• 한국미생물·생명공학회지
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• 제21권1호
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• pp.30-35
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• 1993

E.coli에서 발견된 ATP-dependent 효소인 Clp효소 중에서 Clp A의 ATPase 활성에 대한 영향을 검토하였다. Clp효소의 limiting amount으로 나타난 specific 활성은 일정하게 증가하는 효소의존성을 보였다. ATPase 활성을 나타내고 있는 ClP A는 casein에 의하여 활성화되어지며 2분자의 ATP가 결합하고 ATPase 활성을 나타내기 위한 ATP의 분해는 Clp효소의 단백질 분해 활성에 필요하다.

• Tuberculosis and Respiratory Diseases
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• 제81권1호
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• pp.1-5
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• 2018

Asthma, remains symptomatic despite ongoing treatment with high doses of inhaled corticosteroids (ICS) in conjunction with long-acting beta-agonists (LABA), is classified as "severe" asthma. In the course of caring for those patients diagnosed with severe asthma, stepping up from ICS/LABA to more aggressive therapeutic measures would be justified, though several aspects have to be checked in advance (including inhaler technique, adherence to therapy, and possible associated comorbidities). That accomplished, it would be advisable to step up care in accordance with the Global Initiative for Asthma (GINA) recommendations. Possible strategies include the addition of a leukotriene receptor antagonist or tiotropium (to the treatment regimen). The latter has been shown to be effective in the management of several subgroups of asthma. Oral corticosteroids have commonly been used for the treatment of patients with severe asthma in the past; however, the use of oral corticosteroids is commonly associated with corticosteroid-related adverse events and comorbidities. Therefore, according to GINA 2017 these patients should be referred to experts who specialize in the treatment of severe asthma to check further therapeutic options including biologics before starting treatment with oral corticosteroids.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2007년도 7th International Meeting on Information Display 제7권1호
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• pp.239-244
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• 2007

Highly efficient and stable white PIN OLED structures have been developed with a focus on possible AM display applications. Due to the use of the novel air-stable Novaled n-dopant material NDN26, the mass production compatibility of the PIN approach is improved. With both a conventional n-dopant, NDN1, and a novel air-stable n-dopant, NDN26, similar performance in efficiency and lifetime are reached. Based on highly a stable red fluorescent emitter system, the Novaled PIN approach allows for reaching ultra-long lifetimes of 1,000,000 hours at a brightness of $1,000\;cd/m^2$, both for top and for bottom emission layouts. Furthermore, inverted PIN structures for a possible use in a-Si backplane applications for AM displays are shown. With a phosphorescent green emitter system it could be demonstrated that for bottom and inverted as well as non-inverted top emission, a brightness of $1,000\;cd/m^2$ can be reached at below 3 V. In addition to low operating voltages and long lifetimes, PIN OLEDs also enable for device structures with extremely low operating voltage drifts, a feature of increasing importance for future AM display developments.

• 대한건축학회논문집:계획계
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• 제35권2호
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• pp.93-104
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• 2019

Minimal art, which began to flourish in the mid-1960s, explores perceptual situations caused by the involvement of objects in given site contexts. This has led to the mentions of minimal art as a site-specific art, but its limitations have also been pointed out. This study specifically addresses the limitations of minimal art as a site-specific art with two perceptual points of view. First, according to Michael Fried, situations described as 'now here' focus largely on the bodily experiences of a place. However, they do not rooted in specific time and space of a certain place. Second, the unique characteristics of a certain place are excluded from the perception of the body which occupies the passage of time. Self-sufficient algorithm, which is far from site-specific conditions, is the autonomous system creating the period in the way of arrangement of objects. In addition, Minimal art regards a body only as the objectivity excluding the subjectivity which is essential creating meaning in a place. In the latter part of the article, these features are dealt with through Donald Judd's works. This study on site-specificity also provides a new perspective on the discussion of Minimal architecture and Minimal landscape.

• 유통과학연구
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• 제21권2호
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• pp.21-34
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• 2023

Purpose: The goal of this study is to examine what makes young people more likely to use digital banking. This is because digital banking services and their distribution channels are technologically advanced, which can be a double-edged sword between ease of use and resistance to technology. Research design, data and methodology: This study included 320 participants from generation Z in Jakarta who use digital bank and used a quantitative method with PLS-SEM. Results: This study explains how, in addition to usefulness, costs, and self-efficacy, resistance to technology has a direct effect on usage attitudes. Meanwhile, if the attitude of use is preceded by aspects of usefulness, self-efficacy, and awareness, resistance to technology will be felt indirectly. Conclusions: This demonstrated that most discussed factors, such as Ease-of-Use and security of use, are important for Generation Z users but no longer a major consideration in accepting digital banking. Aside from being more open to the use of technology in digital banks, Generation Z also desires a balance of technology services and benefits. The limitations of this study are that it excludes social variables, uses certain generations, and limits the research area to one large city, which can be expanded in future studies.

• Toxicological Research
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• 제24권2호
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• pp.151-159
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• 2008

Rhus verniciflua Stokes(RVS), one of traditional medicinal plants in Asia, was found to have pharmacological activities such as antioxidative and antiapoptotic effects, raising the possibility for the development of a novel class of anti-cancer drugs. Thus, potential genotoxic effects of RVS in three short-term mutagenicity assays were investigated, which included the Ames assay, in vitro Chromosomal aberration test, and the in vivo Micronucleus assay. In Ames test, the addition of RVS water extracts at doses from 313 up to 5000 mg/plate induced an increase more than 2-fold over vehicle control in the number of revertant colonies in TA98 and TA1537 strains for detecting the frame-shift mutagens. The similar increase in reversion frequency was observed after the addition of RVS ethanol extracts. To assess clastogenic effect, in vitro chromosomal aberration test and in vivo micronucleus assay were performed using Chinese hamster lung cells and male ICR mice, respectively. Both water and ethanol extracts from RVS induced significant increases in the number of metaphases with structural aberrations mostly at concentrations showing the cell survival less than 60% as assessed by in vitro CA test. Also, there was a weak but statistically significant increase in number of micronucleated polychromatic erythrocytes(MNPCEs) in mice treated with water extract at 2000 mg/kg while ethanol extracts of RVS at doses of up to 2000 mg/kg did not induce any statistically significant changes in the incidence of MNPCEs. Therefore, our results lead to conclusion that RVS acts as a genotoxic material based on the available in vitro and in vivo results.

• Journal of Microbiology and Biotechnology
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• 제20권3호
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• pp.602-608
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• 2010

An atrazine-degrading bacterium, strain KU001, was obtained from a sugarcane field at the Cane and Sugar Research and Development Center at the Kasetsart University, Kamphaeng Saen Campus, Thailand. Strain KU001 had a rod-to-coccus morphological cycle during growth. Biolog carbon source analysis indicated that the isolated bacterium was Arthrobacter histidinolovorans. Sequence analysis of the PCR product indicated that the 16S rRNA gene in strain KU001 was 99% identical to the same region in Arthrobacter sp. The atrazine degradation pathway in strain KU001 consisted of the catabolic genes trzN, atzB, and atzC. Strain KU001 was able to use atrazine as a sole nitrogen source for growth, and surprisingly, atrazine degradation was not inhibited in cells grown on ammonium, nitrate, or urea, as compared with cells cultivated on growth-limiting nitrogen sources. During the atrazine degradation process, the supplementation of nitrate completely inhibited atrazine degradation activity in strain KU001, whereas ammonium and urea had no effect on atrazine degradation activity. The addition of strain KU001 to sterile or nonsterile soils resulted in the disappearance of atrazine at a rate that was 4- to 5-fold more than that achieved by the indigenous microbial community. The addition of citrate to soils resulted in enhanced atrazine degradation, where 80% of atrazine disappeared within one day following nutrient supplementation.

• The Plant Pathology Journal
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• 제21권4호
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• pp.334-342
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• 2005

The prototype Chlorella virus PBCV-l encodes 11 tRNA genes and over 350 protein-encoding genes in its 330 kbp genome. Initial attempts to overexpress the recombinant A189/192R protein, a putative virus attachment protein, in E. coli strain BL21(DE3) SI were unsuccessful, and multiple protein bands were detected on Western blots. However, the full-length A189/192R recombinant protein or fragments derived from it were detected when they were expressed in E. coli BL21 CodonPlus (DE3) RIL, which contains extra tRNAs. Codon usage analysis of the a189/192r gene showed highly biased usage of the AGA and AVA codons compared to genes encoded by E. coli and Chlorella. In addition, there were biases of XXA/U($56\%$) and XXG/ C($44\%$) in the codons recognized by the viral tRNAs, which correspond to the codon usage bias in the PBCV-1 genome of XXA/U ($63\%$) over those ending in XXC/G ($37\%$). Analysis of the codon usage in the major capsid protein and DNA polymerase showed preferential usage of codons that can be recognized by the viral tRNAs. The Asn (AAC) and Lys (AAG) codons whose corresponding tRNA genes are duplicated in the tRNA gene cluster were the most abundant (i.e., preferred) codons in these two proteins. The tRNA genes encoded in the PBCV-l genome seem to play a very important role during the synthesis of viral proteins through supplementing the tRNAs that are frequently used in viral proteins, but are rare in the host cells. In addition, these tRNAs would help the virus to adapt to a wide range of hosts by providing tRNAs that are rare in the host cells.

• Structural Monitoring and Maintenance
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• 제2권3호
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• pp.283-300
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• 2015

Visual condition inspections remain paramount to assessing the current deterioration status of a bridge and assigning remediation or maintenance tasks so as to ensure the ongoing serviceability of the structure. However, in recent years, there has been an increasing backlog of maintenance activities. Existing research reveals that this is attributable to the labour-intensive, subjective and disruptive nature of the current bridge inspection method. Current processes ultimately require lane closures, traffic guidance schemes and inspection equipment. This not only increases the whole-of-life costs of the bridge, but also increases the risk to the travelling public as issues affecting the structural integrity may go unaddressed. As a tool for bridge condition inspections, Unmanned Aerial Vehicles (UAVs) or, drones, offer considerable potential, allowing a bridge to be visually assessed without the need for inspectors to walk across the deck or utilise under-bridge inspection units. With current inspection processes placing additional strain on the existing bridge maintenance resources, the technology has the potential to significantly reduce the overall inspection costs and disruption caused to the travelling public. In addition to this, the use of automated aerial image capture enables engineers to better understand a situation through the 3D spatial context offered by UAV systems. However, the use of UAV for bridge inspection involves a number of critical issues to be resolved, including stability and accuracy of control, and safety to people. SLAM (Simultaneous Localisation and Mapping) is a technique that could be used by a UAV to build a map of the bridge underneath, while simultaneously determining its location on the constructed map. While there are considerable economic and risk-related benefits created through introducing entirely new ways of inspecting bridges and visualising information, there also remain hindrances to the wider deployment of UAVs. This study is to provide a context for use of UAVs for conducting visual bridge inspections, in addition to addressing the obstacles that are required to be overcome in order for the technology to be integrated into current practice.

• 산업진흥연구
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• 제6권4호
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• pp.11-21
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• 2021

본 연구는 콘텐츠 산업 대표 기업인 CJ E&M를 대상으로 기업 성장성 요인을 분석하고자 하였다. 먼저 CJ E&M 성장 동력을 분석하고자 마이클 포터의 다이아몬드 모델을 활용하여 핵심요인을 검토하였으며, 이후 4P 모델을 기준하여 향후 기업 성장을 도모할 수 있는 방향을 제시하고자 하였다. 연구결과, 기업 성장요인으로는 생산조건 측면에 다양한 장르에 기준한 미디어 콘텐츠와 스타급 인재 영입을 제시할 수 있으며, 수요조건 측면에서는 중국시장 수요조건을 충족 시켜왔다. 또한 관련 산업 측면에 K-Culture를 겨냥한 한류 산업을 뽑을 수 있으며 경영 여건 즉 전략, 구조, 경쟁 측면에 '투 트랙 전략인 글로벌·글로컬 전략, 미디어 커머스 전략이 유효하였다. 향후 발전 방향을 제시해 보면, 계열사 협업체계에 기초한 다양한 제품, 가격 측면에서 넷플릭스를 벤치마킹한 티빙을 제시하고자 하며, 유통경로 측면에서는 OTT 플랫폼의 글로벌 확장과 촉진 측면에서는 틱톡 플랫폼을 활용한 챌린지 마케팅을 활성화 시켜나갈 필요성이 있다.