• Title/Summary/Keyword: Metabolism.

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Goiter Frequency Is More Strongly Associated with Gastric Adenocarcinoma than Urine Iodine Level

  • Tabaeizadeh, Mohammad;Haghpanah, Vahid;Keshtkar, Abbasali;Semnani, Shahryar;Roshandel, Gholamreza;Adabi, Khadijeh;Heshmat, Ramin;Rohani, Davood;Kia, Alireza;Hatami, Ehsan;Jahangirrad, Ataollah;Nabizadeh, Ramin;Larijani, Bagher
    • Journal of Gastric Cancer
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    • v.13 no.2
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    • pp.106-110
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    • 2013
  • Purpose: We designed our study to evaluate the hypothesis that gastric cancer is correlated with iodine deficiency or thyroid dysfunction. Materials and Methods: We investigated the total body iodine reserve, thyroid function status and autoimmune disorder in 40 recently diagnosed gastric adenocarcinoma cases versus 80 healthy controls. The participants came from a region with high gastric cancer rate but sufficient iodine supply due to salt iodination. The investigation included urine iodine level, thyroid gland clinical and ultrasonographic examination, and thyroid function tests. Results: Goiter was detected more frequently in the case group (P=0.001); such a finding, however, was not true for lower than normal urine iodine levels. The free T3 mean level was significantly lower in the case group compared to the control group (P=0.005). Conclusions: The higher prevalence of goiter rather than low levels of urinary iodine in gastric adenocarcinoma cases suggests that goiter, perhaps due to protracted but currently adjusted iodine deficiency, is more likely to be associated with gastric adenocarcinoma compared to the existing iodine deficiency itself.

형질전환 벼에서 Cyanobacterial Sucrose-Phosphate Synthase 유전자의 발현

  • Sang-Kyu Lee;Soo-Jung Lee;Na-Yeon Ryoo;Jang-Wook Lee;Seok-Yoon Yoon;Woon-Chul Shin;Se-Ho Ko;Deok Chun Yang;Youn-Hyung Lee
    • Proceedings of the Plant Resources Society of Korea Conference
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    • 2003.04a
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    • pp.126-126
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    • 2003
  • Sucrose-phosphate synthase (SPS) is a key regulatory enzyme in sucrose synthesis. To investigate the role of SPS in carbon partitioning, we produced transgenic rice plants overexpressing a cyanobacterial SPS from Synechocystis sp. PCC 6803. The gene was expressed under the control of the maize Ubil promoter in transgenic plants. Southern and Northern blot analyses confirmed the integration and the expression of the transgene in four transgenic rice lines. All of the four transgenic! lines analyzed showed abnormal vegetative and reproductive developments. Analysis of SPS activities and primary metabolites in the transgenic rice plants will be presented.

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Long-term Observation of Gastric Adenocarcinoma of Fundic Gland Mucosa Type before and after Helicobacter pylori Eradication: a Case Report

  • Takahashi, Keitaro;Ueno, Nobuhiro;Sasaki, Takahiro;Kobayashi, Yu;Sugiyama, Yuya;Murakami, Yuki;Kunogi, Takehito;Ando, Katsuyoshi;Kashima, Shin;Moriichi, Kentaro;Tanabe, Hiroki;Kamikokura, Yuki;Yuzawa, Sayaka;Tanino, Mishie;Okumura, Toshikatsu;Fujiya, Mikihiro
    • Journal of Gastric Cancer
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    • v.21 no.1
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    • pp.103-109
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    • 2021
  • Gastric adenocarcinoma of the fundic gland mucosa type (GA-FGM) was proposed as a new variant of gastric adenocarcinoma of the fundic gland type (GA-FG). However, at present, the influence of Helicobacter pylori and the speed of progression and degree of malignancy in GA-FGM remain unclear. Herein, we report the first case of intramucosal GA-FGM that was endoscopically observed before and after H. pylori eradication over 15 years. The lesion showed the same tumor size with no submucosal invasion and a low MIB-1 labeling index 15 years after its detection using endoscopy. The endoscopic morphology changed from 0-IIa before H. pylori eradication to 0-IIa+IIc and then 0-I after H. pylori eradication. These findings suggest that the unaltered tumor size reflects low-grade malignancy and slow growth, and that the endoscopic morphology is influenced by H. pylori eradication.