• Advances in nano research
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• v.10 no.4
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• pp.313-325
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• 2021

This paper is concerned with the buckling behavior of 2D and quasi-3D problem of functionally graded nanobeam founded on high order shear deformation beams theory and made by two different types of porous distribution materials in Nano- and micro-scales. The used Quasi-3D formulation takes into account the transverse shear effect and uses only three variables. Both formulations do not include the correction factor that is required in the first shear deformation theory proposed by Timoshenko. Governing equations are derived using the principle of virtual work. Analytical resolutions for buckling of FG nanobeam are introduced under tow different boundary conditions, and the results obtained are compared to those proposed in literatures.

• Advances in materials Research
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• v.11 no.4
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• pp.279-298
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• 2022

In this paper, the important novelty and the defining a physical phenomenon of the resent research is the development of nonlocal stress and strain parameters on the porous sandwich beam with functionally graded materials in the top and bottom face sheets.Also, various beam models including Euler-Bernoulli, Reddy and the generalized formulation of two-variable beam theories are obtained in this research. According to a nonlocal strain elasticity theory, the strain at a reference point in the body is dependent not only on the stress state at that point, but also on the stress state at all of the points throughout the body. Thus, the nonlocal stress-strain elasticity theory is defined that can be actual at micro/nano scales. It can be seen that the critical buckling load and transverse deflection of sandwich beam by considering both nonlocal stress-strain parameters is higher than the nonlocal stress parameter. On the other hands, it is noted that by considering the nonlocal stress-strain parameters simultaneously becomes the actual case.

• Korean Journal of Materials Research
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• v.16 no.4
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• pp.225-230
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• 2006

Nanoimprint lithography (NIL) is a novel method of fabricating nanometer scale patterns. It is a simple process with low cost, high throughput and resolution. NIL creates patterns by mechanical deformation of an imprint resist and physical contact process. The imprint resist is typically a monomer or polymer formulation that is cured by heat or UV light during the imprinting process. Stiction between the resist and the stamp is resulted from this physical contact process. Stiction issue is more important in the stamps including narrow pattern size and wide area. Therefore, the antistiction layer coating is very effective to prevent this problem and ensure successful NIL. In this paper, an antistiction layer was deposited and characterized by PECVD (plasma enhanced chemical vapor deposition) method for metal stamps. Deposition rates of an antistiction layer on Si and Ni substrates were in proportion to deposited time and 3.4 nm/min and 2.5 nm/min, respectively. A 50 nm thick antistiction layer showed 90% relative transmittance at 365 nm wavelength. Contact angle result showed good hydrophobicity over 105 degree. $CF_2$ and $CF_3$ peaks were founded in ATR-FTIR analysis. The thicknesses and the contact angle of a 50 nm thick antistiction film were slightly changed during chemical resistance test using acetone and sulfuric acid. To evaluate the deposited antistiction layer, a 50 nm thick film was coated on a stainless steel stamp made by wet etching process. A PMMA substrate was successfully imprinting without pattern degradations by the stainless steel stamp with an antistiction layer. The test result shows that antistiction layer coating is very effective for NIL.

• Journal of Pharmaceutical Investigation
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• v.39 no.1
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• pp.37-41
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• 2009

The purpose of this study was to compare the efficacy of Lorelin Depot $Injection^{(R)}$ (Dongkook Pharm. Co., LTD) with Lucrin Depot $Injection^{(R)}$ (Abbott) by measuring serum testosterone level in rats. Leuprorelin (leuprolide acetate), which is an active compound for the two formulations, is an LHRH analogue that is used for the treatment of a wide range of sex hormone-related disorders including advanced prostatic cancer, endometriosis and precocious puberty. Lorelin Depot $Injection^{(R)}$ is a micro-encapsulated formulation to suppress testosterone level by releasing leuprorelin continuously for four weeks with a single subcutaneous injection. The comparison study of the efficacy was performed during four weeks, and serum testosterone levels were monitored in the two formulations. The mean serum testosterone levels from the formulations were decreased to that of the castrate range (50 ng/dL or less) after three days after the initial depot injection, and the concentration were remained throughout four weeks' period. There were no significant differences in the $AUC_{0-3day}$ of testosterone and testosterone levels at 3, 7, 14, 21 and 28 days between the two formulations. These results indicate that the two formulations, Lorelin Depot $Injection^{(R)}$ and Lucrin Depot $Injection^{(R)}$, are bioequivalent in terms of the serum testosterone level in rats.

• CELLMED
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• v.11 no.1
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• pp.6.1-6.7
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• 2021

In situ gelling devices, as they enter the body, are dosage forms in the shape of the sol but turn into gel types under physiological circumstances. Transition from sol to gel is contingent on one or a mixture of diverse stimuli, such as transition of pH control of temperature, irradiation by UV, by the occurrence of certain ions or molecules. Such characteristic features may be commonly employed in drug delivery systems for the production of bioactive molecules for continuous delivery vehicles. The technique of in situ gelling has been shown to be impactful in enhancing the potency of local or systemic drugs supplied by non-parenteral pathways, increasing their period of residence at the absorption site. Formulation efficacy is further improved with the use of mucoadhesive agents or the use of polymers with both in situ gelling properties and the ability to bind with the mucosa/mucus. The most popular and common approach in recent years has provided by the use of polymers with different in situ gelation mechanisms for synergistic action between polymers in the same formulation. In situ gelling medicine systems in recent decades have received considerable interest. Until administration, it is in a sol-zone and is able to form gels in response to various endogenous factors, for e.g elevated temperature, pH changes and ions. Such systems can be used in various ways for local or systemic supply of drugs and successfully also as vehicles for drug-induced nano- and micro-particles. In this review we will discuss about various aspects about use of these in situ gels as novel drug delivery systems.

• Food Science of Animal Resources
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• v.35 no.4
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• pp.459-465
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• 2015

Bovine milk provides essential nutrients, including immunologically important molecules, as the primary source of nutrition to newborns. Recent studies showed that RNAs from bovine milk contain immune-related microRNAs (miRNA) that regulate various immune systems. To evaluate the biological and immunological activity of miRNAs from milk products, isolation methods need to be established. Six methods for extracting total RNAs from bovine colostrums were adopted to evaluate the isolating efficiency and expression of miRNAs. Total RNA from milk was presented in formulation of small RNAs, rather than ribosomal RNAs. Column-combined phenol isolating methods showed high recovery of total RNAs, especially the commercial columns for biofluid samples, which demonstrated outstanding efficiency for recovering miRNAs. We also evaluated the quantity of five immune-related miRNAs (miR-93, miR-106a, miR-155, miR-181a, miR-451) in milk processed by temperature treatments including low temperature for long time (LTLT, 63℃ for 30 min)-, high temperature for short time (HTST, 75℃ for 15 s)-, and ultra heat treatment (UHT, 120-130℃ for 0.5-4 s). All targeted miRNAs had significantly reduced levels in processed milks compared to colostrum and raw mature milk. Interestingly, the amount of immune-related miRNAs from HTST milk was more resistant than those of LTLT and UHT milks. Our present study examined defined methods of RNA isolation and quantification of immune-specific miRNAs from small volumes of milk for use in further analysis.

• Journal of Pharmaceutical Investigation
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• v.39 no.2
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• pp.111-115
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• 2009

The pharmacokinetics of cyclosporin A (CsA) after single and multiple oral dosing of new CsA self-micro-emulsifying drug delivery system (SMEDDS) in dogs were estimated. A single dose study was performed following a two-way crossover design against six dogs with reference SMEDDS. For a multiple dose study, three dogs were allocated for each drug, and 100 mg of drug was administered daily for 6 days. Whole blood concentration of CsA was analyzed by radio-immunoassay. Both drug showed identical blood concentration profiles in both studies, and no statistical difference was detected in pharmacokinetic parameters. The relative bioavailabilities of test SMEDDS were 91.4% and 89.1%, respectively, in the single dose study and the last day of multiple dose study. Especially, multiple dose study proved the good relationship between C-0/C-2 and AUC for reference SMEDDS, which is an indispensable part of therapeutic drug monitoring. These results suggest newly formulated CsA SMEDDS possibly shows identical pharmacokinetics and pharmacodynamic behaviors in clinical trials.

• Fisheries and Aquatic Sciences
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• v.1 no.1
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• pp.30-34
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• 1998

Rotifer culture fed on five types of artificial microparticle diets were evaluated to substitute the natural diets such as Chlorella or w-yeast. These microparticle diets including solidified blood using squid oil (SBSO), solidified blood using soybean oil (SBSB), nylon protein walled particle (NPW) simple coacervation oil capsule (SCO), complex coacervation oil capsule(CCO), were tested for the evaluation of feeding efficiency. The prepared micro particle diets had diameters ranging from 3 to 30 Jim. Rotifer culturing experiments were carried out in 3-liter beakers for 13-16 days. The initial inoculum density of rotifers was 10 ind./ml. The rotifers fed on Chlorella or $\omega-yeast$ showed maximal densities of 2,000 ind./ml in 9 days or 500 ind./ml in 7 days, respectively. Those fed on SBSO, SBSB or NPW showed maximal densities of 1568 ind./ml, 586 ind./ml or 503 ind./ml, respectively and the reproductive rates for those diets were equivalent to or better than w-yeast. However, the coacervated oil capsule showed lower maximal densities of 400 ind./ml for SCO and less than 100 ind./ml for CCO due to the unbalanced diet formulation and indigestibility.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.7 no.2
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• pp.105-116
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• 1996

The design and analysis of the transversely fed EMC(electromagnetically coupled) microstrip dipole have been accomplished by using the integral equation and MOM(method of moment)in frequency domain in order to find the current distribution of the dipole. In this study, we proposed the possibilities for design and analysis of EMC micro-strip dipole array antenna by means of calculating the current distribution of each dipole directly using the FDTD(finite difference time domain) method. In this case, we applied the formulation which is the finite difference expression of the Maxwell's integral equation. From the current distribution of each dipole, we calculated the far field electric component and showed that the calculation process and running time was reduced with respect to the method which calculates the radiation field with surface electric and magnetic current density.

• Structural Engineering and Mechanics
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• v.65 no.1
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• pp.33-41
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• 2018

In this paper, using modified couple stress theory in place of classical continuum theory, and using shell model in place of beam model, vibrational behavior of nanotubes is investigated via the finite element method. Accordingly classical continuum theory is unable to correctly compute stiffness and account for size effects in micro/nanostructures, higher order continuum theories such as modified couple stress theory have taken on great appeal. In the present work the mass-stiffness matrix for cylindrical shell element is developed, and by means of size-dependent finite element formulation is extended to more precisely account for nanotube vibration. In addition to modified couple stress cylindrical shell element, the classical cylindrical shell element can also be defined by setting length scale parameter to zero in the equations. The boundary condition were assumed simply supported at both ends and it is shown that the natural frequency of nano-scale shell using the modified coupled stress theory is larger than that using the classical shell theory and the results of Ansys. The results have indicated using the modified couple stress cylindrical shell element, the rigidity of the nano-shell is greater than that in the classical continuum theory, which results in increase in natural frequencies. Besides, in addition to reducing the number of elements required, the use of this type of element also increases convergence speed and accuracy.