• Journal of Environmental Health Sciences
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• v.49 no.2
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• pp.89-98
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• 2023

Background: Organophosphorus flame retardants (OPFRs) are a group of chemical substances used in building materials and plastic products to suppress or mitigate the combustion of materials. Although OPFRs are generally used in mixed form, information on their mixture toxicity is quite scarce. Objectives: This study aims to elucidate the toxicity and determine the types of interaction (e.g., synergistic, additive, and antagonistic effect) of OPFRs mixtures. Methods: Nine organophosphorus flame retardants, including TEHP (tris(2-ethylhexyl) phosphate) and TDCPP (tris(1,3-dichloro-2-propyl) phosphate), were selected based on indoor dust measurement data in South Korea. Nine OPFRs were exposed to the luminescent bacteria Aliivibrio fischeri for 30 minutes and the human hepatocyte cell line HepG2 for 48 hours. Chemicals with significant toxicity were only used for mixture toxicity tests in HepG2. In addition, the observed EC_x values were compared with the predicted toxicity values in the CA (concentration addition) prediction model, and the MDR (model deviation ratio) was calculated to determine the type of interaction. Results: Only four chemicals showed significant toxicity in the luminescent bacteria assays. However, EC₅₀ values were derived for seven out of nine OPFRs in the HepG2 assays. In the HepG2 assays, the highest to lowest EC₅₀ were in the order of the molecular weight of the target chemicals. In the further mixture tests, most binary mixtures show additive interactions except for the two combinations that have TPhP (triphenyl phosphate), i.e., TPhP and TDCPP, and TPhP and TBOEP (tris(2-butoxyethyl) phosphate). Conclusions: Our data shows OPFR mixtures usually have additivity; however, more research is needed to find out the reason for the synergistic effect of TPhP. Also, the mixture experimental dataset can be used as a training and validation set for developing the mixture toxicity prediction model as a further step.

• Archives of Plastic Surgery
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• v.34 no.2
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• pp.163-168
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• 2007

Purpose: The flap delay is a widely used technique to increase the flap survival. Dexamethasone is a well-known drug to have a positive impact on the flap survival. The objective of this study is to investigate the dual synergic effect of epinephrine as a chemical delay agent plus dexamethasone on the TRAM flap survival in rat model. Methods: Forty Sparague-Dawley rats were divided into 4 groups evenly and a right inferior epigastic vessel pedicled TRAM flap, sized $5.0{\times}3.0cm$, was elevated on each upper abdomen. In the control group(N=10), 2 ml saline was injected on transverse abdominis muscle for a week before the flap elevation. In surgical delay group(N=10) all superior pedicles and left inferior pedicle were ligated a week before the flap elevation. In epinephrine group (N=10), 1 : 50000 epinephrine mixed saline was injected to transverse abdominis muscle every day for a week before flap elevation. In epinephrine plus dexamethasone group (N=10), the same procedure as that of epinephrine group was conducted for a week and 2.5 ml/kg dexamethasone was injected transverse abdominis muscle 2 hours before the flap elevation. On the seventh day after flap elevation, the survival area of flaps were measured and the vessel numbers in upper dermis of flap were counted through histologic slides. Results: The results were as follows: the mean percentage of the flap survival area of surgical delay group ($60.5{\pm}2.44%$), epinephrine group ($75{\pm}4.43%$), and epinephrine plus dexamethasone group ($87{\pm}1.94%$) were higher than that of the control group ($35{\pm}6.06%$) significantly(p<0.05). In case of the vessel number though histologic slides, epinephrine group ($79.3{\pm}5.57$) and epinephrine plus dexamethasone group ($96.3{\pm}14.05$) were higher than that of the control group ($44.8{\pm}8.82$) significantly(p<0.05), but the surgical delay group ($54{\pm}4.23$) showed no significant difference (p>0.05) compared to that of the control group. Conclusion: The results indicated that epinephrine plus dexamethasone injection before the flap elevation could be used to increase the TRAM flap survival area in rat model.

• Journal of the Korean Society of Food Science and Nutrition
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• v.30 no.5
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• pp.858-864
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• 2001

This study was performed to investigate the effect of sodium lactate (SL, 60%) and a mixed fat replacer (FR) on the product quality and shelf-life effect of low-fat bologna sausage (LFBS) in a model system during refrigerated storage. Low-fat and regular-fat bologna sausages had pH values ranged from 6.15 to 6.30 and water activity values ranged from 0.95 to 0.96. LFBS had a moisture content of 74~76%, <2% fat and 14~15% protein, whereas regular-fat bologna had 60% moisture, 22% fat and approximately 12% protein in the final products. Expressible moisture (%) increased (p<0.05) in all bolognas, resulting in the soft texture, as the storage time (weeks) increased. LFBS manufactured with SL and a FR had lower (p<0.05) the cooking loss (%) and had higher (p<0.05) texture profile analysis (TPA) values than the regular-fat counterpart. As the sodium lactate level increased up to 5% in the formulation of LFBS, vacuum purge and TPA hardness values also increased (p<0.05), but thiobarbituric acid (TBA) values decreased (p<0.05). Total plate counts of LFBS were reduced (p<0.05) when the addition level of 60% SL solution was more than 3.3%. This result indicated that the increased level of SL (>3.3%) in the combination of a FR in the formulation of LFBS improved the product quality and did inhibit the total microbial growth of LFBS during storage, as compared to the control.

• Journal of Information Technology and Architecture
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• v.11 no.4
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• pp.427-439
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• 2014

Introduction of new information systems due to continuous progress of ICT has made the enterprise IT environment into a mixed pot of various IT resources. Rapidly changing business situation has emphasized the integration of organizational IT resources as one of key competitive advantages. Those distributed IT resources are now demanding to solve the problems not only on their own effective management but also on security and control issues against unauthorized infiltration and information leakages. Under the situation that the number of IT resources is constantly increasing, it is needed to study a management model and its implementation that integrally solves above all problems. In this paper, it is revealed that a directory service can be used to integrally manage distributed IT resources and a directory service based system model for distributed IT resource management is suggested. By implementing an HR solution over active directory service, it is demonstrated that our integrated management model for distributed resources is applicable to real business cases. It is expected that for small and medium sized enterprises with limited IT investments, directory service based IT resource management system can be a cost-effective solution for increasing security threats and lack of governance.

• The Journal of the Korea Contents Association
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• v.13 no.5
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• pp.342-353
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• 2013

Objectives: It attempted to analyze influencing factors on the utilization of outpatient services which were adopted to predisposing, enabling, and need factors in Anderson model. Methods: The current study analyzed "2007 Korean National Health Nutrition Survey" data, which selected 3,335 people nationwide by proportional systematic sampling. This study analyzed data of persons who used outpatient services in two weeks. It adopted Anderson Model to control contextual factors including socioeconomic factors. The study compared means and fitted logistic regression models and multilevel model. Results: The logistic regression model showed that persons purchased private medical insurance were less likely to use outpatient services than the persons did not purchase private medical insurance. Persons with hypertension and diabetes mellitus, overweight, and problem drinkers were more likely to use outpatient services. Persons with high school graduates or higher in education level and experience of accidents or intoxications were more likely to use outpatient services according to the multilevel analysis of mixed model which treated region as random effect. Conclusion: Higher level of perceived stress increased the probability to use outpatient service than lower level of perceived stress. As number of days a person had exercised increased, the probability to use outpatient service decreased. Overweight and problem alcohol drinking increased the probability of outpatient service use. Further research should be conducted to find more factors influencing outpatient service use.

• The Journal of Fisheries Business Administration
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• v.25 no.1
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• pp.37-59
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• 1994

Many studies to cope with the present problems of Korean coastal and offshore fisheries has been performed, but these were done partly in necessities and general studies for Korean inshore and offshore fisheries are in early stage. Most of these studies adopted analytical way of approach for each fishery individually and they could not reflect the effect of correlated interaction among fisheries on the several common species/stocks, and thus optimal effort allocation was impossible. To consider general fisheries and optimal effort allocation among competing mixed species, a linear programming (LP) approach is applied in this study and introduced into 16 important inshore and offshore fisheries with 13 constraining species which were chosen by annual yield order. This study is not based on the biological interaction among species (i.e., prey - predator system) but the technological interaction between species and fishing efforts. For the application of LP model in these fisheries, the standardization of fishing efforts through different fishing gears could not be successful and a new way of effort standardization through CPUE for vessel tonnage was originated. Total standardized fishing effort on a particular species i, Ei, is computed as the linear summation of standardized fishing effort generated by each fishery j. That is, (equation omitted) where $f_{j}$ is the total vessel tonnage of fishery j and aij is the coefficients contributing to the standardized fishing effort per ton for species i taken in fishery j. The total fishing effort level on species i due to both directed fishing and by - catch can thus be accounted in the aij's. Optimal effort allocation among the j fisheries may be considered a minimizing problem (minimize $\Sigma$ $f_{j}$), subject to the constraints that standardized fishing effort levels on particular species are maintained at, above, and below certain predefined levels. Fishing effort goals for individual species can be based on various biological and/or economic criteria, i.e., fishing effort level generating maximum sustainable yield and/or maximum economic yield. But in this study the $F_{0.1}$ criteria which was accepted as an approximate level for $F_{mey}$ by Outland and Boerema's (1973) study. The findings of this study are, (1) LP model can be applied to the Korean inshore and offshore fisheries giobally. (2) Through a new way of combining multiple different fisheries' efforts for a particular species together generating standardized fishing effort, Schaefer curve could be applied to the complex system successfully. (3) The results of this study for total reduction scale were mostly the same as those of prior studies, but different much from the individual scales of reduction. This study showed the necessities for exploitation of more concrete parameters to put into consideration of profitability of fisheries and social factors, and this model can be modified according to the actual constraints. Also, considering the age structure of stocks, this model can be developed into better one for better fisheries management.ent.

• Nuclear Engineering and Technology
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• v.55 no.10
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• pp.3874-3897
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• 2023

A high-fidelity computational fluid dynamics (CFD) analysis was performed using the Large Eddy Simulation (LES) model for the lower plenum of the High-Temperature Test Facility (HTTF), a ¼ scale test facility of the modular high temperature gas-cooled reactor (MHTGR) managed by Oregon State University. In most next-generation nuclear reactors, thermal stress due to thermal striping is one of the risks to be curiously considered. This is also true for HTGRs, especially since the exhaust helium gas temperature is high. In order to evaluate these risks and performance, organizations in the United States led by the OECD NEA are conducting a thermal hydraulic code benchmark for HTGR, and the test facility used for this benchmark is HTTF. HTTF can perform experiments in both normal and accident situations and provide high-quality experimental data. However, it is difficult to provide sufficient data for benchmarking through experiments, and there is a problem with the reliability of CFD analysis results based on Reynolds-averaged Navier-Stokes to analyze thermal hydraulic behavior without verification. To solve this problem, high-fidelity 3-D CFD analysis was performed using the LES model for HTTF. It was also verified that the LES model can properly simulate this jet mixing phenomenon via a unit cell test that provides experimental information. As a result of CFD analysis, the lower the dependency of the sub-grid scale model, the closer to the actual analysis result. In the case of unit cell test CFD analysis and HTTF CFD analysis, the volume-averaged sub-grid scale model dependency was calculated to be 13.0% and 9.16%, respectively. As a result of HTTF analysis, quantitative data of the fluid inside the HTTF lower plenum was provided in this paper. As a result of qualitative analysis, the temperature was highest at the center of the lower plenum, while the temperature fluctuation was highest near the edge of the lower plenum wall. The power spectral density of temperature was analyzed via fast Fourier transform (FFT) for specific points on the center and side of the lower plenum. FFT results did not reveal specific frequency-dominant temperature fluctuations in the center part. It was confirmed that the temperature power spectral density (PSD) at the top increased from the center to the wake. The vortex was visualized using the well-known scalar Q-criterion, and as a result, the closer to the outlet duct, the greater the influence of the mainstream, so that the inflow jet vortex was dissipated and mixed at the top of the lower plenum. Additionally, FFT analysis was performed on the support structure near the corner of the lower plenum with large temperature fluctuations, and as a result, it was confirmed that the temperature fluctuation of the flow did not have a significant effect near the corner wall. In addition, the vortices generated from the lower plenum to the outlet duct were identified in this paper. It is considered that the quantitative and qualitative results presented in this paper will serve as reference data for the benchmark.

• Journal of Animal Science and Technology
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• v.55 no.5
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• pp.359-365
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• 2013

Estimate breeding value can be used as single trait animal model was developed directly using the Fortran language program. The program is based on data computed by using the indirect method repeatedly. The program develops a common algorithm and imprves efficiency. Algorithm efficiency was compared between the two programs. Estimated using the solution is easy to farm and brand the service, pedigree data base was associated with the development of an improved system. The existing program that uses the single trait animal model and the comparative analysis of efficiency is weak because the estimation of the solution and the conventional algorithm programmed through regular formulation involve many repetition; therefore, the newly developed algorithm was conducted to improve speed by reducing the repetition. Single trait animal model was used to analyze Gauss-Seidel iteration method, and the aforesaid two algorithms were compared thorough the mixed model equation which is used the most commonly in estimating the current breeding value by applying the procedures such as the preparation of information necessary for modelling, removal of duplicative data, verifying the parent information of based population in the pedigree data, and assigning sequential numbers, etc. The existing conventional algorithm is the method for reading and recording the data by utilizing the successive repetitive sentences, while new algorithm is the method for directly generating the left hand side for estimation based on effect. Two programs were developed to ensure the accurate evaluation. BLUPF90 and MTDFREML were compared using the estimated solution. In relation to the pearson and spearman correlation, the estimated breeding value correlation coefficients were highest among all traits over 99.5%. Depending on the breeding value of the high correlation in Model I and Model II, accurate evaluation can be found. The number of iteration to convergence was 2,568 in Model I and 1,038 in Model II. The speed of solving was 256.008 seconds in Model I and 235.729 seconds in Model II. Model II had a speed of approximately 10% more than Model I. Therefore, it is considered to be much more effective to analyze large data through the improved algorithm than the existing method. If the corresponding program is systemized and utilized for the consulting of farm and industrial services, it would make contribution to the early selection of individual, shorten the generation, and cultivation of superior groups, and help develop the Hanwoo industry further through the improvement of breeding value based enhancement, ultimately paving the way for the country to evolve into an advanced livestock country.

• Asian-Australasian Journal of Animal Sciences
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• v.8 no.5
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• pp.499-503
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• 1995

The performance records of 410 Holstein Friesian crossbred cows belonging to seven genetic groups (Fl, 3/4, 1/4, 5/8, 3/8, triple cross and miscellaneous cross) maintained at Livestock Production Research Institute, Bahadurnagar, Okara were analyzed for various parameters of lifetime traits. For the analysis 2 data sets were made. Data set I included all the cows disposed off from the herd which have completed at least one lactation while for data set II performance traits for only first five lactations were considered. The data was analyzed by Mixed Model Least squares and Maximum Likelihood computer programme PC-I version. The least squares means ${\times}$ standard errors for data set I (periods are in days and milk yield is in litres) were $994.5{\pm}15.5$, $1,877.0{\pm}70.9$, $1,651.9{\pm}19.3$, $2,533.7{\pm}36.5$, $3,530.0{\pm}40.5$, $15,785.2{\pm}320.0$, $8.46{\pm}0.19$, $5.66{\pm}0.16$ and $3.79{\pm}0.08$, respectively for age at first calving (APC), Ist lactation milk yield (FLMY), productive life (PL), herd life (HL), total life (TL), lifetime milk yield (LTMY), milk yield per day of productive life (MY/PL), milk yield per day of herd life (MY/HL) and milk yield per day of total life (MY/TL). For data set II these values were $1,004.2{\pm}21.2$, $2,220.5{\pm}113.1$, $1,429.1{\pm}40.8$, $2,302.1{\pm}73.3$, $3,307.2{\pm}77.3$, $13,189.7{\pm}667.4$, $9.10{\pm}0.34$, $5.66{\pm}0.25$ and $4.02{\pm}0.18$ in the same order. For data set I the effect of year of first calving was significant for AFC, FLMY, PL, HL, LTMY and MY/PL. The season of Ist calving was significant only for MY/PL. The effect of genetic group was significant for AFC, FLMY, MY/PL and MY/TL while the effect of parity was significant for all the traits. For data set II the effect of year of Ist calving was significant only for AFC, FLMY and PL while the season of Ist calving was significant for FLMY and PL while the effect of genetic groups was significant for MY/HL only. The lifetime production performance is in general close to the various estimates reported in the literature.

• Journal of Animal Science and Technology
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• v.52 no.6
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• pp.475-480
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• 2010

The bovine fatty acid binding protein 4 (FABP4) plays an important role to uptake intracellular fatty acid. It has been previously reported as a positional candidate gene for marbling score in livestock. The re-sequencing of FABP4 gene detected a polymorphic AT repeated sequence in intron II of FABP4 gene. Allelic distribution for this microsatellite marker was examined in other cattle breeds. A total of 8 alleles were detected with diverse repeat units (14 to 21 AT repeat) in Hanwoo and 7 breeds. Of the 8 alleles, the predominant alleles were $[AT]_{16}$, $[AT]_{18}$ and $[AT]_{19}$ in the Hanwoo and 7 cattle breeds. The linear mixed model for genotypic effect (3237AT) on carcass traits showed a significant effect on marbling score (MAR P=0.025) and live weight (LWT; P=0.04) in the 583 Hanwoo cattle population. Live weight (LW) was highest in the homozygous $(AT)_{17}$ genotype ($557.5{\pm}6.94$) and lowest in the heterozygous $(AT)_{16/17}$ genotype ($521.7{\pm}7.70$). On the other hand, the homozygous $(AT)_{17}$ genotype ($3.0{\pm}0.15$) has the highest effect on marbling score and the lowest effect was in homozygous (AT)$_{18}$ genotype ($2.2{\pm}0.15$). The marbling score difference between both groups was 0.8 which is around two times higher than SNP genotype effect on marbling score in Limousin $\times$ Wagyu crosses.