• Archives of Pharmacal Research
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• v.18 no.1
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• pp.8-11
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• 1995

Biodegradability of poly $Poly({\gamma}-benzyl L-Glutamate)/poly(ethylene oxide)/Poly({\gamma}-benzyl L-Glutamate)$ block copolymer (GEG) having different content of poly(ethylene oxide) (PEO) were examined using magnetite as a tracer in mice. GEG microspheres containing magnetite were injected into mice through tail vein. Biodegradability and tissue distribution of microspheres were examined by analyzing the amount of magnetite in the microspheres recollected from mice organs after specific time interval. The results showed that GEG microsphere of high content of PEO was degraded more rapidly than those of low content of PEO in the mice organs.

• Journal of Pharmaceutical Investigation
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• v.22 no.3
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• pp.237-240
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• 1992

A series of biodegradable block copolymers consisting of $poly({\gamma}-benzyl\;L-glutamate)$ (PBLG) and poly(ethylene oxide) (PEO)-lactoselactone were prepared by polymerization of PEO-lactoselactone and ${\gamma}-benzyl$ L-glutamate-N-carboxyanhydride and characterized by IR and NMR. From circular dichroism measurements, it was found that the polymers exist in the ${\alpha}-helical$ conformation. Block copolymer microspheres were prepared by solvent-extraction-precipitation method for their primary evaluation for medical and biological applications.