• Environmental Mutagens and Carcinogens
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• v.21 no.1
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• pp.1-8
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• 2001

We have synthesized $^{99m}$Tc-mercaptoacetyltriglycine (MAG3)-biocytin as a new imaging agent for hepatobiliary scintigraphy. The aim of this study was to evaluate the usefulness of $^{99m}$Tc-MAG3-biocytin scintigraphy in differentiating carbon tetrachloride ( $CCl_4$)-induced hepatotoxicity from $\alpha$-naphthylisothiocyanate (ANIT)-induced cholestasis in mice, which reflecting the differential diagnosis of neonatal jaundice caused by neonatal hepatitis from congenital biliary atresia in humans. Methods: Balb/c mice (female, 20 g, n=4-6) were pretreated with $CCl_4$(0.5 or $1.0m\ell$/kg) and ANIT ($150 or 300 m\ell$/kg) 18 h before scintigraphy. Biochemical and histopathological examinations showed a pattern of typical acute hepatitis (increase of transaminases and hepatocellular necnsis) in $CCl_4$-treated mice and cholestasis (increase of alkaline phosphatase and ${\gamma}$-glutamyltransferase, and biliary hyperplasia) in ANIT-treated mice, respectively, Mice were fasted at least 4 hr prior to the intravenous injection of $^{99m}$Tc-MAG3-biocytin (18.5 MBq/20$\mu\textrm{g}$) in 2% human serum albumin in saline. Scintigraphy was performed with a ${\gamma}$-camera equipped with a 1-mm diameter pin-hole collimator for 30 min and images were acquired every 15 s. We compared the values of physical parameters, such as peak liver/heart ratio ($${\gamma}$_{max}$) and peak ratio time ($t_{max}$) far $^{99m}$Tc-MAG3-biocytin scintigraphy. Results: Scintigraphic parameters of the $CCl_4$-pretreated (0.5 $m\ell$/kg) group showed a 81.9% decrease of r$_{max}$, and 42.2% decrease of $t_{max}$, whereas the ANIT-pretreated ( $150m\ell$/kg) group showed a 53% decrease of $r_{max}$, and 2.36-fold increase of $t_{max}$, (P<0.05). These results demonstrate that the decrease of $r_{max}$ and the shortening of $t_{max}$ are characteristic features for hepatotoxicity, in contrast to the increase of $t_{max}$ and decrease of $r_{max}$ for biliary hyperplasia. Conclusion: $^{99m}$Tc-MAG3-biocytin hepatobiliary scintigraphy can distinguish hepatitis from cholestasis in mice model and may be similarly useful in humans which differentiating the cause of neonatal jaundice in clinical study.cal study.cal study.cal study.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.3
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• pp.30-35
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• 2021

The present study examined the effects of various guide fin structures and boundary parameters on the thermal performance of heat exchangers used in heat recovery thermoelectric generators. The heat transfer rate and pressure drop of the heat exchangers without fins, with circular fins, with triangular fins, and with combined circular and triangular fins were simulated numerically using ANSYS 19.1 commercial code to confirm the effect of the guide fin structures. The heat transfer rate of the heat exchanger with combined fins was 27.0%, 5.2%, and 1.5% higher than those without fins, with circular fins, and with triangular fins, respectively. The pressure drop characteristic of the heat exchanger with the combined fins was 28.3% higher than that without fins but 9.2% and 10.5% lower than those with circular fins and with triangular fins, respectively. The heat exchanger with combined fins as the optimal model showed the highest heat transfer rate of 5664.9 W and pressure drop of 1454.02 Pa for highest hot gas temperature, maximum flow rates of hot gas and coolant, and lowest coolant temperature.

• Korean Journal of Radiology
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• v.23 no.10
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• pp.986-997
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• 2022

Objective: Whether metabolic redistribution occurs in patients with white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) is unknown. This study aimed 1) to propose a measure of the brain metabolic network for an individual patient and preliminarily apply it to identify impaired metabolic networks in patients with WMHs, and 2) to explore the clinical and imaging features of metabolic redistribution in patients with WMHs. Materials and Methods: This study included 50 patients with WMHs and 70 healthy controls (HCs) who underwent ¹⁸F-fluorodeoxyglucose-positron emission tomography/MRI. Various global property parameters according to graph theory and an individual parameter of brain metabolic network called "individual contribution index" were obtained. Parameter values were compared between the WMH and HC groups. The performance of the parameters in discriminating between the two groups was assessed using the area under the receiver operating characteristic curve (AUC). The correlation between the individual contribution index and Fazekas score was assessed, and the interaction between age and individual contribution index was determined. A generalized linear model was fitted with the individual contribution index as the dependent variable and the mean standardized uptake value (SUV_mean) of nodes in the whole-brain network or seven classic functional networks as independent variables to determine their association. Results: The means ± standard deviations of the individual contribution index were (0.697 ± 10.9) × 10^-3 and (0.0967 ± 0.0545) × 10^-3 in the WMH and HC groups, respectively (p < 0.001). The AUC of the individual contribution index was 0.864 (95% confidence interval, 0.785-0.943). A positive correlation was identified between the individual contribution index and the Fazekas scores in patients with WMHs (r = 0.57, p < 0.001). Age and individual contribution index demonstrated a significant interaction effect on the Fazekas score. A significant direct association was observed between the individual contribution index and the SUV_mean of the limbic network (p < 0.001). Conclusion: The individual contribution index may demonstrate the redistribution of the brain metabolic network in patients with WMHs.

• Journal of KIISE:Software and Applications
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• v.28 no.7
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• pp.501-510
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• 2001

Generally, it is essential to estimate exact disparity for the 3D modeling from stereo images. Because existing methods calculate disparities from a whole image, they require too much cimputational time and bring about the mismatching problem. In this article, using the characteristic that the disparity vectors in stereo images are distributed not equally in a whole image but only exist about the background and obhect, we do a wavelet transformation on stereo images and estimate coarse disparity fields from the reduced lowpass field using area-based method at first-step. From these coarse disparity vectors, we generate disparity histogram and then separate object from background area using it. Afterwards, we restore only object area to the original image and estimate dense and accurate disparity by our two-step pixel-based method which does not use pixel brightness but use second gradient. We also extract feature points from the separated object area and estimate depth information by applying disparity vectors and camera parameters. Finally, we generate 3D model using both feature points and their z coordinates. By using our proposed, we can considerably reduce the computation time and estimate the precise disparity through the additional pixel-based method using LOG filter. Furthermore, our proposed foreground/background method can solve the mismatching problem of existing Delaunay triangulation and generate accurate 3D model.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.6
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• pp.2369-2379
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• 2013

The Soil-Water Characteristics Curve (SWCC) is affected by the initial density of soil under unsaturated condition. Also, the characteristic of hydraulic conductivity is changed by the initial density of soil. To study the effect of initial density of unsaturated soil, SWCC and the Hydraulic Conductivity Function (HCF) of Jumoonjin sand with various relative densities, 40%, 60% and 75% were measured in both drying and wetting processes. As the results of SWCC estimated by van Genuchten (1980) model, the parameter related to Air Entry Value(AEV), ${\alpha}$ in the wetting process is larger than that in drying process, but the parameters related to the SWCC slope, n and the residual water content, m are larger than those in wetting process. The AEV is increased or Water Entry Value (WEV) is decreased with increasing the relative density of sand. The AEV is larger than the WEV at the same relative density of sand. As the results of HCF estimated by van Genuchten (1980) model which is one of the parameter estimation methods, the unsaturated hydraulic conductivity maintained at a saturated one in the low level of matric suctions and then suddenly decreased just before the AEV or the WEV. The saturated hydraulic conductivity in drying process is larger than that in wetting process. The saturated hydraulic conductivity is decreased with increasing the relative density of sand in both drying and wetting processes. Also, the hysteresis in unsaturated HCFs between drying and wetting process was occurred like the hysteresis in SWCCs. According to the test results, the AEV on SWCC is decreased and the saturated hydraulic conductivity is increased with increasing the initial density. It means that SWCC and HCF are affected by the initial density in the unsaturated soil.

• Journal of Wetlands Research
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• v.21 no.spc
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• pp.28-38
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• 2019

Climate change on the Korean peninsula is progressing faster than the global average. For example, typhoons, extreme rainfall, heavy snow, cold, and heatwave that are occurring frequently. North Korea is particularly vulnerable to climate change-related natural disasters such as flooding and flooding due to long-term food shortages, energy shortages, and reckless deforestation and development. In addition, North Korea is classified as an unmeasured area due to political and social influences, making it difficult to obtain sufficient hydrologic data for hydrological analysis. Also, as interest in climate change has increased, studies on climate change have been actively conducted on the Korean Peninsula in various repair facilities and disaster countermeasures, but there are no cases of research on North Korea. Therefore, this study selects watershed characteristic variables that are easy to acquire in order to apply localization model to North Korea where it is difficult to obtain observed hydrologic data and estimates parameters based on meteorological and topographical characteristics of 16 dam basins in South Korea. Was calculated. In addition, as a result of reviewing the applicability of the parameter estimation equations calculated for the fifty thousand, Gangneungnamdaecheon, Namgang dam, and Yeonggang basins, the applicability of the parameter estimation equations to North Korea was very high.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.30 no.4
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• pp.617-629
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• 2020

In order to overcome the limitations of the rule-based intrusion detection system due to changes in Internet computing environments, the emergence of new services, and creativity of attackers, network anomaly detection (NAD) using machine learning and deep learning technologies has received much attention. Most of these existing machine learning and deep learning technologies for NAD use supervised learning methods to learn a set of training data set labeled 'normal' and 'attack'. This paper presents the feasibility of the unsupervised learning AutoEncoder(AE) to NAD from data sets collecting of secured network traffic without labeled responses. To verify the performance of the proposed AE mode, we present the experimental results in terms of accuracy, precision, recall, f1-score, and ROC AUC value on the NSL-KDD training and test data sets. In particular, we model a reference AE through the deep analysis of diverse AEs varying hyper-parameters such as the number of layers as well as considering the regularization and denoising effects. The reference model shows the f1-scores 90.4% and 89% of binary classification on the KDDTest+ and KDDTest-21 test data sets based on the threshold of the 82-th percentile of the AE reconstruction error of the training data set.

• Journal of KIISE:Information Networking
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• v.28 no.3
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• pp.389-405
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• 2001

In these days, we have increasing demands on the real-time services, especially for the multimedia data transmission in both of wired and wireless environments and thus efficient and stable ways of transmitting realtime data are needs. Although RTP is widely used for internet-based realtime applications, it cannot avoid packet losses, due to the use of UDP stack and its underlying layers. In the case of mobile computing applications, the packet losses are more frequent and consecutive because of the limited bandwidth. In this paper, we first statistically analyze the characteristics of packet losses in the wired and wireless communications, based on Gilbert model, and a new packet recovery scheme for realtime data transmission is presented. To reflect the transmission characteristics of the present network environment, our scheme makes the sender to dynamically adjust the amount of redundant information, using the current packet loss characteristic parameters reported by the receiver. Additionally, we use relatively large and discontinuous offset values, which enables us to recover from both of the random and consecutive packet losses. Due to these characteristics, our scheme is suitable for the mobile computing environment where packet loss rates are relatively high and varies rapidly in a wide range. Since our scheme is based on the analytic model form statistics, it can also be used for other network environments. We have implemented the scheme with Mobile IP and RTP/RTCP protocols to experimentally verify its efficiency.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.6
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• pp.2739-2746
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• 2011

This paper proposes the method for more effectively calculating X/R which is the ratio of equivalent reactance(X) and resistance(R) of the bulk power system and analyses the characteristic of X/R values by applying the proposed method to the real bulk power systems. X/R is used to determine the rating of the relay in the bulk power systems and its value has been accepted to be big enough to ignore the equivalent resistance of the bulk power systems. However, X/R is calculated as a big number when only the upper transformer and transmission line are considered. The correct approach to calculating X/R needs to consider all the parameters including generators, transformers, lines and loads. This paper calculates X/R of the bulk power systems using dynamic models which have been used to analyse the power system stability. The effectiveness of the proposed method is verified by applying it to the test system and X/R values of the real bulk power systems are analyzed. In addition, the dependence of X/R on the closeness of its calculating locations to the generator is verified by using the marginal loss factor which has been used in the electricity market.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.3
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• pp.937-945
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• 2013

The accuracy of flood inundation maps is determined by the uncertainty propagated from all variables involved in the overall process including input data, model parameters and modeling approaches. This study investigated the uncertainty arising from key variables (flow condition and Manning's n) among model variables in flood inundation mapping for the Missouri River near Boonville, Missouri, USA. Methodology of this study involves the generalized likelihood uncertainty estimation (GLUE) to quantify the uncertainty bounds of flood inundation area. Uncertainty bounds in the GLUE procedure are evaluated by selecting two likelihood functions, which is two statistic (inverse of sum of squared error (1/SAE) and inverse of sum of absolute error (1/SSE)) based on an observed water surface elevation and simulated water surface elevations. The results from GLUE show that likelihood measure based on 1/SSE is more sensitive on observation than likelihood measure based on 1/SAE, and that the uncertainty propagated from two variables produces an uncertainty bound of about 2% in the inundation area compared to observed inundation. Based on the results obtained form this study, it is expected that this study will be useful to identify the characteristic of flood.