• 한국임상수의학회지
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• 제30권1호
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• pp.57-60
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• 2013

개에서 포도중독에 의한 신부전 치료결과에 대한 임상적 분석을 위하여 205-2008년 기간 중 강원대학교 수의과대학 동물병원에 내원한 환자의 의료기록부를 분석하였다. 총 11두 (암컷 8두) 중 4두는 완전히 회복하였고, 3두는 폐사, 4두는 안락사로 처리되었다. 1두를 제외한 모든 환자는 포도를 섭취하였으나 정확한 섭취량은 알 수 없었다. 환자의 평균 연령은 5.3세 (범위 0.2-11.3세), 체중은 4.1 kg (범위 1.4-13 kg)였으며, 평균 입원기간은 7.1일 (범위 2-22일)로 나타났다. 모든 환자에서 구토와 식욕부진 증상을 보였으며, 일부 환자는 설사 (4두), 핍뇨 (5두), 무뇨 (4두) 소견을 보였다. 모든 환자에서 혈청 phosphorous, creatinine, BUN 농도가 증가된 소견을 보였으며, 고칼슘혈증 2두, 저칼슘혈증 2두, 나머지 7두는 정상소견이었다. 혈청 농도가 증가한 항목은 amylase 8두, ALP 7두, ALT 5두였으며, 혈액 가스 분석에서 8두는 대사성산증을 보였다. 경미하거나 중등도의 빈혈 소견이 5두에서 관찰되었으며, 회복한 환자와 비교할 때 폐사축의 경우 혈소판과 림프구 수가 상대적으로 낮았다.

• 환경생물
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• 제24권2호
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• pp.172-178
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• 2006

골재채취가 수층의 세균군집구조에 미치는 영향을 알아보기 위해 낙동강 중류, 골재채취가 이루어 지지 않은 수역인 구미대교와 장기간에 걸쳐 연속적으로 골재채취가 행해지는 지역인 성주군 소학리 (성주대교 인근)에서 $\alpha\;\beta\;\gamma-subclass$ proteobacteria, Cytophaga-Flavobacterium (CF) group 세균군과 황산염화원세균을 FISH법으로 정량분석하였다. 아울러 수온, pH, EC, 엽록소-$\alpha$ 양 등의 이화학적인 환경요인도 측정하였다. DAPI로 염색된 세균수로 측정한 총세균수의 경우, 두 정점간의 괄목할 만한 양적인 차이는 없었으나 그 시간차에 따른 변동이 골재채취 수역에서 더욱 심했다. 또한 높은 엽록소-$\alpha$ 양을 나타낸 골재채취 수역에서 검출한 CF group 세균군과 황산염환원세균이 총세균수에서 차지하는 비율이 비골재채취 수역에 비해 높았다. 이같은 결과는 저니질이 수층으로 재유입되었기 때문으로 판단된다. 그러나 본 연구에서 검출한 세균군이 총세균수에서 차지하는 비율을 합하면 그 비율은 골재채취 수역보다 비골재채취 수역에서 더 높았다. FISH법에 의한 세균의 검출가능성이 해당세균의 물질대사능과 연관이 있으므로 골재채취 수역에서의 낮은 세균 검출율은 골재채취가 세균의 물질순환에서의 역기능을 초래하고 이는 또한 연차적으로 그들의 먹이연쇄에 부정적인 영향을 미칠 가능성을 시사하는 것이다.

• Clinical and Experimental Pediatrics
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• 제45권3호
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• pp.413-417
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• 2002

증후군은 원위세뇨관 Na-Cl 공동운반체 유전자 이상으로 발생하는 상염색체 열성 유전질환으로, 저칼륨혈증, 저마그네슘혈증, 대사성 알칼리증, 그리고 저칼슘뇨증 등의 임상적 특징을 보이는 질환이다. 저자들은 Bartter 증후군과의 감별진단과 Gitelman 증후군의 확진을 위해 임상적으로 Gitelman 증후군이 의심되는 두명의 환아에서 신장청소검사를 시행하였다. 각각의 환아는 밤사이 금식을 시킨 후 물 20 mL/kg를 30분에 걸쳐 경구 투여하였고, 곧 이어 half saline을 정맥을 통해 분당 5 mL의 속도로 투여하기 시작하였다. 소변양이 분당 10 mL에 도달했을 때의 검체로 삼투질제거율, 유리수분제거율, 염소제거율, 원위분획염소재흡수율을 계산하였다. 그 후에 첫째 날은 furosemide, 둘째 날은 hydrochlorothiazide를 각각 투여하고 나서 같은 신장청소검사를 시행하였다. 이뇨제를 투여하기 전 원위분획염소재흡수율은 각각 73%, 75%로 정상범위에서 약간 감소되어 있었다. furosemide를 투여한 후 삼투질제거율은 증가하였고 유리수분제거율은 감소하였다. 염소제거율은 10배 이상 증가하였으며, 원위분획염소재흡수율은 현저한 감소를 보였다. Thiazide를 투여한 후에는 위와 같은 청소율의 변화들을 관찰할 수 없었다. 신장청소 검사의 소견은 본 연구의 환아들이 헨레의 고리 상행각의 이상보다는 원위세뇨관 Na-Cl 공동운반체의 이상이 있음을 보여주고 있어 Gitelman 증후군의 병태 생리와 잘 일치한다고 사료된다.

• Journal of Korean Neurosurgical Society
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• 제63권5호
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• pp.607-613
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• 2020

Objective : Spontaneous intracranial hemorrhage is a life-threatening disease, and non-lesional spontaneous intraparenchymal hemorrhage (nIPH) and aneurysmal subarachnoid hemorrhage (aSAH) are the leading causes of spontaneous intracranial hemorrhage. Only a few studies have assessed the association between prior physical activity or triggering events and the occurrence of nIPH or aSAH. The purpose of this study is to investigate the role of specific physical activities and triggering events in the occurrence of nIPH and aSAH. Methods : We retrospectively reviewed 824 consecutive patients with spontaneous intracranial hemorrhage between January 2010 and December 2018. Among the 824 patients, 132 patients were excluded due to insufficient clinical data and other etiologies of spontaneous intracranial hemorrhage. The medical records of 692 patients were reviewed, and the following parameters were assessed : age, sex, history of hypertension, smoking, history of stroke, use of antiplatelet or anticoagulation agents, season and time of onset, physical activities performed according to the metabolic equivalents, and triggering event at onset. Events that suddenly raised the blood pressure such as sudden postural changes, defecation or urination, sexual intercourse, unexpected emotional stress, sauna bath, and medical examination were defined as triggering events. These clinical data were compared between the nIPH and aSAH groups. Results : Both nIPH and aSAH most commonly occurred during non-strenuous physical activity, and there was no significant difference between the two groups (p=0.524). Thirty-two patients (6.6%) in the nIPH group and 39 patients (8.1%) in the aSAH group experienced triggering events at onset, and there was a significant difference between the two groups (p=0.034). The most common triggering events were defecation or urination in both groups. Conclusion : Specific physical activity dose no affect the incidence of nIPH and aSAH. The relationship between the occurrence of intracranial hemorrhage and triggering events is higher in aSAH than nIPH.

• Journal of Nutrition and Health
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• 제44권4호
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• pp.292-302
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• 2011

본 연구는 직장인 남성 근로자를 대상으로 12주 심혈관질환예방 중재프로그램이 신체계측, 혈중지질 및 아디포사이토카인, 영양소 섭취상태에 어떠한 영향을 미치는지 파악하고자 성인 남성 157명을 대상으로 실시되었다. 중재프로그램 전과 후를 비교 분석한 결과, 체중감량, 혈중지질 농도 및 인슐린 저항성 개선과 아디포사이토카인의 농도가 개선 되는 등 심혈관질환 위험 인자에 바람직한 영향을 미치는 것으로 나타났다. 아디포넥틴은 HDL-콜레스테롤, HOMA-IR과 연관성을 보였고, 렙틴은 허리둘레, 레지스틴은 HDL-콜레스테롤, HbA1c, 열량섭취와 연관성이 있는 것을 확인하였다. 이상의 연구에서처럼 12주 심혈관질환 예방 중재프로그램 수행 후에, 신체계측, 혈중 지질 농도 및 아디포사이토카인 농도가 효과적으로 개선됨을 알 수 있었고, 심혈관질환 위험 인자와 아디포사이토카인과의 연관성을 파악할 수 있었다. 향후에는 직장인 남성 근로자를 대상으로 심혈관질환 예방을 위한 전향적 연구가 이루어져야 할 것이다.

• Asian-Australasian Journal of Animal Sciences
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• 제27권3호
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• pp.357-364
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• 2014

The study evaluated replacement of Egyptian berseem clover (BC, Trifolium alexandrinum) with spent rice straw (SRS) of Pleurotus ostreatus basidiomycete in diets of lactating Baladi goats. Nine lactating homo-parity Baladi goats (average BW $23.8{\pm}0.4$ kg) at 7 d postpartum were used in a triplicate $3{\times}3$ Latin square design with 30 d experimental periods. Goats were fed a basal diet containing 0 (Control), 0.25 (SRS25) and 0.45 (SRS45) (w/w, DM basis) of SRS. The Control diet was berseem clover and concentrate mixture (1:1 DM basis). The SRS45 had lowered total feed intake and forages intake compared to Control. The SRS25 and SRS45 rations had the highest digestibilities of DM (p = 0.0241) and hemicellulose (p = 0.0021) compared to Control which had higher (p<0.01) digestibilities of OM (p = 0.0002) and CP (p = 0.0005) than SRS25 and SRS45. Ruminal pH and microbial protein synthesis were higher (p<0.0001) for SRS25 and SRS45 than Control, which also had the highest (p<0.0001) concentration of TVFA, total proteins, non-protein N, and ammonia-N. All values of serum constituents were within normal ranges. The Control ration had higher serum globulin (p = 0.0148), creatinine (p = 0.0150), glucose (p = 0.0002) and cholesterol (p = 0.0016). Both Control and SRS25 groups had the highest (p<0.05) milk (p = 0.0330) and energy corrected milk (p = 0.0290) yields. Fat content was higher (p = 0.0373) with SRS45 and SRS25 groups compared with Control. Replacement of BC with SRS in goat rations increased milk levels of conjugated linoleic acid and unsaturated fatty acids compared with Control. It was concluded that replacing 50% of Egyptian berseem clover with SRS in goat rations improved their productive performance without marked effects on metabolic indicators health.

• 한국수산과학회지
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• 제28권3호
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• pp.237-246
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• 1995

담수산 징거미새우, Macrobrachium nipponeue의 유생을 수온 $25^{\circ}$, 염분 $7\%o$의 일정한 조건하에서 사육하면서 섭이율, 호흡률 및 성장률을 측정하였으며, 이를 토대로 하여 생물에너지학적 효율을 분석하기 위하여 모든 유생기간 동안 탄소의 흡수 및 분배에 대한 탄소수지를 구명하였다. 생리적, 생화학적 자료로서 시간의 경과에 따른 발생변화의 양상과 섭이율, 성장률 및 호흡률 등을 회귀방정식으로 나타내었다. 일일 섭이율(F)과 비탄소섭이율(F/C)은 대체로 탈피후기에서 최소를 나타내었다. 그리고 성장율(G, G/C)은 탈피주기 동안 감소하는 경향을 나타내었다. 탈피주기 동안 탄소는 초기에 증가하는 경향을 나타내었으며, 질소는 탈피전기까지 꾸준히 증가하는 경향을 나타내었다. 단백질은 탈피전기의 중기에 다소 높은 축적을 보이면서 탈피전기의 말기까지 일정량을 유지하면서 체물질을 구성하는 우점성분으로 일정하게 유지되었다. 유생의 섭이(F), 성장(G), 호흡(R) 및 동화량(A)의 절대값은 탈피주기동안 뚜렷한 변화를 나타내었다. 탈피주기 가운데 탈피전기로 진행하면서, 성장률보다 호흡율이 더 커졌으며, 탈피주기 동안 변화하고 있는 호흡을 대사계수, 즉 호흡이 탄소로 전환되어 이화되고 있는 부분으로 나타내었다. 탈피후기에서 R/G<1, (R1, (R>G)로 변동하였다. 부화후부터 후기 유생단계까지의 누적탄소수지를 보면, 총섭이량은 $491.54{\mu}g\;C/ind$였으며, 동화효율은 $85.3\%$ 호흡율은 $47.7\%$ 그리고 성장율은 $37.6\%$였다. 그리고 총섭이량중 동화되지 않고 소실된 양은 $72.19{\mu}g\;C/ind$로서 $14.6\%$를 차지하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제33권1호
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• pp.53-60
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• 2020

Objective: The current study was carried out to examine the response of different levels of fat and protein in calf starter on nutrient utilisation, nitrogen metabolism, weight gain, blood parameters, and immunity level in pre-ruminant calves. Methods: Twenty four calves (5 days old) were divided into six groups in a 2×3 factorial design, with two levels of fat (10% and 14%) and three levels of protein (18%, 21%, and 24%). The calves were kept in individual pens for 120 days and fed with whole milk (1/10th of body weight) and calf starter ad-libitum. Daily dry matter intake was recorded; whereas body weight was taken on fortnightly basis to calculate average daily gain. During the growth trial blood samples were collected at 30 days interval to estimate blood glucose, albumin, total protein, total leucocyte count, total immunoglobulins and immunoglobulin G levels. A metabolic trial of seven days was carried out to find out the digestibility of different nutrients. Results: The dry matter intake was reduced (p<0.05) with higher fat and protein levels whereas feed conversion efficiency was improved (p<0.05) with higher protein level. Different levels of fat and protein in calf ration did not affect average daily gain in calves. The dry matter, organic matter, and crude protein digestibility were significantly (p<0.01) higher with increased level of protein. The nitrogen retention was also significantly higher (p<0.05) at 24% protein level, similarly the total immunoglobulin was significantly (p<0.05) high in higher protein fed groups, showed better immunity. Conclusion: The present finding suggested that 10% fat and 18% protein level of calf starter could be used in Sahiwal calves for optimum performance in terms of weight gain and immunity.

• Preventive Nutrition and Food Science
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• 제9권1호
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• pp.71-78
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• 2004

Adrenergic receptors play a major role in thermogenesis and lipolysis in brown and visceral adipose tissues, and have been implicated in the pathogenesis of obesity and metabolic disorders. The purpose of this study was to estimate the effects of $\beta$2-adrenergic receptor ($\beta$2AR) and $\beta$3-adrenergic receptor ($\beta$3AR) genotypes on hyperglycemia and obesity in the Korean population. A representative sample consisting of 530 Korean men and women were measured for height, weight, BMI, WHR, obesity index and body composition. The genotypes of $\beta$2AR polymorphism in codon 27 and $\beta$3AR polymorphism in codon 64 were analyzed by the PCR RFLP method. Serum concentrations of fasting glucose, total cholesterol, HDL cholesterol and triglyceride were determined. The frequencies of $\beta$2AR and $\beta$3AR genotype were: both wild type, 62.5% ; only $\beta$2AR variant type, 12.8% ; only $\beta$3AR variant type, 18.8% ; and both variant type, 5.8% ; the frequency of E and R alleles were 0.098 and 0.137, respectively. Among the physiological parameters, fasting glucose level was significantly higher in subjects with both variant type compared with the three other types (p <0.05), Subjects with both variant type had 12%, 12% and 9.3% increases in serum glucose levels compared with wild type, only $\beta$2AR variant type, and only $\beta$3AR variant type, respectively. When logistic regression analysis was conducted to estimate the risk for hyperglycemia, the subjects were selected for fasting blood glucose concentrations of more than 6.105 m㏖/L (110 mg/dL), and the odds ratios were 1.215 (p=0.636) for only $\beta$2AR variant type,1.659 (p=0.089) for only $\beta$3AR variant type, and 3.078 (p=0.011) for both variant type. These results suggest that the interaction of $\beta$2AR and $\beta$3AR variant genotypes has a strong association with increased glucose levels, and might be a significant risk factor for hyperglycemia among Korean subjects.

• Clinical and Experimental Pediatrics
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• 제55권4호
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• pp.121-127
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• 2012

Purpose: Improved survival of patients with childhood acute lymphoblastic leukemia (ALL) has drawn attention to the potential for late consequences of previous treatments among survivors, including metabolic syndrome. In this study, we evaluated changes in 3 parameters, namely, random blood glucose, body mass index (BMI), and Z score for BMI (Z-BMI), in children with ALL during chemotherapy and after completion of treatment. Methods: Patients newly diagnosed with ALL from January, 2005 to December, 2008 at Saint Mary's Hospital, The Catholic University of Korea, who completed treatment with chemotherapy only were included (n=107). Random glucose, BMI, and Z-BMI were recorded at 5 intervals: at diagnosis, before maintenance treatment, at completion of maintenance treatment, and 6 and 12 months after completion of maintenance treatment. Similar analyses were conducted on 2 subcohorts based on ALL risk groups. Results: For random glucose, a paired comparison showed significantly lower levels at 12 months post-treatment compared to those at initial diagnosis ($P$ <0.001) and before maintenance ($P$ <0.001). The Z-BMI score was significantly higher before maintenance than at diagnosis ($P$ <0.001), but decreased significantly at the end of treatment ($P$ <0.001) and remained low at 6 months ($P$ <0.001) and 12 months ($P$ <0.001) post-treatment. Similar results were obtained upon analysis of risk group-based subcohorts. Conclusion: For a cohort of ALL patients treated without allogeneic transplantation or cranial irradiation, decrease in random glucose and Z-BMI after completion of chemotherapy does not indicate future glucose intolerance or obesity.