• Journal of Biomedical Engineering Research
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• v.29 no.1
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• pp.8-16
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• 2008

The aim of this study was to evaluate the motor recovery in 4 chronic hemiparetic patients with Fugl-Meyer (FM) and EMG characteristics before and after the training program. The training was performed at 1hr/day, 5days/week during 6 weeks in 4 chronic stroke patients. Electromyographic activities of the affected hand were recorded during isometric wrist flexion/ extension movements. In all patients, FM was significantly improved after the 6-week training. Onset/offset delay of muscle contraction significantly decreased in the affected wrist after the training. The co-contraction ratio of flexor/extensor muscles decreased significantly. Also, onset/offset delay of muscle contraction and co-contraction ratio correlates significantly with upper limb motor impairment and motor recovery. This EMG technique allows an objective evaluation of changes in muscle activity in post-stroke patients, providing easily measurable, quantitative indices of muscle characteristics.

• The Korean Journal of Pharmacology
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• v.19 no.1
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• pp.77-84
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• 1983

The behavioral pattern of an animal is influenced by endogenous and endogenous stimuli such as humoral secretion, neurohumoral transmitters, drugs, light and environmental change. It has teen known that adenosine is a normal constituent of brain, and has sedative or hypnotic effects and anticonvulsant effects, inhibiting the spontaneous firing of cells in the brain via membrane adenosine receptors. Recent studies suggest that the excitatory responses to xanthines in the CNS might be related to the competitive antagonism of xanthines to adenosine. This study was undertaken to Investigate the effects of adenosine and the CNS stimulants such as picrotoxin, strychnine and caffeine on the spontaneous activity of mire, and to examine the influence of adenosine on the seizures induced by large doses of CNS stimulants. Subjects were $20{\sim}30\;g$ adult mice, and the spontaneous activity was measured using the Selective Activity Meter after intraperitoneal injection of adenosine (10 mg/kg), caffeine (100 mg/kg), strychnine(0.2 mg/kg) or picrotoxin(0.5 mg/kg) with or without adenosine pretreatment. The seizures were induced with caffeine(200, 250 and 300 mg/kg), strychnine(1.25 and 1.5 mg/kg) or picrotoxin(10 and 15 mg/kg). The results are summarized as follows : 1) The spontaneous activity in mite was significantly inhibited between 10 and 20 minutes after adenosine treatment. 2) Caffeine and picrotoxin increased the motor activity significantly while strychnine had no effect on the activity. 3) The ambulatory activity in the caffeine, strychnine and picrotoxin treated groups was significantly inhibited by adenosine pretreatment. 4) The seizures were observed with caffeine(200, 250 and 300 m9/kg), strychnine(1.25 and 1.5 mg/kg) or picrotoxin(10 and 15 mg/kg). The caffeine induced seizures were inhibited by adenosine pretreatment, but the strychnine or picrotoxin induced seizures were not affected.

• The Journal of Korean Physical Therapy
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• v.21 no.1
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• pp.73-80
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• 2009

Purpose: In order to examine difference in the activity of potential of spinal neurons and cortical neurons according to muscle contraction type in post stroke hemiplegic subjects and healthy subjects, the present study conducted an experiment as follows. Methods: The subjects in the experimental group were 17 left-side hemiplegic subjects (9 female, 8 male; mean age, 63.41$\pm$9.86 years) with the right hand as the dominant hand selected among post stroke hemiplegic subjects, and 17 age matched healthy control subjects (10 female, 7 male; mean age, 64.12$\pm$12.07 years). Movement-related cortical potentials (MRCPs) were measured using surface electromyography and electroencephalography while concentric and eccentric movements were made alternately. Results: As to the pattern of the activity of MRCP, which indicates the activity of motor cortical neurons, we found that the amplitude is high (p<0.01), the length of excitement is short (p<0.01) and the ascending gradient of amplitude to the peak increases (p<0.05) in post stroke hemiplegic subjects' lesion sites different from healthy subjects. Conclusion: The activity of cortical neurons was no difference in activity according to contraction type was observed in post stroke hemiplegic subjects' lesion sites. This suggests that there is no distinction in the activity of cortical neurons between concentric contraction and eccentric contraction. Accordingly, if post stroke hemiplegic subjects' activity of motor cortex is analyzed by measuring MRCPs, it is considered useful in research on neural plasticity or as a ground of clinical effects in the area of physical therapy for the central nervous system.

• The Journal of Korea Robotics Society
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• v.8 no.4
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• pp.273-282
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• 2013

The purpose of this study was to investigate effect of robot-assisted hand rehabilitation(Amadeo(R)) on hand motor function in chronic stroke patients. This study used a single-subject experimental design with multiple baselines across individuals. Three chronic stroke survivors with mild to sever motor impairment took part in study. Each participants had 2 weeks interval of starting intervention. Participants received robot-assisted therapy(45min/session. 3session/wk for 6wks). Finger active range of motion(AROM) was assessed by Range of Assessment program in Amadeo(R), and test-retest reliability was verified using Pearson correlation analysis. To investigate effect of Amadeo(R), finger AROM was measured immediately after each sessions and Fugl-Meyer Assessment of Upper extremity, Motor Activity Log, Nine hole peg board test and Jebsen-Taylor hand motor function test were assessed at pre-post intervention. Results were analyzed by visual analysis and comparison of pre-post tests. The test-retest reliability of Range of Assessment was good(r=.99). After robot-assisted therapy, finger AROM of participant 1, 2, and 3 was respectively improved by 18%, 3.6%, and 6% each. Hand motor function of participant 1, 3 was improved on all four tests, but not effect in participant 2. Robot-assisted hand rehabilitation could improve finger AROM and effect on hand motor function in chronic stroke patients.

• Journal of Korean Academy of Nursing
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• v.35 no.8
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• pp.1451-1460
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• 2005

Purpose. The purpose of this study was to evaluate the premature infants' responses to infant massage (tactile and kinesthetic stimulation). These responses measured by weight, physiological (vagal tone, heart rate, oxygen saturation) and behavioral responses (behavioral states, motor activities, and behavioral distress). Methods. This study was conducted using an equivalent control pretest-posttest design. The sample was divided into two groups of 13 infants with gestational age less than 36 weeks at birth, birth weight less than 2000g, and no congenital anomalies. The experimental group received the massage intervention twice daily for 10 days. The data were collected for 10 minutes prior to and 10 minutes after the massage. Results. The vagal tone was significantly higher after massage than before massage in the experimental group, while no change in the control group. The experimental group had significantly higher scores for awake state and motor activity than the control group. Significantly greater awake state, more fidgeting or crying, and increased motor activity were reported after massage than before massage. Conclusions. The results of this study showed that massage therapy might enhance optimal physiological responses and behavioral organization of premature infants. Nursing staff in the NICU can use massage to promote the infant's capability to respond positively to his environment and to provide developmental support for healthy premature infants.

• Physical Therapy Korea
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• v.9 no.3
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• pp.125-135
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• 2002

In most of the medical literature that discusses the common problem of movement in patients with cerebral lesions. This critical problem is ascribed to a mechanism involving uninhibited neural activity. The goals of neurological physical therapy are focus on reduce of muscle hypertonicity, facilitates muscle activities, and improve of performance in living environment. A variety of studies suggest that spasticity is a distinct problem and separate from the muscle weakness. It has become increasingly recognized that the major functional deficits following brain damage are largely due to negative features such as muscle weakness and loss of performance rather than spasticity. Adequate recruitment of prime mover, not release was able to carry out the movement tasks well. The strengthening exercise of spastic limbs on changes in muscle properties and performance skill, the repeated motor practice has been identified as crucial for motor recovery. This article support the concept that strengthening is an appropriate intervention to improve the quality of physical function in patients with central nervous system lesions. Further studies and therapeutic approaches should be efforts at improving motor neuron recruitment in agonist rather than reducing activity in antagonists while retraining muscle strengthening.

• Journal of Korean Physical Therapy Science
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• v.18 no.1
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• pp.61-67
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• 2011

Background: The purpose of the present study was to determine correlations between the Berg Balance Scale (BBS), Modified Barthel Index(MBI), Mini-Mental State Examination(MMSE) and Fugl-Meyer motor function Assessment(FMA) in persons with strokes. Methods: We recruited 77 stroke patients from the Seoul Bukbu Geriatric Hospital in Seoul, Korea. Balance was measured by BBS. Activity of Daily Living was assessed using MBI. Cognitive function was examined using MMSE. Motor Recovery was measured using FMA. Data was analyzed using Pearson' correlation. Resurts: There were a statistically significant correlation between BBS and MBI, BBS and MMES, BBS and FMA upper extremity, BBS and FMA lower extremity. There were a statistically significant correlation between MBI and MMSE, MBI and FMA upper extremity, MBI and FMA lower extremity. There were a statistically significant correlated between FMA upper extremity and FMA lower extremity. Conclusions: This study will help rehabilitation program for stroke patients and will be the reference data for selection of therapy and evaluation method.

• Environmental Analysis Health and Toxicology
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• v.4 no.3_4
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• pp.15-28
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• 1989

The effects of ethanol on the toxicity of 2, 4-Dichlorophenoxyacetic acid in ICR mice were examined. The results were summerized as follows; 1. The LD$\sub$50/ of 2.4-dichlorphenoxyacetic acid sodium injected intraperitoneally in mice was approximately 367 mg/kg. When the animals were administered with ethanol, 2 ml/kg or 4 ml/kg the LD$\sub$50/ of 2.4-D sodium were decreased to 338 mg/kg or 32 mg/kg, respectively. 2. In the acute experimental group, spontaneous motor activity in the ANIMEX system exhibited dose-dependent decrease in mice administered with 2.4-D sodium and ethanol. 3. However, in subacute experimental group, spontaneous motor activity in the ANIMEX system exhibited dose-dependent increase in mice treated with ethanol.

• Archives of Pharmacal Research
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• v.18 no.3
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• pp.146-152
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• 1995

To achieve a better understanding of the effects on behavioral safety caused by possible neuroprotective doses (50 mg/kg, p.o.) of dextromethorphan HBr (DM), several motor activity measures were monitored in two generations of mice through a long-term period of ten months. Adult male mice (G1), in the presence of DM, developed behavioral tolerance after an initial suppression period. Prenatally exposed, second generation (G2) mice formed two groups, prenatal exposure alone (G2C) and prenatally exposed with additional postnatal exposure (G2T). In the presence of DM, group G2T was characterized by significant behavioral impairment; while G2C exhibited behavioral activation. These results suggest that more attention should be given to the prenatal effects of DM on a developing organism.

• Journal of Wellbeing Management and Applied Psychology
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• v.5 no.1
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• pp.31-35
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• 2022

Purpose: This study was conducted to investigate the effects of change in the unstable support surface location during bridge exercise on the muscle activity of erector spinae and gluteus maximus. Research design, data and methodology: 12 healthy participants aged 23.32 ±1.02 were measured muscle activities of erector spinae and gluteus maximus during bridge exercise and compared between the exercise conditions; unstable support surface located on upper back and feet during bridge exercise. Paired t-test was performed to identify whether there was a significant difference in the muscle activities between the exercise conditions. Results: As a result, even though higher levels of the averaged muscle activities of both erector spinae and gluteus maximus during exercise in unstable support surface located on feet than upper back were observed, no significant differences were found. Conclusions: The change of unstable support surface location during bridge exercise for low back pain rehabilitation would be more appropriate to be used to increase levels of tension of muscle activities and train fine motor control rather than to strengthening muscle strength.