• Mass Spectrometry Letters
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• v.8 no.2
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• pp.23-28
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• 2017

Arctigenin is the main active ingredient of Fructus Arctii, which has been reported with a variety of therapeutic activities including anti-cancer, anti-inflammation, anti-virus, and anti-obesity effects. In this study, a simple and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of arctigenin in rat plasma. The assay utilized a simple protein precipitation with methanol and the mobile phase consisted of 100% methanol and water containing 0.1% formic acid (65:35 v/v). Arctigenin and the internal standard (psoralen) were monitored using a positive electrospray turbo ionspray mode with multiple reaction monitoring transitions of m/z $373.2{\rightarrow}136.9$ and m/z $187.2{\rightarrow}130.9$, respectively, and total chromatographic run time was within 5 min. The lower limit of quantification (LLOQ) of arctigenin was 5 ng/mL in the rat plasma. The intra- and inter-day accuracy of arctigenin at LLOQ and matrix-matched quality control samples ranged 97.4 - 104.8% and 97.2 - 102.0%, respectively. The intra-day precision was within 4.80% and the inter-day precision was within 5.92%. Application of the present method was demonstrated through a pharmacokinetic study after intravenous and oral administration of arctigenin in male Sprague Dawley rats.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.9
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• pp.2354-2360
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• 2009

Healthcare is a field where ubiquitous computing is most widely used. We propose a mining-based healthcare multi-agent system for ubiquitous computing environments. This proposed scheme select diagnosis patterns using mining in the real-time biosignal data obtained from a patient's body. In addition, we classify them into normal, emergency and be ready for an emergency. This proposed scheme can deal with the enormous quantity of real-time sensing data and performs analysis and comparison between the data of patient's history and the real-time sensory data. We separate Association rule exploration into two data groups: one is the existing enormous quantity of medical history data. The other group is real-time sensory data which is collected from sensors measuring body temperature, blood pressure, pulse. Proposed system has advantage that can handle urgent situation in the far away area from hospital through PDA and mobile device. In addition, by monitoring condition of patient in a real time base, it shortens time and expense and supports medical service efficiently.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.11
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• pp.2179-2184
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• 2007

The Intelligent Space(ISpace) provides challenging research fields for surveillance, human-computer interfacing, networked camera conferencing, industrial monitoring or service and training applications. ISpace is the space where many intelligent devices, such as computers and sensors, are distributed. According to the cooperation of many intelligent devices, the environment, it is very important that the system knows the location information to offer the useful services. In order to achieve these goals, we present a method for representing, tracking and human following by fusing distributed multiple vision systems in ISpace, with application to pedestrian tracking in a crowd. This paper described appearance based unknown object tracking with the distributed vision system in intelligent space. First, we discuss how object color information is obtained and how the color appearance based model is constructed from this data. Then, we discuss the global color model based on the local color information. The process of learning within global model and the experimental results are also presented.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.9
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• pp.1665-1671
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• 2007

Mobile Ad hoc Networks (MANETs) refer to autonomous networks in which wireless data communications are established between multiple nodes in a given coverage area without a base station or centralized administration. Because of node mobility and limited battery life, the network topology may changes frequently. Selecting the most reliable path during route discovery process is important to improve performance in ad-hoc networks. In this study, we proposed an enhanced routing protocol based on AODV by monitoring variation of receiving signal strength. New metric function that consists of node mobility and hops of path is used for routing decision. From extensive experiments by using NS-2, The performance of the proposed routing scheme has been imp개ved by comparison to AODV protocol.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2009.05a
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• pp.899-902
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• 2009

As computer network and wireless technology continue to grow rapidly, a wide range of remote application has been applied to medical field such as remote medical consulting and remote patient monitoring. This research aims to design RF telecommunication-based healthcare application to collect and manage patient's physiological data, and describe the overall procedure of experiment. MySQL database is designed to record patient's physiological data including temperature, blood pressure and heart rate and save information about medical behaviors such as doctor's prescription for patients. Therefore, users approved by healthcare application can query patient's data and collected data can be used to reorganize data for clinical test. As a result, temperature and humidity of patient's room which must be checked frequently can be processed automatically through ubiquitous sensor network. The information entered from mobile phones or web is saved in database, ensuring systematical management through computer. Moreover, patient's family members can easily access hospital data, improving their experience with medical service.

• Korean Journal of Soil Science and Fertilizer
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• v.48 no.6
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• pp.593-601
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• 2015

The NDVI (Normalized difference vegetation index) is used as indicators of crop growth situation in remote sensing. To measure or validate the NDVI, reliable NDVI sensors have been needed. We tested new fixed-field NDVI sensor, "SRS (Spectral Reflectance Sensor)" developed by Decagon Devices, during Kimchi cabbage growing season at the cultivation area located in Gochang, Gangneung and Taebaek in Korea from 2014 to 2015. The diurnal variation of NDVI measured by SRS (SRS NDVI) showed a slight ${\cap}$-profile shape and was affected by water on the sensor surface. This means that SRS NDVI around noontime is resonable, except rainy day. Comparisons were made between the SRS NDVI and NDVI of used widely mobile sensor (Cropcircle NDVI). The comparisons indicate that SRS NDVI are close to Cropcircle NDVI (R=0.99). SRS NDVI time series displayed change of the plant height and leaf width of Kimchi cabbage. An obvious exponential relationship is found between SRS NDVI and the plant height ($R^2{\geq}0.92$) and leaf width ($R^2{\geq}0.92$) of Kimchi cabbage. Thus, SRS NDVI will be used as indicator of crop growth situation and a very powerful tool for evaluation of remote sensing NDVI estimates and associated corrections.

• Applied Chemistry for Engineering
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• v.32 no.6
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• pp.700-705
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• 2021

A portable and disposable pH sensor based on Ti wire was successfully developed for monitoring hydronium ion concentrations. A sensing electrode was prepared by electrochemically depositing iridium oxide onto a Ti wire, while a reference electrode was fabricated by coating Ag/AgCl ink on a Ti wire. Combining the two electrodes in the pH sensor enabled the collection of open circuit potential signals when the sensor was immersed in solutions of various pH values. The pH sensor exhibited excellent electrochemical sensing performance in terms of sensitivity, response time, repeatability, selectivity, and stability. To demonstrate point-of-measurement applications, the pH sensor was integrated with a wireless electronic module that could communicate with a mobile application. The portable pH sensor accurately measured pH changes in real samples. The results obtained were consistent with those of using a commercial pH meter.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.5
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• pp.251-256
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• 2021

Unlike general cameras, a high-speed camera capable of capturing a large number of frames per second can enable the advancement of some image processing technologies that have been limited so far. This paper proposes a method of removing undesirable noise from an high-speed input color image, and then detecting a human face from the noise-free image. In this paper, noise pixels included in the ultrafast input image are first removed by applying a bidirectional filter. Then, using RetinaFace, a region representing the person's personal information is robustly detected from the image where noise was removed. The experimental results show that the described algorithm removes noise from the input image and then robustly detects a human face using the generated model. The model-based face-detection method presented in this paper is expected to be used as basic technology for many practical application fields related to image processing and pattern recognition, such as indoor and outdoor building monitoring, door opening and closing management, and mobile biometric authentication.

• Journal of Environmental Impact Assessment
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• v.28 no.3
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• pp.287-298
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• 2019

This study found that wildlife crossing created through environmental impact assessments didn't reduce the number of wildlife accidents on the road by review of "A Study on the Legal and Institutional Review for Reproving Bio-Mobile in Environmental Impact Assessment(2018)". Specific considerations to be reviewed at each stage of the environmental impact assessment consultation were presented for practical site application. Therefore, in this study, the consultation steps for environmental impact assessment were presented in five stages, including planning, design, construction, monitoring, maintenance and management, and detail of the items to be reviewed by public officer. It will be able to prevent loss of habitats and improve biodiversity by improving the practice and institutional problems that were planned and designed at the time of construction.

• Journal of Biomedical and Translational Research
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• v.19 no.4
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• pp.130-139
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• 2018

This study aimed to analyze a high-performance liquid chromatography (HPLC) separation using a pentafluorophenyl column of parent drug hydroxychloroquine (HCQ) and its active metabolite, desethylhydroxchloroquine (DHCQ) applying to determine bioequivalence of two different formulations administered to patients. A rapid, simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for bioanalysis of HCQ and its metabolite DHCQ in human whole blood using deuterium derivative $hydroxychloroquine-D_4$ as an internal standard (IS). A triple-quadrupole mass spectrometer was operated using electrospray ionization in multiple reaction monitoring (MRM) mode. Sample preparation involves a two-step precipitation of protein techniques. The removed protein blood samples were chromatographed on a pentafluorophenyl (PFP) column ($50mm{\times}4.6mm$, $2.6{\mu}m$) with a mobile phase (ammonium formate solution containing dilute formic acid) in an isocratic mode at a flow rate of 0.45 mL/min. The standard curves were found to be linear in the range of 2 - 500 ng/mL for HCQ; 2 - 2,000 ng/mL for DHCQ in spite of lacking a highly sensitive MS spectrometry system. Results of intra- and inter-day precision and accuracy were within acceptable limits. A run time of 2.2 min for HCQ and 2.03 min for DHCQ in blood sample facilitated the analysis of more than 300 human whole blood samples per day. Taken together, we concluded that the assay developed herein represents a highly qualified technology for the quantification of HCQ in human whole blood for a parallel design bioequivalence study in a healthy male.