• 제목/요약/키워드: Method of displacement

검색결과 4,884건 처리시간 0.032초

A useful additional medial subbrow approach for the treatment of medial orbital wall fracture with subciliary technique

  • Kim, Seung Min;Kim, Cheol Keun;Jo, Dong In;Lee, Myung Chul;Kim, Ji Nam;Choi, Hyun Gon;Shin, Dong Hyeok;Kim, Soon Heum
    • 대한두개안면성형외과학회지
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    • 제20권2호
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    • pp.101-108
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    • 2019
  • Background: To date, a variety of surgical approaches have been used to reconstruct the medial orbital wall fracture. Still however, there is still a controversy as to their applicability because of postoperative scars, injury of anatomical structures and limited visual fields. The purpose of this study was to introduce a useful additional medial subbrow approach for better reduction and securement more accurate implant pocket of medial orbital wall fracture with the subciliary technique. Methods: We had performed our technique for a total of 14 patients with medial orbital wall fracture at our medical institution between January 2016 and July 2017. All fractures were operated through subciliary technique combined with the additional medial subbrow approach. They underwent subciliary approach accompanied by medial wall dissection using a Louisville elevator through the slit incision of the medial subbrow procedure. This facilitated visualization of the medial wall fracture site and helped to ensure a more accurate pocket for implant insertion. Results: Postoperative outcomes showed sufficient coverage without displacement. Twelve cases of preoperative diplopia improved to two cases of postoperative diplopia. More than 2 mm enophthalmos was 14 cases preoperatively, improving to 0 case postoperatively. Without damage such as major vessels or extraocular muscles, enophthalmos was corrected and there was no restriction of eyeball motion. Conclusion: Our ancillary procedure was useful in dissecting the medial wall, and it was a safe method as to cause no significant complications in our clinical series. Also, there is an only nonvisible postoperative scar. Therefore, it is a recommendable surgical modality for medial orbital wall fracture.

Nanopharmaceutical Approach for Enhanced Anti-cancer Activity of Betulinic Acid in Lung-cancer Treatment via Activation of PARP: Interaction with DNA as a Target -Anti-cancer Potential of Nano-betulinic Acid in Lung Cancer-

  • Das, Jayeeta;Samadder, Asmita;Das, Sreemanti;Paul, Avijit;Khuda-Bukhsh, Anisur Rahman
    • 대한약침학회지
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    • 제19권1호
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    • pp.37-44
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    • 2016
  • Objectives: This study examined the relative efficacies of a derivative of betulinic acid (dBA) and its poly (lactide-co-glycolide) (PLGA) nano-encapsulated form in A549 lung cancer cells in vivo and in co-mutagen [sodium arsenite (SA) + benzo[a]pyrene (BaP)]-induced lung cancer in mice in vivo. Methods: dBA was loaded with PLGA nanoparticles by using the standard solvent displacement method. The sizes and morphologies of nano-dBA (NdBA) were determined by using transmission electron microscopy (TEM), and their intracellular localization was verified by using confocal microscopy. The binding and interaction of NdBA with calf thymus deoxyribonucleic acid (CT-DNA) as a target were analyzed by using conventional circular dichroism (CD) and melting temperature (Tm) profile data. Apoptotic signalling cascades in vitro and in vivo were studied by using an enzyme-linked immunosorbent assay (ELISA); the ability of NdBA to cross the blood-brain barrier (BBB) was also examined. The stage of cell cycle arrest was confirmed by using a fluorescence-activated cell-sorting (FACS) data analysis. Results: The average size of the nanoparticles was ~ 110 nm. Confocal microscopy images confirmed the presence of NdBA in the cellular cytoplasm. The bio-physical properties of dBA and NdBA ascertained from the CD and the Tm profiles revealed that NdBA had greater interaction with the target DNA than dBA did. Both dBA and NdBA arrested cell proliferation at G0/G1, NdBA showing the greater effect. NdBA also induced a greater degree of cytotoxicity in A549 cells, but it had an insignificant cytotoxic effect in normal L6 cells. The results of flow cytometric, cytogenetial and histopathological studies in mice revealed that NdBA caused less nuclear condensation and DNA damage than dBA did. TEM images showed the presence of NdBA in brain samples of NdBA fed mice, indicating its ability to cross the BBB. Conclusion: Thus, compared to dBA, NdBA appears to have greater chemoprotective potential against lung cancer.

열차운행 안정화를 위한 주회로 기기의 고조파 제한장치 개발에 관한 연구 (A Study on the Development of Harmonic Limit Device for Stabilizing Main Circuit Equipment of Train)

  • 김성준;채은경;강정원
    • 예술인문사회 융합 멀티미디어 논문지
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    • 제8권6호
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    • pp.853-861
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    • 2018
  • 본 논문에서는 전기철도차량이 운행할 때 이상 전압상승에 의한 문제점을 해결할 수 있는 고조파 제한장치의 적용을 제안한다. 운행 중 열차에 전력을 공급하는 교류가선은 25kV/60Hz의 전기를 공급하기 위하여 사용되지만 철도차량 전기장치의 기술발전에 따라 점차 가선에 포함되는 고조파의 크기 및 주파수의 변형이 다양해지고 있다. 최근 열차안전운행에 심각한 문제가 되고 있는 주회로 기기인계기용변압기(Potential Transformer, PT)의 파손이나 주변압기 등의 열손증가는 가선 전원의 고조파로 인한 순간적인 무효전류의 증가로 생기는 현상이다. 주회로 기기의 저주파형 트랜스포머로 고주파수 성분이 유입되면 트랜스 코어의 히스테리시스에 의한 철손 증가 및 기생 커패시턴스에 흐르는 전류가 증가하므로 발열이 발생하게 된다. 이러한 문제 해결을 위해 최근 시퀀스의 조정으로 전력변환 장치의 인위적인 NOTCH OFF가 적용되었다. 그러나, OFF 신호를 받아 제어하는 방식은 지상과 차상 장치의 상호작용으로 동작하므로 불량 발생 시 무효화 되며, 실제 사고가 발생되고 있다. 따라서, 근본적인 문제해결을 위한 방법으로 고조파 전류가 가급적 변압기에 유입되지 않도록 하는 것이 필요하며, 고조파 전류의 유입으로 인해 빈번하게 발생되고 있는 열차사고를 방지하고 안전한 운행을 위해 열차의 실험 분석과 고조파 제한장치의 시뮬레이션을 통한 장치의 타당성 검증을 위한 연구를 수행하였다.

무수치 표백술 후 잔존 과산화수소수 제거를 위한 수종의 치수강 세척제의 효과에 관한 정량적 연구 (A QUANTITATIVE STUDY ON THE DEGRADING EFFECT OF THE VARIOUS IRRIGATING AGENTS IN THE ELIMINATION OF RESIDUAL HYDROGEN PEROXIDE FOLLOWING WALKING BLEACHING)

  • 금기연;한원섭;정일영;이승종;이찬영;오병훈
    • Restorative Dentistry and Endodontics
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    • 제23권2호
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    • pp.656-669
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    • 1998
  • Hydrogen peroxide at high concentration during walking bleaching may cause damage to the tooth structure and to the surrounding periodontal tissues and may develop external root resorption. Clinically, It is so important to find a method of prevention or minimization of these complications. The efficacy of various chamber-irrigating agents to eliminate residual hydrogen peroxide after walking bleaching was examined and compared with water rinse in this study. Extracted human 46 premolars without any cementoenamel junction defects were treated endodontically and based with IRM to 1 mm below CEJ and totally bleached 3 times for each tooth with 30% hydrogen peroxide and sodium perborate. Upon completion of the 3rd walking bleaching procedure, the cervical portion and pulp chamber of each group of teeth were irrigated with catalase, 70% ethylalcohol, acetone, and distilled water. And then, a radicular hydrogen peroxide penetration was measured with spectrophotometer immediately after each bleaching and following treatment with each chamber-irrigating agents, and the significance of their eliminating efficacy of residual hydrogen peroxide was analyzed by Kruskal-Wallis test. The results were obtained as follows. 1. Cervical root penetration of hydrogen peroxide was increased as the bleaching procedure was repeated(P<.01). 2. The most effective irrigant that removed residual hydrogen peroxide was the catalase, and the least effective one was water rinsing (P<.01).; there was no significant difference between the acetone and ethanol group. 3. The Irrigation with antioxidant enzyme or water-displacement solutions can eliminate residual oxygen radicals from the pulp chamber effectively after walking bleaching. So, these agents can reduce adverse effects such as cervical external resorption and periapical inflammation and prevent residual $O_2$ from impeding composite resin polymerization, thus increase the bonding strength of composite resin. This, in turn reduces microleakage and discoloration of the esthetic restoration, extending its service-life.

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설측 브라켓 부착을 위한 기준평면 설정에 관한 3차원 유한요소법적 연구 (Three-dimensional finite element analysis of the bracket positioning plane in lingual orthodontics)

  • 김선화;박수병;양훈철
    • 대한치과교정학회지
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    • 제36권1호
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    • pp.30-44
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    • 2006
  • 교정치료 영역에서 성인들의 심미적인 요구도가 증가되면서 설측 교정치료는 여러 가지 단점에도 불구하고, 가장 심미적이라는 이유로 많은 주목을 받아왔지만 실제 치아이동을 결정지을 수 있는 브라켓을 부착하는 기준평면의 위치에 대해서는 거의 보고된 바가 없다. 이에 본 연구는 실제 브라켓이 부착되는 평면의 상하 평행이동이나 기울기 변화에 따라 치아이동 양상이 어떻게 변화되는지 알아보고, 바람직한 전치부 치체이동을 얻기 위해서 힘의 적용점을 어디에 두어야 하는지, 그리고 전치부에 어느 정도의 모멘트를 부여해야 하는지 알아보고자 3차원 유한요소법을 이용하여 치아 변위 및 응력분포를 비교 분석하였다. 실험 결과 설측 브라켓 부착평면을 치은연쪽으로 평행이동 혹은 회전이동 시키고 견인하였을 경우, 절단연쪽으로 이동시켰을 때와 비교했을 때 비조절성 설측 경사이동이 감소하기는 하였으나 상하악 전치부 치아들의 설측경사 양상은 지속되었으며, 이러한 양상은 견치 브라켓의 hook 길이를 증가시켜도 계속 나타났다. 이와는 달리 설측 중심평면에 브라켓을 부착하고 각 치아별로 모멘트를 부여하였을 경우 설측 방향으로 개개 치아들의 치체이동이 발생하여 설측 교정치료 시 효과적인 전치부 치아의 후방견인이 가능함을 알 수 있었다.

방사면역측정을 위한 항 Gastrin 혈청의 생산 및 평가 (Production and Evaluation of Anti-Gastrin Serum for Radioimmunoassay)

  • 박형진;권혁일;이윤렬;신원임;서상원;오양석
    • The Korean Journal of Physiology
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    • 제23권1호
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    • pp.89-98
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    • 1989
  • New Zealand white 계의 토끼에게 EDC를 사용하여 hemocyanin에 접합시킨 human G-17-I을 면역한 결과 gastrin의 방사면역측정에 적합한 항 gastrin 혈청을 얻는데 성공하였다. 본 실험에서 얻은 항 gastrin 혈청의 역가는 1:25,000이며 human G-17-I과 human big gastrin에 매우 친화력이 높은 반면 다른 위장관 peptide 들과는 교차반응성이 아주 낮았다. 본 항 gastrin 혈청의 effective affinity constant는 $1.77{\times}10^{11}/M$이었다. 또한 총 결합부위(total binding sites)는 255 nM, 이질성지수(heterogeneity index)는 0.84 그리고 average affinity constant는 $0.79{\times}10^{11}/M$이었다. 본 실험에서 얻은 항 gastrin 혈청을 사용하여 사람과 흰쥐의 혈장 gastrin 농도를 방사면역측정법으로 측정한 결과 이미 잘 알려진 결과와 동일한 성적을 얻을 수 있었다. 이러한 결과들을 종합하여 볼때 본 실험에서 얻은 항 gastrin 혈청은 생리적농도로 존재하는 gastrin의 방사면역측정에 적합한 것으로 생각된다.

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현대 패션에 나타난 패러디(Parody)에 관한 연구 (A Study on Parody Expressed in Modern Fashion)

  • 고현진;김민자
    • 복식
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    • 제25권
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    • pp.249-268
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    • 1995
  • Parody has recently prevailed as one of the important techniques of creation in art. The purposes of this study are to reaffirm the pos-ition of fashion as an art by clarifying parody depicted in fashion and to make an opportunity to reconsider the meaning of creation in fashion design through the significance of par-ody. For these purposes, documentary studies about parody in literature and art which had been discussed more often were preceded as a framework of this research. framework of this research. Basedd upon that, parody phenomena in fashion as well as art were analyzed. The synthetic results are as follows ; 1. Parody is a kind or critical technique and can be conceived as a process of creation. The established primary style (material) which is well-known and familiar is imitated and then is recreated in new manner through the three types of parodization, that is, the change of its external form, the change of its internal mean-ing and the shift from its place (i.e. displace-ment). 2. Parody in fashion is also analyzed based upon the three types of parodization which designer's will and expression is necessarily required. First, the parody through the change of external form is to have its effect of novelty, unexpectedness, playfulness, wit, mackery, satire, irony, paradox by changing the form of the original through imitation with similarity, transformation, exaggeration, em-phasis. Second, the parody through the change of internal meaning is to bring about paradox, irony, contempt, satire, unex-pectedness by applying the original to inappro-priate subject through its substitution, inver-sion. Third, the parody through displacement is to pursue a jarring incongruity that results from shifting the original to other context. Its effect consists of paradox, unexpectedness, playfulness, ridicule, mockery, satire, irony. In general, the parody technique in fashion can be used to have an intention of expressing seriousness, playfulness, satire, grotesque. The representative designers using the parody technique are Lagerfeld, Ricci, YSL, Yama-moto, Castelbajac, Gaultier, Mugler, West-sood, Steiner and so on. 3. Parody is the technique which imitates and then recreates the preceding style ; is at the same time the method which challenges the existing concept of originality-singleness and uniqueness. It reflects the more flexible concept of modern creation in art as well as fashion. The imitation as the creation, the characteristic of parody is recognized as an creative expressiveness, publicity, intention. Thus it differenciates from copy which is uncritical mimicry.

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변형적 Carpentier 방법에 의한 Ebstein 기형의 수술적 교정 -1 례 보고- (Surgical Repair of Ebstein's anomaly by Modified Carpentier's Method - 2 cases report -)

  • 이건;김웅한;이창하;나찬영;정윤섭;정도현;김수철;이영탁;김종환;홍승록;박영관
    • Journal of Chest Surgery
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    • 제31권2호
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    • pp.216-219
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    • 1998
  • Ebstein 기형은 복잡 심기형중 하나로 치료 또한 비정상적인 삼첨판막의 교정 또는 판막치환 등으로 방법이 다양하다. 이질환의 병리소견은 삼첨판의 중격엽과 후엽이 하방전위되어서 심방화된 심실을 형성하는 것으로 수술적 목표는 삼첨판의 기능이상을 교정하고 심방화된 우심실을 주름성형하는 것이다. 본원에서는 매우 심한 삼첨판막 폐쇄 부전증이 동반된 Carpentier type A의 Ebstein기형으로 진단된 12개월된 여아에 대해 심방화된 우심실을 수직방향으로 주름성형하고 판막을 새로이 형성된 판륜에 재부착시키는 이른바 변형적 Carpentier방법으로 성공적으로 수술하였다. 수술후 환아는 심장의 크기가 매우 줄어들었고 심초음파상 미미한 정도의 삼첨판 폐쇄부전증만 남아 술후 14일째 퇴원하였다.

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누소관 열상환자에서 Mini Monoka$^{(R)}$를 이용한 지연된 스텐트 삽입술 (Delayed Lacrimal Stent Implantation Using Mini Monoka$^{(R)}$ in Canalicular Laceration)

  • 황재하;김홍민;김지훈;김광석;이삼용
    • Archives of Reconstructive Microsurgery
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    • 제20권1호
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    • pp.32-37
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    • 2011
  • Purpose: Canalicular laceration is relatively common due to its exposed, vulnerable location in case of facial trauma. Conjunctivodacryocystorhinostomy has been the standard treatment for canalicular obstruction secondary to unrepaired canalicular laceration. In spite of a high rate of relieving tear-duct obstruction, this method is noted to be associated with low rate of patient satisfaction and a number of complications. The goal of this study is to report the good results of delayed lacrimal stent implantation with Mini Monoka$^{(R)}$ for patients whose canaliculi were not repaired by initial surgery. Methods: From May of 2005 to February of 2007, four patients who underwent delayed lacrimal stent implantation using Mini Monoka$^{(R)}$ in canalicular laceration were retrospectively reviewed. First, the previous scar incision was made over the lower lid and we identified the cut end of proximal lacerated canaliculus. The Mini Monoka$^{(R)}$ was passed through the punctum to the cut end of the proximal lacerated canaliculus. We identified the cut end of the distal lacerated canaliculus, whose cut end has rolled white edges after careful excision of the scarred lid tissue. We then passed Mini Monoka$^{(R)}$ through the lacerated inferior canaliculus. Using an operating microscope, we placed three interrupted sutures of 8-0 Ethilon to join the canalicular ends. Silicone stent was left in place for 6 months. The mean age of the patients was 48.5 years (range, 35 to 59 years). The time interval from initial trauma to delayed lacrimal stent implantation was between 3 and 31 days. Follow-up periods ranged from 12 and 20 months. Results: The results of reconstruction were classified into normal, fair and poor. Patent lacrimal drainage systems were achieved in three of the four cases. In one case, epiphora was encountered. No cases of stent displacement, conjunctivitis or granuloma formation were encountered. Conclusion: Even though canalicular reconstruction was delayed for a long time, attempting canalicular reconstruction would be acceptable before considering secondary operations like dacryocystorhinostomy and conjunctivodacryocystorhinostomy.

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Static and Dynamic FEM Simulation of Packaging Tray Cup Pad for Korean Pears

  • Choi, Dong-Soo;Son, Jea-Yong;Kim, Jin-Se;Kim, Yong-Hoon;Park, Chun-Wan;Jung, Hyun-Mo;Hwang, Sung-Wook
    • 한국포장학회지
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    • 제25권3호
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    • pp.89-94
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    • 2019
  • Among the many packaging materials used in cushion packaging, there is a lack of optimum design for the tray cup pad used in fruit packaging for export and domestic distribution. It causes over-packaging due to excessive material input, and this could be solved by applying various parameters needed to optimize the design of the tray cup pad considering the packaging material and the quantity of fruits in the box. In the case of a tray cup for fruits, the economic efficiency of material and thickness should be considered. Therefore, it is possible to design a tray cup pad depending on the packaging material used by applying appropriate design parameters. The static and dynamic characteristics of the materials used for packaging of pears were analyzed by using the FEM (finite element Method) simulation technique to derive the optimal design parameters. And by applying the appropriate design parameters considering the quantity of fruit and distribution environment, it is possible to design an appropriate fruit tray cup pad. In this study, as a result of simulating the contact stresses between the fruit and the tray cup for the PP, PE, and PS materials used in the fruit tray cup, the material with the lowest contact stress was PP and the value was found to be 398 Pa. The contact displacement between fruit and tray cup using this material was about 0.0463 mm, which was the lowest value compared with other materials. Also the resonance frequency band of tray cup made of PP material was below 36.81 Hz, and the strain energy was below 12.20 J. The resonant frequency band of the pear is more than 80 Hz and it could be applied to all the tray cup materials as compared with the resonance band of 38.81 Hz or less which is the resonance band of all tray cup pads for packaging. Finally, PP is the most suitable material for the tray cup pad.