• Journal of the Korean Data and Information Science Society
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• 제25권5호
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• pp.1025-1038
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• 2014

가족 자료를 활용한 연속형 표현형의 전장유전체분석 (genome-wide association analysis)은 주로 선형혼합모형을 이용하며, 분산공분산행렬은 가족 구성원간의 유전적 거리를 고려하여 결정된다. 그러나 가족 구성원들의 표현형의 유사성은 유전적 요인과 환경적 요인에 의하여 발생함에도 불구하고, 표현형의 유사성은 단지 유전적 요인에 의해서 발생한다고 가정한다. 예를 들어 키의 경우 부부 사이에 양의 상관관계가 존재하나 유전적 요인만 고려하여 독립으로 가정한다. 선형혼합 모형에서 분산공분산 구조를 잘못 가정하는 경우, 검정통계량의 1종 혹은 2종의 오류를 적절히 관리할 수 없다. 본 논문에서는 다양한 유형의 분산공분산구조를 가정할 수 있는 선형혼합모형과 이를 기반으로 한 검정통계량을 제안하였다. 모의실험을 통하여 제안한 방법이 기존의 모형보다 통계적 검정력이 우수함을 확인하였다. 또한 체질량지수 (body mass index; BMI)의 전장유전체 분석에 적용하여 기존에 알려지지 않은 새로운 원인 유전자를 규명하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제22권1호
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• pp.57-71
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• 2009

Crop-livestock mixed farming systems depend on the efficiency with which nutrients are conserved and recycled. Home-grown forage is used as animal feed and animal excretions are applied to cultivated crop lands as manure. The objective of this study was to develop a mixed farming system model for dairy cattle in Japan. The model consisted of four sub-models: the nutrient requirement model, based on the Japanese Feeding Standards to determine requirements for energy, crude protein, dry matter intake, calcium, phosphorus and vitamin A; the optimum diet formulation model for determining the optimum diets that satisfy nutrient requirements at lowest cost, using linear programming; the herd dynamic model to calculate the numbers of cows in each reproductive cycle; and the whole farm optimization model to evaluate whole farm management from economic and environmental viewpoints and to optimize strategies for the target farm or system. To examine the model' validity, its predictions were compared against best practices for dairy farm management. Sensitivity analyses indicated that higher yielding cows lead to better economic results but higher emvironmental load in dairy cattle systems integrated with forage crop production.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1996년도 한국자동제어학술회의논문집(국내학술편); 포항공과대학교, 포항; 24-26 Oct. 1996
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• pp.560-564
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• 1996

A mixed H$^{2}$/$H^{\infty}$ controller design method for linear systems with time delay in all variables and parameter uncertainties in all system matrices is proposed. Robust $H^{\infty}$ performance and H$^{2}$ performance condition that accounts for model-matching of closed loop system and disturbance rejection is also derived. With expressing uncertain system with linear fractional transformation form, we transform the robust stability and performance problem to the H$^{2}$/$H^{\infty}$ optimization problem and design a mixed H$^{2}$/$H^{\infty}$ controller. Using the proposed method, mixed H$^{2}$/$H^{\infty}$ controller for underwater vehicle with time delay and parameter variations are designed. Simulations of a design example with hydrodynamic parameter variations and disturbance are presented to demonstrate the achievement of good robust performance.t performance.ance.

• 무역학회지
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• 제46권2호
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• pp.213-228
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• 2021

In recent year, US government requires local investment ,unlike in the past, when import restrictions and tariff were imposed. In this situation, many companies are considering new investment in the US and entering the local market. However, research on the optimal investment plan along with the case analysis on trade regulation is extremely limited and more research needs to be conducted. Accordingly, this study aims to suggest the implications and countermeasure of the SCM and logistical perspective by studying the optimal measures for the new investment of each company due to trade regulation. As a research method, the gravity location model, Mixed Integer Linear Programming Model were used to select the optimal automobile manufacturing factory considering each state's population. This study will be implication of SCM and logistics perspective not only for companies considering new investment in the US but also for the government to conduct trade negotiations. In the future, it is expected that the US trade pressure will increase and affect Korea in many ways. Therefore, in order to cope with such difficult situation in a timely manner, continuous research considering various possibilities is needed in the future.

• 응용통계연구
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• 제28권2호
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• pp.123-136
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• 2015

관측 가능한 변수들 사이의 관계를 묘사한 갈릴레오의 물리학 법칙 발견 이후, 과학은 큰 성과를 거두며 발전해왔다. 그러나, 관측할 수 없는 변량효과를 함께 이용하여 더 많은 자연 현상을 설명할 수 있게 되었고, 이를 이용한 최초의 통계적 모형인 혼합효과모형이 소개되었다. 계산기술의 발달과 더불어 복잡한 현상에 대한 추론을 위하여 혼합효과모형은 그 중요성이 더욱 커지고 있다. 이러한 혼합효과모형은 최근 다단계 일반화 선형모형을 포함한 여러 모형으로 확장되었으며, 관측할 수 없는 변량효과를 추론하기 위한 다단계 가능도가 제시되었다. 혼합효과모형 특집호를 통해 이러한 모형들이 여러 통계학적 문제점을 해결하는 과정을 제시하고, 앞으로 어떤 확장이 추가적으로 요구되는 지에 대하여 논할 것이다. 빈도록적 접근법과 베이지안 접근법을 함께 다룬다.

• 대한산업공학회지
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• 제32권2호
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• pp.74-81
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• 2006

In this paper, we deal with the separation of data by concurrently determined, piecewise nonlinear discriminant functions. Toward the end, we develop a new $l_1$-distance norm error metric and cast the problem as a mixed 0-1 integer and linear programming (MILP) model. Given a finite number of discriminant functions as an input, the proposed model considers the synergy as well as the individual role of the functions involved and implements a simplest nonlinear decision surface that best separates the data on hand. Hence, exploiting powerful MILP solvers, the model efficiently analyzes any given data set for its piecewise nonlinear separability. The classification of four sets of artificial data demonstrates the aforementioned strength of the proposed model. Classification results on five machine learning benchmark databases prove that the data separation via the proposed MILP model is an effective supervised learning methodology that compares quite favorably to well-established learning methodologies.

• 응용통계연구
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• 제30권6호
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• pp.957-981
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• 2017

관측되지 않는 효과 또는 고정효과로 설명할 수 없는 분산 구조가 포함되어 정확한 모수 추정이 어려운 경우 체계적인 분석을 위해 일반화 선형 모형은 임의효과가 포함된 일반화 선형 혼합 모형으로 확장되었다. 본 연구에서는 일반화 선형 모형 중에서도 이분적인 반응변수를 다루는 로지스틱 회귀모형에 임의효과를 포함한 최대 우도 추정 방법을 설명한다. 그중에서도 라플라스 근사법, 가우스-에르미트 구적법, 적응 가우스-에르미트 구적법 그리고 유사가능도 우도에 대한 최대우도 추정법을 자세히 알아본다. 또한 제안한 방법을 사용하여 한국 복지 패널 데이터에서 정신건강과 생활만족도가 자원봉사활동에 미치는 영향에 대해 분석한다.

• Communications for Statistical Applications and Methods
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• 제29권3호
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• pp.373-391
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• 2022

The distribution of observations in most econometric studies with spatial heterogeneity is skewed. Usually, a single transformation of the data is used to approximate normality and to model the transformed data with a normal assumption. This assumption is however not always appropriate due to the fact that panel data often exhibit non-normal characteristics. In this work, the normality assumption is relaxed in spatial mixed models, allowing for spatial heterogeneity. An inference procedure based on Bayesian mixed modeling is carried out with a multivariate skew-elliptical distribution, which includes the skew-t, skew-normal, student-t, and normal distributions as special cases. The methodology is illustrated through a simulation study and according to the empirical literature, we fit our models to non-life insurance consumption observed between 1998 and 2002 across a spatial panel of 103 Italian provinces in order to determine its determinants. Analyzing the posterior distribution of some parameters and comparing various model comparison criteria indicate the proposed model to be superior to conventional ones.

• 대한산업공학회지
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• 제10권1호
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• pp.11-16
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• 1984

An economic model is developed for determining optimal locations of screening inspection stations in a multistage production system. The effect of screening inspection on the production rate is explicitly considered, and a fixed cost for maintaining an inspection station is assumed. The product is allowed to have multiple defects, each of which may be inspected at any inspection station after the defect-generating operation. The problem is formulated as a mixed 0-1 linear program which offers the advantage of versatility in handling various system constraints.

• 응용통계연구
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• 제17권1호
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• pp.1-12
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• 2004

본 논문에서는 2001년 경기도 양평 지역의 주민 880여명을 대상으로 반복측정되어 얻어진 혈압자료를 이용하여 반복요인이 세 개인 경우에 적절한 공분산구조를 선택하는 방법에 대해서 알아보고 혼합선형모형(mixed linear model)을 이용한 분석을 통해서 혈압에 영향을 주는 공변량(covariates)에 대해서 알아보았다.