• Clinical and Experimental Pediatrics
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• 제55권9호
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• pp.330-336
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• 2012

Purpose: Fractional exhaled nitric oxide (FeNO) and forced expiratory flow between 25% and 75% of vital capacity ($FEF_{25-75}$) are not included in routine monitoring of asthma control. We observed changes in FeNO level and $FEF_{25-75}$ after FeNO-based treatment with inhaled corticosteroid (ICS) in children with controlled asthma (CA). Methods: We recruited 148 children with asthma (age, 8 to 16 years) who had maintained asthma control and normal forced expiratory volume in the first second ($FEV_1$) without control medication for ${\geq}3$ months. Patients with FeNO levels >25 ppb were allocated to the ICS-treated (FeNO-based management) or untreated group (guideline-based management). Changes in spirometric values and FeNO levels from baseline were evaluated after 6 weeks. Results: Ninety-three patients had FeNO levels >25 ppb. These patients had lower $FEF_{25-75}$ % predicted values than those with FeNO levels ${\leq}25$ ppb (P<0.01). After 6 weeks, the geometric mean (GM) FeNO level in the ICS-treated group was 45% lower than the baseline value, and the mean percent increase in $FEF_{25-75}$ was 18.7% which was greater than that in other spirometric values. There was a negative correlation between percent changes in $FEF_{25-75}$ and FeNO (r=-0.368, P=0.001). In contrast, the GM FeNO and spirometric values were not significantly different from the baseline values in the untreated group. Conclusion: The anti-inflammatory treatment simultaneously improved the FeNO levels and $FEF_{25-75}$ in CA patients when their FeNO levels were >25 ppb.

• 한국의료질향상학회지
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• 제14권1호
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• pp.55-59
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• 2008

Background : The purpose of inner cannula is to protect the upper air way and permit air to pass freely, in addition, to provide endotracheal suction, artificial respiration and to maintain adequate oxygen saturation. The tube needs to be sterilized for maintenance and cleanness of air way and for prevention of bronchospasm. However, it has been reported that there is no guideline for sterilization and many hospitals conduct their own sterilization methods, for example, once a day(13's general hospital), three times a day(The Catholic University of Korea ST Mary's hospital) or even no cleansing. Consequently, the QI team of our hospital suggested the SOP(standard operating procedure) of sterilization and evaluate cost and time effect in nursing. Method : 1) Benchmarking of 13's neurosurgery department of general hospital in Seoul 2) Investigation of test records of sputum culture from patients with intubation for tracheotomy 3) Check of results of O2 Sat. monitoring to confirm of maintaining opened air way Result : 1) Improvement of process: decrease of excess sterilization of inner cannula (from 3 times a day to once a day) 2) Cost effects: saving over 10 million won per one year 3) Providing better nursing: time effects (30 min a day) permit to conduct more nursing activities Conclusion : It can get Cost and time effects in nursing with improved sterilization method of inner cannula. It needs to do research on improvement of the monthly exchange protocol of outer cannula and provide supporting data for the proper exchange schedule. The result of additional microorganism detection from patients with new process needs to be evaluated further more.

• 한국수산과학회지
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• 제46권6호
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• pp.930-940
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• 2013

We evaluated contamination with organic matter and trace metals by analyzing grain size, ignition loss (IL), chemical oxygen demand (COD), acid volatile sulfide (AVS), and trace metals (Al, Fe, Cu, Pb, Zn, Cd, Ni, Cr, Mn, Hg, and As) in surface sediments at 28 stations around the Geum River estuary in July 2008. The surface sediments in the estuary were mainly composed of coarse sediment (sand and muddy sand), with mean grain size (Mz) ranging between $2-4{\O}$. The high concentrations of IL, COD, and trace metals were mainly found at stations in front of the Gusan outer port and industrial complex, and near the Seocheon coast with relatively fine sediments. In addition, the concentrations of IL and all trace metals, except Pb and As, showed good positive correlations with Mz, indicating that the concentrations of organic matter and trace metals were mainly dependent on sediment grain size. The concentrations of COD, AVS, and trace metals in most sediments did not exceed the sediment quality guideline (SQGs). Although the sediments in the study region are not polluted with organic matter and trace metals, there are many point sources of pollutants, such as Gusan port and industrial complex, Janghang refinery, and a thermoelectric power plant around the Geum River estuary. Thus, the management of coastal environments through periodic monitoring of organic matter and trace metals is required in the future.

• 대한환경공학회지
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• 제30권1호
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• pp.37-44
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• 2008

본 연구에서는 퍼클로레이트 분석에 주로 사용되고 있는 IC와 LC/MS를 사용해 퍼클로레이트 분석법을 정립하고 각 분석법의 장단점 및 효율을 파악해 수질 및 토양 시료에서의 퍼클로레이트를 모니터링 하고자 하였다. 각 분석기기를 사용한 최적분석 방법을 정립한 결과 IC에서의 MDL은 1 ppb였으며 LC-MS에서의 MDL은 0.005 ppb였다. 정립된 분석방법으로 부산시 내의 지하수 및 약수터, 하수처리장과 토양 시료를 대상으로 하여 퍼클로레이트 모니터링을 실시하여 퍼클로레이트에 대한 노출정도를 평가하였다. 평균 퍼클로레이트 농도는 약수터에서는 0.013 $\pm$ 0.014 ppb, 지하수 0.031 $\pm$ 0.011 ppb로 나타났고 하수처리장 폐수에서는 0.007$\sim$0.380 ppb의 범위로 퍼클로레이트가 검출되었다. 모든 시료에서의 퍼클로레이트 농도는 EPA 기준인 24.5 ppb 이하로 나타났다.

• 한국수자원학회논문집
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• 제44권9호
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• pp.741-751
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• 2011

본 연구에서는 대표적 3차원 수리 수질해석모형인 EFDC의 수온성층해석 능력 제고를 위해 적정 매개변수를 도출하고자 하였다. 이를 위해 태양복사 분포, 하상 초기온도, 활성 하상 수온층 깊이, 열전달계수 등 태양에너지와 관련된 5가지 매개변수에 대하여 용담호 수온성층해석 결과를 비교 분석하였다. 모의기간은 2005년 6월부터 12월까지였으며 수온 성층 재현성 수행 결과는 통계 지표인 AME, RMSE, $R^2$을 적용하여 비교하였다. 그 결과 IASWRAD는 하상으로 분포하는 경우, 활성 하상 수온층 깊이는 10m를 사용하는 것이 타당할 것으로 판단되었다. 본 연구에서 도출된 결과는 EFDC 모형의 수온성층모의시 적용 가이드라인으로 활용될 수 있을 것이다.

• 한국연초학회지
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• 제36권1호
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• pp.20-25
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• 2014

As part of a balanced testing battery, subchronic inhalation studies on rats are performed to ensure that proposed cigarette modifications do not increase the toxicity of smoke and to demonstrate any instances where a modification may actually contribute to harm reduction. For subchronic inhalation studies with aerosols, the OECD suggests an exposure regimen of 6 hours/day (OECD Guideline 413, 1981), but alternative regimens have also been published: 1 hour/day and $2{\times}1$ hour/day. The aim of this study was to validate a rodent nose-only exposure system for the assessment of inhalation toxicity of cigarette smoke. In this study, cigarette smoke exposure system is consisted of cigarette smoke generator, smoke concentration adjusting system, and 20-port nose-only exposure system. Male SD rats were exposed for 35 days ($2{\times}1$ hour/day) to 3R4F Reference cigarette smoke and analysed major monitoring items of OECD Gudeline 413. WTPM, was measured in the test atmosphere, respiratory function (Buxco Biosystems) during exposure, postexposure urinary exposure biomarkers and alveolar neutrophiles in BAL fluid (Day 35) were evaluated. Validation demonstrated steady WTPM ($257{\pm}20ug/L$, $502{\pm}27ug/L$) and spatial uniformity (<10%). Nose port temperature ($22{\sim}26^{\circ}C$ and RH (45~75%) were acceptable over 35 days. Reductions in respiratory rate and minute volume and increase in the neutrophiles in BALF and the urinary exposure biomarkers were observed cigarette smoke dose dependently. This validation and 35-day inhalation study has shown that the rodent nose-only exposure system may be useful in the inhalation toxicity assessment of cigarette smoke.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2004년도 춘계학술발표회
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• pp.946-951
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• 2004

ITIS is applied to the several tunnel construction sites in Korea. Tunnel construction properties which are acquired from these sites are transferred to information management server(SQL 2000 server)by client application program in real time. Access permission to DB server depends on the user's roles. Some functions which cannot be embodied in SQL Server are serviced through XML and GMS server is used for spatial data based on GIS part. This system is supposed to give engineers the advantages which are not only easy handling of the program and computerized documentation on every information during construction but also analyzing the acquired data in order to predict the structure of ground and rock mass to be excavated later and show the guideline of construction. Neung-Dong tunnel and Mu-Gua express way tunnel are now under construction and with this system they have 3D visualized map of the geology and tunnel geometry and accumulate database of construction information such as tunnel face mapping results, special notes and pictures of construction and 3D monitoring data, all matters on the stability of rock bolts and shotcrete, and so on. Ground settlement prediction program included in ITIS, based on the artificial neural network(ANN) and supported by GIS technology is applying to the subway tunnel. This prediction tool can make it possible to visualize the ground settlement according to the excavation procedures by contouring the calculated result on 3D GIS map and to assess the damage of buildings in the vicinity of construction site caused by ground settlement.

• 한국가스학회지
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• 제20권2호
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• pp.66-71
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• 2016

현재 산업단지에는 수많은 센서로부터 얻는 정보를 이용해 누출 발생지역을 감지 감시하고 있다. 그러나 화학물질 누출사고는 꾸준히 발생하고 있으며, 때에 따라 다량의 화학물질이 누출되는 경우에는 큰 피해가 발생하고 있다. 이때 중요하게 작용하는 센서 배치가 현재까지는 과거의 경험을 통하여 그 결정이 이루어지거나, 또는 센서제작 업체에서 제시하는 가이드를 통하여 설치되고 있다. 따라서 본 연구에서는 화학물질 누출이 일어났을 때 빠른 감지 및 대응을 위해 가장 중요한 요소인 센서 배치 최적화 방법론을 제시하였다. 특히 공정구조에 따른 누출흐름이 미반영된 상태에서 초기 배치 최적화를 위해 센서 개수 최소화 측면과 화학물질감지확률 측면으로 나누어 일반적으로 사용할 수 있는 수식을 제시하였다. 제시된 방법은 간단한 누출 시나리오를 이용하여 검증을 진행하였고, 이를 통해 각 공정의 안전성 목표치를 성취함으로써 안전한 공정 운영이 가능하도록 하였다.

• 한국식품조리과학회지
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• 제25권1호
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• pp.45-54
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• 2009

Contamination levels of aerobic colony counts, coliforms and pathogenic bacteria were tested in fried rice dishes to monitor quality for risk management. The prevalence of Bacillus cereus in dishes from 8 Chinese-style restaurants and 2 institutional foodservices was 10%, and the bacteria's contamination levels was 3.47 log CFU/g. Echerichia coli, Staphylococcus aureus, and Salmonella were not detected in any of the 10 samples. However, for their aerobic colony counts and numbers of isolated coliforms, the samples were 30% and 70% over the microbial criteria, respectively, for ready-to-eat foods presented in the Korean Food Code. This suggests that fried rice dishes, although cooked with oil at high temperature, require special care. For the prediction of the growth curve of B. cereus spp. in the fried rice samples, an experiment design of 3 storage temperatures ($7^{\circ}C$, $35^{\circ}C$, $57^{\circ}C$) x 5 storage times (0 h, 2 h, 4 h, 6 h, 24 h) was applied. The sample exposed to $35^{\circ}C$ showed no B. cereus spp. at 0 h; however, there was a tendency of slow growth (1.0 log CFU/g) after 4 hours of storage and then faster growth at 6 h (3.7 log CFU/g) and 12 h (4.7 log CFU/g), showing a growth rate of 0.56 log CFU/g/hr. These results indicate that fried rice, despite being heat-treated, can become heavily contaminated with B. cereus spp. when held over 2 hours at room temperature. However, the samples stored at $7^{\circ}C$ and $57^{\circ}C$ over 24 hours were not contaminated with B. cereus. Based on these results, management guidelines for controlling B. cereus are suggested.

• 한국물환경학회지
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• 제28권3호
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• pp.460-466
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• 2012

Perchlorate is used in a number of applications as an oxidizer in solid propellants, munitions and fireworks and is one of the endocrine disrupting chemicals, which interferes with iodide uptake into the thyroid gland. The purpose of this study was to investigate perchlorate occurrence and distribution with a results of analysis of 94 samples collected from military facilities in Korea from October 11 to October 23, 2011. Overall, among all of the 94 samples analyzed, perchlorate was detected in 6.4% of the total number of samples above $4{\mu}g/L$ (minimum reported limit) and the average concentration was $26.1{\mu}g/L$ and the maximum concentration was $107.7{\mu}g/L$ which was observed in surface water near manufacturing site of ammunition. By site classification, perchlorate was detected at one site in 4 manufacturing sites of ammunition and the maximum concentration was $107.7{\mu}g/L$ which was six times higher than that in guideline for perchlorate in Nakdong River and resulted from point source discharge. Perchlorate was detected at 3 sites in 78 measurements for shooting area and the maximum concentration was $12.4{\mu}g/L$ which was collected in dringking water and perchlorate in another sample was detected above MRL in shooting area was collected right away after shooting. These results showed that long term monitoring was needed considering weather conditions and shooting schedules.