• 한국임상수의학회지
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• 제30권5호
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• pp.366-370
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• 2013

7개월령 암컷 포메라니안견이 오른쪽 후지 파행 증상으로 내원하였다. 내원시 신체 검사에서 오른쪽 대퇴 관절을 신장하였을 때 통증을 호소하였고 일반 방사선 사진에서 오른쪽 대퇴골두에 미약한 방사선 투과성 병변과 오른쪽 대퇴관절 공간의 확장을 확인하였다. 14일 후 일반 방사선 사진에서 오른쪽 대퇴골두 골단의 변위를 확인하였고 컴퓨터단층촬영에서 오른쪽 대퇴골두에 저음영의 병변과 골절선을 확인하였다. 오른쪽 대퇴골두 절제술을 실시하였고 조직학적 검사에서 골두 골간단과 골단의 괴사를 확인하였다. 본 증례는 초기 허혈성 대퇴골두 괴사증이 있는 개의 방사선학적, 컴퓨터단층촬영, 수술적, 조직학적 소견을 기술하였다.

• 치과방사선
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• 제29권1호
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• pp.119-147
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• 1999

The purpose of this study was to investigate the effects of the Co-60 γ irradiation on the osseointegration. 2.0 mm titanium alloy screw implants(Sankin Industry Co. Ltd., Japan) were placed in the tibial metaphysis of the rabbits, bilaterally. The mean length of the implants was 6.0 mm. The right tibia was irradiated with a single dose of 15Gy from 60Co teletherapic machine at 5th postoperative day. The experimental group was irradiated tibia. The control group was non­irradiated tibia. To observe the phase of bone formation, the bone labeling by intramuscular injection of 20mg/Kg of Tetracycline, Calcein, Alizarin red S, was performed. The rabbits were sacrificed on the 1st, 2nd, 4th, 6th, 8th week and the tibia including implants were taken, and then the specimens were examined by the microradiography, light microscopy, and fluorescent microscopy. The obtained results were as follows: 1. There were connective tissue between bone and titanium at 1st week, in both group. Especially, the many empty lacunae without nucleus and obscure cytoplasm in experimental group, were observed. 2. The osteons were observed at 4th week in control group, and at 6th week in experimental group. The bone formation in experimental group was retarded as compared to the control group. 3. In fluorescent microscopy, bone labelling band was observed as linear, arc or concentric shape. Occasionary interrupted labelling band was observed, which is demonstrated bone remodeling. 4. In microradiographic examination, the radiolucent image was found between bone and implant with widening of bone marrow spaces as compared to the control group.

• The Journal of Advanced Prosthodontics
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• 제6권6호
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• pp.505-511
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• 2014

PURPOSE. The purpose of this study was to assess the effect of systemically administered oxytocin (OT) on the implant-bone interface by using histomorphometric analysis and the removal torque test. MATERIALS AND METHODS. A total of 10 adult, New Zealand white, female rabbits were used in this experiment. We placed 2 implants (CSM; CSM Implant, Daegu, South Korea) in each distal femoral metaphysis on both the right and left sides; the implants on both sides were placed 10 mm apart. In each rabbit, 1 implant was prepared for histomorphometric analysis and the other 3 were prepared for the removal torque test (RT). The animals received intramuscular injections of either saline (control group; 0.15 M NaCl) or OT (experimental group; $200{\mu}g/rabbit$). The injections were initiated on Day 3 following the implant surgery and were continued for 4 subsequent weeks; the injections were administered twice per day (at a 12-h interval), for 2 days per week. RESULTS. While no statistically significant difference was observed between the two groups (P=.787), the control group had stronger removal torque values. The serum OT concentration (ELISA value) was higher in the OT-treated group, although no statistically significant difference was found. Further, the histomorphometric parameter (bone-to-implant contact [BIC], inter-thread bone, and peri-implant bone) values were higher in the experimental group, but the differences were not significant. CONCLUSION. We postulate that OT supplementation via intramuscular injection weakly contributes to the bone response at the implant-bone interface in rabbits. Therefore, higher concentrations or more frequent administration of OT may be required for a greater bone response to the implant. Further studies analyzing these aspects are needed.

• 한국임상수의학회지
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• 제27권1호
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• pp.117-120
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• 2010

A 5-years-old 3.7 kg intact female Pomeranian dog was presented with the history of swelling and pain in the distal part of the right forelimb. The swollen lesion was firm as bony material on palpation. On radiographic examination, there was a well-marginated, radiolucent, and expansile bone lesion in the distal metaphysis of the right ulna. Because of very narrow zone of transition, well-defined margins and absence of any periosteal reactivity, benign bone cyst was strongly suspected. The lesion was removed by en bloc resection and packed the space with $Gelfoam^{(R)}$ and aneurysmal bone cyst was finally diagnosed according to histopathological examination. Normal gait was showed on postoperative day 9 and there have been no pain and complication for 1 year since then.

• 대한골관절종양학회지
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• 제20권2호
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• pp.89-93
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• 2014

투명세포연골육종은 매우 드문 골종양으로 장골의 골단이나 골간단에 발생한다. 많은 연구에서 대퇴골의 근위부를 가장 흔하게 발생하는 부위로 보고하였고, 상완골의 근위부가 그 다음으로많이 보고되었다. 조직학적으로 이 종류의 종양 세포들은 투명한 세포질과 뚜렷한 세포질막과 함께 중심성으로 위치하는 둥근 핵소체를 가지고 있다. 일반적으로 투명세포연골육종은 고식적인 연골육종과 혼동되지 않는다. 하지만, 방사선학적으로 장골의 간부에 발생한 경우 진단이 어려우며, 이전 문헌을 통하여 단 3례만이 보고된 바 있다. 저자들은 이전에 보고된 바 없는 42세 남자 환자의 경골 간부에서 발생된 투명세포연골육종을 보고하고자 한다.

• Journal of Yeungnam Medical Science
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• 제36권1호
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• pp.43-49
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• 2019

Background: In the osseointegration of dental implants, the implant surface properties have been reported to be some of the most important critical factors. The effect of implant's surfaces created by resorbable blast media (RBM) followed by laser ablation on bone tissue reactions was examined using the removal torque test and histomorphometric analysis. Methods: Two types of dental implants, RBM-laser implants (experimental group) and RBM implants (control group) (CSM implant system, Daegu, Korea; L=6 mm, diameter=3.75 mm) were placed into the right and left distal femoral metaphysis of 17 adult rabbits. Six weeks after placement, removal torque was measured and histomorphometric analysis was performed. Results: The mean removal torque was $24.0{\pm}10.2Ncm$ and $46.6{\pm}16.4Ncm$ for the control and test specimens, respectively. The experimental RBM-laser implants had significantly higher removal torque values than the control RBM implants (p=0.013). The mean values of total and cortical bone to implant contact (BIC) were respectively $46.3{\pm}10.8%$ and $65.3{\pm}12.5%$ for the experimental group, and $41.9{\pm}18.5%$ and $57.6{\pm}10.6%$ for the control group. The experimental RBM-laser implants showed a higher degree of total and cortical BIC compared with RBM implants, but there was no statistical significance (p=0.482, 0.225). Conclusion: The removal torque and BIC of the test group were higher than those of the control group. In this study, the surface treatment created by RBM treatment followed by laser ablation appears to have a potential in improving bone tissue reactions of dental implants.

• 생약학회지
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• 제51권4호
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• pp.332-339
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• 2020

Lentinus edodes (LE) is the first medicinal macrofungus to enter the realm of modern biotechnology. Lentinus edodes is well-known to have anti-tumor, anti-inflammatory, and immunomodulatory effects. In this study, osteoporosis was induced by ovariectomy in female rats, and the prevention and treatment efficacy of the climacteric disease the postmenopausal type I pattern was examined using the experimental substance. Female rats were either sham-operated (sham; n = 5) or surgically ovariectomized (OVX; five animals per group) and then administered to OVX control, raloxifene hydrochloride 1 mg/kg/day, or LE (20 and 200 mg/kg/day) for 12 weeks. LE treatment suppressed the ovariectomy-induced reduction of bone mineral density in the entire tibia as well as its metaphysis with a decrease of serum osteocalcin and interleukin-6 levels. In addition, LE is suggested to elevate the serum levels of progesterone hormones and prevent bone loss in ovariectomized rats. In conclusion, LE 200 mg/kg/day may have inhibitory effects on osteoporosis in OVX rats.

• 대한치과교정학회지
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• 제36권5호
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• pp.324-330
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• 2006

Sandblasted large grit, acid etched(SLA)표면처리 된 교정용 미니 임플랜트와 평활면을 가진 교정용 미니 임플랜트 사이에 제거회전력과 조직학적 소견을 통해 표면처리된 교정용 임플랜트의 임상적 가능성에 대하여 알아보고자 하였다. 실험재료로는 길이가 9.5 mm, 외경이 1.8 mm인 custom made, screw shaped, titanium implants가 사용되었다. 미니 임플랜트는 두개의 군으로 분류되었는데 SLA군은 20개의 SLA 표면처리된 미니 임플랜트이었고, 평활면군은 크기와 형태가 같지만 SLA처리공정이 생략되어 제작된 20개의 미니 임플랜트로 구성되었다. 이들은 10마리 가토의 경골에 식립되었다. 각각의 가토의 우측 경골에는 SLA군의 미니 임플랜트 2개가 식립되었고, 좌측 경골에는 평활면군의 미니 임플랜트 2개가 식립되었다. 각 군에는 식립 직후 Ni-Ti coil spring에 의해 약 150 g의 지속적인 견인력이 주어졌다. 식립 6주 후에 10마리의 가토를 희생하였고, 안정된 상태에서 Ni-Ti coil spring을 제거하였으며 digital torque gauge를 이용하여 제거 회전력을 측정하였다. 식립 6주 후에 SLA군의 경우 (8.29 Ncm) 평활면군 (3.34 Ncm)에 비해 더 높은 평균 제거회전력을 나타내었고 조직학적 소견에서도 screw 하방에서의 신생골 형성이 관찰되었다. SLA 표면처리된 미니 임플랜트는 평활면 미니 임플랜트에 비해 좀 더 강한 교정력에 저항할 수 있을 것으로 예상되었다.

• 대한치과교정학회지
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• 제38권5호
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• pp.328-336
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• 2008

본 연구에서는 교정 치료 시 골내 고정원으로 사용되는 교정용 임플랜트의 표면처리 여부가 골유착능에 있어서 어떠한 효과를 보이는지 제거회전력의 측정을 통해 알아보고자 하였으며, 그에 따른 교정력 적용의 확장과 임상적 의의를 알아보고자 하였다. 실험군은 분사처리 후 산부식(Sand-blasted Large grit, and Acid etched, SLA) 표면 처리된 교정용 미니 임플랜트인 C-implant (Cimplant, Seoul, Korea)를 사용하였으며 대조군은 같은 디자인이지만 표면 처리를 하지 않은 평활면 C-implant를 사용하였다. 실험군과 대조군을 각각 2개씩 11마리의 가토 경골에 식립하였고 식립 후 6주에 가토를 희생시켜 제거회전력을 측정하여 t-test를 통하여 두 군의 제거회전력 차이의 통계적 유의성을 알아보았으며 조직표본을 만들어 조직소견을 관찰하였다. 실험결과 제거회전력은 SLA 처리한 C-implant 군이 평활면 C-implant 군보다 통계적으로 유의성 있게 높은 결과를 보였다 (p < 0.05). 평활면 C-implant 군의 평균 제거회전력 값은 4.614 Ncm이고, SLA C-implant 군의 평균 제거회전력 값은 6.286 Ncm로, SLA 군이 평활면 군보다 73% 더 높은 제거회전력에 대한 저항성을 나타내었다. 이상의 연구 결과에서 SLA표면처리가 C-implant의 골유착능을 증가시켰음을 알 수 있었다. 따라서 표면 처리된 교정용 미니 임플랜트는 기존의 임플랜트에 비해 좀 더 강한 힘에 저항할 수 있으며 탈락률을 낮출 수 있을 것으로 생각된다.

• 대한치과보철학회지
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• 제42권5호
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• pp.556-571
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• 2004

Statement of problem: Surface texture of the implant is one of the important factors of the implant success, especially in the immediate implant loading. Many methods of the surface treatment of implant have developed and introduced. Purpose : This study was to evaluate the effects of the Ca-P coating implant crystallized the hydroxyapatite on the surface by the removal torque test and the histomorphometric analysis in vivo. Material and methods: 135 screw type implants, 4.0mm in length and 3.75mm in diameter were used in this study. Implants were divided into 3 groups and treated in the different mothods. Group I was not treated, Group II was treated in the SLA method, and Group III was treated in the Ca-P coating with the anodizing method and the hydroxyapatite was crystallized on the surface with the hydrothermal treatment. Firstly, the surface roughness of each group was measured, 45 rabbits were used in this experiment. Two implants were inserted on right tibial metaphysis and one implant was inserted on left side with the alternating order. After the healing periods of 3, 5, and 12 weeks, the rabbits were sacrificed to evaluate the osseointergration by the removal torque test and the histomorphometric analysis. Results : 1. In the analysis for the surface roughness, Group II showed the highest roughness. And Group III showed higher secondly. There was a significant difference one another statistically 2. In the removal torque test, Group III and II were significantly higher than Group I. There was no statistical difference between Group III and Group II. 3. For all Groups, the removal torque values at 12th week were significantly higher than at 3rd and 5th week. 4. In histomorphometric analysis, the bone implant contact rates of Group III and II were higher than that of Group I at 3rd and 5th week. There was a significant difference at 5th week. 5. In histomorphometric analysis, the bone implant contact rate of Group III and II increased from 3rd week to 5th week, but decreased at 12th week. In Group I, the contact rate at 12th week was significantly higher than at 3rd week and 5th week.