• Journal of Biomedical Engineering Research
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• v.38 no.1
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• pp.49-55
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• 2017

The prevalence of obesity has noticeably increased worldwide over several decades with various complication. Even though anti-obesity drug treatments have been spotlighted by resulting in effective mean weight losses, its adverse effects cannot be overlooked. Thus, this study aimed to evaluate the effects of multi-frequency whole body vibration, one of the mechanical stimulus, as a countermeasure against obesity. Thirty-two-6-week-old C57BL/6J male mice were equally assigned to four groups: the Control group (CON, n = 8), the Sham group (Sham, n = 8), the sham with single frequency whole body vibration (S+V, n = 8), and the sham with multi frequency whole body vibration (S+MV, n = 8). After 4 weeks, morphologic changes in the adipose tissue were evaluated from three-dimensional images using in vivo micro-computed tomography. At 4 weeks, the volume of the abdominal adipose tissue, which had the highest value in Sham group, noticeably reduced in S+MV group compared to it in S+V group. These results implied that the accumulation of abdominal adipose tissue can be effectively reduced through applying multi-frequency whole body vibration.

• Journal of the Korean association of regional geographers
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• v.15 no.2
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• pp.192-203
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• 2009

The purpose of this paper is to elucidate the formative processes of depositional landforms in Jiwoo drainage basin which located in the most upstream reach of Namgang River. Through the analysis of morphologic characteristics and sedimentary facies, the formative processes can be summarized as follow: First, the high depositional landforms(Sapyeong, Eungam, Naedongdyttle site) were formed by gelifluction process in the periglacial environment during the last glacial period. And the relative height over river bed of them is getting lower from upper to downstream. The extent of the high depositional landforms is assumed about 1 kilometer downstream far from the confluence of Jiwoo stream and Namgang River. Second, the sediments in the gentle slope at Jangseungbuldle were carried by gelifluction process during the last glacial stage after the deep-weathered bedrock had formed a gentle slope. Third, the high depositional landforms were dissected during warm and humid environment of postglacial stage, and some sediments of them were left in the river bed. Later, as the more upstream high depositional landforms were dissected completely, stream power was getting more than resistance(sediment storage) and the low depositional landforms(Sapyeong, Yongchusa, Deungbangdle site) were formed.

• Journal of Korean Library and Information Science Society
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• v.36 no.2
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• pp.13-30
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• 2005

This paper is a morphologic-bibliographic analysis on every printed books of Hanmunbon Great Learn(大學), one of $\lceil$FourBooks(四書)$\rfloor$, in Chosun Dynasty. Through examination of the physical characteristics of oks in many institutes and private collections, $\lceil$Daehakjanggudaejun(大學章句大全)$\rfloor$, was systematically explored, which was the most frequently Published Great Learn (大學) in Chosun Dynasty. The Hanmunbon Great Learn (大學) was published mainly in Central Publishing Office in Hansung Area and Kyungsang provinces, and in the period of 17C to 19C. There are two streams of $\lceil$Daehakjanggudaejun$\rfloor$. One is the reprinted edition of Myungbon(明本覆刻), originated from $\lceil$Saseookyungdaejun(四書五經大全)$\rfloor$, compiled by Hokwang(胡廣) and colleagues in Myung(明). The second is movable type books of Chosun(朝鮮活字本), the contents of which being the same as the other stream.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.23 no.3
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• pp.205-211
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• 2001

Cleft palate is one of the most serious congenital anomalies in human that causes a sucking problem in newborn babies and morphologic deformity that usually leads to death in newborn mouse offspring due to an insufficient ability to suck milk. Therefore cleft palate had been researched with epidemiologic and molecular methods, and many etiologic factors were examined closely. Among of the research methods, biologic molecule researches have been more important method for cleft palate formation study. The $TGF-{\beta}$ had an important role in the cell migration, epithelial-mesenchymal transdifferentiation, extracellular matrix synthesis and deposition. But there was a little research which was study about correlation cleft palate induced by beta-aminonitroproprionitrile(BAPN) with $TGF-{\beta}$ expression. A purpose of this presented study was examed how $TGF-{\beta}$ expression in cleft palate mice. At gestation days 13, BAPN-monofumarate salts($(C_3H_6N_2)_2$ ${\cdot}$ $C_4H_4O_4$, Sigma Co.) was single oral administered to 4 pregnant rats according to 1g/kg body weight. And pregnant rats were sacrificed on day 20 post coitus(p.c.), The $TGF-{\beta}$ expression patterns of cleft formed fetus mice was followed that; 1.Osteoblast, mesenchymal cell and epithelial cell of cleft mice were low expression compare to control mice. 2.There was no $TGF-{\beta}$ difference expression pattern of osteocyte of cleft mice compare to control mice. 3. In western blot analysis, thickness of band of $TGF-{\beta}$ in cleft mice was thin and dilute compare to control mice.

• Journal of Korean Clinical Health Science
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• v.3 no.3
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• pp.427-434
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• 2015

Purpose: This study was to investigate the relationship between the palpebral fissure and the exophthalmos in an elder women population in Korea subjects with normal eye status. Methods. From November 2014 to July 2015, The author analyzed the morphological values in 81 Korean elder women population. The clinical test was performed using the Hertel exophthalometer and verner califer. Analysis of data were described using the spss 20 and Pearson's test. Results. The mean age of the 81 subjects (162 eyes) was (73.938+/8.585)mm. The mean value of palpebral fissure was (5.673+/-2.065)mm in width and (24.179+/-4.409)mm in height. The mean value of exophthalmos was (5.537+/-2.151)mm. There were a significant relationship(P>0.01) in the mean size between the width and height in palpebral fissure. Also, there were a significant relationship(P>0.01) in the mean size between the palpebral fissure width and exophthalmos. Also, there were a significant relationship(P>0.01) in the mean size between the palpebral height width and exophthalmos. However, there were not significant relationship(P>0.01) in the mean size between the palpebral fissure width and exophthalmos in right eye. On the other hand, The relationship between right eye and left eye of the palpebral fissure and exophthalmos was similar results. Conclusions. In this study, these results suggested that the palpebral fissure and exophthalmos was a significant relationship in the mean value of morphologic characters in Korean elder women population.

• Journal of the Korean Society for Precision Engineering
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• v.30 no.4
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• pp.442-449
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• 2013

This study was to compare a domestic comfort shoes to the popular import(SAS$^{(R)}$) to gain a better understanding in biomechanical characteristics for shoe design for the elderly. For each shoe type, morphologic dimensions, shock absorption, and flexibility were assessed. From subjects(n = 20, $72.4{\pm}5.5$ years, $67.7{\pm}7.9$ kg), mean peak pressure(MPP) and contact area(CA) at the plantar surface were analyzed. The domestic shoes reflecting anatomic contour of the plantar surfaces of Asians resulted in wider CA(by 30.4 $cm^2$), higher shock absorption(by 2.4%) and stiffness(by 0.5 N/mm) than the import. With the domestic shoes, significantly less MPPs were found at the forefoot(by 42~49%) regions(p < .05) and higher CA was noted additionally at hallux and lessor toes(by 26~63%). More anatomically-contoured insole and favorable mechanical characteristics may help reduce the plantar pressures more effectively and more evenly, especially across the central forefoot and midfoot regions of the plantar surface, especially for the design of the comfort shoes for the elderly.

• The Journal of Korean Medicine
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• v.23 no.4
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• pp.45-54
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• 2002

Objectives: In order to investigate the relationship of Radix Trichosanthis components and the melanin synthesis, the author has analyzed the cell viability and tyrosinase activity, melanin content and morphologic changes in n-hexane, EtOAc, n-BuOH, and H2O fraction. Methods: At first, in order to determine the concentration of the Radix Trichosanthis component, the author investigated the viability of B16 melanoma cell. To measure the effects of Trichosanthes kirilowii extracts (n-BuOH, n-Hexane, EtOAc, H2O fractions) on the viability of A549 cells, A549 cells were treated with various concentrations (from 0.5 to $25{\;}\mu\textrm{g}/ml$) of components of Trichosanthes kirilowii. After 24hrs, the cell viability was measured by MTT assay. The EtOAc components of Trichosanthes kirilowii decreased the viability of A549 cells in a dose-dependent manner. H2O and n-BuOH components had no cell toxicity till $25{\;}\mu\textrm{g}/ml$, the n-hexane component showed minor cell toxicity at $25{\;}\mu\textrm{g}/ml$ and the EtOAc component cell toxicity was revealed at $5{\;}\mu\textrm{g}/ml$ concentration. Results: 1. The results of tyrosinase activity and the Radix Trichosanthis component; n-hexane and EtOAc components controlled it effectively; the n-BuOH components were less effective. 2. The results of melanin content analysis showed that the n-hexane and EtOAc components effectively inhibited, the n-BuOH fraction inhibited less, and H2O component didn't inhibit the terminal melanin formation. 3. In the n-BuOH and H2O component there were no changes, but in the n-hexane component the melanin content was effectively inhibited. 4. In the EtOAc fraction, although the melanin content was inhibited, the cell count was evidently suppressed, Of all of the Radix Trichosanthis components, the n-Hexane and EtOAc fractions inhibited the melanin synthesis best, but owing to its toxicity, the EtOAc components inhibited the cell count. Conclusion: The above results demonstrated that Radix Trichosanthis n-hexane fraction efficiently inhibited the tyrosinase activity and melanin synthesis.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10819-10824
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• 2015

Aims: To explore the effect and probable mechanism of a synthetic retinoid 4-amino-2-tri-fluoromethylphenyl ester (ATPR) on apoptosis of MDA-MB-231 breast cancer cells. Materials and Methods: MTT assays were performed to measure the proliferation of MDA-MB-231 cells treated with different concentrations of all-trans retinoic acid (ATRA) and ATPR. Morphologic changes were observed by microscopy. The apoptosis rates and cell cycling of MDA-MB-231 cells treated with ATRA or ATPR were assessed using flow cytometry analysis. Expression of retinoic acid receptor and phosphorylation of ERK, JNK, p38 proteins were detected by Western blotting. Results: Treatment of the cells with the addition of $15{\mu}mol/L$ ATPR for 48 h clearly demonstrated reduced cell numbers and deformed cells, whereas no changes in the number and morphology were observed after treatment with ATRA. The apoptosis rate was 33.2% after breast cancer MDA-MB-231 cells were treated by ATPR ($15{\mu}mol/L$) whereas ATRA ($15{\mu}mol/L$) had no apoptotic effect. ATPR inhibited the phosphorylation of ERK, JNK, and p38 while ATRA had no significant effect. ATPR inhibited the expression of BiP and increased the expression of Chop at the protein level compared with control groups, ATRA and ATPR both decreased the protein expression of $RXR{\alpha}$, ATPR reduced the protein expression of $RAR{\beta}$ and $RXR{\beta}$ while ATRA did not decrease $RAR{\beta}$ or $RXR{\beta}$. Conclusions: ATPR could induce apoptosis of breast cancer MDA-MB-231 cells, possible mechanisms being binding to $RAR{\beta}/RXR{\beta}$ heterodimers, then activation of ER stress involving the MAPK pathway.

• The korean journal of orthodontics
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• v.28 no.6 s.71
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• pp.937-946
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• 1998

The patient with an anterior open bite has one of the most difficult orthodontic problem to correct. Previous studies have yielded different conclusions as to exactly where the morphologic problems associated with vertical dysplasia-high angle cases are located. In order to identify the cephalometric features of high angle cases and highlight the measurements that characterize high angle cases, 109 pretreatment cephalograms, 35 high angle, 37 average angle, and 37 low angle cases, were analyzed and compared statistically. As the mandibular plane was steeper, the anterior facial height, especially lower anterior facial height, became greater, and the posterior facial height became smaller. All the dentoalveolar vertical dimensions, especially in upper, increased. And all the skeletal angular measurements increased. Especially Lower genial angle had most positive correlation to mandibular Plane angle. Upper incisor was lingually inclined, and lower incisor was labially inclined in high angle cases.

• Imaging Science in Dentistry
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• v.37 no.3
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• pp.133-138
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• 2007

Purpose: The purpose of this study was to evaluate the morphologic features of posterior edentulous mandible for Korean patients using cross-sectional CT images. Materials and Methods: Computed tomographic cross-sectional views taken in 2004 and 2005 at Seoul National University Dental Hospital were analyzed by an oral and maxillofacial radiologist. Four indices were measured to meet the purpose of this study: 1) the horizontal distance between the alveolar crest and mandibular canal (Type), 2) the angle of the mandibular long axis (Angle), 3) the bucco-lingual location of mandibular canal, and 4) the depth of the submandibular fossa. The averages and standard deviations of the measurements were compared according to the location (the first and second molar area) and sex of the patients. Results: Statistically significant difference was found in Type, Angle, and submandibular fossa depth between the first and second molar area (p<0.05). However, there was no significant difference between men and women in any of the measured indices. Most of the mandibular canals were located in lingual side of posterior mandible. Conclusion: More care should be taken when an implant is installed on the mandibular second molar area.