• 대한의용생체공학회:의공학회지
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• 제33권4호
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• pp.202-206
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• 2012

In this study, we developed transdermal direct drug delivery device using micro-needle painlessly. We has fabricated micro-needle that is 130 ${\mu}m$ thickness and 250 ${\mu}m$length with 10 ${\mu}m$ spiral groove for rolling down drug. Head part of micro-needle device is composed of 20ea micro-needles, an on-off valve and a protective cap. Glass bottle for containing drug is connected to head part of micro-needle device. We examined the puncture characteristic testing using porcine skin and drug delivery testing using porcine, rat skin with Indian Ink.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년 학술대회 논문집 정보 및 제어부문
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• pp.288-290
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• 2006

This paper presents the real-time water tank wireless control in a ship using duplex RF modules and PLC(Programmable logic Controller). The purpose of this paper is developing HMI(Human Machine Interface) for automation equipments. The system can low a cost because long wires are no more used. Analog signals of the water gauge and flow meter are changed to discrete signals by the micro-processor. The PLC checks the volume of water and runs On or Off of the valve and pump. Duplex RF modules send and receive data between the water tank and control room. Everywhere the Internet is used, operators are able to check the status of the system by the web-server.

• 대한기계학회논문집B
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• 제40권10호
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• pp.681-687
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• 2016

마이크로 인젝션을 바이오분야에 적용하기 위해 고압생성을 통해 침투하는 방법을 채택하였다. 그러나 고압의 액체를 인젝션 할 경우 그 양을 미세하게 하기 어렵다. 이러한 문제를 해결하기 위해는 고속으로 동작하는 개폐밸브에 의한 방법이 있다. 본 연구에서는 수백 Hz로 동작가능한 압전 액추에이터로 구성된 개폐밸브를 적용하여 실험하였다. 압전밸브를 구동하는 파형을 다양하게 조절하고 노즐의 구조에 의한 영향을 알아보기 위해 5가지 서로 다른 치수의 노즐을 제작하였다. 다양한 노즐과 구동파형 변수를 조절하면서 무엇이 인젝션 볼륨과 인젝션 힘에 큰 영향을 미치는지 확인하였다. 이 실험을 통해, 인젝션 볼륨을 줄이고 인젝션 힘을 증가시키는 방법을 알아냈고 목표치가 있다면 그에 맞는 다양한 값을 결정할 수 있게 되었다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 제37회 하계학술대회 논문집 C
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• pp.1629-1630
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• 2006

This paper describes a micro total analysis system ($\mu$ TAS) for detecting and digesting the target protein which includes a bead based temperature controllable microchip and computer based controllers for temperature and valve actuation. We firstly combined the temperature control function with a bead based microchip and realized the on-chip sequential reactions using two kinds of beads. The PEG-grafted bead, on which RNA aptamer was immobilized, was used for capturing and releasing the target protein. The target protein can be chosen by the type of RNA aptamer. In this paper, we used the RNA aptamer of HCV replicase. The trypsin coated bead was used for digesting the released protein prior to the matrix assisted laser desorption ionization time of flight mass spectrometer (MALDI TOF MS). Heat is applied for release of the captured protein binding on the bead, thermal denaturation and trypsin digestion. PDMS microchannel and PDMS micro pneumatic valves were also combined for the small volume liquid handling. The entire procedures for the detection and the digestion of the target protein were successfully carried out on a microchip without any other chemical treatment or off-chip handling using $20\;{\mu}l$ protein mixture within 20 min. We could acquire six matched peaks (7% sequence coverage) of HCV replicase.

• 대한기계학회논문집B
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• 제30권2호
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• pp.110-116
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• 2006

A syringe pump or a device using high electric voltage has been used for controlling flows inside a LOC (lab-on-a-chip). Compared to LOC, however, these microfluidic devices are large and heavy that they are burdensome for a portable ${\mu}-TAS$ (micro total analysis system). In this study, a new flow control technique employing pressure regulators and pressure chambers was developed. This technique utilizes compressed air to control the micro-scale flow inside a LOC, instead of a mechanical actuator or an electric power supply. The pressure regulator controls the output air pressure by adjusting the variable resistor attached. We checked the feasibility of this system by measuring the flow rate inside a capillary tube of $100{\mu}m$ diameter in the Re numbers ranged from 0.5 to 50. In addition, the performance of this flow control system was compared with that of a conventional syringe pump. The developed flow control system was found to show superior performance, compared with the syringe pump. It maintains automatically the: air pressure inside a pressure chamber whether the flow inside the capillary tube is on or off. Since the flow rate is nearly proportional to the resistance, we can control flow in multiple microchannels precisely. However, the syringe pump shows large variation of flow rate when the fluid flow is blocked in the microchannel.

• 감성과학
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• 제7권4호
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• pp.35-41
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• 2004

본 연구에서는 운전자의 피로감을 경감시킬 수 있는 자동차용 향 분사 시스템을 개발하였다. 또한 향 분사시스템의 운전자 적응 특성을 분석하였다. 향 분사 시스템은 휘발된 향을 산소 (공기)와 혼합시켜 외부로 분사하는 방식을 이용하였다. 8051 마이크로프로세서를 이용하여 2-Port Solenoid Valve의 on/off 시간을 변경 가능하도록 하였고 이를 통해 향 분사량을 제어할 수 있도록 하였다. 평균나이 22$\pm$2세인 남녀 대학생 20명을 대상으로 네 가지 천연 향 (쟈스민 30%, 쟈스민 50%, 페파민트 30%, 페파민트 50%)을 사용하여 향의 적응화가 발생하는 시간과 향에 대한 적응화가 제거되는 시간을 결정하는 실험을 수행하였다. 실험 결과 쟈스민 30% 향의 적응화 발생시간은 1분 28초, 적응화 제거시간은 3분 15초, 쟈스민 50% 향의 적응화 발생시간은 2분 41초, 적응화 제거시간은 4분 3초, 페파민트 30% 향의 적응화 발생시간은 1분 47초, 적응화 제거시간은 2분 59초, 페파민트 50% 향의 적응화 발생시간은 1분 58초, 적응화 제거시간은 4분 11초였다.