• International Journal of Oral Biology
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• v.46 no.1
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• pp.15-22
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• 2021

Alpha-lipoic acid (ALA) is a naturally occurring antioxidant and has been previously used to treat diabetes and cardiovascular disease. However, the autophagy effects of ALA against oxidative stress-induced dopaminergic neuronal cell injury remain unclear. The aim of this study was to investigate the role of ALA in autophagy and apoptosis against oxidative stress in the SH-SY5Y human dopaminergic neuronal cell line. We examined SH-SY5Y phenotypes using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay (cell viability/proliferation), 4′,6-diamidino-2-phenylindole dihydrochloride nuclear staining, Live/Dead cell assay, cellular reactive oxygen species (ROS) assay, immunoblotting, and immunocytochemistry. Our data showed ALA attenuated hydrogen peroxide (H2O2)-induced ROS generation and cell death. ALA effectively suppressed Bax up-regulation and Bcl-2 and Bcl-xL down-regulation. Furthermore, ALA increased the expression of the antioxidant enzyme, heme oxygenase-1. Moreover, the expression of Beclin-1 and LC-3 autophagy biomarkers was decreased by ALA in our cell model. Combined, these data suggest ALA protects human dopaminergic neuronal cells against H2O2-induced cell injury by inhibiting autophagy and apoptosis.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.27 no.3
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• pp.175-180
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• 2021

Although it has recently been regulated for use as an eco-friendly policy in Korea, the use of EPS (Expanded Polystyrene) cooling boxes, which are used as cold chain delivery insulation boxes for fresh agricultural and livestock products, is also increasing rapidly as e-commerce logistics such as delivery have increased rapidly due to COVID-19. Studies were conducted to optimize the EPS cooling container through internal air heat flow of CFD (Computational Fluid Dynamics) analysis and FEM (Finite Element Method) random vibration analysis using domestic PSD (Power Spectral Density) profile of the EPS cooling box to which the refrigerant is applied in this study. In the analysis of the internal air heat flow by the refrigerant in the EPS cooling box, the application of vertical protrusions inside was excellent in volume heat flow and internal air temperature distribution. In addition, as a result of random vibration analysis, the internal vertical protrusion gives the rigid effect of the cooling box, so that displacement and stress generation due to vibration during transport are smaller than that of a general cooling container without protrusion. By utilizing the resonance point (frequency) of the EPS cooling box derived by the Model analysis of ANSYS Software, it can be applied to the insulation and cushion packaging design of the EPS product line, which is widely used as insulation and cushion materials.

• Journal of The Korean Association For Science Education
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• v.42 no.2
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• pp.177-184
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• 2022

This article aims to explain the concept and characteristics of the 'Intelligent Science Lab', which is being promoted nationwide in Korea since 2021. The Korean Ministry of Education creates a master plan containing a vision for science education every five years. The most recently announced '4th Master plan for science education (2020-2024)' emphasizes the policy of setting up an 'intelligent science lab' in all elementary and secondary schools as an online and offline space for scientific inquiry using advanced technologies, such as Internet of Things and Augmented and Virtual Reality. The 'Intelligent Science Lab' project is being pursued in two main directions: (1) developing an online platform named 'Intelligent Science Lab-ON' that supports science inquiry classes, and (2) building a science lab space in schools that encourages active student participation while utilizing the online platform. This article presents the key features of the 'Intelligent Science Lab-ON' and the characteristics of intelligent science lab spaces newly built in schools. Furthermore, it introduces inquiry-based science learning programs developed for intelligent science labs. These programs include scientific inquiry activities in which students generate and collect data ('data generation' type), utilize datasets provided by the online platform ('data utilization' type), or utilize open and public data sources ('open data source' type). The Intelligent Science Lab project is expected to not only encourage students to engage in scientific inquiry that solves individual and social problems based on real data, but also contribute to presenting a model of online and offline linked scientific inquiry lessons required in the post-COVID-19 era.

• Nuclear Engineering and Technology
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• v.54 no.2
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• pp.523-531
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• 2022

In order to study the sensitivity and the uncertainty of the Moroccan research reactor TRIGA Mark II, a model of this reactor has been developed in our ERSN laboratory for use with the N-Particle MCNP Monte Carlo transport codes (version 6). In this article, the sensitivities of the effective multiplication factor of this reactor are evaluated using the ENDF/B-VII.0, ENDF/B-VII.1 and JENDL-4.0 libraries and in 44 energy groups, for the cross sections of the fuel (U-235 and U-238) and the moderator (H-1 and O-16). However, the quantification of the uncertainty of the nuclear data is performed using the nuclear code NJOY99 for the generation and processing of covariance matrices. On the one hand, the highest uncertainty deviations, calculated using the ENDFB-VII.1 and JENDL4.0 evaluations, are 2275, 386 and 330 pcm respectively for the reactions U₂₃₅(n, f), $ U_{235}(n\bar{\nu})$ and H₁(n, γ). On the other hand, these differences are very small for the neutron reactions of O-16 and U-238. Regarding the neutron spectra, in CT-mid plane, they are very close for the three evaluations (ENDF/B-VII.0, ENDF/B-VII.1 and JENDL-4.0). These spectra present two peaks (thermal and fission) around the energies 0.05 eV and 1 MeV.

• Journal of Advanced Navigation Technology
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• v.26 no.3
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• pp.179-184
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• 2022

The accurate wing flexure model is required to improve the transfer alignment performance of guided weapon system mounted on a wing of fighter aircraft or armed helicopter. In order to solve this problem, mechanical or stochastical modeling methods have been studying, but modeling accuracy is too low to be applied to weapon systems. The deep learning techniques that have been studying recently are suitable for nonlinear. However, operating fighter aircraft for deep-learning modeling to secure a large amount of data is practically difficult. In this paper, it was used to generate amount of flexure data samples that are similar to the actual flexure data. And it was confirmed that generated data is similar to the actual data by utilizing "measures of similarity" which measures how much alike the two data objects are.

• Land and Housing Review
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• v.13 no.3
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• pp.57-68
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• 2022

This study investigates what influences the 2030 households' intention to utilize housing support policies for the younger generation. Using the logistic regression model, our empirical results show that the 'the recognition of youth housing support projects', 'the housing occupation', 'employment type', 'housing type', and 'age' factors have a significant effect on the intention to use the housing support policies. Specifically, the intention is positively associated with economic activity, one-room residence, monthly rent, employment status during the Covid-19 period, and policy recognition, while negatively related to age. In addition, willingness to use the housing support policies is greater when respondents lived in a studio, lived on a monthly rent, recognized the policy, and improved their employment status. The results suggest that housing support programs need to be expanded and improved. Moreover, information on housing support policies should be efficiently delivered to eligible households, and more sophisticated housing support policies should be provided for young people early in their careers.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.50 no.2
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• pp.119-125
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• 2022

In this paper, we present design, implementation and test results of CTM (Chirp Transceiver Module) EM (Engineering Model) for C-Band SAR (Synthetic Aperture Radar) Payload. The CTM is designed to operate dual frequency scan method that simultaneously operate two frequencies in each 50MHz bandwidth to achieve 120Km swath with 10m resolution at about 500Km altitude. The CTM used radiation tolerant RTG4 FPGA for space environment, and implemented with the Parallel DDS (PDDS) method which uses a small memory capacity compared to the memory-map method. Test results show high purity chirp signal generation and excellent IRF performance from received chirp signal after direct digital conversion.

• The Journal of the Acoustical Society of Korea
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• v.40 no.6
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• pp.571-577
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• 2021

This study is a study on System On Chip (SOC) that implements virtual engine sound in electric vehicles without engines, and realizes vivid engine sound by combining Adaptive Difference PCM (ADPCM) method and frequency modulation method for satisfaction of driver's needs and safety of pedestrians. In addition, by proposing an electronic sound synthesis algorithm applying Musical Instrument Didital Interface (MIDI), an engine sound synthesis method and a constitutive model of an engine sound generation system are presented. In order to satisfy both drivers and pedestrians, this study uses Controller Area Network (CAN) communication to receive information such as Revolution Per Minute (RPM), vehicle speed, accelerator pedal depressed amount, torque, etc., transmitted according to the driver's driving habits, and then modulates the frequency according to the appropriate preset parameters We implemented an interaction algorithm that accurately reflects the intention of the system and driver by using interpolation for the system, ADPCM algorithm for reducing the amount of information, and MIDI format information for making engine sound easier.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.26 no.8
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• pp.1111-1120
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• 2022

Image Capturing is a matter of viewing images and describing images in language. The problem is an important problem that can be solved by keeping, understanding, and bringing together two areas of image processing and natural language processing. In addition, by automatically recognizing and describing images in text, images can be converted into text and then into speech for visually impaired people to help them understand their surroundings, and important issues such as image search, art therapy, sports commentary, and real-time traffic information commentary. So far, the image captioning research approach focuses solely on recognizing and texturing images. However, various environments in reality must be considered for practical use, as well as being able to provide image descriptions for the intended purpose. In this work, we limit the universally available Korean and English image captioning models and text generation techniques for the purpose of image captioning.

• Molecules and Cells
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• v.45 no.10
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• pp.749-760
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• 2022

Osteoclast generation from monocyte/macrophage lineage precursor cells needs to be tightly regulated to maintain bone homeostasis and is frequently over-activated in inflammatory conditions. PARK2, a protein associated with Parkinson's disease, plays an important role in mitophagy via its ubiquitin ligase function. In this study, we investigated whether PARK2 is involved in osteoclastogenesis. PARK2 expression was found to be increased during the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation. PARK2 gene silencing with siRNA significantly reduced osteoclastogenesis induced by RANKL, LPS (lipopolysaccharide), TNFα (tumor necrosis factor α), and IL-1β (interleukin-1β). On the other hand, overexpression of PARK2 promoted osteoclastogenesis. This regulation of osteoclastogenesis by PARK2 was mediated by IKK (inhibitory κB kinase) and NF-κB activation while MAPK (mitogen-activated protein kinases) activation was not involved. Additionally, administration of PARK2 siRNA significantly reduced osteoclastogenesis and bone loss in an in vivo model of inflammatory bone erosion. Taken together, this study establishes a novel role for PARK2 as a positive regulator in osteoclast differentiation and inflammatory bone destruction.