• 감성과학
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• 제20권2호
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• pp.45-58
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• 2017

본 연구에서는 기분 인식과 정서 표현이 학업 스트레스와 적응 간의 부적인 관계를 약화시킬 것이라는 가설을 검증하였다. 대학생과 대학원생 100명을 대상으로 연구를 실시한 결과, 우선 정서 표현은 학업 스트레스와 적응 간의 관계를 조절하였다. 즉, 정서표현성은 학업스트레스와 학업 적응 간의 부적 관계를 완화하는 기능을 하는데 이런 효과는 학업 스트레스가 심할 때 더 강하게 나타났다. 흥미로운 점은, 기분 인식의 두 요인인 기분모니터링과 기분명명화가 학업 스트레스-적응 간의 관계에서 보이는 다른 양상인데, 두 요인이 모두 학업 스트레스- 적응 간의 관계를 조절할 것이라는 가설과는 다르게, 기분 모니터링은 둘 사이의 관계를 조절한 반면 기분명명화는 조절효과 없이 주효과 만을 보였다. 구체적으로, 학생들이 자신의 기분에 주의를 기울이는 것은 스트레스 많은 상황에서 학업 적응에 도움이 되었고, 본인의 기분이 무엇인지 명명하는 것은 스트레스의 수준에 관계없이 긍정적 효과를 보였다. 전체적으로, 기분 모니터링과 정서 표현이 학업스트레스 상황에 적응해야 하는 경우 인지적 행동적 보호요인으로 작용한다는 점이 이 연구의 결과이다. 마지막으로, 본 연구의 함의와 함께 후속 연구에 대한 방향이 함께 제시되었다.

• 한국융합학회논문지
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• 제9권1호
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• pp.419-431
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• 2018

본 논문은 개인 사용자의 트윗을 분석하여 사용자의 감정 흐름을 모니터링할 수 있는 새로운 방법을 제안한다. 본 논문에서는 사용자의 감성 흐름을 정확하게 예측하기 위해서 기존의 텍스트 위주의 시스템과 달리 본 연구에서는 사용자가 쓴 텍스트와 영상 등으로부터 감성을 인식하는 멀티 모달 분석 기법이 개발된다. 제안된 방법에서는 먼저 어휘분석 및 문맥을 이용한 텍스트분석기와 학습기반의 영상감성인식기를 이용하여 텍스트 및 영상 트윗에 숨겨진 개별 감성을 추출한다. 이후 이들은 규칙기반 통합 방법에 의해 날짜별로 통합되고, 마지막으로 개인의 감성흐름을 보다 직관적으로 관측할 수 있도록 감성흐름그래프로 시각화한다. 제안된 방법의 효용성을 평가하기 위해 두 단계의 실험이 수행되었다. 먼저 4만여 개의 트윗으로부터 제안된 방법의 정확도 평가 실험이 수행되고, 최신 트윗 분석 기술과 비교 분석되었다. 두 번째 실험에서는 40명의 우울증을 가진 사용자와 일반사용자를 구분할 수 있는지에 대한 실험이 수행된 결과, 제안된 기술이 실제 사용자의 감성흐름을 모니터하는데 효율적임을 증명하였다.

• 생물정신의학
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• 제14권2호
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• pp.129-141
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• 2007

Objectives : Empathy has been conceptualized as the ability of emotional resonance and perspective-taking. Emotional awareness has been proposed as the basis of empathy. In this study we examined the relationship between empathy and mood awareness and their neural correlates in resting-state activity in normal controls and patients with schizophrenia. Methods : Empathy and mood awareness scale scores were compared between 29 patients with schizophrenia and 21 normal controls by voxel-based t-tests and voxel-based correlation analyses of resting-state $^{18}F$-FDG PET images. Results : Empathy and mood labeling scale scores were significantly decreased in schizophrenic patients. Mood monitoring was positively correlated with empathy score in normal controls, but not in schizophrenic patients. In normal controls, empathy was positively correlated with resting-state activities in the intraparietal sulcus and mood monitoring was positively correlated with the temporal pole, frontopolar cortex, inferior temporal gyrus, entorhinal cortex and the subgenual prefrontal cortex resting activities. The orbitofrontal cortex resting activity was positively correlated with mood monitoring-related subgenual prefrontal cortex activity in the normal controls. Patients with schizophrenia showed decreased orbitofrontal resting activity and loss of its correlations with mood monitoring-related regional activities. Conclusion : This study showed that alteration in the resting-state activity in schizophrenia may reflect dysfunctional empathy and distorted characteristic of emotional awareness. However, the resting-state activity may not reflect the relationship between emotional awareness and empathy.

• 생물정신의학
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• 제8권2호
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• pp.220-225
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• 2001

As numbers of serotonin's function are so many, studies of serotonin are numerous nowadays. In the beginning, concentration of metabolites such as 5-HIAA was a key issue, but recent studies have been challenged for serotonin receptor genes and their relation to mood disoder. Serotonin transporter(5-HTT) gene is a strong candidate gene of mood disoder for following reason. Serotonin transporter is a key protein in the serotonin pathway as it regulate the concentration of serotonin in the synaptic clept and essential pathophysiology of depression is dysregulation of 5-HTT so that all antidepressants have effect of 5-HTT antagonist. The decrease of 5-HTT in the platelet and in brain of the depressive patients is much consistent results in the studies of the pathophysiology of mood disorder till now. By this, we will be able to develop simple and easy marker for diagnosis, type, and treatment monitoring of depression. Many psychiatrists have sought the independent genes in relation to depression or schizophrenia. Obviously, the hereditary vulnerability contributes to etiology of mood disorders, but it is difficult to discriminate the independent genes because of many environmental factors. Moreover, in the hereditarily complex diseases such as mood disorder, the only vulnerability of gene can not sufficiently explain the etiology. In the future, to exclude the role of the gene-environmental interaction, the methods such as gene transfer can be considered. In the opposite direction, by using the gene destruction method, the role of target genes can be examined. As yet the concept of the gene expression, neural plasticity, neurogenesis and etc, is the elementary stage. The development of this field will help to establish the treatment strategy of chronic and refractory mood disorders.

• 한국콘텐츠학회논문지
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• 제13권1호
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• pp.322-332
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• 2013

본 연구는 간호대학신입생의 정서인식, 정서표현, 정서표현양면성과 대학생활적응을 확인하고 대학생활 적응에 영향을 미치는 요인을 파악하고자 수행되었다. 연구대상은 4년제 대학 2곳에 재학 중인 간호학과 신입생 159명이었고, 구조화된 설문지를 이용하여 2012년 5월 20일부터 6월10일까지 자료조사를 실시하였다. 대학생활적응은 정서주의와 정서명명과는 유의미한 양의 상관관계를 보였고, 긍정표현에 대한 양면성과 부정표현에 대한 양면성과는 유의미한 음의 상관관계를 나타냈다. 대학생활적응에 가장 큰 영향을 미치는 요인은 정서주의였으며, 정서주의, 긍정표현에 대한 양면성, 부정표현에 대한 양면성, 정서명명은 대학생활 적응에 대해 31.8%의 설명력을 나타내었다. 간호대학신입생의 대학생활적응 향상을 위해서 정서인식 및 정서표현양면성을 돕는 교육 프로그램의 개발이 필요하다.

• 대한불안의학회지
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• 제2권1호
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• pp.28-32
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• 2006

Objectives : Non-cardiac chest pain (NCCP) can be divided into gastroesophageal reflux disease (GERD) related NCCP and non-GERD related NCCP. Our study was designed to examine the differences in clinical characteristics and psychological mood states between the two clinical syndromes. Methods : After some cardiologic evaluations such as treadmill exercise, coronary angiography, and echocardiography, 27 patients with NCCP were enrolled in this study. They were divided into patients with GERD related NCCP (12 patients) and those with non-GERD related NCCP (15 patients) using the upper gastrointestinal endoscopy and the ambulatory 24 hour esophageal pH monitoring. Clinical characteristics such as typical reflux symptoms and psychological mood states were measured. Patients who showed scores more than 10 on the Beck Depression Inventory (BDI) or Beck Anxiety Inventory (BAI) were defined as depressed or anxious group. Anxiety sensitivity Index (ASI) was also measured in all patients. All parameters were compared between patients with GERD related NCCP and those with non-GERD related NCCP. Results : The two groups showed a difference in typical reflux symptoms. Patients with non-GERD related NCCP had higher scores on the BDI, BAI and ASI than those with GERD related NCCP. Among all NCCP patients, 14 patients (51.9%) were suggested to have possible depression or anxiety disorders. Conclusion : The non-GERD related NCCP was shown to be associated with psychological mood states such as anxiety and depression. Thus, we suggest that routine measurement of psychological mood states should be necessary in the evaluation and treatment of NCCP.

• 산업융합연구
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• 제21권5호
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• pp.77-85
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• 2023

자살은 한국 청소년의 주요 사망 원인입니다. 자살 생각과 우울 증상의 위험 요인으로서 외로움의 역할에 대한 관심이 높아지고 있다. 그러나 한국 상황에 대해서는 알려진 바가 거의 없다. 본 연구는 2020년과 2021년 한국청소년건강행태조사에 참가한 총 109,796명의 응답자를 분석하였다. 외로움과 자살 생각 및 우울감 사이의 연관성을 시험하기 위해 다중 로지스틱 회귀 모델을 이용하였다. 공변량으로는 인구학적 특성, 학교, 가계 소득, 생활 방식, 자가 평가 건강, 및 폭력으로 인한 치료 횟수가 포함되었다. 보정 오즈비(OR) 및 95% 신뢰 구간(CI)을 산출하였다. 청소년의 12.0%는 자주, 3.0%는 항상 외로움을 느낀다고 보고하였다. 자살생각과 우울감의 유병률은 각각 11.8%과 26.0%이었다. 자살생각의 유병률은 자주 외로운 청소년(35.1%)보다 항상 외로운 청소년(52.6%)에서 더 높았다. 전혀 외로움을 느끼지 않은 청소년에 비해서 항상 외로운 청소년은 자살 생각(OR=30.7; 95% CI, 27.1 - 34.8)과 우울함(OR=32.5; 95% CI, 29.2 - 36.4)을 가질 위험이 훨씬 더 높았다. 결론적으로 외로움은 한국 청소년의 자살생각과 우울감의 주요 위험요인이다. 외로움의 상태를 모니터링하고 해결하는 것이 자살생각과 우울감을 줄이는데 도움이 될 수도 있다.

• 생물정신의학
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• 제20권4호
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• pp.151-158
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• 2013

Objectives To investigate the pattern of subclinical hypothyroidism (SCH) in patients with bipolar disorders managed by lithium or valproic acid. Methods The study participants were 106 patients with DSM-IV bipolar disorders receiving planned maintenance treatment at the Mood Disorders Clinic of Seoul National University Bundang Hospital (aged between 17 and 64, mean duration of follow-up = 875.65 days). Using the bipolar disorder registry, thyroid function data were analyzed to assess the frequency of and the risk factors for SCH in patients managed by lithium (n = 64) or valproic acid (n = 42) for more than 5 months. Results Overall frequencies of SCH were 20.3% (13/64) in the lithium group, 14.3% (6/42) in the valproic acid group, and between the two groups there is no difference (p = 0.43). No differences were observed in the potential risk factors for SCH between the two groups including age, sex, subtype of bipolar disorder, baseline TSH, and concomitant antipsychotic use. In cases with SCH, thyroid-stimulating hormone (TSH) showed a tendency to increase at 3 month after the initiation of lithium or valproic acid. A gradual increase in the number of patients showing SCH was found within the first 3 years of medication. Conclusions With regular monitoring and careful assessment, there was no difference in the risk of SCH between lithium and valproic acid maintenance. The risk of mood stabilizer-associated SCH may gradually increase within 3 years following the commencement of medication, thereby mandating close monitoring for the first 3 years of treatment. Further studies with large sample size would be needed to confirm these findings.

• 대한불안의학회지
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• 제9권2호
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• pp.128-134
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• 2013

Objective : As treatments for breast cancer require long period of time, the patients need continuous monitoring and management of their health related quality of life. The purpose of this preliminary study is to explore the utility of monitoring quality of life using a mobile phone based application, which was developed to enable the patients to report daily quality of life more efficiently. Methods : Department of psychiatry, breast cancer center and U-health team of Asan Medical Center collaborated in developing a mobile application titled 'DugunDugun'. Through the application, patients with breast cancer receiving neo-adjuvant chemotherapy could report on various questions about their daily quality of life. We extracted and explored the daily basis of the data of sleep duration, number of awake, sleep satisfaction, mood and anxiety from nine patients who reported on the questionnaire for more than a month. Results : The longitudinal data collected using our mobile application well represented the characteristics of individual sleep patterns and daily emotional changes. Most of the patients showed high daily variations in the scores of their quality of life while their averaged scores were similar among patients. The patient with highest daily variations in the subjective sleep quality and daily emotional change had highest score corresponding to moderate depression in Beck Depression Inventory (BDI). Conclusion : The results suggest that mobile application could be a useful tool for monitoring and collecting the daily quality of life in the patients with breast cancer. We expect that mobile application could facilitate early detection and proper intervention for the cancer patients at psychological crisis.

• 생물정신의학
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• 제24권3호
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• pp.134-141
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• 2017

Objectives A retrospective case series study was conducted to investigate the clinical characteristics of psychotic disorders induced by appetite suppressants, phentermine and phendimetrazine. Methods A retrospective electronic medical record review identified 5 admitted patients who had psychotic symptoms after taking phentermine or phendimetrazine. Clinical information was reviewed and summarized in each case. Results Hallucinations were reported in all cases, including auditory, visual, olfactory and somatic hallucinations. After discontinuation of phentermine or phendimetrazine, the symptoms rapidly improved with low dose of antipsychotics. Patients tended to have less prominent negative symptoms and higher insight into illness, and often showed depressive mood. These clinical characteristics were similar to psychosis induced by amphetamines. Two patients developed stimulant use disorder while using phentermine. Conclusions These findings call for awareness of the risks associated with use of appetite suppressants. Prescription of phentermine or phendimetrazine should be accompanied by close monitoring of mental status, and suspicion for substance/medication-induced psychotic disorder.