• Journal of Pharmaceutical Investigation
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• 제25권2호
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• pp.101-108
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• 1995

The surface of albumin microspheres could be modified with methotrexate (MTX) by using 1,3-dicyclohexylcarbodiimide (DCC). Surface-modified albumin microspheres entrapping no MTX (SAMS), free MTX (SAMSF) and MTX-bovine serum albumin (BSA) conjugates (SAMSC) were prepared. respectively, and their release characteristics were investigated in the presence of trypsin using a dissolution tester. The mean diameters of all the microspheres were $5{\sim}8\;{\mu}m$, and their shapes was small and uniform. MTX bound tn their surfaces was released slower than the entrapped free MTX, and laster than the entrapped MTX-BSA conjugates. Also, surface-modified MTX was scarcely released in the absence of a proteolytic enzyme. Therefore, the surface-modified MTX may be released rapidly from SAMSC at the target site, and thereafter MTX may be released slowly from the encapsulated MTX-BSA conjugates in SAMSC for a long period.

• 한국토양비료학회지
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• 제48권1호
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• pp.1-7
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• 2015

Global population is expected to reach nine billion in 2050 and the total demand for food is expected to increase approximately by 60 percent by 2050 as compared to 2005. Therefore, it is important to increase crop production in order to meet the global demand for food. Slow release fertilizers have been developed and designed in order to improve the efficiency of fertilizers. Mineral-based slow release fertilizers are useful because the minerals have a crystalline structure and are environmentally friendly in a soil. This review focuses on slow release fertilizers based on montmorillonite, zeolite, and layered double hydroxide phases as a host for nutrients, especially N. Urea was successfully stabilized in the interlayer space of montmorillonite by the formation of urea-Mg or Ca complex, $[(Urea)_6Mg\;or\;Ca]^{2+}$ protecting its rapid degradation in soils. Naturally occurring zeolites occluded with ammonium nitrate and potassium nitrate by molten salt treatment could be used as slow release fertilizer because the occlusion process increased the capacity of zeolites to store nutrients in addition to exchangeable cations. Additionally, surface-modified zeolites could also be used as slow release fertilizer because the modified surface showed high affinity for anionic nutrients such as nitrate and phosphate. Moreover, there were attempts to develop and use synthetic layered double hydroxide as a carrier of nitrate because it has positively charged layers which electrostatically bond nitrate anions. Kaolin was also tested by combining with a polymer or through the mechanical-chemical process for slow release of nutrients.

• International Journal of Concrete Structures and Materials
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• 제19권1E호
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• pp.25-32
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• 2007

The fracture energy evaluated from the previous experimental results can be simulated by using the modified singular fracture process zone (S-FPZ) model. The fracture model has two fracture properties of strain energy release rate for crack extension and crack close stress versus crack width relationship $f_{ccs}(w)$ for fracture process zone (FPZ) development. The $f_{ccs}(w)$ relationship is not sensitive to specimen geometry and crack velocity. The fracture energy rate in the FPZ increases linearly with crack extension until the FPZ is fully developed. The fracture criterion of the strain energy release rate depends on specimen geometry and crack velocity as a function of crack extension. The behaviors of micro-cracking, micro-crack localization and full development of the FPZ in concrete can be explained theoretically with the variation of strain energy release rate with crack extension.

• Journal of Pharmaceutical Investigation
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• 제24권3호
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• pp.139-144
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• 1994

The effect of some formulation variables on the release rate of famotidine, a $H_2$ receptor antagonist, from cellulose matrices containing hydroxypropylcellulose (HPC) in different ratios and types was investigated. The effects of tablet shape and compression pressure on dissolution rate of famotidine were studied. And the effect of the pH of dissolution media was also studied. Increase in the ratio of polymer to drug decreased the release rate of famotidine. Increase of the polymer viscosity also decreased the release rate. The release rate of famotidine was dependent on the pH of dissolution media. The release rate of drug was not much dependent on the compression pressure but dependent on the tablet shape and/or surface area. Consequently, the release rate of famotidine can be modified by changing the HPC contents, types of polymers with different viscosity grades or using appropriate fillers.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2008년도 추계 학술논문 발표대회
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• pp.63-66
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• 2008

Not only mechanical properties, bonding properties, electro chemical properties, etc. but also fire safety is required in patch repair materials such as polymer modified cement mortar (PCM) which are used to deteriorated reinforced concrete structure. Unfortunately, it is very difficult to choice the appropriate repair materials because there are not enough information about fire safety properties of PCM. In this study, The combustion characters of PCM were evaluated through the heat release rate test and non-combustibility test. The pyrogenicity test uses the cone calorimeter based on the oxygen consumption method. The non-combustibility test is from the temperature change inside the furnace during the test. The effect of the types of polymer and polymer content were evaluated from the series of test. The results are like followings. 1) The higher the W/C of PCM, the lower the gross calorific value and heat generation rate in the heat release rate test. The amount of heat generation of PCM is like the order of VVA, EVA, and SBR in this study. 2) Some materials such as E45-100, E50-100, E60-100, S50-50, and S50-100 were estimated as not appropriate building materials in the non combustibility test.

• Journal of Pharmaceutical Investigation
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• 제22권2호
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• pp.133-137
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• 1992

A novel oral controlled release tablet which may offer more uniform drug level in the body than simple zero-order was developed. The tablet is composed of three layers; outer film layer, middle part compression-coated hydroxypropylmethylcellulose (HPMC) matrix layer, and inner core layer. Each layer contains nicardipine HCl as a model drug. In vitro dissolution test showed that the tablet released the drug in clear three steps; a rapid initial release, followed by a constant rate of release, and then a second phase of fast release of drug. The dissolution characteristics could be modified easily by changing the grade of HPMC, thickness of matrix layer, content of methylcellulose in matrix layer, content of active ingredient in each layer. The pH of dissolution medium did not affect the release profile. This three-step release system is expected to raise the blood concentration rapidly to effective level and to maintain effective blood level longer than simple slow-release systems.

• 대한화학회지
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• 제47권3호
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• pp.257-264
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• 2003

본 연구에서는 외부온열 온도$(~40^{\circ}C)$에서 항암약물(doxorubicin)이 방출되는 온도민감성 리포좀에 대하여 연구하였다. 온도민감성 리포좀은 외부온열온도에서 하한임계용액온도의 성질을 나타내는 N-isopropylacrylamide (NIP-AAm)와 Acrylamide(AAm)의 합성고분자에 의하여 변형되었다. 변형된 리포좀으로부터 약물(doxorubicin)의 방출은 온도와 시간의 변화에 따라서 형광강도를 측정하여 결정하였다. Poly(NIPAAm-co-AAm) copolymer에 의하여 변형된 리포좀으로부터 약물(doxorubicin)의 방출은 Poly(NIPAAm-co-AAm) copolymer가 온열온도 범위$(~40{\pm}2^{\circ}C)$에서 적절한 전이를 나타내기 때문에 증가하였다. 또한, 리포좀으로부터 약물의 방출은 5분 이내에 완료되었고, 변형된 리포좀의 크기는 120~170 nm 이었다. 본 연구에서는 온도에 의하여 제어 할 수 있는 온도민감성 리포좀을 제조하였다. 이것은 온도 제어에 따른 종양 표적화에 대한 약물전달시스템에서 활용 될 수 있을 것이다.

• Nuclear Engineering and Technology
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• 제22권2호
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• pp.116-127
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• 1990

SPEAR-BETA코드에서 사용된 핵분열 기체 방출 모델을 핵연료와 피복관 사이의 갭(gap)과 플레넘(plenum) 사이에서 축방향 핵분열 기체 혼합과 균열된 핵연료에 대한 유효 열전도도를 사용함으로써 개량하여, P$_{max}$와$\Delta$P가 변하는 다양한 출력 감발 조건하에서 핵분열기체 방출 거동을 해석하였다. 핵연료 균열의 영향을 고려한 유효 열전도도는 핵연료의 온도 분포와 내부 기체 압력을 계산하는데 사용되었고, 축방향 기체 유동으로 인한 혼합(mixing)과 회석(dilution)효과는 갭의 폭과 열전도도를 해석하는데에 고려되었다. 축방향 기체 유동 효과를 계산하는데 있어서 계산속도를 빠르게 하기 위하여 유한차분법의 하나인 Crank-Nicholson 방법을 사용하였다. 개량된 모델은 다양한 출력 감발 조건하에서 얻어진 실험 자료들과 SPEAR-BETA와 FEMAXl-IV 코드들에서 사용되는 모델들로부터 얻은 결과들을 비교함으로써 검증하였다. 개량된 모델의 결과는 위의 두 코드로부터 얻은 결과 보다는 실험자료들과 잘 일치하였다. 균열된 핵연료에 대해 유효 열전도도를 사용하여 계산한 핵연료의 중심 온도는 균열되지 않은 핵연료의 경우에 비해 20$0^{\circ}C$ 정도보다 높은 값을 나타냈고, 개량된 핵분열 기체 생성물의 분율은 SPEAR-BETA코드에서 얻은 값보다 평균 6% 정도가 높게 나타났다.평균 6% 정도가 높게 나타났다.다.

• 대한의용생체공학회:의공학회지
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• 제41권1호
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• pp.62-66
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• 2020

Controlled drug release is important for effective treatment of cancer. Poly(DL-lactide-co-glycolide) acid (PLGA) is a Food and Drug Administration (FDA) approved polymer and have been extensively studied as drug delivery carriers with biodegradable and biocompatible properties. However, PLGA drug delivery carriers are limited due to the initial burst release of drug. Certain drugs require an early rapid release, but in many cases the initial rapid release can be inefficient, reducing therapeutic effects and also increasing side effects. Therefore, sustained release is important for effective treatment. Poly Lactic Acid stereo complex (PLA SC) is resistant to hydrolysis and has high stability in aqueous solutions. Therefore, in this work, PLGA based discoidal polymeric particles are modified by Poly Lactic Acid stereocomplex (PLAsc DPPs). PLAsc DPPs are 3 ㎛ in diameter, also showing a relatively sustained release profile. Fluorescein 5(6)-isothiocyanate (FITC) released from PLAsc DPPs was continuously observed until 38 days, which showed the initial release of FITC from PLAsc DPPs was about 3.9-fold reduced as compared to PLGA based DPPs at 1 hour.

• Archives of Pharmacal Research
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• 제28권5호
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• pp.619-625
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• 2005

Beads loaded with the water-soluble drug, phenylpropanolamine HCl (PPA), were prepared using an extruder and double arm counter-rotating roller modified from a traditional pill machine. The mean diameter of the cylindrical rod-like extrudate from the ram extruder was 3 mm; that of the uncoated bead after cutting and spheronization by the modified double arm counter-rotating roller was 3.26~3.28 mm. Although the surface of the beads was moderately rough and irregular, some exhibited hump-shaped protrusions, the sphericity was acceptable (roundness 1.15) and adequate for the subsequent coating process. An increase in mean diameter of the coated beads and improvements in friability and sphericity were observed in proportion to the amount of coating material applied (ethylcellulose or Eudragit？？ RS 100). It was also found that the release rate of PPA from the coated beads could be controlled by the amount and type of coating materials applied or with the incorporation of Eudragit ？？ RS 100 into the core matrix. Further modifications to the double arm counter-rotating roller, including adjustment of the rotation speed and distance between the rollers, would yield smaller uncoated beads with improved roundness and surface roughness. In conclusion , the present method could be potentially applied to prepare controlled release drug delivery beads or pellet dosage forms.