• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제31권5호
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• pp.409-416
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• 2005

Purpose of study: The temporomandibular joint (TMJ) occupies a key functional role in mastication and contributes to normal deglutition, speech as well as cosmesis. When a large amount of mandible including the condyle head is resected, it is very difficult to reconstruct it as a functional unit. In this retrospective study, we present the functional, radiographic and cosmetic results of reconstructed temporomandibular joint using free fibular flap. Patients and Methods: Total 12 patients (M:F = 6:6) who underwent condylar reconstruction with the fibular flap were interviewed and examined by radiographs and Bio-PAK$^{(R)}$. Mean follow up periods was $47.7{\pm}20.0$ months and the average age was $38.7{\pm}15.3$ years. Remodeling of condyle and function of TMJ were evaluated and facial contour was judged subjectively. Results: All flaps were viable and no immediate postoperative complication had happened. One patient showed decreased mouth opening, so interpositional gap arthroplasty was performed. The resorption rates of reconstructed fibular were minimal and the condyle heads were changed into domeshaped neocondyle after 2 years. All patients had normal diet and no speech difficulty was reported. Nine patients were satisfied with their facial contour but three patients complained about the depression of cheek. Conclusion: The reconstruction of TMJ with free fibular flap was reliable methods and very effective means of restoring mandibular function. The functional and morphologic results were excellent and showed little complications.

• 대한한방내과학회지
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• 제26권2호
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• pp.320-332
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• 2005

Objectives: The aim of the experiment is to identify any anti-tumor effects of Duchesnea indica(Andr.) Focke on stomach, liver, urinary bladder, prostate and kidney cancer cells. Materials & Methods: For cancer cells, AGS stomach, Hep3B and Hep3G2 liver, HT-1197, HT-1376 urinary bladder, PC3 prostate, and A-704 kidney cancer cells, all obtained from Korean Ce 11 Line Bank, were used. The boiled extract of Duchesnea indica(Andr.) Focke (10 and 20 microliters) was injected into cultures, and the cultures were observed at 0, 6 and 12 hours, and from then on at 12 hours intervals up to 72 hours. The destruction of stomach, liver, urinary bladder, prostate and kidney cancer cells were measured through Trypan blue exclusion testing. The suppresion on viability of stomach, liver, urinary bladder, prostate and kidney cancer cells was measured via MTT assay. Anti-cancer mechanisms were assessed by analyzing the cell cycle. Results: In morphologic change, AGS, Hep3B, HepG2 showed the withdrawn and floating appearance that is typical in cellular impairment. The destruction of AGS, HT-1197, HT-1376, A-704, PC-3, Hep3B and HepG2 cancer cells in each test group was greater than that in the control group to a statistically significant degree. The suppression on viability of AGS, HT-1197 and Hep3G in each test group was greater than that in the control group to a statistically significant degree. Analysis of the cell cycle after injection of D... Focke showed inhibition of cell division in all test groups(AGS, Hep3B, HepG2, HT-1197, HT-1376, PC3, A-704). Conclusions: The results of this experiment suggest that Duchesnea indica(Andr.) Focke has statistically significant anti-tumor effects on stomach, urinary bladder, kidney, prostate and liver cancer, of which stomach and liver cancer are prominently significant. This in vitro experiment supports a role for Duchesnea indica(Andr.) Focke as a potential cancer treatment, but progressive research on Duchesnea indica(Andr.) Focke and its anti-tumor effects is needed to develop a practical application for it in cancer treatment.

• 대한치과교정학회지
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• 제25권2호
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• pp.129-142
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• 1995

본 연구는 한국성인의 두경부자세와 두개안면형태를 두개내 및 두개외 기준선에 대하여 알아보고 그 상관성을 평가하여 향후 진단시 보조적 자료로 사용하고자하여 시행되었다. 양호한 안모와 1급 구치관계를 지닌 성인 남, 녀 각 25명씩 총 50명에 대하여 natural head position 측모 두부 X-선 계측사진을 촬영하여 투사도를 그린후 posterior nasal spine을 지나는 true vertical line과 sella를 지나는 true horizontal line을 기준으로하여 자세변수 및 형태변수를 계측, 계산하였다. SPSS통계처리 프로그램을 이용하여 남녀평균, 표준편차를 구하고 student t-test로 유의차를 검정한후 자세변수와 형태변수간의 상관관계를 보았으며, 또한 자세변수를 이용하여 두경부자세의 재현성을 평가하여 다음과같은 결과를 얻었다. 1. 한국성인에서의 두경부자세변수와 두개안면형태변수의 평균과 표준편차를 얻었다. 2. 한국성인은 OPT/CVT간 각에 있어서 $3.55{\pm}2.58^{\circ}$의 경추 전방만곡을 보였다. 3. 자세변수와 형태변수의 상관관계에서는 두경부자세와 안면의 수직적인 비율, 안면돌출도, 하악골의 회전이 높은 상관성을 보였다. 4. 두경부자세와 상하악간 관계, 전후방적 악골비율의 상관관계는 미약하였다. 5. Natural head position에서의 head positioning error는 $1.65^{\circ}$로 SN line의 개인간 변이도 $3.31^{\circ}$ 보다 작았다. 다른 자세변수도 head positioning error가 각 변수들의 개인간 변이도보다 작았다.

• 대한치과보철학회지
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• 제45권4호
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• pp.492-505
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• 2007

Statement of problem: An orthodontic miniscrew implant has been used as a skeletal anchorage for orthodontic treatment. However, any relation among the influence of the cortical bone, morphologic differences of orthodontic miniscrew implants and new bone formation hasn't been made clear yet. Purpose: The purpose of this study was to evaluate whether the orthodontic miniscrew implant could work as an intraoral skeletal anchorage immediately and stably for orthodontic treatment after insertion of it. Material and methods: Two types of orthodontic miniscrew implants were used in this experiment; tapered type and straight type. One hundred and sixty eight orthodontic miniscrew implants were inserted into the tibiae of 21 rabbits and sacrificed on 3, 7, 11, 14, 21 and 28days later after insertion of them to study removal torque values and histologic and histomorphometric analyses. Results: The results were as follows. 1. The removal torque values of the tapered type were higher than those of the straight type in all groups(p<0.05). 2. There wasn't any distinguishing differences between the tapered type and the straight type about the new bone formation percentage. 3. The removal torque values for both the tapered type and the straight type were gradually decreased at early stages of the test but started to increase at the 7 days group of the straight type and the 11 days group of the tapered type. 4. New bone formation percentage was increased gradually for both the tapered and the straight types as time passed(p<0.05). 5. It was found that the tapered type showed lower values in the cortical bone about both the maximum equilibratory stress distribution and the maximum principal stress distribution than the straight type in linear finite elements analysis. Conclusion: According to the research, the removal torque values were decreased at 7 days group of the tapered type and 11 days group of the straight type after the insertion of the orthodontic miniscrew implants in tibiae of rabbits. Considering the human bone activity, it is better to apply the orthodontic force $3{\sim}4$ weeks later than to apply it immediately after the insertion of orthodontic miniscrew implants. Considering that general orthodontic force is about $250{\sim}500$ grams, the tapered type can be worked as a stable skeletal anchor age in an orthodontic treatment even if the orthodontic force is applied on it immediately after the insertion of it.

• 생물정신의학
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• 제25권3호
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• pp.60-71
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• 2018

Objectives A growing body of evidence has suggested that morphologic changes in cerebellum may be implicated with pathophysiology of major depressive disorder (MDD). The aim of this study is to investigate a difference in the volume and cortical thickness of the specific region of cerebellum between patients with MDD and healthy controls (HC). Methods A total of 127 patients with MDD and 105 HC participated in this study and underwent T1-weighted structural magnetic resonance imaging. We analyzed volume and cortical thickness of each twelve cerebellum regions divided by left and right and the volume and cortical thickness of the whole cerebellum from T1-weigted image of participants. One-way analysis of covariance was used to investigate the volume and cortical thickness difference of total and specific regions between two groups adjusting for age, gender, medication, and total intracranial cavity volume. Results We found that the patients with MDD had significantly greater volume in the left cerebellum lobule III region [false discovery rate (FDR)-corrected p = 0.034] compared to HC. Also, our findings indicate that cortical thickness of left lobule VIIB (FDR-corrected p = 0.032) and lobule VIIIB (FDR-corrected p = 0.032) are significantly thinner in the patients with MDD compared with the HC. No significant volume and cortical thickness differences were observed in other sub-regions of the cerebellum. The volumes and cortical thickness of whole cerebellum between patients with MDD and HC did not differ significantly. Conclusions We observed the region-specific volume and cortical thickness difference in cerebellum between the patients with MDD and HC. The results of our study implicate that the information about structural alterations in cerebellum with further replicative studies might provide a stepping stone toward a specific marker to diagnose MDD.

• Parasites, Hosts and Diseases
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• 제56권4호
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• pp.379-383
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• 2018

The present study was performed with morphological and molecular analysis (cox1 and nad1 mitochondrial genes) to identify the proglottids of spirometrid tapeworm found in the stool of an African lion, Panthera leo, in the Serengeti plain of Tanzania. A strand of tapeworm strobila, about 75 cm in length, was obtained in the stool of a male African lion in the Serengeti National Park ($34^{\circ}$ 50' E, $02^{\circ}$ 30' S), Tanzania, in February 2012. The morphological features of the adult worm examined exhibited 3 uterine coils with a bow tie appearance and adopted a diagonal direction in the second turn. The posterior uterine coils are larger than terminal uterine ball and the feature of uteri are swirling rather than spirally coiling. The sequence difference between the Spirometra species (Tanzania origin) and S. erinaceieuropaei (GenBank no. KJ599680) was 9.4% while those of S. decipiens (GenBank no. KJ599679) differed by 2.1% in the cox1 and nad1 genes. Phylogenetic tree topologies generated using the 2 analytic methods were identical and presented high level of confidence values for the 3 major branches of the 3 Spirometra species in the cox1 gene. The morphological and molecular findings obtained in this study were nearly coincided with those of S. ranarum. Therefore, we can know for the first time that the African lion, Panthera leo, is to the definitive host of this tapeworm.

• Spatial Information Research
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• 제18권4호
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• pp.1-11
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• 2010

본 연구는 2차원적 도시특성변수를 이용한 기존 선행연구와 달리, 도시기하학적인 특성을 중심으로 도시열섬현상에 관한 설명모형을 구축하고 이에 대한 정책적 시사점을 제시하고 자하는 연구이다. 오하이오주 콜럼버스 도시(Columbus, Ohio)의 3차원 도시공간구축을 위하여 LiDAR 데이터가 활용되었고, 건축물의 외부공간을 구축하기 위하여 건물수치지도가 이용되었다. 또한 식생지수와 도시온도 자료를 추출하기 위하여 Landsat TM 영상의 band 3, band 4, Thermal band 가 이용되었다. 복잡한 자료 추출 과정을 통해 획득된 6가지 변수들(건물의 총 부피, 건물의 총 표면적, 평균 건물의 높이-도로폭 비율, 공극률, 건물바닥면적비율, 식생지수)을 도입하여 단순회귀 및 다중회귀 모형을 구축하였다. 회귀모형구축에 있어서는 비선형관계에 있는 변수를 선형화하기 위해 Box-Tidwell 변형기법을 적용하였으며 최적화된 변수변형을 통한 선형회귀모형을 구축하였다. 공극률, 식생지수, 건축 표면적 변수로 추정된 다중회귀모형은 전체 온도변이의 57%를 설명할 수 있는 것으로 나타났으며, 도시열섬을 저감시키기 위한 다양한 정책수립(오픈스페이스 확대정책, 옥상녹화, 벽면녹화 등)에 의미있는 결과를 제공하였다.

• Journal of Periodontal and Implant Science
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• 제26권1호
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• pp.266-275
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• 1996

The purpose of this study was to evaluate the effect of anatomical predisposing factors on the development of furcation involvement. Root trunk length, root divergency angle, buccal root trunk concavity and cervical enamel projection of the mandibular 1st and 2nd molars with(l03 teeth) and without(42 teeth) furcation involvement and enamel projection were classified by Lindhe's degree and Masters's classification, respectively, and buccal root trunk concavity was examined by probing. Statistical analysis was performed by means of ANOVA and CHI-SQUARE test in Microstat. The obtained results were as follows : 1. Root trunk length was longer in teeth without furcation involvement($4.20{\pm}1.05mm$) than teeth with furcation involvement(I : $3.62{\pm}0.68mm$, II : $3.64{\pm}0.86mm$, III: $3.61{\pm}0.74mm$)(p<0.05), but there was fno significant difference among furcation involvement group according to the degree of furcation involvement(p0>.05). 2. The root divergency angle was wider in teeth with furcation involvement(I : $53.14^0{\pm}15.11^0$, II : $44.82^0{\pm}14.26^0$, III : $52.69^0{\pm}16.09^0$) than teeth without furcation involvement($34.81^0{\pm}16.57^0$(p<0.05). 3. The group of teeth without furcation involvement showed significantly hign percentage of teeth without buccal root concavity, and the group of teeth with furcation involvement showed significantly hign percentage of teeth with buccal root concavity(p<0.05) 4. The group of teeth without furcation involvement showed higher percentage of teeth with grade I cervical enamel projection, teeth with furcation involvement I or II defect showed higher percentage of teeth with grade II enamel projection, and teeth with furcation involvement III defect showed higher percentage of teeth with grade III enamel projection(p<0.05) The results suggest that short root trunk length, wide root divergency, buccal root concavity and well-developed enamel projection could affect development and progression of furcation involvement as anatomical predisposing factors of periodontal diseases.

• Journal of Korean Neurosurgical Society
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• 제63권6호
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• pp.698-706
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• 2020

Objective : To study the physiochemical characteristics of podophyllotoxin (PPT) conjugated stearic acid grafted chitosan oligosaccharide micelle (PPT-CSO-SA), and evaluate the ability of the potential antineoplastic effects against glioma cells. Methods : PPT-CSO-SA was prepared by a dialysis method. The quality of PPT-CSO-SA including micellar size, zeta potential, drug encapsulation efficiency and drug release profiles was evaluated. Glioma cells were cultured and treated with PPT and PPT-CSO-SA. The ability of glioma cells to uptake PPT-CSO-SA was observed. The proliferation of glioma cells was determined by 3-[4, 5-dimethyl-2-thiazolyl]-2, 5-diphenyl-2H-tetrazolium bromide (MTT) assay. The apoptosis and morphology of U251 cells were observed by 4',6-Diamidino-2-phenylindole dihydrochloride (DAPI) dye staining. Cell cycle analysis was performed by flow cytometry. The migration ability of U251 cells was determined by wound healing test. Results : PPT-CSO-SA had nano-level particle size and sustained release property. The encapsulation efficiency of drug reached a high level. The cellular uptake percentage of PPT in glioma cells was lower than that of PPT-CSO-SA (p<0.05). The inhibitory effect of PPT-CSO-SA on glioma cells proliferation was significantly stronger than that of PPT (p<0.05). The morphologic change of apoptosis cell such as shrinkage, karyorrhexis and karyopyknosis were observed. The percentage of U251 cells in G2/M phase increased significantly in the PPT-CSO-SA group compared with PPT group (p<0.05). Compared with the PPT group, the cell migration ability of the PPT-CSO-SA group was significantly inhibited after 12 and 24 hours (p<0.05). Conclusion : PPT-CSO-SA can effectively enhance the glioma cellular uptake of drugs, inhibit glioma cells proliferation and migration, induce G2/M phase arrest of them, and promote their apoptosis. It may be a promising anti-glioma nano-drug.

• 대한치과교정학회지
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• 제35권5호
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• pp.398-407
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• 2005

본 연구는 안면비대칭이 있는 환자의 측두하악관절원반 형태와 위치를 평가하고 악관절내장증과 안면비대칭 간의 관계를 규명하기 위하여 시행되었다. 남자 10명 및 여자 27명으로 구성된 안면비대칭 환자 37명의 74개의 TMJ MRI를 사용하였으며, 대상 집단의 연령은 12세에서 44세까지의 범위로 평균 21.4세였다. 시상 및 두정 TMJ MRI를 최대감합위 및 최대개구위에서 채득한 후 부분전방변위, 전방변위, 회전 또는 측방원반변위 등 원반변위의 종류를 기록하였으며, 원반의 모양위치, 그리고 원반의 변위 및 회전을 MRI tracing 상에서 판독하였다. 악관절내장증의 증상은 정상, 정복성 전방원반변위(ADDR), 그리고 비정복성 전방원반변위 (ADDNR) 집단으로 분류하였으며, 환자는 양측성 정상. 편측 혹은 양측 내장증 집단으로 분류하였다. 약$70\%$의 환자에서 편측성 또는 양측성 내장증을 보였으며. 통계분석 결과 ADD, 특히 회전성 ADD가 변위측에서 더 높은 빈도로 나타났으나 반대측에서는 원반의 위치가 정상인 경우가 많았다. (p<0.01). 변위측의 원반은 모양의 변형 및 하전방 변위를 유의하게 더 나타냈다. 그러나 반대쪽은 개구시 원반이 수직방향으로 과운동성이 관찰되었다. 이 연구는 안면비대칭 환자에서 ADD의 종류가 원반의 모양, 경사 변위 각도, 변위의 수직거리 및 회전각도와 연관이 있다는 것을 제시한다