• Title/Summary/Keyword: Mg reduction

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Reproduction and Development Toxicity of Anti-Alzheimer′s Drug Dehydroevodiamine-HCl (치매 치료제 염산 디히드로에보다이아민의 생식 및 발생 독성)

  • 성이숙;정성윤;서영득;진미령;최봉웅;장병모;김대경
    • YAKHAK HOEJI
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    • v.46 no.6
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    • pp.452-458
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    • 2002
  • Dehydroevodiamine-HCl (DHED), which is a component separated from Evodia rutaecarpa Bentham, has novel anticholinesterase and antiamnesic activities in a scopolamine-induced amnesia model. Several studies suggest that DHED might be an effective drug for Alzheimer's disease and a vascular type of dementia. DHED was at dose levels of 0, 50, 100 and 200 mg/kg/day administered intraperitoneally to Sprague-Dawley male rats for 60 days before mating and to females from 14 days before mating to 7 days after mating. Effects of the DHED on general symptom and reproductive performance of parent animals and embryonic development were examined. In male parents, whereas no death was observed, reduction in the increase rate of body weight was found at 200 mg/kg. In female parents, both of the mating performance and the fertility of parent animals were decreased at 200 mg/kg, but not significantly. In 200 mg/kg treated group, the fetal death rate was increased but total fetuses showed no changes compared to the control group. There were no malformed F1 fetuses in all groups.

Removal of Simultaneously Biological Organic, Nitrogen, and Phosphorus Removal in Sequencing Batch Reactors using Night-soil (연속회분식 반응기(Sequencing Batch Reactor)를 이용한 분뇨중 유기물과 질소 및 인의 동시제거)

  • 한기백;박동근
    • Journal of Environmental Science International
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    • v.6 no.6
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    • pp.697-709
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    • 1997
  • Sequencing Batch Reactor(SBR) experiments for organics and nutrients removal have been conducted to find an optimum anaerobic/anoxic/aerobic cycling time and evaluate the applicability of oxidation-reduction potential(ORP) as a process control parameter. In this study, a 61 bench-scale plant was used and fed with night-soil wastewater in K city which contained TCODcr : 10, 680 mg/l, TBm : 6, 893 mg/l, $NH_4^+-N$ : 1, 609 mg/l, $PO_4^{3-}-P$ : 602 mg/l on average. The cycling time In SBRs was adjusted at 12 hours and 24 hours, and then certainly included anaerobic, aerobic and inoxic conditions. Also, for each cycling time, we performed 3 series of experiment simultaneously which was set up 10 days, 20 days and 30 days as SRT From the experimental results, the optimum cycling time for biological nutrient removal with nlght-soil wastewater was respctively 3hrs, 5hrs, 3hrs(anaerobic-aerobic-anoxic), Nitrogen removal efficiency was 77.9%, 77.9%, 81.7% for each SRT, respectively. When external carbon source was fed in the anoxic phase, ORP-bending point indicating nitrate break point appeared clearly and nitrogen removal efficiency increased as 96.5%, 97.1%, 98.9%. Phosphate removal efficiency was 59.8%, 64.571, 68.6% for each SRT. Also, we finded the applicability of ORP as a process control parameter in SBRs.

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Low Serum Cholesterol Level in Major Depression Patients with Suicidal Attempt (자살을 시도한 주요우울증 환자에서 혈청 콜레스테롤 농도의 저하)

  • Kim, Yong Ku;Lee, Heon Jeong;Kwak, Dong II
    • Korean Journal of Biological Psychiatry
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    • v.3 no.2
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    • pp.258-261
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    • 1996
  • Objective : Several studies hove suggested that reduction of cholesterol concentration and low cholesterol level increases suicide, homicide, and depression. The authors sought to determine whether low cholesterol is associated with a history of suicidal attempts among major depression patients. Method : The subjects were 105 patients with major depression, diagnosed according to the DSM-III-R criteria, and 105 age, sex matched healthy controls. Blood was token following overnight fast and serum cholesterol concentration were measured by a enzymatic method Results : The serum cholesterol level was significantly lower in the patients with major depression than in healthy controls($180.4{\pm}43.4mg/dl$ vs $199.7{\pm}35.8mg/dl$). And the serum cholesterol level was significantly lower in major depression patients with suicidal attempt than in major depression patients without suicidal attempt($156.7{\pm}38.2mg/dl$ vs $ 187.8{\pm}42.5mg/dl$) Conclusion : It is hypothesized that low cholesterol level is associated with depression by modifying the serotonin metabolism and the production of interleukin-2, low cholesterol concentration should be further investigated as a potential biological marker of suicidal risk in major depression. Prospective study with serial cholesterol determinations should be done.

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Sludge Reduction in Activated Sludge Process by solubilizing Return Sludge using Electric Field/Ultrasonification (전기장 및 초음파에 의한 반송슬러지의 가용화에 따른 활성슬러지에서의 슬러지 감량화)

  • Yoon, Soon-Uk;Ahn, Chang-Min;Kim, Chang-Gyun
    • Journal of Korean Society on Water Environment
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    • v.29 no.3
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    • pp.329-336
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    • 2013
  • This study was conducted to reduce excess sludge generation by recycling of return sludge to the aeration tank after solubilization by electric field charger and ultrasonifier. The return sludge was purposely broken-up to the ratio of $SCOD_{Cr}/TCOD_{Cr}$ at 0.1, 0.2, and 0.3, which was tested along with control (i.e., untreated). Solubilized sludge was subsequently treated in a bench-scaled conventional activated sludge reactor. According to varying $SCOD_{Cr}/TCOD_{Cr}$ ratios, TSS in the reactor was correspondingly increased from 129 to 219 mg/L and $TCOD_{Cr}$ was also from 257 to 335 mg/L. However, TSS in the effluent was nevertheless kept lower at below 30 mg/L and $TCOD_{Cr}$ was also unvaryingly below 40 mg/L. For $SCOD_{Cr}/TCOD_{Cr}$ = 0.3, the amount of excess sludge produced was at the highest decreased up to as high as 78%.

Effects of Intra-peritoneal Injection of Inorganic Mercury on Blood Parameters and Hepatic Oxidative Stress Enzyme Activities in Common Carp (Cyprinus carpio L.)

  • Jee, Jung-Hoon;Kang, Ju-Chan
    • Korean Journal of Environmental Biology
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    • v.22 no.4
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    • pp.559-564
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    • 2004
  • The effects of intra-peritoneal injection of inorganic mercury on haemato-logical parameters and hepatic oxidative stress enzyme activities were studied in common carp, Cyprinus carpio. The fish were injected thrice intra-peritoneally with mercuric chloride TEX>$(5,\;10mg\;Hg\;kg\;b.W.^{-1})$. After exposure of three different mercury concentrations a physiological stress response was exerted on C. carpio by causing changes in the blood status such as erythropenia in blood and oxidative stress in liver. Red blood cell counts, hemoglobin concentration and hematocrit level were reduced in most cases by inorganic mercury. Remarkable low level of serum chloride, calcium and osmolality were also observed in the mercury- exposed fish. However, serum magnesium and phosphate were not altered by exposure to mercury. An increased activity of hepatic glutathione peroxidase was observed in the lowest treatment group of carp $(1mg\;Hg\;mg\;b.w.^{-1})$, hence, hepatic catalase and glutathione peroxidase of carp exposed to higher concentration of mercury $(5,\;10mg\;Hg\;kg\;b.W.^{-1})$ showed significant reduction in such activities.

Synthesis of Titanium Carbide Nano Particles by the Mechano Chemical Process

  • Ahn, In-Shup;Park, Dong-Kyu;Lee, Yong-Hee
    • Journal of Powder Materials
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    • v.16 no.1
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    • pp.43-49
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    • 2009
  • Titanium carbides are widely used for cutting tools and grinding wheels, because of their superior physical properties such as high melting temperature, high hardness, high wear resistance, good thermal conductivity and excellent thermal shock resistance. The common synthesizing method for the titanium carbide powders is carbo-thermal reduction from the mixtures of titanium oxide($TiO_2$) and carbon black. The purpose of the present research is to fabricate nano TiC powders using titanium salt and titanium hydride by the mechanochemical process(MCP). The initial elements used in this experiment are liquid $TiCl_4$(99.9%), $TiH_2$(99.9%) and active carbon(<$32{\mu}m$, 99.9%). Mg powders were added to the $TiCl_4$ solution in order to induce the reaction with Cl-. The weight ratios of the carbon and Mg powders were theoretically calculated. The TiC and $MgCl_2$ powders were milled in the planetary milling jar for 10 hours. The 40 nm TiC powders were fabricated by wet milling for 4 hours from the $TiCl_4$+C+Mg solution, and 300 nm TiC particles were obtained by using titanium hydride.

Effect of Berberis tinctoria leaf (Berberidaceae) extract on antidiabetic, antihyperlipidemic and antioxidant status in streptozotocin induced diabetes in rats

  • Murugesh, K;Yeligar, Veerendra C;Dash, Deepak Kumar;Maiti, BC;Maity, Tapan K
    • Advances in Traditional Medicine
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    • v.6 no.4
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    • pp.336-343
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    • 2006
  • The present study was carried out to investigate the antidiabetic and antioxidant effect of methanolic extract of Berberis tinctoria leaves (MEBT), in streptozotocin induced diabetic rats. Oral administration of MEBT extract (150 mg/kg and 300 mg/kg) for a period of 14 days. Blood glucose levels, body weight food and liquid intake were measured on every $5^{th}$ day over a period of 14 days. In diabetic rats, MEBT at the dose of 150 mg/kg and 300 mg/kg body weight resulted in significant reduction in blood glucose levels. The study was further investigated to determine antioxidant and antihyperlipidemic potential of MEBT in streptozotocin (STZ) induced diabetic rats. These results suggest that the MEBT possess antidiabetic activity and is able to ameliorate biochemical damages in STZ induced diabetic rats and the results were found to be in a dose dependent manner.

Anti-tumor effect of Euphorbia hirta on Ehrlich's ascites carcinoma in mice

  • Kumarappan, CT;Sunderi, S Karpagam Kumara;Jaswanth, A;Lakshmi, S Mohana;Mandal, Subhash C
    • Advances in Traditional Medicine
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    • v.7 no.2
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    • pp.133-140
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    • 2007
  • Anti-tumor activity of Euphorbia hirta (50 mg/kg and 100 mg/kg) has been evaluated against Ehrlich's ascites carcinoma (EAC) in Swiss albino mice. Intraperitoneal (i.p) administration of Euphorbia hirta was effective in reducing solid tumor mass development induced by EAC cells. It exhibited significant anti-tumor activity in mice, when used at the dose of 100 mg/kg/day i.p., for 14days. The administration of Euphorbia hirta (100 mg/kg/day i.p.) resulted in an increase (P<0.001) of the life span (59.9%) of ascites tumor bearing mice as compared to the control group. After 14 days, on developed tumor masses, Euphorbia hirta administration brought about significant reduction in tumor volume and it reverse the changes in the hematological parameters, responding to tumor inoculation. The results are indicative of the anti-tumor activity of Euphorbia hirta against EAC induced tumor in a dose dependent manner.

Recycling of Spent Dry Batteries for Deflection Yoke Core Applications

  • Murase, Taku;Takahashi, Hiroyasu;Nomura, Takeshi
    • Proceedings of the IEEK Conference
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    • 2001.10a
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    • pp.245-248
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    • 2001
  • Nomura Kohsan Corp. is producing oxides, such as ZnMn$_2$O$_4$, ZnFe$_2$O$_4$, and ZnO, by burning the used dry manganese cells and by sorting out the remnant materials. It is possible to use the recycled materials of the spent dry batteries as the raw materials of deflection yoke cores. Making hish roasting temperature in the recycling system has an effect in reduction of the impurities. As a result, the loss of the cores using the recycled materials is lower. When using the recycled materials, it is required to add Mg (OH)$_2$. ZnO, and Fe$_2$O$_3$in order to rectify the composition of the MnMgZn ferrite for deflection yoke core applications. Furthermore, in order to disappear ZnMn$_2$O$_4$in the formation, it is necessary to control at higher calcining temperatures. The MnMgZn ferrite of using the recycled materials becomes Toss equivalent to the conventional material. TDK Corp. is manufacturing the deflection yoke cores from 1996 using the material recycled from the spent dry batteries.

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Airborne Concentrations of Welding Fume and Metal Components by Type of Welding (용접작업 형태별 공기중 용접흄 농도와 금속 성분에 관한 조사연구)

  • Lee, Kwon Sup;Paik, Nam Won
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.4 no.1
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    • pp.71-80
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    • 1994
  • This study was conducted to evaluate worker exposure to welding fume in automobile body shop and to evaluate metal components by type of welding. The results are summarized as follows: 1. Average concentrations of total welding fume without and with ventilation were $5.2mg/m^3$ and $2.49mg/m^3$, respectively. Thus, the average reduction rate of total fume by ventilation was 52.1 %. 2. The highest fume concentration was indicated at shielded arc welding, followed by $CO_2$ gas welding, argon arc welding, and spot welding in order of decreasing concentration. 3. Average respirable fume concentrations without and with ventilation were $2.97mg/m^3$ and $1.64mg/m^3$, respectively. 4. Further analysis of welding fume indicated that total fume consisted of $Fe_2O_3$, ZnO, Mn, Pb, and CuO, in order of decreasing amount. Combined effect of metals was below the American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Values (TLVs).

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