• (The)Study of the Eastern Classic
• /
• no.62
• /
• pp.177-207
• /
• 2016

This essay is dealing with Yang-Ming Studies' fundamental ideas, which are the goal of learning, the cultivation theory, and the ultimate goal in Yang-Ming-Xin-Xue. The first, what is the goal of learning in Yang-Ming-Xin-Xue: It is generally accepted idea that the goal of learning in Yang-Ming-Xin-Xue is to be a sage. But there are different suggestions about the ideas above. The reason is like this: Zhu-Zi-Studies was eager to be a sage through its cultivation theory. Yang-Ming-Xin-Xue criticized the cultivation theory in Zhu-Zi-Studies. Therefore, some people don't agree with the idea that the goal of learning in Yang-Ming-Xin-Xue is to be a sage. In this essay, I try to demonstrate that the goal of learning in Yang-Ming-Xin-Xue is to be a sage. The second, What is the major cultivation theory in Yang-Ming-Xin-Xue: The core cultivation theory is the Zhi-Ling-Zhi(Fulfillment Innate Knowledge of Goodness). For this, there is no question, but it is difficult how to learn and practice Zhi-Ling-Zhi in the daily life. I try to explain the right meaning and practice over Zhi-Ling-Zhi. The third, what is the ultimate goal in Yang-Ming-Xin-Xue: It is general method in examine Yang-Ming-Xin-Xue that is comparing with Zhu-Zi-Studies. So there is a natural tendency focusing on the differences and similarity between Yang-Ming-Xin-Xue and Zhu-Zi-Studies. But If I say, what is the ultimate goal in Yang-Ming-Xin-Xue? That is the realization of Ren, Which is the harmony with all things in heaven and earth.

• Journal of Korean Medical classics
• /
• v.20 no.2
• /
• pp.289-313
• /
• 2007

Many of newly emerging diseases such as hypertension, stroke, diabetes, obesity, and atoptic dermatities are categorized into "Fire heat-disease(火熱病)" according to oriental medicine. It is because factors such as stress, overeating, and high fat diet are major causes of heat in the human body. Sun Yi-Kui(孫一奎), a well-known oriental medical doctor during Ming Dynasty's "Jia Jing Wan Li Nian Jian"(嘉靖萬歷年間 : A.D $1522^{\sim}1619$), established new theories on "Fire heat-disease-mechanism(火熱病機)". This study aims to investigate Dr. Sun's "Fire heat-disease-mechanism(火熱病機)"theory. For this purpose, I thoroughly examined the concepts of "Dong-Qj(動氣)", "Ming-Men(命門)", king fire(君火) and minister fire(相火) as well as pathological theory on "Fire heat(火熱)". In addition, I compared Sun's theory with those of Li Dong-yuan and Zhu dan-Xi.

• BMB Reports
• /
• v.42 no.1
• /
• pp.59-64
• /
• 2009

Hepatitis B virus (HBV) infection is highly prevalent worldwide. The major challenge for current antiviral treatment is the elevated drug resistance that occurs via rapid viral mutagenesis. In this study, we developed AAV vectors to simultaneously deliver two or three shRNAs targeting different HBV-related genes. These vectors showed markedly better antiviral effects than ones that delivered a single shRNA in vitro. A dual shRNA expression vector (AAV-157i/1694i), which simultaneously expressed two shRNAs targeted the S and X genes of HBV, reduced HBsAg, HBeAg and HBV DNA levels by $87{\pm}4$, $80.3{\pm}2.6$ and $86.2{\pm}7%$ respectively, eight days post-transduction. In a mouse model of prophylactic treatment, HBsAg and HBeAg were reduced to undetectable levels and the serum HBV DNA level was reduced by at least 100 fold. These results indicate that AAV-157i/1694i generates potent anti-HBV effects and that the strategy of constructing multi-shRNA expression vectors may lead to enhanced anti-HBV efficacy and overcome the evading mechanism of the virus and thus the development of drug resistance.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.14
• /
• pp.5793-5798
• /
• 2014

Background: Golgi phosphoprotein-3 (GOLPH3) is implicated in cancer development and progression. The aim of this study was to evaluate the prognostic significance of GOLPH3 protein and its association with tumor angiogenesis in patients with early-stage NSCLC. Materials and Methods: Immunohistochemistry was performed to determine GOLPH3 protein expression and allow assessment of intratumoral microvessel density (MVD) by counting CD-34 positive immunostained endothelial cells. Correlations of expression with MVD, clinicopathologic features and clinical prognosis were analyzed. Results: A notably higher level of GOLPH3 expression was found in early-stage NSCC tissues at the protein level. However, we do not find any correlation between GOLPH3 expression and clinicopathologic features (p>0.05), although higher MVD was positively associated with GOLPH3 overexpression (p<0.001). Expression of GOLPH3 was found to be an independent prognostic factor in early-stage NSCLC patients, those expressing high levels of GOLPH3 exhibiting a substantially lower 5-year overall survival than GOLPH3-negative patients (adjusted HR =1.899, 95% CI: 1.021-3.532, p=0.043). Conclusions: High expression of the GOLPH3 protein is common in early-stage NSCC, and is closely associated with tumor progression, increased tumor angiogenesis, and poor survival. We conclude a possibility of its use as a diagnostic and prognostic marker in early-stage NSCC patients.

• Bulletin of the Korean Chemical Society
• /
• v.31 no.7
• /
• pp.1839-1840
• /
• 2010

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
• /
• v.7 no.1
• /
• pp.10-19
• /
• 2014

The purpose of the present study is to examine the satisfaction level towards residential environment forecast on directions in geomantic studies, or Feng Shui and Ming Lihak. For the subjects of this study, 100 ordinary people aged from teens to sixties were chosen for research from August through December in 2012. Frequency analysis and Krushkal Wallis test were used for the analysis, and all empirical analyses were performed at 5% significance level. Analysis results show that satisfaction level towards directions in the residential environment is high where individual preferences are adjusted to form harmony with the force and balance of the directions. And, in a residential environment, the highest level of satisfaction was marked with directions of wood pillows, or Duchim, signifying improved efficacy of forecast of residential environment change. Findings of the study suggest that high satisfaction level in the directions of Feng Shui and the Ming Lihak forecasts high quality life in the given residential structure and structural forms. bstract.

• Journal of architectural history
• /
• v.25 no.4
• /
• pp.19-29
• /
• 2016

This study is based on the 15th century's architecture Mohwagwan and Taepyeonggwan and the architects behind it. The results were as follows: First, inline with Ming dynasty's protocol, the King of Joseon marched with honor guard in front of his people. Therefore, the Joseon dynasty needed to match space was implemented and result in Mohwagwan and Taepyeonggwan. Second, King Taejong founded Mohwaru to share the role with Taepyeonggwan. He appropriately utilized Mohwaru as a place in manners before people enter the Seoul city wall. And He organized this architecture on the level of the palace. Third, Pak Jacheong was overseer the whole constructive process, from the selection of site, landscaping, construction, maintenance to civil engineering of Mohwaru. There are many difficulties, but he completed through the construction work owing to the protection of King Taejong. Forth, Hong Li worked with Pak Jacheong to build Taepyeonggwan and Mohwagwan from Taejong to Sejong. Supervisors in King Sejong times were required not only private capability but also understanding the Confucianism ritual. Hong Li was faithfully performed the role. Fifth, Sejong was recognized only an excellent ruler but he was also a great coordinator with a professional knowledge about architecture. These Sejong's action fully can be seen as an architect.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
• /
• 2000.06a
• /
• pp.197-200
• /
• 2000

In this paper, three parts study Zhangbaogao's reaction on the sea trade on Huang Hai in 8-9 centenary, it includes: 1. Mabe a period about the person's sea trade on Huang Hai. 2. Set up the range of sea trade about Tang. Silla and Japan, which the central was korea Peninsula. 3. Extend the termination of the silk Route at eastern, Link-ups the Huang Hai sea trade and silk Route.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.2
• /
• pp.797-802
• /
• 2015

Background: The purpose of this study was to prospectively evaluate the predictive value of perfusion computed tomography (CT) for response of local advanced esophageal carcinoma to radiotherapy and chemotherapy. Materials and Methods: Before any treatment, forty-three local advanced esophageal squamous cell carcinomas were prospectively evaluated by perfusion scan with 16-row CT from June 2009 to January 2012. Perfusion parameters, including perfusion (BF), peak enhanced density (PED), blood volume (BV), and time to peak (TTP) were measured using Philips perfusion software. Seventeen cases received definitive radiotherapy and 26 received concurrent chemo-radiotherapy. The response was evaluated by CT scan and esophagography. Differences in perfusion parameters between responders and non-responders were analyzed, and ROCs were used to assess predictive value of the baseline parameters for treatment response. Results: There were 25 responders (R) and 18 non-responders (NR). Responders showed significantly higher BF (R:34.1 ml/100g/min vs NR: 25.0 ml/100g/min, p=0.001), BV (23.2 ml/100g vs 18.3 ml/100g, p=0.009) and PED (32.5 HU vs 28.32HU, P=0.003) than non-responders. But the baseline TTP (R: 38.2s vs NR: 44.10s, p=0.172) had no difference in the two groups. For baseline BF, a threshold of 36.1 ml/100g/min achieved a sensitivity of 56%, and a specificity of 94.4% for detection of clinical responders from non-responders. Conclusions: The results suggest that the perfusion CT can provide some helpful information for identifying tumors that may respond to radio-chemotherapy.

• Journal of Korean Academy of Nursing
• /
• v.50 no.6
• /
• pp.778-786
• /
• 2020

Purpose: This study aimed to explore the motives of clinical nurses for experiencing empathy with patients and their families based on a self-determination theory framework. Methods: Semi-structured face-to-face interviews with twenty-one nurses at four tertiary hospitals in Anhui, China, were conducted, recorded and transcribed. A content analysis with a directed approach was performed. Results: An analysis of the interview transcripts revealed three categories of empathy motivation: autonomous motivation, controlled motivation and a lack of empathy motivation. Autonomous motivation included personal interests, enjoyment and a sense of value, pure altruism, assimilation, and recognition of the importance of empathy. Controlled motivation highlighted pressures from oneself and others, the possibility of tangible or intangible rewards, and avoidance of adverse effects. Finally, a lack of empathy motivation referred to a lack of intention for empathy and denial of the value of empathy. Conclusion: This study provides a deep understanding of the motives underlying empathy in nurses. The results reveal the reasons for empathy and may support the development of effective strategies to foster and promote empathy in nurses.