• 대한예방의학회:학술대회논문집
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• 2004.10a
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• pp.63.2-64
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• 2004

• Korean Journal of Social Welfare Studies
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• v.44 no.3
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• pp.395-420
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• 2013

This study was performed to test the influence of older people's satisfaction factors (safety and convenience) of housing environment on their quality of life and the mediating effect of self-esteem and depression. In this study, from 386 older people over the age of 60 in senior welfare center and senior club of Cheongju region, the data were collected by questionnaire during October, 2012. The findings of this study are as follows: First, safety had not any significant influence on older people's quality of life, while convenience had a significant positive influence on their quality of life. Second, safety had not any significant influence on older people's self-esteem and depression, while convenience had a significant positive influence on older people's self-esteem and it had a significant negative influence on their depression Third, older people's self-esteem had a significant positive influence on their quality of life, while older people's depression had a significant negative influence on their quality of life. Fourth, between safety and older people's quality of life, the indirect effects of older people's self-esteem and depression as mediating variables were not found. However, between convenience and older people's quality of life, the indirect effects of older people's self-esteem and depression as mediating variables were found. This study shows that various measures for convenience of housing environment need to be prepared to increase older people's quality of life and self-esteem and to lessen their depression.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3949-3953
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• 2013

Aim: To investigate the effectiveness and adverse effects of gemcitabine by fixed-dose rate infusion plus oxaliplatin (GEMOX regimen) as second-line therapy for advanced ovarian cancer. Methods: 64 patients with advanced ovarian cancer were divided into an experimental group (44 cases) and a control group (20 cases). The experimental group was treated with continuous intravenous infusion of gemcitabine at 1000 $mg/m^2$ with a fixed-dose rate of 10 $mg/m^2/min$, on days 1 and 8 and oxaliplatin at 100 $mg/m^2$ on day 1, IVGTT, repeated every 3 weeks. The control group was treated with intravenous infusion of gemcitabine at 1000 $mg/m^2$ within 30 min on days 1 and and oxaliplatin at 100 $mg/m^2$ on day 1, IVGTT, again repeated every 3 weeks. CT scans or MRI were used for review every 1-2 cycles. Results: The effective rate in the experimental group was significantly high than control group (43.2% vs 35.0%; P < 0.05), with no obvious difference of hematologic or non-hematologic toxicity between the two groups (P > 0.05). Conclusion: GEMOX regimen is very effective to treat advanced ovarian cancer, with low toxicity, good tolerance and improved life quality in patients.

• The Journal of Korean Association of Computer Education
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• v.14 no.3
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• pp.13-23
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• 2011

Information Culture Index (ICI) is the quantitative value that represents people's information literacy levels. Also, it diagnoses the people's knowledge, ethics, emotion, and practice synthetically. As the Internet and cell phone addiction have been increasing when people access information on the web recently, it is necessary to analyze the meaning of the ICI from the Internet and cell phone addiction perspectives and to confirm if it goes well in the right direction. In this paper, we analyze the characteristics of the people who have high ICIs. At the same time, we perform the statistical analysis combining ICIs with the Internet and the cell-phone addiction levels. In particular, the meaning of the Information Practicing factor, which is one of the ICI factors, is examined. By doing these, we confirm if the current ICI works correctly or not, and propose a better way for measuring ICIs. In order to do these, we survey and analyze data with basic statistical methods and structural equation model.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.3
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• pp.239-252
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• 2024

Dexmedetomidine displays multiple mechanisms of neuroprotection in ameliorating ischemic brain injury. In this study, we explored the beneficial effects of dexmedetomidine on blood-brain barrier (BBB) integrity and neuroinflammation in cerebral ischemia/reperfusion injury. Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) for 1.5 h and reperfusion for 24 h to establish a rat model of cerebral ischemia/reperfusion injury. Dexmedetomidine (9 ㎍/kg) was administered to rats 30 min after MCAO through intravenous injection, and SB203580 (a p38 MAPK inhibitor, 200 ㎍/kg) was injected intraperitoneally 30 min before MCAO. Brain damages were evaluated by 2,3,5-triphenyltetrazolium chloride staining, hematoxylin-eosin staining, Nissl staining, and brain water content assessment. BBB permeability was examined by Evans blue staining. Expression levels of claudin-5, zonula occludens-1, occludin, and matrix metalloproteinase-9 (MMP-9) as well as M1/M2 phenotypes-associated markers were assessed using immunofluorescence, RT-qPCR, Western blotting, and gelatin zymography. Enzyme-linked immunosorbent assay was used to examine inflammatory cytokine levels. We found that dexmedetomidine or SB203580 attenuated infarct volume, brain edema, BBB permeability, and neuroinflammation, and promoted M2 microglial polarization after cerebral ischemia/reperfusion injury. Increased MMP-9 activity by ischemia/reperfusion injury was inhibited by dexmedetomidine or SB203580. Dexmedetomidine inhibited the activation of the ERK, JNK, and p38 MAPK pathways. Moreover, activation of JNK or p38 MAPK reversed the protective effects of dexmedetomidine against ischemic brain injury. Overall, dexmedetomidine ameliorated brain injury by alleviating BBB permeability and promoting M2 polarization in experimental cerebral ischemia/reperfusion injury model by inhibiting the activation of JNK and p38 MAPK pathways.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.23 no.2
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• pp.201-208
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• 2023

Visually impaired people have difficulty accessing medical services and drug information, and it is not easy for them to take the correct drugs. A health law has been established to deal with this, but the plans are not unified and not applicable to all over-the-counter medicines. Therefore, we planned an application that provides instructions for taking general medicines using image recognition technology, bar code, and QR recognition technology for visually impaired people who are in the blind spot of taking general medicines. In this research, we will optimize the camera shooting environment standards and UI and UX screens for image recognition for the visually impaired, and improve the accessibility for the visually impaired to make it more convenient. If you can apply the results of your research to an application and provide it, it will help people with visual impairments learn the correct way to take over-the-counter medicines.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4305-4309
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• 2012

Background: Previous studies on the association between the TP53 Arg72Pro polymorphism and hepatocellular carcinoma (HCC) risk obtained controversial findings. This study aimed to quantify the strength of the association by meta-analysis. Methods: We searched PubMed and Wangfang databases for published studies on the association between the TP53 Arg72Pro polymorphism and HCC risk, using the pooled odds ratio (OR) with its 95% confidence intervals (95% CI) for assessment. Results: 10 studies with a total of 2,026 cases and 2,733 controls were finally included into this meta-analysis. Overall, the TP53 Arg72Pro polymorphism was not associated with HCC risk (all P values greaterth HCC risk in Caucasians in three genetic models (For Pro versus Arg, OR = 1.20, 95%CI 1.03-1.41; For ProPro versus ArgArg, OR = 1.74, 95%CI 1.23-2.47; For ProPro versus ArgPro/ArgArg, OR = 1.85, 95%CI 1.33-2.57). However, there was no significant association between the TP53 Arg72Pro polymorphism and HCC risk in East Asians (all P values greater than 0.10). No evidence of publication bias was observed. Conclusion: Meta-analyses of available data suggest an obvious association between the TP53 Arg72Pro and HCC risk in Caucasians. However, the TP53 Arg72Pro polymorphism may have a race-specific effect on HCC risk and further studies are needed to elucidate this possible effect.

• Journal of Agricultural Extension & Community Development
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• v.20 no.4
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• pp.1149-1179
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• 2013

The purpose of this study was to examine the participation of rural elderly people in senior employment programs, their satisfaction level and needs in an effort to provide some information on the improvement of rural elderly people's quality of life. The findings of the study were as follows: First, the largest group of the rural elderly people investigated took part in senior employment programs for the public good. The biggest group engaged in activities for environmental improvement, and the greatest group participated in these programs to earn their livelihood. Second, they were most satisfied with their relationship with the working-level employees of the institutions that were in charge of these programs, and they were least contented with their own pay. Third, the rural elderly people perceived that in terms of senior education for employment, customized education should primarily be conducted in consideration of the differences and diversity of senior citizens, and they faced the most difficulty due to traffic while they participated in these programs. Given the findings of the study, it's required to take measures to bolster the self-support of rural elderly people.

• Transactions of the Korean Society of Automotive Engineers
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• v.18 no.1
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• pp.105-111
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• 2010

In the field of 'Human Vibration', it has been interested subjects to make equal sensation curves related to translational and rotational direction of whole-body, hand-transmitted and head-transmitted vibration, etc. When we consider the vibration of a vehicle, the main factor is vertical whole-body vibration. Until now, most of equal sensation curves used to derive frequency weighting function had been made using Western people. However, because of the inherent differences (for example, characteristic and shape of body parts, muscular and cellular tissue) between the Western people and the Oriental people, equal sensation curves based on Oriental people might be required. Also, the weight differences between the samples which consist of average-weighted and over-weighted group might cause the difference of equal sensation curves. So, in this study, 20 male Korean people were used to find equal sensation curves subject to vertical whole-body vibration on seated posture. Among 20 males, an over weighted group consisted of 10 male persons and an average weighted group was the others. Integrating and analyzing the data of two groups, some of non-parametric tests such as 'The Wilcoxon Signed Rank Test' and 'The Mann Whitney U test' were used.

• Korean Journal of Social Welfare
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• v.65 no.1
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• pp.33-58
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• 2013

This study aims to explore the lived experiences of middle-aged people with disabilities after a stroke. Using van Manen's phenomenological qualitative method, this study obtained information through interviews with middle-aged people with disabilities after a stroke. The following main themes were extracted from the lived experiences of middle-aged people with disabilities who were interviewed: 'a life broken in half', 'discontinuity and isolation of life', 'being born again', 'fear of stroke relapse', and 'overcoming all difficulties through harmony in a family'. Therefore, the core theme on the lived experiences of middle-aged people with disabilities after a stroke is a shadow of relapse over lives that have to protect families. The implication of this study's results on policy making and actual practices are discussed focusing on the well-being of people with disabilities and their families.