• Biotechnology and Bioprocess Engineering:BBE
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• 제10권5호
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• pp.462-469
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• 2005

A top-down approach is known to be a useful and effective technique for the design and analysis of metabolic systems. In this Study, we have constructed a grouped metabolic network for Lactococcus lactis under aerobic conditions using grouped enzyme kinetics. To test the usefulness of grouping work, a non-grouped system and grouped systems were compared quantitatively with each other. Here, grouped Systems were designed as two groups according to the extent of grouping. The overall simulated flux values in grouped and non-grouped models had pretty similar distribution trends, but the details on flux ratio at the pyruvate branch point showed a little difference. This result indicates that our grouping technique can be used as a good model for complicated metabolic networks, however, for detailed analysis of metabolic network, a more robust mechanism Should be considered. In addition to the data for the pyruvate branch point analysis, Some major flux control coefficients were obtained in this research.

• 제어로봇시스템학회논문지
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• 제11권10호
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• pp.823-829
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• 2005

We have newly constructed an in silico model of fermentative metabolism for Lactococcus lactis in order to analyze the characteristics of metabolite flux for dynamic network. A rigorous mathematical model for metabolic flux has been developed and simulation researches have been performed by using GEPASI program. In this simulation task, we were able to predict the whole flux distribution trend for lactate metabolism and analyze the flux ratio on the pyruvate branch point by using metabolic flux analysis(MFA). And we have studied flux control coefficients of key reaction steps in the model by using metabolic control analysis(MCA). The role of pyruvate branch seems to be essential for the secretion of lactate and other organic byproducts. Then we have made an effort to elucidate its metabolic regulation characteristics and key reaction steps, and find an optimal condition for the production of lactate.

• 한국안광학회지
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• 제14권3호
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• pp.103-108
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• 2009

목적: 백내장에 대사증후군 및 그 구성요소가 어떠한 영향을 미치는지 알아보고자 본 연구를 수행하였다. 방법:2005, 2007년의 국민건강영양조사 자료를 이용하여 대사증후군 및 구성요소와 백내장과의 관계를 분석하였다. 이를 위해 본 연구에서는, 60세 이상의 성인 2,120 명을 대상으로 대사증후군 이상인자의 수(${\leq}$1, 2, 3, ${\geq}$4) 에 따른 백내장 발생의 위험도(Odds ratio: OR)를 살펴보고, 대사증후군 관련치료제가 백내장에 미치는 영향 또한 다중 로지스틱 회귀분석으로 분석하였다. 결과: 대사증후군의 구성요소를 하나도 가지지 않은 대상자를 기준으로 하고, 성, 연령, 생활습관변수 및 사회경제적 변수를 보정했을 때 보유하고 있는 대사증후군의 구성요소가 늘어날수록 백내장의 위험도는 더욱 커지는 경향을 보였다(p for trend < 0.0001). 또한, 대사증후군 요소 중 혈압(OR(95% Confidence Interval): 1.32(1.05,1.65))과 공복혈당(1.35(1.09,1.67))에 이상이 있는 경우는 성과 연령을 보정한 후에도 백내장의 위험을 유의하게 증가시키는 것으로 나타났다. 그 중 공복혈당장애의 경우는 앞서 보정한 변수에 사회경제적 변수를 함께 보정하여도 백내장 발생에 유의미한 위험도(1.35(1.09,1.67))를 나타내었다. 대사증후군이 있는 경우에도 동일한 보정 후에 백내장에 대한 유의한 위험도(1.26(1.01,1.58))를 보였다. 마지막으로 높은 혈압이 있는 대상자들을 대상으로 시행된 분석에서, 고혈압 치료제의 경우 백내장의 위험도(1.49(1.14,1.96))를 증가시키는 것으로 나타났다. 결론: 대사증후군 및 그 구성요소는 백내장 발생의 위험을 높이는 것으로 확인되었고, 고혈압 치료제의 경우도 백내장의 위험도를 높이는 것으로 추정된다.

• 한국보건간호학회지
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• 제33권1호
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• pp.20-32
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• 2019

Objectives: This study identified biopsychosocial factors associated with metabolic syndrome among Korean men and women aged over 40 years. Methods: Secondary data from the 2010-2016 Korean National Health and Nutrition Examination Survey were used for this study. Based on the biopsychosocial model, psychosocial factors (stress, depression, smoking, binge alcohol consumption, physical activity) were assessed with control of biomedical (age, body mass index, family history of hypertension, dyslipidemia, type 2 diabetes mellitus, and cardiovascular disease) and biosocial factors (educational level and economic status). Data from 8,624 men and 7,321 women were analyzed by logistic regression analysis using a complex sample procedure. Results: Among men, current or past smoking habits (Adjusted Odds Ratio [AOR]: 1.349; 95% Confidence Interval [CI]: 1.155-1.575, p<.001) and binge alcohol consumption (AOR: 1.570, CI: 1.389-1.774, p<.001) were associated with metabolic syndrome. In addition, moderate (AOR: 1.205, CI: 1.038-1.400, p=.014) and low levels of physical activity (AOR: 1.296, CI: 1.109-1.514, p=.001) were associated with metabolic syndrome. Among women, low level of physical activity (AOR: 1.276, CI: 1.017-1.602, p=.036) was associated with metabolic syndrome. Conclusion: Gender specific interventions such as encouraging physical activity and prevention of smoking and excessive alcohol drinking are important to prevention of metabolic syndrome.

• 동아시아식생활학회지
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• 제23권3호
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• pp.282-296
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• 2013

The study classified 83 obese adults by constitution and had them follow a strict diet according to their constitution in order to see if the Yin-Yang method would be effective on the metabolic syndrome, which is one of the main causes of death in Korea. Overall, the application of both Yin and Yang methods improved the following factors: weight, body fat percentage, systolic blood pressure, diastolic pressure, neutral fats and total cholesterol. In particular, the Yin constitution group of men showed more improvements than the Yang constitution group. Furthermore, waist circumference and the prevalence rate of systolic blood pressure, diastolic pressure, total cholesterol and metabolic syndrome were decreased noticeably. Total energy intake was increased in both men and women after the constitutional diet, along with the increase of nutrient intake, such as dietary fiber, vitamins and minerals, among others. Among various nutrients, vitamin A, vitamin C, thiamine, vitamin B6, folic acid, calcium, phosphorus, potassium, magnesium and iron intake were increased noticeably after the constitutional diet. In addition, subjects' intake of all nutrients, except for magnesium, satisfied the nutrition intake standards. Further, the nutrients adequacy ratio (NAR) and the mean adequacy ratio (MAR) improved for both men and women. The intake of potatoes, starch, greens and mushrooms increased noticeably, whereas the intake of meat, dairy, drinks and alcohol decreased after the constitutional diet. For the Yin constitution, the intake of Yin foods noticeably decreased, where as the intake of Yang foods decreased for the Yang constitution. In conclusion, the constitutional diet effectively improves the metabolic syndrome. Among many nutrients, the intake of dietary fiber, vitamins A, C and E, potassium and magnesium is positively associated with the improvement of metabolic syndrome biomarkers.

• Clinical and Experimental Reproductive Medicine
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• 제50권3호
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• pp.206-212
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• 2023

Objective: The aim of the present study was to evaluate the associations between hematologic parameters related to systemic inflammation and insulin resistance-associated metabolic parameters in women with polycystic ovary syndrome (PCOS). Methods: Eighty-two women between the ages of 18 and 35 years who were diagnosed with PCOS were included in this study. A 2-hour 75-g oral glucose tolerance test (OGTT) was administered to all study participants; fasting and postprandial glucose and insulin levels were measured simultaneously during the 2-hour OGTT. Hematologic parameters were derived from a standard complete blood count and a differential count of fasting-state blood samples. The correlations between hematologic parameters and insulin resistance-associated clinical and metabolic parameters were evaluated using the Spearman rank correlation and partial correlation coefficients. Hematologic parameters related to systemic inflammation were compared between the two groups, categorized by the presence or absence of insulin resistance. Results: Significant differences in the absolute neutrophil count, absolute monocyte count, platelet count, and neutrophil-lymphocyte ratio were found between the insulin-resistant group and insulin-nonresistant group. Correlation analysis found that all hematological parameters, except for the platelet-lymphocyte ratio, were associated with at least one insulin resistance-associated metabolic parameter. However, these significant correlations between hematological and metabolic parameters were attenuated after controlling for the effects of other covariates using partial correlation analysis. Conclusion: The association between hematologic parameters indicative of systemic inflammation and insulin resistance-associated metabolic parameters seems to be strongly influenced by other anthropometric covariates in women with PCOS.

• 대한임상검사과학회지
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• 제50권1호
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• pp.44-53
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• 2018

WHtR과 ABSI는 기존 비만지표의 단점을 보완하기 위해 개발된 복부비만을 반영한 지표이다. 이 연구는 성인남녀를 대상으로 ABSI와 WHtR의 인슐린저항성과 대사증후군에 대한 예측능력을 허리둘레, WHR과 비교하여 알아보고자 하였다. 이 연구는 횡단면 조사에 기초하여 2017년 1월부터 2017년 9월까지 경기지역 일개 종합병원에서 건강진단을 받은 20세 이상 4,395명을 대상으로 하였다. 대사증후군은 AHA/NHLBI (American Heart Association/National Heart, Lung, and Blood Institute)의 진단기준에 따라 정의하였다. 인슐린저항성은 HOMA-IR값이 3.0 이상인 경우 인슐린저항성으로 판정하였다. WHtR 및 ABSI와 대사적 위험요인간에 상관계수를 비교한 결과 남성과 여성 모두에서 ABSI보다 WHtR과 대사적 위험요인간의 상관성이 더 높았다. 대사증후군을 예측하기 위한 WHtR의 AUC 값은 0.849, ABSI의 AUC 값은 0.676 이었다(각각 p<0.001). 인슐린저항성을 예측하기 위한 WHtR의 AUC 값은 0.818, ABSI의 AUC 값은 0.641 이었다(각각 p<0.001). 결론적으로, 한국인을 대상으로 ABSI가 허리둘레, WHR, WHtR 지표보다 인슐린저항성과 대사증후군에 대한 예측력이 낮은 지표였으며, WHtR은 인슐린저항성 및 대사증후군 위험 예측력이 가장 높은 지표임을 확인하였다.

• Journal of Preventive Medicine and Public Health
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• 제45권2호
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• pp.98-104
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• 2012

Objectives: A positive association between serum albumin levels and metabolic syndrome has been reported in observation studies, but it has not been established in the Korean population. The purpose of this study was to evaluate the association between serum albumin levels and the presence of metabolic syndrome among a sample of apparently healthy Korean adults. Methods: This cross-sectional study analyzed data of 3189 community-dwelling people (1189 men and 2000 women) who were aged 40 to 87 years and were living in a rural area in Korea. Serum albumin levels were classified into quartile groups for each sex. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III guidelines with an adjusted waist circumference cut-off value ${\geq}90\;cm$ for men and${\geq}85\;cm$ for women). An independent association between serum albumin levels and metabolic syndrome was assessed by multiple logistic regression analysis. Results: Higher serum albumin levels were associated with increased prevalence of metabolic syndrome. The odds ratio (95% confidence interval) of the prevalence of metabolic syndrome for the highest versus the lowest serum albumin quartiles was 2.81 (1.91 to 4.14) in men and 1.96 (1.52 to 2.52) in women, after adjusting for age, smoking status, alcohol consumption, and physical activity. When each metabolic abnormality was analyzed separately, higher serum albumin levels were significantly associated with hypertriglyceridemia and hyperglycemia in both sexes, and with abdominal obesity in men. Conclusions: These results suggest that higher serum albumin levels are positively associated with an increased risk of metabolic syndrome in Korean adults.

• 치위생과학회지
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• 제20권3호
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• pp.178-186
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• 2020

Background: The purpose of this study was to evaluate the association between metabolic syndrome and periodontal disease in Korean adults. Methods: This study analyzed the screening data of 12,686 adults aged ≥19 years, including demographic characteristics, lifestyle habits, and each component of metabolic syndrome, obtained from the sixth Korea National Health and Nutrition Examination Survey database. Periodontal health status was measured by the community periodontal index. Subjects with three or more risk factors were considered as having metabolic syndrome. The Rao-Scott chi-square test was performed to assess the relationships between demographic characteristics, lifestyle habits, components of metabolic syndrome, and periodontal disease. Logistic regression analysis was performed based on the complex sample to evaluate the relationship between metabolic syndrome and periodontal disease. Results: The prevalence of periodontal disease was higher among the subjects with advancing age, lower average household income and education level, those working in production, residents of eup-myeon areas, in past or current smoker, those with excessive alcohol consumption habit in a week, and reduced brushing frequency and the use of oral care products (p<0.001). Each component of metabolic syndrome was associated with higher prevalence of periodontitis in the subjects with abnormal than in those with normal levels (p<0.001). The prevalence of periodontal disease in subjects with metabolic syndrome was approximately 1.443 times higher than that in normal subjects (odds ratio,1.443; p<0.001). Conclusion: This study confirmed the association between metabolic syndrome and periodontitis in Korean adults, and further studies will be needed to determine the causal relationship between the two conditions.

• 지역사회간호학회지
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• 제29권1호
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• pp.108-119
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• 2018

Purpose: The purpose of this study is to estimate the prevalence of the metabolic syndrome in pre-menopausal housewives and to explore controllable and uncontrollable factors regarding metabolic syndrome. Methods: The study population of this cross-sectional survey was from the Korean Health and Nutrition Examination Survey (KHANES) 2010 through 2015, including the fifth and sixth population-based studies. The criteria for metabolic syndrome include waist circumference, blood pressure, fasting plasma glucose, triglyceride, high-density lipoprotein (HDL) based on Korean Clinical Practice Guideline for Metabolic Syndrome by the Korean Academy of Family Medicine 2015. Results: Among the 2,498 subjects, 247 subjects had metabolic syndrome and the prevalence was estimated to be 9.9%. The number of subjects who met the criterion of HDL was 936 (36.2%), which was the most prevalent among the criteria for metabolic syndrome. Statistically significant (p<.05) factors include age, livinghood benefit group, perceived health status, obesity, family history of DM, sleeping time, awareness of stress,leukocyte, and erythrocyte count. The odds ratio of obesity in the BMI ${\geq}25$ group was 12.59 times as high as that of the BMI <25 group (p<.001) for metabolic syndrome. Conclusion: The prevalence of metabolic syndrome in pre-menopausal housewives in the survey was not low, and it is necessary to develop and apply comprehensive health habit management programs to improve controllable factors including exercise and food intake.