• The Journal of Korean Physical Therapy
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• 제22권3호
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• pp.31-35
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• 2010

Purpose: The aim of this study was to use fMRI and clinical prognosis criteria to evaluate therapeutic interventions in stroke patients with corona radiata infarct and acquire fundamental information about recovery mechanisms. Methods: Four subjects (2 men, 2 women) who had strokes with corona radiata infarct were recruited. For all subjects, motor functions such as motricity index (MI), modified brunnstrom classification (MBC), functional ambulatory category (FAC), and bathel index (BI) were evaluated. Evaluations were done at least 4 times over a period of approximately 6~7 months from stroke onset. We compared the final evaluation with the first. Results: All patients with corona radiata infarct showed improvement in motor outcomes with the passing of time. The strength of all patients improved from zero or trace levels to normal or good levels in the MI (Motricity Index) test. Other motor outcomes including the modified brunnstrom classification (MBC), the functional ambulatory category (FAC), and the bathel index (BI) also improved with the passing of time. Conclusion: Stroke patients with corona radiata infarcts change for the better over time. Therefore, one can introduce clinical interventions by the aspect of progress in functional motor recovery.

• 융합정보논문지
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• 제11권8호
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• pp.168-175
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• 2021

본 연구는 뇌성마비 아동의 대동작 기능과 먹기, 마시기 기능, 구강 운동 기능과의 상관관계를 확인해보고, 뇌성마비 아동의 대동작 기능의 심한 정도에 따른 연하 재활의 필요성을 확인하기 위해 시행되었다. 뇌성마비 진단을 받은 아동 61명을 대상으로 대동작 기능 분류 체계(GMFCS), 먹기와 마시기 기능분류 체계(EDACS), 구강 운동 기능 검사(OMAS)를 사용하여 대동작 기능, 먹고 마시기 기능, 구강 운동 기능 수준을 평가하고 각 기능 간 상관관계를 확인하였다. 본 연구의 결과는 대동작, 먹고 마시기 기능, 구강 운동 기능 사이에서 유의한 상관관계를 보였다. 즉, 대동작 기능 저하가 심할수록 먹고 마시기 기능과 구강 운동 기능 저하 역시 낮은 기능 수준을 보였다. 본 연구를 통하여 뇌성마비 아동의 섭식활동을 평가하고 치료함에 있어, 아동의 대동작 기능에 따른 먹고 마시기 기능, 구강 운동 기능에 대한 확인이 필요할 것으로 보인다.

• 한방재활의학과학회지
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• 제20권1호
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• pp.13-26
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• 2010

Objectives : This study was designed to evaluate neuroprotective effects of Neutral Pharmacopuncture for Blood Stasis(NPBS) into SP10 and Tangguisusangami-tang (dangguixusanjiawei-tang)(TGT) in the experimental Traumatic Brain Injury(TBI)rats. Methods : Male rats were divided into 4 groups. Group I was no treatment after TBI. Group II was treatment with NPBS into SP10 after TBI. Group III was treatment with TGT after TBI. Group IV was NPBS into SP10 and TGT after TBI. The author carried out neurological motor behavioral, histological assessment test. Results : 1. In neurological motor behavior tests, motor and cognitive function recovery was significantly increased in the Group II, III, IV. Also Group IV was increased as compared with Group II, III. 2. In BAX expression, according to priority Group IV, III, II, I were decresed in 7 and 14 days later. Especially Group IV was significantly decreased in 14 days later. 3. In BCL-2 expression, Group IV was increased slightly in 7 days later. Most incresed expression was experimented in the Group IV in 14 days later. 4. In TUNEL expression, IV was decreased as compared with each Group I, II, III in 7 days later. Group IV, III were decreased as compared with each Group I, II, III in 14 days later. Conclusions : According to the results, NPBS and TGT can inhibit apoptosis of cells after TBI in rats by contol of BAX and BCL-2, TUNEL expression. And also can help neurological motor behavioral function.

• 한방재활의학과학회지
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• 제19권3호
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• pp.69-80
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• 2009

Objectives : The purpose of this study was to evaluate the effects of core stability training on postural control and balance of hemiplegia patients who are difficult to control posture due to stroke. Methods : Subjects of the study were consisted of 25 adult hemiplegia patients(experimental 12, control 13) who were receiving rehabilitation therapy in hospital. Its group had a core stability training program by a physical therapists for 40 minutes, five times a week for nine-week period. Measurements of postural assessment scale for stroke(PASS), berg balance scale(BBS) and manual function test(MFT) were evaluated at initial presentation(pretest) and after completion of the each therapy program(posttest). Independent t-test and paired t-test was utilized to detect the mean difference between the groups. Results : Firstly, the result of PASS showed that postural control was significantly increased after the completion of core stability training(p<.01). Secondly, the result of BBS showed that balance control was significantly increased after the completion of core stability training(p<.01) and general physical therapy(p<.01). Lastly, the result of MFT showed that upper extremity's motor function was significantly increased after the completion of core stability training(p<.001). Conclusions : This study showed that core stability training is an effective treatment strategy on postural control, balance and upper extremity's motor function.

• Journal of Korean Neurosurgical Society
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• 제58권1호
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• pp.14-21
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• 2015

Objective : To study the effect of early intervention and rehabilitation in the expression of aquaporin-4 and ultrastructure changes on cerebral palsy pups model induced by intrauterine infection. Methods : 20 pregnant Wistar rats were consecutively injected with lipopolysaccharide intraperitoneally. 60 Pups born from lipopolysaccharide group were randomly divided into intervention group (n=30) and non-intervention group (n=30); intervention group further divided into early intervention and rehabilitation group (n=10), acupuncture group (n=10) and consolidate group (n=10). Another 5 pregnant rats were injected with normal saline intraperitoneally; 30 pups born from the normal saline group were taken as control group. The intervention group received early intervention, rehabilitation and acupuncture treatment. The motor functions of all pups were assessed via suspension test and modified BBB locomotor score. Aquaporin-4 expression in brain tissue was studied through immunohistochemical and western-blot analysis. Ultrastructure changes in damaged brain and control group were studied electron-microscopically. Results : The scores of suspension test and modified BBB locomotor test were significantly higher in the control group than the intervention and non intervention group (p<0.01); higher in the intervention group than the non-intervention group (p<0.01). The expression of Aquaporin-4 was lower in intervention and non intervention group than in the control group (p<0.01); also lower in non-intervention group than the intervention group (p<0.01). Marked changes were observed in ultrastructure of cortex and hippocampus CAI in brain damaged group. Conclusion : Early intervention and rehabilitation training can improve the motor function in offspring with brain injury and reduce the expression of aquaporin-4 in damaged brain.

• 한국전문물리치료학회지
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• 제12권3호
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• pp.56-66
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• 2005

The purposes of this study were to test that complex motor training enhance motor function significantly, to test change in cerebellum, and to test the synaptic plasticity into the immunohistochemistry response of synaptophysin. Using an animal model of fetal alcohol syndrome - which equates peak blood alcohol concentrations across developmental period - the effects of alcohol on body weight during periods were examined. The effect of complex motor training on motor function and synaptic plasticity of rat exposed alcohol on postnatal days 4 through 10 were studied. Newborn rats were assigned to one of two groups: (1) normal group (NG), via artificial rearing to milk formula and (2) alcohol groups (AG), via 4.5 g/kg/day of ethanol in a milk solution. After completion of the treatments, the pups were fostered back to lactating dams, where they were raised in standard cages (two-and three animals per cage) until they were postnatal 48 days. Rats from alcohol group of postnatal treatment then spent 10 days in one of two groups: Alcohol-experimental group was had got complex motor training (learning traverse a set of 6 elevated obstacles) for 4 weeks. The alcohol-control group was not trained. Before consider replacing with "the experiment/study", (avoid using "got" in writing) the rats were examined during four behavioral tests and their body weights were measured, then their coronal sections were processed in rabbit polyclonal antibody synaptophysin. The synaptophysin expression in the cerebellar cortex was investigated using a light microscope. The results of this study were as follows: 1. The alcohol groups contained significantly higher alcohol concentrations than the normal group. 2. The alcohol groups had significantly lower body weights than the normal group. 3. In alcohol groups performed significantly lower than the normal group on the motor behavioral test. 4. In alcohol-control group showed significantly decreased immunohistochemistric response of the synaptophysin in the cerebellar cortex compared to the nomal group. These results suggest that improved motor function induced by complex motor training after postnatal exposure is associated with dynamically altered expression of synaptophysin in cerebellar cortex and that is related with synaptic plasticity. Also, these data can potentially serve as a model for therapeutic intervention.

• 대한의용생체공학회:의공학회지
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• 제34권3호
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• pp.148-155
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• 2013

This study is about the development of the wrist rehabilitation system for the patient who has limited capability of movement after stroke. Electromyography triggered training system (ETTS) can play the role between complete passive training and patient activating training system. Surface EMG was measured on pronator teres muscle and biceps brachii muscle for wrist pronation and supination. Our system detects whether the subject makes muscular effort for pronation or supination or nothing in every 50 ms. When the effort level exceeds the preset percentage of maximal voluntary contraction, the motor rotates according to the direction of the intention of the subject. EMG triggers the motor rotation for the wrist rehabilitation training until the preset angle. To evaluate its performance, the maximum voluntary contraction level was measured for 4 subjects at first. With the audio-visual instruction to rotate the wrist (pronation or supination) the subjects made effort to follow the instruction. After calculating root mean square (RMS) for 50 ms, the controller determines whether there was muscular effort to rotate while holding the motor. When there was an effort to rotate, the controller rotates the motor 0.8 degree. By comparing the RMS values from two channels of EMG, the controller determines the rotational direction. The onset delay is $0.76{\pm}0.24$ s and offset delay is $0.65{\pm}0.22$ s for pronation. For supination the onset delay is $1.24{\pm}0.41$ s and offset delay is $0.77{\pm}0.22$ s. The system responded fast enough to be used for rehabilitation training. The controller perceived the direction of rotation 100% correctly for the pronation and 97.5% correctly for supination. ETTS was developed and the fundamental functions were validated for normal subjects. The clinical validation should be done with patients for real world application. With ETTS, the subjects can train voluntarily over the limitation of the range of motion which increases the effectiveness of the rehabilitation training.

• Journal of Magnetics
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• 제20권4호
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• pp.427-431
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• 2015

The aim of this study was to investigate whether repetitive transcranial magnetic stimulation (rTMS) can improve motor recovery in the lower extremities of the patients with subacute stage spinal cord injury (SCI). This study was conducted with 19 subjects diagnosed with paraplegia because of SCI. The experimental group included 10 subjects who underwent active rTMS, and the control group included 9 subjects who underwent sham rTMS. The SCI patients in the experimental group underwent conventional rehabilitation therapy, and active rTMS was applied daily to the hotspot of the lesional hemisphere. The SCI patients in the control group underwent sham rTMS and conventional rehabilitation therapy. The participants in both the groups received therapy five days per week for six weeks. Latency, amplitude, and velocity were assessed before and after the six-week therapy period. A significant difference in post-treatment gains for the latency and velocity was observed between the experimental and control groups (p < 0.05). However, no significant differences in the amplitude were observed between the two groups (p > 0.05). The results of this study indicate that rTMS may be beneficial in improving motor recovery in the lower extremities of subacute stage SCI patients.

• The Journal of Korean Physical Therapy
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• 제23권3호
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• pp.65-70
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• 2011

Purpose: We investigated the changes in the stop-signal reaction time (SSRT) and the no-signal reaction time (NSRT) following motor sequential learning in the stop-signal task (SST). This study also determined which of the reduction0s of spatial processing time was better between blocked- and random-SST. Methods: Thirty right-handed healthy subjects without a history of neurological dysfunction were recruited. In all subjects, both the SSRT and the NSRT were measured for the SST. Tasks were classified into two categories based on the stop-signal patterns, the blocked-SST practice group and random-SST practice group. All subjects gave written informed consent. Results: In the blocked-SST group, both the SSRT and the NSRT was significantly decreased (p<0.05) but not significantly changed in the random-SST group. In the SSRT and the NSRT, the blocked-SST group was faster than the random-SST group (p<0.05). In the post-test SST after practice of each group, the SSRT was significantly decreased in the random-SST group (p<0.05), but the NSRT showed no significant changes in either group. Conclusion: These findings demonstrate that random-SST practice resulted in a decrease in internal processing times needed for a rapid stop to visual signals, indicating motor skill learning is acquired through improved response selection and inhibition.

• The Journal of Korean Physical Therapy
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• 제12권1호
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• pp.119-127
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• 2000

In this case report we demonstrated the improvemen of gait pattern and the facilitation of postwalk locomotion on the child who has severe mental retardation with Incomplete gait pattern. Treatments included to stimulate vestibular using balance board and vestibular stimulator, to train weight hearing and shifting, to facilitate visual perception motor coordination, and to train walk ann postwalk locomotion in environment similar to actual daily life. It was performed 130 sessions for 10 months. With this treatment, she could accomplished dynamic stability so that she didn't fall at walk after $1\~2$ months of treatment, and could have done climbing up and down without hand support after 10 months. In gross motor function measure(GMFM), total motor function was improved to $89.98\%$ from $73.53\%$.