• Title/Summary/Keyword: Molecular biology

Search Result 9,900, Processing Time 0.035 seconds

The Genetic Diversity of Seven Pig Breeds in China, Estimated by Means of Microsatellites

  • Li, X.;Li, K.;Fan, B.;Gong, Y.;Zhao, S.;Peng, Z.;Liu, B.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • v.13 no.9
    • /
    • pp.1193-1195
    • /
    • 2000
  • The polymorphisms of six microsatellites were investigated in four indigenous pig breeds (Erhualian, Tongcheng, Qingping and Wannanhua) and three introduced breeds (Large White, Landrace and Duroc) in China, and the genetic variations within and among populations were analyzed. The results showed that genetic diversity of Chinese indigenous pig breeds is higher than that of the introduced pig breeds. The clustering of seven breeds is consistent with their geographical distribution approximately. Estimated time of breed divergence ranged from 653 to 1856 years.

Recent Advances in Molecular Basis of Lung Aging and Its Associated Diseases

  • Kang, Min-Jong
    • Tuberculosis and Respiratory Diseases
    • /
    • v.83 no.2
    • /
    • pp.107-115
    • /
    • 2020
  • Aging is often viewed as a progressive decline in fitness due to cumulative deleterious alterations of biological functions in the living system. Recently, our understanding of the molecular mechanisms underlying aging biology has significantly advanced. Interestingly, many of the pivotal molecular features of aging biology are also found to contribute to the pathogenesis of chronic lung disorders such as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis, for which advanced age is the most crucial risk factor. Thus, an enhanced understanding of how molecular features of aging biology are intertwined with the pathobiology of these aging-related lung disorders has paramount significance and may provide an opportunity for the development of novel therapeutics for these major unmet medical needs. To serve the purpose of integrating molecular understanding of aging biology with pulmonary medicine, in this review, recent findings obtained from the studies of aging-associated lung disorders are summarized and interpreted through the perspective of molecular biology of aging.