• Journal of Microbiology and Biotechnology
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• v.34 no.3
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• pp.663-672
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• 2024

The use of nanoparticles as a delivery system for a specific antigen could solve many limitations of mucosal vaccine applications, such as low immunogenicity, or antigen protection and stabilization. In this study, we tested the ability of nasally administered chitosan nanoparticles loaded with glycoprotein B of murine cytomegalovirus to induce an immune response in an animal model. The choice of chitosan nanoparticle type was made by in vitro evaluation of sorption efficiency and antigen release. Three types of chitosan nanoparticles were prepared: crosslinked with tripolyphosphate, coated with hyaluronic acid, and in complex with polycaprolactone. The hydrodynamic size of the nanoparticles by dynamic light scattering, zeta potential, Fourier transform infrared spectroscopy, scanning electron microscopy, stability, loading efficiency, and release kinetics with ovalbumin were evaluated. Balb/c mice were immunized intranasally using the three-dose protocol with nanoparticles, gB, and adjuvants Poly(I:C) and CpG ODN. Subsequently, the humoral and cell-mediated antigen-specific immune response was determined. On the basis of the properties of the tested nanoparticles, the cross-linked nanoparticles were considered optimal for further investigation. The results show that nanoparticles with Poly(I:C) and with gB alone raised IgG antibody levels above the negative control. In the case of mucosal IgA, only gB alone weakly induced the production of IgA antibodies compared to saline-immunized mice. The number of activated cells increased slightly in mice immunized with nanoparticles and gB compared to those immunized with gB alone or to negative control. The results demonstrated that chitosan nanoparticles could have potential in the development of mucosal vaccines.

• Journal of the Korea Institute of Military Science and Technology
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• v.18 no.6
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• pp.755-761
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• 2015

Satellite Air-defence Warning System receives the aircraft/ballistic track information and air defense control command obtained from Master Control & Reporting Center (MCRC) and Air Missile Defence Cell (AMD Cell) Systems. It consists of terminal and control system to propagate track information and air defense control command control via the military satellite communications. In this paper, there were described track information, air defense control command, the frame structure of modem to transmit a voice information and modulation/demodulator design, network synchronization methods via the satellite network.

• Journal of National Security and Military Science
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• s.7
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• pp.91-128
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• 2009

Society is developing fast. Nobody could expect that computer could be used in purpose of trajectory calculation when the ANIAC was developed in the past. However, nowadays technology development brought computerization which substitutes to mankind's working. And personal computer including internet make our society to be IT age. Such age is in revolutionizing now that could be able to bring a new paradigm. We should prepare to such change which scholars predict the end of revolution could be reached at ubiquitous age. This study is purposing firstly for predicting which changes are arisen in the defence sector when social system will become ubiquitous age. That is how change of ubiquitous paradigm could influence to the defence sector and which appearance could be arisen in ubiquitous defence environment. The second purpose of this study is to predict the characteristics of Planing, Programing, Budgeting, Executing, Evaluating, System (PPBEES) of the defence sector.

• Journal of the military operations research society of Korea
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• v.28 no.1
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• pp.1-16
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• 2002

The object of this study is to suggest the direction of building the defence logistics system of Korea Armed Forces in the future. For the purpose of this, we surveyed the best practices among the enterprises and U.S. Defence which reformed successfully the physical distribution and logistic in recent year. Also, we analyzed our current logistics system and suggested the vision, operational concept, and the way of building this system. This system is expected to reduce the total logistics cost, speed up the logistics velocity and increase the efficiency of the combat support.

• Strategy21
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• s.31
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• pp.142-163
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• 2013

Ieodo is a submerged rock within a Korea's Exclusive Economic Zone(EEZ) in the East China Sea with its most shallow part about 4.6m below the sea level which has no specific rights for the EEZ delimitation. The United Nations Convention on the Law of the Sea (UNCLOS) stipulates that any coastal state has the rights to claim an EEZ that stretches up to 200 nautical miles from its shore, except where there is an overlap with a neighboring country's claims. Korea claims that Ieodo is within its EEZ as it sits on the Korean side of the equidistant line and the reef is located on the Korea section of the continental shelf. China does not recognize Korea's application of the equidistance principle and insists that Ieodo lies on its continental shelf. According to UNCLOS, Ieodo is located in international waters, rather than one country's EEZ as the two countries have failed to reach a final agreement over the delimitation of the maritime border. This study seeks to understand the evolution of the People's Liberation Army Navy(PLAN) strategy as main obstacles for the EEZ delimitation between Korea and China. PLAN's Strategy evolves from "coastal defense" to "offshore defence", since the late 1980s from a "coastal defence" strategy to an "offshore defence" strategy which would extend the perimeter of defence to between 200 nm and 400 nm from the coast. China's economic power has increased It's dependence on open trade routes for energy supplies and for its own imports and exports. China want secure Sea Lane. PLAN's "offshore defence" strategy combines the concept of active defence with the deployment of its military forces beyond its borders. China's navy try to forward base its units and to achieve an ocean going capability. China's navy expects to have a 'Blue Water' capability by 2050. China insists that coastal states do have a right under UNCLOS to regulate the activities of foreign military forces in their EEZs. China protests several times against US military forces operating within It's EEZ. The U.S. position is that EEZs should be consistent with customary international law of the sea, as reflected in UNCLOS. U.S. has a national interest in the preservation of freedom of navigation as recognized in customary international law of the sea and reflected in UNCLOS. U.S. insists that coastal states under UNCLOS do not have the right to regulate foreign military activities in their EEZs. To be consistent with its demand that the U.S. cease performing military operations in china's EEZ, China would not be able to undertake any military operations in the waters of South Korea's EEZ. As such, to preserve its own security interests, China prefers a status quo policy and used strategic ambiguity on the Ieodo issue. PLAN's strategy of coastal defence has been transformed into offensive defence, Korea's EEZ can be a serious limitation to PLAN's operational plan of activities. Considering China'a view of EEZs, China do not want make EEZ delimitation agreement between Korea and China. China argues that the overlapping areas between EEZs should be handled through negotiations and neither side can take unilateral actions before an agreement is reached. China would prefer Ieodo sea zone as a international waters, rather than one country's EEZ.

• Journal of the military operations research society of Korea
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• v.35 no.1
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• pp.51-62
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• 2009

In this study, the establishment strategies introduced here are based on the applicable PLM system to Defence Configuration Management. These are applied to enlargement area advanced nations and commercial fields already. Additional1y, the study analyze the problem of current Defence Configuration Management and the establishment strategies improving Defence Configuration Management by adapting PLM system to increase efficiency.

• Journal of National Security and Military Science
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• s.1
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• pp.35-70
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• 2003

President Lee, Syngman was ROK supreme commander at the Korean war. But, it is doubt that he executed his authority and responsibility by the ROK constitution and law. At the phase of the Korean War conduct, his role may be divided into 'military operation execution one' and 'political-diplomacy one'. He appointed unqualified person to the important position of the national defence, didn't make war execution system, and was not make to meet the war. And, after transferring the ROK force operation commanding authority to the Commander in Chief, UN Command, his role was extremely trivial at the military operation execution phase. Any way, he intended to recover the inferior national strength and military capacity with USA aid, and concentrated his effort toward diplomacy with USA. At last, he succeeded in making a mutual defence treaty and gained a big result to harden Korea national security after war. In sum, president Lee was shrewd politician and diplomat than military leader. And, it can be evaluated that he supplemented the lost part of military affairs side with diplomat one.

• Journal of the Korea Institute of Military Science and Technology
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• v.12 no.5
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• pp.557-562
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• 2009

Weapon system currently considers the research about effect analysis including cost effectiveness methodology for a budget management and an achievement of the military strategy goal. So that, this study considers the theoretical background, strength and weakness of several Multi-Criteria Decision Making, and an effect analysis of weapon system. And AHP(Analytic Hierarchy Process) is selected for the best effect analysis methodology of weapon system. Therefore, we applied AHP to the case study of the new generation Multiple Launcher Rocket System, performing the analysis of cost effectiveness methodology. Using AHP and cost effectiveness methodology, we propose the actual and proper decision making result.

• Journal of the Korea Institute of Military Science and Technology
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• v.13 no.6
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• pp.1113-1120
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• 2010

In this paper, we have proposed Architecture Development methodology which can connect both operational view and system view. The Functional Architecture can connect both user and developer, and it is located between Activity analysis and System analysis. We suggest the new architecture methodology using the Functional Architecture and it provides effect to analyze the connection between user(military) and developer(enterprise) in Defence R&D and the new Architecture with the feedback analyze activity on a point of system view and the new architecture make the functional architecture.

• Journal of the military operations research society of Korea
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• v.1 no.1
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• pp.89-97
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• 1975