• Transactions of the Korean hydrogen and new energy society
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• v.23 no.4
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• pp.323-329
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• 2012

A thermal management system of a proton exchange membrane fuel cell is taken charge of controlling the temperature of fuel cell stack by rejection of electrochemically reacted heat. Two major components of thermal management system are heat exchanger and pump which determines required amount of heat. Since the performance and durability of PEMFC system is sensitive to the operating temperature and temperature distribution inside the stack, it is necessary to control the thermal management system properly under guidance of operating strategy. The control study of the thermal management system is able to be boosted up with hardware in the loop simulation which directly connects the plant simulation with real hardware components. In this study, the plant simulation of fuel cell stack has been developed and the simulation model is connected with virtual data acquisition system. And HIL simulator has been developed to control the coolant supply system for the study of PEMFC thermal management system. The virtual data acquisition system and the HIL simulator are developed under LabVIEWTM Platform and the Simulation interface toolkit integrates the fuel cell plant simulator with the virtual DAQ display and HIL simulator.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.23 no.8
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• pp.2064-2071
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• 1998

A new digital clock level translator has been designed in order to produce a clock source of the internal logic circuits. The translator output has 50% duty ratio from small sinusoidal input such as TCXO which oscillates itself in poratable components. The circuit consists of positive and negative comparators, RS latch, charge pump, and reference vol- tage generator. It detects pulse width of the output waveform and feedbacks the control signal to the input com-parator. It detects pulse width of the output waveform and feedbacks the control signal to the input com-parator reference, producing output waveform with valid 50% duty ratio of the digital signal level. The designed level translator can be used as a sampling clock source of ADC, PLL and the colck source of the clock synthesizer. The circuit wasdesigned in a 0.8.mu.m analog CMOS technology with double metal, double poly, and BSIM3 circuit simulation model. From our experimental results, a stable operating characteristics of 50 +3% duty ratio was obtained from the sinusoidal input wave of 370 mV.

• Journal of the Korea institute for structural maintenance and inspection
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• v.15 no.6
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• pp.110-117
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• 2011

Seashore landfill projects use undersea pump dredging method for construction of airport and factory site. Coarse grain soil from the dredging is considered for use at inland. West sea shore bottom consists of primarily coarser grained silt-sand and this component contains far more percentage than is the case with East sea and South sea area. This soil shows very different characteristic at consolidation and compaction behavior. This research targets to utilize this type of dredging soil. Test specimen is from West sea (Saemangum) dredged soil landfill site. Model analysis is done for getting prediction of original soil relative density and N-value from dynamic compaction energy variance. Dynamic compaction energy is calculated for efficient foundation design.

• The Korean Journal of Physiology and Pharmacology
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• v.25 no.6
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• pp.507-515
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• 2021

Postoperative ileus (POI), a symptom that occurs after abdominal surgery, reduces gastrointestinal motility. Although its mechanism is unclear, POI symptoms are known to be caused by inflammation 6 to 72 h after surgery. As proton pump inhibitors exhibit protective effect against acute inflammation, the purpose of this study was to determine the effect of ilaprazole on a POI rat model. POI was induced in rats by abdominal surgery. Rats were divided into six groups: control: normal rat + 0.5% CMC-Na, vehicle: POI rat + 0.5% CMC-Na, mosapride: POI rat + mosapride 2 mg/kg, ilaprazole 1 mg/kg: POI rat + ilaprazole 1 mg/kg, ilaprazole 3 mg/kg: POI rat + ilaprazole 3 mg/kg, and ilaprazole 10 mg/kg: POI rat + ilaprazole 10 mg/kg. Gastrointestinal motility was confirmed by measuring gastric emptying (GE) and gastrointestinal transit (GIT). In the small intestine, inflammation was confirmed by measuring TNF-α and IL-1β; oxidative stress was confirmed by SOD, GSH, and MDA levels; and histological changes were observed by H&E staining. Based on the findings, GE and GIT were decreased in the vehicle group and improved in the ilaprazole 10 mg/kg group. In the ilaprazole 10 mg/kg group, TNF-α and IL-1β levels were decreased, SOD and GSH levels were increased, and MDA levels were decreased. Histological damage was also reduced in the ilaprazole-treated groups. These findings suggest that ilaprazole prevents the decrease in gastrointestinal motility, a major symptom of postoperative ileus, and reduces inflammation and oxidative stress.

• The Korean Journal of Pain
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• v.34 no.4
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• pp.405-416
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• 2021

Background: This study investigated the effect of intrathecal Sec-O-glucosylhamaudol (SOG) on the p38/c-Jun N-terminal kinase (JNK) signaling pathways, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-related inflammatory responses, and autophagy in a spinal nerve ligation (SNL)-induced neuropathic pain model. Methods: The continuous administration of intrathecal SOG via an osmotic pump was performed on male Sprague-Dawley rats (n = 50) with SNL-induced neuropathic pain. Rats were randomized into four groups after the 7th day following SNL and treated for 2 weeks as follows (each n = 10): Group S, sham-operated; Group D, 70% dimethylsulfoxide; Group SOG96, SOG at 96 ㎍/day; and Group SOG192, SOG at 192 ㎍/day. The paw withdrawal threshold (PWT) test was performed to assess neuropathic pain. Western blotting of the spinal cord (L5) was performed to measure changes in the expression of signaling pathway components, cytokines, and autophagy. Additional studies with naloxone challenge (n = 10) and cells were carried out to evaluate the potential mechanisms underlying the effects of SOG. Results: Continuous intrathecal SOG administration increased the PWT with p38/JNK mitogen-activated protein kinase (MAPK) pathway and NF-κB signaling pathway inhibition, which induced a reduction in proinflammatory cytokines with the concomitant downregulation of autophagy. Conclusions: SOG alleviates mechanical allodynia, and its mechanism is thought to be related to the regulation of p38/JNK MAPK and NF-κB signaling pathways, associated with autophagy during neuroinflammatory processes after SNL.

• Transactions of the Korean hydrogen and new energy society
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• v.30 no.2
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• pp.136-146
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• 2019

A solid oxide fuel cell (SOFC) based hybrid desiccant cooling system model is developed to study the effect of fuel utilization rate of the SOFC on the reduction of energy consumption and $CO_2$ emission. The SOFC-based hybrid desiccant cooling system consists of an SOFC system and a Hybrid desiccant cooling system (HDCS). The SOFC system includes a stack and balance of plant (BOP), and HDCS. The HDCS consists of desiccant rotor, indirect evaporative cooler, electric heat pump (EHP), and heat exchangers. In this study, using energy load data of a commercial office building and SOFC-based HDCS model, the amount of ton of oil equivalent (TOE) and ton of $CO_2$ ($tCO_2$) are calculated and compared with the TOE and $tCO_2$ generation of the EHP using grid electricity.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.20 no.1
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• pp.40-53
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• 2021

Recently, shared dockless e-scooter usage has rapidly increased, rather than the station-based shared mobility service, because of convenience. This transition leads to new social problems in urban areas such as increased traffic accidents and hindrance of pedestrian environments. In this study, we analyze the usage characteristics of shared e-scooters in Seoul, and identify factors influencing demand for shared e-scooters by developing a negative binomial regression model. As a result, the usage characteristics show that the average trip distance, the average trip duration, and the average trip speed were 1.5km, 9.4min, and 10.3km/h, respectively. Demographic factor, transport facility factors, land use factors, and weather factors have statistically significant impacts on demand for shared e-scooters. The results of this study will be used as basic data for suggesting effective operation strategies for areas with higher shared e-scooter demand and for establishing transport policies for facilitating shared e-scooter usage.

• Herbal Formula Science
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• v.31 no.4
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• pp.389-413
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• 2023

Objectives : This study aimed to review the current trends in experimental studies on the use of natural products for treatment of gastroesophageal reflux disease (GERD). Methods : Experimental studies assessing the efficacy of natural products against GERD were searched on PubMed. Articles were selected based on predefined inclusion and exclusion criteria and then analyzed for experimental methods, interventions, and result analysis techniques. Results : A total 37 studies were included in this review. Predominantly, in vivo experiments were conducted to induce GERD through surgery, involving the ligation of the pylorus and the transitional junction between the corpus and the forestomach using 7-week-old male Sprague-Dawley rats. The acute induction model, sacrificing animals after a single administration following GERD induction, was mainly used.The utilization of cell experiments was relatively infrequent, with a focus on assessing antioxidant and anti-inflammatory effects via the treatment of the RAW 264.7 cell line with lipopolysaccharides treatment. Glycyrrhizae Radix et Rhizoma, Pinelliae Tuber, Ginseng Radix and Zingiberis Rhizoma were used as single ingredients, and herbal formula, STW-5 (iberogast), Rikkunshito (六君子湯), Banhasasim-tang (半夏瀉心湯), and Hewei Jiangni granule (和胃降逆湯) were used. Outcome analysis methods encompassed Macroscopic evaluation, esophageal function assessment, blood biomarker analysis, histological examination, protein analysis, gene expression analysis, and gastric juice analysis. Proton pump inhibitors were predominantly employed as positive controls. Conclusions : This study revealed the current trends in non-clinical research evaluating natural products for GERD. Based on the results of this study, we expect that non-clinical research on clinically effective natural products will be revitalized.

• Journal of Chest Surgery
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• v.32 no.6
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• pp.495-503
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• 1999

Background: We tested the technical feasibility of fetal cardiac bypass and collected baseline data on the fetal hemodynamics and placental functions related to the cardiopulmonary bypass in the fetal lamb model. Material and Method: Eleven fetuses at 120 to 150 days of gestation were subjected to bypass via trans-sternal approach with a 12 G pulmonary arterial cannula and 14 to 18 F venous cannula for 30 minutes. All ewes received general anesthesia with ketamine. In all the fetuses, no anesthetic agents were used except muscle relaxant. Eight served as a group in which placenta was excluded from the extracorporeal circulation by clamping the umbilical cord during the bypass(the oxygenator group) and in the remaining three, the placenta worked as the only source of oxygen supply(the placenta group). Observations were made every 10 minute during a 30-minute bypass and 30-minute post bypass period. No prostaglandin inhibitors were used both in ewes and in fetuses. Result: Weights of the fetuses ranged from 1.9 to 5.2 kg. In the oxygenator group, means of arterial pressure, PaO2, atrial pressure, heart rate, and bypass flow rate ranged 69.8 to 82.6 mmHg, 201.7 to 220.9 mmHg, 4.1 to 4.3 mmHg, 169 to 182/min, and 140.3 to 164.0 ml/kg/min, respectively during bypass, but rapid deterioration of the fetal cardiac functions and the placental gas exchange was observed after the cessation of bypass. In the placenta group, means of arterial pressure decreased from 44.7 to 14.4 mmHg and means of PaCO2 increased from 61.9 to 129.6 mmHg during bypass. Flow rate was suboptimal(74.3 to 97.0 ml/kg/min) during bypass. All hearts fibrillated immediately after the discontinuation of bypass. Conclusion: In this study, the technical feasibility of fetal cardiopulmonary bypass was confirmed in the fetal lamb model. However, further studies with modifications of the bypass including an addition of prostaglandin inhibitor, an application of the total spinal anesthesia on the fetus, a creation of more concise bypass circuit, and a use of active pump are mandatory to improve the outcome.

• Proceedings of the Acoustical Society of Korea Conference
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• autumn
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• pp.233-236
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• 2001

일반적으로 스피커를 동작시키게 되면, 스피커 보이스 코일에 열이 발생하게 되고, 열에 의한 보이스코일의 저항의 증가가 나타나게 되는데, 기존의 연구는 저음용 스피커(Woofer) 만을 대상으로 스피커의 음향특성 변화들에 관해 수행되었다. 그러나, 현대의 스피커는 A/V시스템분야의 발전에 따라 고음재생의 충실도가 강조되고 있는 경향이므로, 고음용 스피커(Tweeter)에 대한 열 발생의 영향을 조사하였다. 본 연구에서는 고음용 스피커의 입력전력에 따른 특성 변화를 조사하고, 입력전력의 증가로 인한 보이스코일(voice coil)의 저항 증가에 따른 고음용 스피커의 특성변화에 관해 실험하였다. 그리고, 스피커의 진동에 의한 펌프(pump) 역할을 이용하는 냉각용 구멍을 뚫어 스피커의 특성변화를 검토하였다. 실험대상으로는 직경 25mm의 돔(Dome)형 진동판을 가진 고음용 스피커와 이 스피커의 후면 중심부에 구멍을 뚫어 열 방출구가 형성된 3종의 시료를 대상으로 특성변화를 비교$\cdot$측정하였다. 여기에서, 사용된 시료는 국내 Y사의 판매용 고음용 스피커로 제품의 원 상태인, 구멍이 없는 것을 기준시료로 하고, 이와 동일한 제품들의 후면에 각각 직경 5mm, 10mm, 15mm의 구멍을 가공하여 비교시료로 하였다. 기준 및 비교시료의 스피커 특성을, 한국산업규격 KS C 6027의 측정법에 따라, 입력 1W 상태에서 기준시료의 사양을 측정하였고[1], 입력을 0.5W, 1W, 2W, 4W, 8W, 16W로 가하여, 시료별 입력증가에 따른 스피커의 주파수 응답특성, 임피던스(Impedance), 조화 왜(Harmonic Distortion)의 변화율 측정을 통해 스피커의 특성변화 정도를 검토하였다. 향후, 본 연구의 결과는 고음용 스피커의 특성 열화에 대한 예측 및 개선 방안을 제시하는 기본 자료로 활용이 가능할 것으로 사료된다.용하여 현금흐름예측을 할 수 있는 Model을 제시하였다. 특히 건설공사의 현금흐름 예측의 중요한 요소인 Cash-Out에 대하여, 공사비 구성요소인 자재, 노무, 중기, 외주, 경비등 각 Resource의 보할(Weights)을 실 공사원가에 따른 보할의 변화와 Resource들의 Time Lag를 적용 기존 연구자의 Model과 다른 Model을 제시하였다. 또한 기존 연구자들의 Model과 비교하여 편리성, 정확도 및 신뢰성이 높은 Model임도 증명하였다.세대까지도 발현수준이 유지될 것으로 판단된다. 이러한 연구결과는 계통으로 확립된 형질전환 동물에 부여된 새로운 유전형질은 지속적으로 후대로 유전될 수 있음을 제시한다.잖⨀瘀Ā퀇Āゑ잖⨀Ā퀇Ԁ￿™잖⨀䌀Ā퀇ĀꄏĀꀏꄏĀꀏ₱?⨀Ā Ԁ￿䂱?⨀ऀĀ耀Ā삱?⨀؀Ā Ā?⨀ጀĀ耀Ā?돀ꢘ?⨀硩?⨀ႎ?⨀?⨀넆돐쁖잖⨀쁖잖⨀／ࠐ?⨀焆덐瀆倆Āⶇ퍟ⶇ퍟ĀĀĀĀ磀鲕좗?⨀肤?⨀⁅Ⴅ?⨀쀃잖⨀䣙熸ጁ↏?⨀