 투여한 경우 보다 apoptosis비율이 매우 높은것으로 나타났다(p<0.05). 세포의 형태를 도립현미경과 투과전자현미경으로 관찰한 결과, 대조군은 세포의 정상적인 형태를 유지하고 있는 반면에 CDDP와 ETCMG를 각각 처리한 암세포는 세포의 성장이 현저히 억제되었고, 염색질의 응축과 apoptotic body가 관찰되었다. 세포의 성장억제가 apoptosis에 의한 것인지를 확인하고자 DNA를 분리하여 전기영동한 결과, HeLa 세포에서 ETCMG의 농도가 증가할수록 ladder가 뚜렷이 관찰되었고, CDDP를 복합 처리한 것 역시 ETCMG의 농도에 비례하여 ladder가 선명하게 나타났다. Flow cytometry (FC)에 의한 세포주기 분석 결과, ETCMG를 농도별로 처리한 경우에 apoptosis를 나타내는 Sub-$G_1$기의 양이 농도에 비례하여 증가하였고, 항암제인 CDDP와 복합 투여한 경우에 Sub-$G_1$기 DNA양이 눈에 띠게 증가한 것으로 나타났다. 이상의 실험 결과를 종합하면, ETCMG는 인체 자궁암에서 항암효과를 가지고 있으며, 항암제 CDDP의 단독 투여보다는 ETCMG와 함께 사용하는 경우에 암 치료제로서의 상승효과가 있는 것으로 사료된다.

• Water Engineering Research
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• 제1권2호
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• pp.147-158
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• 2000

In this study, we characterized the seasonal variation of rainrate fields in the Han river basin using the WGR multi-dimensional precipitation model (Waymire, Gupta, and Rodriguez-Iturbe, 1984) by estimating and comparing the parameters derived for each month and for the plain area, the mountain area and overall basin, respectively. The first-and second-order statistics derived from observed point gauge data were used to estimate the model parameters based on the Davidon-Fletcher-Powell algorithm of optimization. As a result of the study, we can find that the higher rainfall amount during summer is mainly due to the arrival rate of rain bands, mean number of cells per cluster potential center, and raincell intensity. However, other parameters controlling the mean number of rain cells per cluster, the cellular birth rate, and the mean cell age are found invariant to the rainfall amounts. In the application to the downstream plain area and upstream mountain area of the Han river basin, we found that the number of storms in the mountain area was estimated a little higher than that in the plain area, but the cell intensity in the mountain area a little lower than that in the plain area. Thus, in the mountain area more frequent but less intense storms can be expected due to the orographic effect, but the total amount of rainfall in a given period seems to remain the same.

• Structural Engineering and Mechanics
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• 제76권2호
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• pp.207-222
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• 2020

Due to the rugged terrain, metro lines in mountain city across numerous wide rivers and deep valleys, resulting in instability of high-pier bridge and insecurity of metro train subjected to fluctuating crosswind. To ensure the safe operation in metro lines in mountain cities, running safety of the metro train over the high-pier bridge under crosswind is analyzed in this paper. Firstly, the dynamic model of the wind-train-bridge (WTB) system is built, in which the speed-up effect of crosswind is fully considered. On the basis of time domain analysis, the basic characteristics of the WTB system with high-pier are analyzed. Afterwards, the dynamic responses varies with train speed and wind speed are calculated, and the safety zone of metro train over a high-pier bridge subjected to fluctuating crosswind in mountain city is determined. The results indicate that, fluctuating crosswind triggers drastic vibration to the metro train and high-pier bridges, which in turn causes running instability of the train. For this reason, the corresponding safety zone for metro train running on the high-pier is proposed, and the metro traffic on the high-pier bridge should be closed as the mean wind speed of standard height reaches 9 m/s (15.6 m/s for the train).

• 한국태양에너지학회:학술대회논문집
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• 한국태양에너지학회 2008년도 추계학술발표대회 논문집
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• pp.81-84
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• 2008

This paper discussed the validity of wind force power generation in consideration of the topographical characteristics of Korea. In order to estimate the exact generation of wind power plants, we analyzed and compared wind resources in mountain areas and plain areas by introducing not only wind velocity, the most important variable, but also wind distribution and wind standard deviation that can reflect the influence of landform sufficiently. According to the results of this study, generation was higher at wind power plants installed in southwestern coastal areas where wind velocity was low than at those installed in mountain areas in Gangwondo where wind velocity was high. This suggests that the shape parameter of wind distribution is low due to the characteristics of mountain areas. and the standard deviation of wind velocity is large due to the effect of mountain winds, and therefore, actual generation is low in mountain areas although wind velocity is high.

• 한국환경과학회지
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• 제16권1호
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• pp.73-79
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• 2007

The purpose of this study is to clarify the effect of mountain-valley wind on heat island formed in urban area which is located around valley mouth. The meteorological observations were carried out over the Dalbi-valley under a clear summer pressure patterns, and some consideration were tried from the results. In order to make clear the climatological characteristics and air-mass modification process of the mountain-valley wind over the valley, the meteorological observations were done simultaneously at two points. The observational points were located at the breast and valley mouth parts, respectively. The results were as follows: First, it was found that the valley wind was observed through the daytime, and it was replaced by a mountain wind after sunset. Second, the heat budget is also investigated with observation data. The sensible heat flux over the breast of Dalbi-valley reached to about $200 W/m^2$ during daytime, which is a little more than one third of net radiation. On the other hand, the sensible heat flux represented negative values during nighttime. But the sensible heat flux over the valley mouth covered by asphalt showed plus value(about $20{\sim}30 W/m^2$) during the nighttime.

• 한국태양에너지학회 논문집
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• 제28권6호
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• pp.24-32
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• 2008

This paper discussed the Feasibility study of wind power generation considering the topographical characteristics of Korea. In order to estimate the exact generation of wind power plants, we analyzed and compared wind resources in mountain areas and plain areas by introducing not only wind speed, the most important variable, but also wind distribution and wind standard deviation that can reflect the influence of landform sufficiently. According to the results of this study, generation was almost the same at wind power plants installed in southwestern coastal areas where wind speed was low as at those installed in mountain areas in Gangwondo where wind speed was high. This demonstrates that the shape parameter of wind distribution is low due to the characteristics of mountain areas, and the standard deviation of wind speed is large due to the effect of mountain winds, therefore, actual generation compared to southwestern coastal areas is almost similar in mountain areas even though wind speed is high.