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Effects of Sagunjatang and Samultang on the Immunosuppression induced by Methotrexate in Rats (사군자탕(四君子湯) 및 사물탕(四物湯)이 methotrexate로 유도(誘導)된 흰쥐의 면역기능저하(免疫機能低下)에 미치는 영향(影響))

  • Choi Yun-Jung;Kim Jang-Hyun
    • The Journal of Pediatrics of Korean Medicine
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    • v.13 no.1
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    • pp.253-275
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    • 1999
  • The effects of Sagunjatang and Samultang on the immunosuppression induced by methotrexate(MTX) in rats were investigated in this study. The multiple parameters of immunity assessed in each rats included leukocyte count, lymphocyte rate, the number of lymphocyte in tibial bone marrow, contact hypersensitivity to DNFB, morphological change of thymocyte and IgG antibody on SDS-PAGE. Sprague-Dawley male rats were used and divided into five groups at random. Group A was normal control. Group B, the MTX treatment control, was injected i.v. with 2mg/kg of on days 9, 11 after sensitization with SRBC on 5th day. Group C, the experimental control, was treated Sagunjatang for 18days and MTX. Group D was treated Samultang for 18days and MTX. Group E was treated Sagunjatang-Samultang for 18days and MTX. The dosage of Sagunjatang and Samultang was $1m{\ell}/day$ respectively. In the case of Group E, rats Were fed Sagunjatang $1m{\ell}$ in the morning and Samultang $1m{\ell}$ in the afternoon. The results are summarized as follows: 1. Leukocyte count in rats induced by intravenous sensitization with SRBC was decreased significantly in Group E. 2. Leukocyte counts of 2weeks later after being treated MTX were increased significantly in Groups C and D. 3. Lymphocyte rate in rats induced by intravenous sensitization with SRBC wasn't changed significantly in all the experimental groups. 4. Lymphocyte rate of 2weeks. later after being treated MTX was increased significantly in Group D. 5. The number of lymphocyte in tibial bone marrow was incereased significantly in Group C. 6. Contact hypersensitivity wasn't changed significantly in all the experimental groups. 7. Morphological finding of thymocyte in group C was similar to normal group as compared with control group. 8. Purified IgG of all the experimental groups showed two bands of 50,000 and 25,000 on SDS-PAGE. But there was no difference among experimental groups.

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A Study of the Intraocular Pressure of Korean Youth (한국인 청년의 안압 측정)

  • Kim, Sang-Moon
    • Journal of Korean Ophthalmic Optics Society
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    • v.11 no.2
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    • pp.91-97
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    • 2006
  • The intraocular pressure for Korean youth were measured by using tonometer (AT555-Reichert). The relative frequency distributions of intraocular pressures have been studied for samples of 1,027 persons(475 males, 552 females). The most commonly recorded IOP for both men and women was around 14.5mmHg and 17.5mmHg, respectively. They were in the range of 7 to 23mmHg(males) and 7 to 22mmHg(females). The median pressure(cumulative frequency=0.5%) is 13.0~16.5mmHg for males and 16.5~18.5mmHg for females, so the values for females are slightly higher than males. The mean pressure is 15.2mmHg for males and 15.8mmHg for females, respectively. The 98% of population was in the range of the normal IOP. There are long-term diurnal variation in mean intraocular pressure and the IOP was decreased as a function of time from morning to night. The measured IOP was affected by several factors: exercise made to decrease the IOP and tight collars, dark places and posture of decubitus position got to elevate the IOP.

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Evaluation of Pharmacist Intervention Program for Dosage Adjustment and IV-to-PO Conversion for $H_2$-Receptor Antagonist (신기능을 고려한 $H_2$-receptor antagonist의 용량, 용법 및 투여경로의 적절성 및 약사자문의 수용성)

  • Hwang, Bo Young;Oh, Jung Mi
    • Quality Improvement in Health Care
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    • v.9 no.2
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    • pp.230-240
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    • 2002
  • Background : The purpose of this study was to develop, implement and evaluate the pharmacist intervention program designed to identify and correctly adjust the dosage of $H_2$-receptor antagonists ($H_2RA$) in renally impaired patients and promote timely conversion of $H_2RA$ from IV to PO therapy. Methods : The study population consisted of renally impaired patients who received $H_2RA$ therapy from April 9 to May 8, 2001 at Hallym Medical Center. Each morning a specifically developed software program identified patients with serum creatinine (Scr) greater than 1.2 mg/dl or age greater than 65 years. The pharmacist, then screened the pharmacy profiles of the identified patients to determine if the patient was on $H_2RA$. For these patients on $H_2RA$ with renal impairement the creatinine clearance (CrCl) was calculated using Cockroft & Gault equation. The pharmacist determined the proper dosage for each identified patients based on the calculated CrCl and the oral dosage that would be appropriate for whom IV therapy was no longer indicated. Result : A total of 149 cases (101 patients) were monitored during the study period. The dosage was inappropriately prescribed for renal function in 61 of 149 cases (41%), and of those, pharmacist made recommendations for 58 cases of which 33 cases (57%) were accepted by the physicians. The administration route of H2RA was inappropriately used as IV in 22 of 53 cases (42%), and pharmacist made recommendations for those 22 cases of which 15 cases (68%) were accepted. Conclusion : Monitoring of patients with renal dysfunction by a pharmacist improved the dosing of $H_2RA$ and a dosing program of patients with renal impairment would be of benefit to other clinicians and institutions seeking to optimize patient care.

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Improvement of Multicultural Awareness and Story Building by Community Radio (공동체 라디오를 통한 다문화 인식개선과 스토리설계 방안)

  • Hong, Sook-Yeong
    • The Journal of the Korea Contents Association
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    • v.15 no.5
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    • pp.98-107
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    • 2015
  • This study analyzed the story of 'Good Morning, Ladies of the World', a multicultural program of a community radio Gwanak FM. Furthermore, the study performed an in-depth interview on Korean producing staffs and migrant casts in order to figure out the contents for the improvement of awareness and for the design of multicultural media story telling. As a result, the migrant women presented overall public discourses on their own culture, climate and customs as a sense of representative. While Korean staffs wanted to understand and communicate with their culture and to share private experiences, migrant women wished understanding and respect to their culture and removal of discrimination or prejudice. Accordingly, the storytelling design for the improvement of multicultural awareness must be a private discourse on the basis of a public discourse, and it turned out that the user of a mediator who experienced and knew culture of Korea and the migrant is necessary. And, this study recommended the need of education of migrant women and media support for a proper story planning, structuring and delivery.

Dental Caries and Oral Health Behavior of Kindergarten Children in a County Area of Kangwondo (강원도 군지역 유아들의 구강관리 행태와 치아 우식증)

  • Song Byung Sun;Moon Jung Soon
    • Journal of Korean Public Health Nursing
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    • v.16 no.1
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    • pp.123-134
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    • 2002
  • In order to investigate dental caries and oral health status of Kindergarten children, a study was conducted from 1st December, 2000 to 21st January 2001. The subjects were consisted of 117 toddler and pre-school children who were enrolled in 4 kindergartens in a county of Kangwondo. A structured questionnaire was used for dental health behavior and dental examination was given by dentist for detecting dental caries The result were as follows: 1. As for the oral health behavior, 71.8% of subjects brushed their tooth twice a day, 18.8% of them once a day, 8.5% of them 3 times a day and 0.9% of them do not brushed. 68.6% of children brushed their teeth in the morning and evening, 20.7% of them before go to bed, 7.4%, and 2.5% of them after meal and before brak first. 71.7% of children used combined with scrubbing and vertical method, 28.3% of them used scrubbing method. 61.5% of their mother answered they observed oral status of children regularly. 2. Prevalence rate of dental caries (dft) was 68.4%. The prevalence rate of dft were significantly higher in the old age children, mother's lower educational level. nourishing with breast feeding, using bottle, irregular eating of snacks 3. Mean dft was 2.95 ; decayed and filled teeth was 1.97 and 0.98, respectively. The mean dft were significantly higher in the old age children, mother's lower educational level

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A Study on Satisfaction with and Use Behavior of Mobile Navigation Service (모바일 내비게이션 서비스의 만족도와 이용행태에 관한 연구)

  • Lee, Je-Sung;Kim, Hae-In;Moon, Ji-Hye;Lee, June-Young
    • Journal of Digital Convergence
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    • v.18 no.3
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    • pp.111-121
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    • 2020
  • The purpose of this study is to examine the satisfaction of consumers using the mobile navigation service which is continuously growing. This study examined variables that affect the service use behaviors and satisfaction of 1200 consumers using service. According to the results of the study, consumers used the service 1-2 or 3-4 times per week, more frequently used in the lunch time(weekends) and in the morning(weekdays). The core functional dimension was shown to have the largest effect on satisfaction with the service. Among consumption emotions, positive emotions had effects in the positive direction while negative emotions had effects in the negative direction, and the effect of innovativeness was not significant. Through the foregoing, the use behavior and the formation of satisfaction could be analyzed and the results of this study can be used in establishing service strategies later and can be also used as basic data of the navigation industry.

EFFECT OF DRAINAGE AS A STRESS REDUCTION METHOD BEFORE EXTRACTION OF ADVANCED INFECTED TEETH IN DISABLED PATIENTS : REVIEW OF LITERATURE & REPORT OF CASES (장애환자에서 과도한 감염치아 발치전 스트레스 감소법으로서 배농술의 효과 : 문헌적 고찰 및 증례보고)

  • Yoo, Jae-Ha;Choi, Byung-Ho;Lee, Chun-Ui;Kim, Jong-Bae
    • The Journal of Korea Assosiation for Disability and Oral Health
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    • v.7 no.2
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    • pp.107-114
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    • 2011
  • Dental extraction is potentially stress-inducing in many disabled patient. The body's response to dental stress involves the cardiovascular system(an increase in cardiovascular workload), the respiratory organ and the endocrine system(change in metabolism). To minimize the stress, the stress reduction method was established. The obtained contents were as follows: (1) Recognize the patient's degree of medical risk, (2) Complete medical consultation before dental therapy, (3) Schedule the patient's appointment in the morning, (4) Monitor and record preoperative and postoperative vital signs, (5) Use psychosedation during therapy, (6) Use adequate pain control during therapy, (7) Short length of appointment : do not exceed the patient's limits of tolerance, (8) Follow up with postoperative pain/anxiety control, (9) Telephone the risk patient later on the same day that treatment was given. Though the stress reduction method above was applied to the dental extraction in disabled patients with the advanced infected teeth, the complications(syncope, shock, bleeding & infection, etc.) may be occurred. For prevention of complications associated with the extraction, the authors treated the advanced infected teeth with endodontic drainage and incision & drainage before extraction. The final extraction and wound closure were then done after about 3 weeks.

Studies on Population of Rumen Ciliates as Affected by Feeding (사료급여후(飼料給與後) 시간경과(時間經過)에 따른 젖소의 제일위내(弟一胃內) 섬모충류(纖毛蟲類)의 동태(動態))

  • Rhee, Jae Ku;Lee, Ho Il;Lee, Sang Bork;Baek, Byeong Kirl
    • Korean Journal of Veterinary Research
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    • v.19 no.2
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    • pp.143-147
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    • 1979
  • Eight Holstein cows weighing 419-673kg with 2 to 10 years of age were allocated into two groups, four animals each, to study the effect of feeding urea and urea plus Zeolite on rumen pH and the population of rumen ciliates. Rumen fluid samples were taken after morning feed for 7 times at one hour intervals. Experimental results obtained were as follows; 1. Rumen pH was gradually dropped from 7.272 to 7.163 by 3.01 hour and from 7.18 to 7.07 by 2.87 hour and reached 7.352 and 7.29 at 7 hour after feeding, respectively on urea and urea plus Zeolite feeding group. 2. Total ciliate numbers decreased from 209,540 to 113,755 by 4.311 hour and from 381,430 to 203.125 by 4.406 hour and gradually increased to 151,030 and 265,230 by 7 hour after feeding, respectively on urea and urea plus Zeolite feeding group. 3. Population of ruminal ciliates was not changed and Entodinium simplex was the major ciliate population for both treatments. It was from 81.21 to 89.12% on urea feeding group and from 84.6 to 88.3% of total number of ciliates on urea plus Zeolite feeding group.

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An Analysis on the Contents Related to Hypertension In the Television Broadcast (영상매체의 고혈압관련 기사 내용 분석)

  • Ko Il Sun;Kim Tae Wha;Kim Eui Sook;Lee Sun Mi;Lee Jung Ja
    • Journal of Korean Public Health Nursing
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    • v.18 no.1
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    • pp.90-102
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    • 2004
  • The purpose of the study was to analyze the current status of hypertension related information on the mass-media. Data were collected on the hypertension related reports in three major broadcasting centers, KBS1$\cdot$2, MBC, SBS, for 2 years, 1999-2001. Sample of the study was 134 reports. The results were as follows: 1. There were differences in frequencies by broadcasting center and programs. KBS and 9PM News were highest in proportions, $62.6\%\;and\;37.3\%$ respectively. 2. In regard to reporting time, $90\%$ were reported in the afternoon. and $62.5\%$ of those reports were in 9 PM, followed by 8PM. & 7PM. and 6AM. 3. In regard to area of the report, $35.8\%$ belonged to social section, followed by $26.1\%$ science. $15.7\%$ international. and $11.2\%$ life and health. 4. In terms of monthly distribution, December, November, and August had higher proportion of reports than other months as well as fall and winter. 5. There were higher proportion of reports containing 'treatment and management' with 'complication management' targeted to 'patients' than 'prevention' targeted to 'general population' in terms of content of the report. In summary, MBC and SBS were more focused on 'treatment and management' with KBS more focused on 'prevention'. There were more 'prevention' related reports in summer, and 'complication management' reports in the morning with 'treatment and management' reports in the afternoon.

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Effect of Poncirus Trifoliata on Colonic Motility in Spinal Cord Injured Rats (척수손상 흰쥐에서 대장 운동에 대한 지실의 효과)

  • Choi, Chul-Won;Joo, Min-Cheol;Lee, Moon-Young
    • Journal of Korean Medicine Rehabilitation
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    • v.18 no.4
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    • pp.13-24
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    • 2008
  • Objectives : The purpose of this study was to investigate the effect of Poncirus Trifoliata(PT) on improvement of fecal impaction in spinal cord injured(SCI) rats. Methods : Fifteen adult Sprague-Dawley female rats were used weighing 200~250 g. A complete spinal cord transection was performed surgically at the T10 cord level. Experimental groups were assigned into 3 groups: Control(n=5), SCI+vehicle(n=5) and SCI+PT(n=5). PT was administered 100mg/kg in 0.5ml every 24 hours from 1st operation day to 7th day. We measured the body weight and food intake as well as the number and the weight of fecal pellet every morning. After 1 week of operation, whole colon was divided into proximal and distal segments under anesthesia. Each segment of colon was mounted with longitudinal direction in a organ bath. We measured spontaneous contraction and compared the area under the curve in each segments. Enhanced responses were observed by acetylcholine($10^{-6}M$), 40 mM KCl solution, L-NAME($10^{-4}M$). Results : The fecal number and weights were significantly higher in the group of SCI+PT than SCI+vehicle group(p<0.05). In organ bath study, area under the curves of the spontaneous contraction in SCI+vehicle and SCI+PT groups were significantly increased compared to control group. Contractility of distal colon in response to acetylcholine or KCl in SCI+vehicle group was significantly decreased compared to other groups(p<0.05). Conclusions : These results suggest that PT might be useful to promote bowel emptying in spinal cord injured rats.