• Translational and Clinical Pharmacology
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• v.26 no.4
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• pp.160-165
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• 2018

Indobufen ($Ibustrin^{(R)}$), a reversible inhibitor of platelet aggregation, exists in two enantiomeric forms in 1:1 ratio. Here, we characterized the anti-platelet effect of S- and R-indobufen using response surface modeling using $NONMEM^{(R)}$ and predicted the therapeutic doses exerting the maximal efficacy of each enantioselective S- and R-indobufen formulation. S- and R-indobufen were added individually or together to 24 plasma samples from drug-naïve healthy subjects, generating 892 samples containing randomly selected concentrations of the drugs of 0-128 mg/L. Collagen-induced platelet aggregation in platelet-rich plasma was determined using a Chrono-log Lumi-Aggregometer. Inhibitory sigmoid $I_{max}$ model adequately described the anti-platelet effect. The S-form was more potent, whereas the R-form showed less inter-individual variation. No significant interaction was observed between the two enantiomers. The anti-platelet effect of multiple treatments with 200 mg indobufen twice daily doses was predicted in the simulation study, and the effect of S- or R-indobufen alone at various doses was predicted to define optimal dosing regimen for each enantiomer. Simulation study predicted that 200 mg twice daily administration of S-indobufen alone will produce more treatment effect than S-and R-mixture formulation. S-indobufen produced treatment effect at lower concentration than R-indobufen. However, inter-individual variation of the pharmacodynamic response was smaller in R-indobufen. The present study suggests the optimal doses of R-and S-enantioselective indobufen formulations in terms of treatment efficacy for patients with thromboembolic problems. The proposed methodology in this study can be applied to the develop novel enantio-selective drugs more efficiently.

• Journal of the Earthquake Engineering Society of Korea
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• v.1 no.2
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• pp.69-78
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• 1997

Recent test results of steel moment connections repaired with a haunch on the bottom side of the beam have been shown to be a very promising solution to enhancing the seismic performance of steel moment-resisting frames. Yet, litle is known about the effects of using such a repair scheme on the system seismic performance of structures. To investigate the effects of haunch repair on the system seismic performance, a case study was conducted for a 13-story steel frame building damaged during the 1994 Northridge earthquake. When haunches are incorporated in a steel moment frame, the response prediction is complicated by the presence of "dual" panel zones in the column. A new analytical modeling technique for the dual panel zone recently developed by the author was incorporated in the analysis. Incorporating the behavior of dual panel zone was among the most significant consideration in the analyses. Both the inelastic static and dynamic analyses did not indicate detrimental side effects resulting from the repair.he repair.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.14 no.2
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• pp.317-324
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• 1994

The circulation of Lake Paldang is analysed numerically as an ultimate goal to develop a vehicle predicting the dispersion and concentration of pollutants and sediment flowed into the lake. In finite difference formulation of 2-D depth averaged governing equations. Abbott's 3-time level scheme is employed and for nonlinear terms time centering iteration technique in time and space is used. Model parameters for shear stresses and eddy diffusivities are determined through measured data in and near the lake. Predicted velocities for steady flow are shown to be close to the measured velocities and further improved by taking into account of wind effect. This indicates that the wind effect is needed for proper circulation analysis and it calls for the inclusion of the wind effect. Simulated results of unsteady flow caused by flood inflows and release through Paldang dam are found to characterize the flow features quite well as expected. This implies that the developed model can be used as a tool to analysing the circulation in the lake.

• Journal of the Ergonomics Society of Korea
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• v.24 no.3
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• pp.11-27
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• 2005

The objectives of this study are to analyze representative wrist postures while using hand tools and parts at general assembly processes, to evaluate perceived discomfort on the wrist when external loads are present, and to suggest an evaluation and prediction model of perceived discomfort. Sixteen subjects participated in an experiment to appraise perceived discomfort. Three types of the wrist postures with five levels of non-neutralities were analyzed when five levels of external load were applied to each posture. The ANOVA results showed that the perceived discomfort of wrist postures was significantly affected by both the wrist posture and external load (p$<$0.001). It was also shown that some of the interactions between external loads and the wrist postures(Flexion/$Extension^*$Load, Flexion/$Extension^*$supination/pronation, ulnar/radial $deviation^*$supination/pronation) were significant(p$<$0.001). The result implies that a new posture classification scheme for workload assessment methods may be needed to reflect such effects of external load and wrist posture. A regression model of perceived discomfort was developed with respect to wrist posture and external load from the experimental data. A subsequent experiment revealed that the correlation coefficient between the predicted values of perceived discomfort from the model and the actual values obtained from the experiment was about 0.98. It is expected that the results help to properly estimate the body stress resulting from worker's postures and external loads and can be used as a valuable design guideline to analyze potential hazard of musculoskeletal diseases in industry.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.39 no.12
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• pp.529-538
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• 2002

Conventional method to reduce the handoff call blocking probability(PBH) in mobile communication system is to reserve a predetermined number of channels only for handoff calls. To determine the number of reserved channels, an optimization problem, which is generally computationally heavily involved, must be solved. In this Paper, we propose a call admission control (CAC) scheme that can be used to reduce the PBH without reserving channels in advance. For this, we define a new measure, gain, which depends on the state of the system upon the arrival of a new call. The proposed CAC decision rule relies on the gain computed when a new call arrives. SRN, an extended stochastic Petri nets, provides compact modeling facilities for system analysis can be calculated performance index by appropriate reward to the model. In this Paper, we develop SRN models which can perform the CAC with gain. The SRN models are 2 level hierarchical models. The upper layer models are the structure state model representing the CAC and channel allocation methods considering QoS with multimedia traffic The lower layer model Is to compute the gain under the state of the upper layer models.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.48 no.11
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• pp.18-26
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• 2011

This paper describes a multi-mode LDPC decoder which supports three block lengths(648, 1296, 1944) and four code rates(1/2, 2/3, 3/4, 5/6) of IEEE 802.11n wireless LAN standard. To minimize hardware complexity, it adopts a block-serial (partially parallel) architecture based on the layered decoding scheme. A novel memory reduction technique devised using the min-sum decoding algorithm reduces the size of check-node memory by 47% as compared to conventional method. From fixed-point modeling and Matlab simulations for various bit-widths, decoding performance and optimal hardware parameters such as fixed-point bit-width are analyzed. The designed LDPC decoder is verified by FPGA implementation, and synthesized with a 0.18-${\mu}m$ CMOS cell library. It has 219,100 gates and 45,036 bits RAM, and the estimated throughput is about 164~212 Mbps at 50 MHz@2.5v.

• Korean Journal of Construction Engineering and Management
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• v.17 no.6
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• pp.24-30
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• 2016

Building Information Modeling, and its associated work practices, requires project participants to share not only 3D geometric data, but also information in the model that may be considered proprietary and even trade secrets. Thus protection of intellectual property, or BIM copyrights, must be in place for participants to share proprietary information among project stakeholders. Currently Korea does not have adequate copyright laws or mechanisms to provide such protection. This research examined three BIM copyright legal documents, namely U.S.' ConsensusDOCS 301, AIA Document E203/G202, and U.K.'s CIC BIM Protocol to determine how copyright protection is realized, and to formulate appropriate stipulations within the Korean construction context. The resultant requirements include stipulating ownership at to the BIM originator, adopting a license-sublicense scheme, employing a federated model, and use of a formal model delivey table to allocate responsibilities. Given Korea's adoption stage, liability should be minimal, and license revocation should be allowed if payments are not met. The three BIM legal documents focus on practical measures that allow participants to customize requirements for individual projects, and such conventions should be emulated in Korea.

• Journal of Computational Design and Engineering
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• v.3 no.4
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• pp.385-397
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• 2016

Scaffolds are essential in bone tissue engineering, as they provide support to cells and growth factors necessary to regenerate tissue. In addition, they meet the mechanical function of the bone while it regenerates. Currently, the multiple methods for designing and manufacturing scaffolds are based on regular structures from a unit cell that repeats in a given domain. However, these methods do not resemble the actual structure of the trabecular bone which may work against osseous tissue regeneration. To explore the design of porous structures with similar mechanical properties to native bone, a geometric generation scheme from a reaction-diffusion model and its manufacturing via a material jetting system is proposed. This article presents the methodology used, the geometric characteristics and the modulus of elasticity of the scaffolds designed and manufactured. The method proposed shows its potential to generate structures that allow to control the basic scaffold properties for bone tissue engineering such as the width of the channels and porosity. The mechanical properties of our scaffolds are similar to trabecular tissue present in vertebrae and tibia bones. Tests on the manufactured scaffolds show that it is necessary to consider the orientation of the object relative to the printing system because the channel geometry, mechanical properties and roughness are heavily influenced by the position of the surface analyzed with respect to the printing axis. A possible line for future work may be the establishment of a set of guidelines to consider the effects of manufacturing processes in designing stages.

• Smart Structures and Systems
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• v.20 no.3
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• pp.311-328
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• 2017

The characteristics of boundary layers have significant effects on the aerodynamic forces and vibration of the wind turbine blade. The incorporation of active trailing edge flaps (ATEF) into wind turbine blades has been proven as an effective control approach for alleviation of load and vibration. This paper is aimed at investigating the effects of external trailing edge flaps on the flow pattern and velocity distribution within a boundary layer of a NREL 5MW reference wind turbine, as well as designing a new type of velocity sensors for future validation measurements. An aeroelastic-aerodynamic simulation with FAST-AeroDyn code was conducted on the entire wind turbine structure and the modifications were made on turbine blade sections with ATEF. The results of aeroelastic-aerodynamic simulations were combined with the results of two-dimensional computational fluid dynamic simulations. From these, the velocity profile of the boundary layer as well as the thickness variation with time under the influence of a simplified load case was calculated for four different blade-flap combinations (without flap, with $-5^{\circ}$, $0^{\circ}$, and $+5^{\circ}$ flap). In conjunction with the computational modeling of the characteristics of boundary layers, a bio-inspired hair flow sensor was designed for sensing the boundary flow field surrounding the turbine blades, which ultimately aims to provide real time data to design the control scheme of the flap structure. The sensor element design and performance were analyzed using both theoretical model and finite element method. A prototype sensor element with desired bio-mimicry responses was fabricated and validated, which will be further refined for integration with the turbine blade structures.

• KIISE Transactions on Computing Practices
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• v.24 no.1
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• pp.40-45
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• 2018

With the advent of big data and social networks, large-scale graph processing becomes popular research topic. Recently, an optimization technique called Gorder has been proposed to improve the performance of in-memory graph processing. This technique improves performance by optimizing the graph layout on memory to have better cache locality. However, since it is designed for in-memory graph processing systems, the technique is not suitable for disk-based graph engines; also the cost for applying the technique is significantly high. To solve the problem, we propose a new graph ordering called I/O Order. I/O Order considers the characteristics of I/O accesses for SSDs and HDDs to improve the performance of disk-based graph engine. In addition, the algorithmic complexity of I/O Order is simple compared to Gorder, hence it is cheaper to apply I/O Ordering. I/O order reduces the cost of pre-processing up to 9.6 times compared to that of Gorder's, still its performance is 2 times higher compared to the Random in low-locality graph algorithms.