• 대한임상독성학회지
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• 제2권2호
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• pp.129-132
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• 2004

Ethylene glycol poisoning can cause profound morbidity and is almost universally fatal if untreated. Central nervous system depression, pulmonary edema, and acute oligulic renal failure with crystalluria are among the most commonly encountered complication of ingestion. Ingestion of ethylene glycol may be an important contributor in patients with metabolic acidosis and subsequent renal failure. The diagnosis of ethylene glycol poisoning is based on nonspecific clinical symptoms and signs and indirect and direct laboratory measurement of ethylene glycol. As a result, diagnosis and treatment sometimes can be delayed. We describe 52-year-old man who visited to emergency department with mental change of unknown origin. The patient has high anion gap metabolic acidosis and renal failure due to ingestion of antifreeze that contained ethylene glycol. We used hemodialysis for elimination technique. The patient was discharged with minimal complication.

• 한국콘텐츠학회논문지
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• 제20권10호
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• pp.401-410
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• 2020

본 연구에서는 심혈관계 질환 합병증을 동반하지 않은 국내 본태성 고혈압 환자의 안정시 심박수에 따른 대사증후군 세부요인 변화에 대한 12개월 추적 조사 결과를 확인해 보고자 한다. 2013년부터 국내 25개 대학병원에서 진행되어 온 대규모 전향적 관찰 연구인 KorHR(Korean Hypertension Registry) 자료를 이용하였고 총 951명의 데이터를 R 통계 프로그램을 이용하여 분석하였다. 본 연구결과 초진과 재진 고혈압 환자의 안정시 심박수 그룹에 따라 대사증후군 세부요인의 변화 및 대사증후군 세부요인 증가 위험이 다른 것으로 나타났다. 따라서 초진과 재진 고혈압 환자에 따른 맞춤형 안정시 심박수 조절을 위한 지침 마련과 안정시 심박수 조절을 위한 다양한 중재방안 마련이 필요하다고 생각된다. 이를 통해 대표적인 만성질환인 고혈압에 따른 심혈관계 질환 발생을 예방하여 환자 및 가족의 삶의 질을 향상시킬 뿐만 아니라 보건 의료 분야에서의 효율성을 증대시키는데 기여하고자 한다.

• 지역사회간호학회지
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• 제9권1호
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• pp.128-142
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• 1998

The purpose of this study was to identify the degree of self-efficacy, sick-role behavior and metabolic control in patients with diabetes and to identify the relationships among those variables. The subject of the study were composed of 204 NIDDM patients from 2 hospitals, who were visiting the outpatient clinic in Taegu. Data were collected from Sep. 18th to Oct. 5th, 1996. In data analysis, an SPSS/PC+ program was utilized for descriptives correlation, T-test, and ANOVA. The results are as follows. 1) The mean scores for self-efficacy were 65.74 (range 30.83-90.68), on a 100 point scale. 2) The mean scores for sick-role behavior were 3.36(range 1.80-4.67), on a 5 point scale. 3) The mean score for metabolic control was 7.63 (range 5.0-13.2). 4) Self-efficacy was significantly correlated with sick-role behavior(r=.3614, p<0.01) but there were no significant correlations with self-efficacy and metabolic control (r=-.1045, p>0.01), sick-role behavior and metabolic control (r= - .1288, p>0.01). 5) There were significant differences in self-efficacy according to sex(t=4.47, p=0.000) and education(F=8.27, p=0.000). 6) There were no significant differences in sick -role behavior according to demographic characteristics. 7) There were significant differences in metabolic control according to the duration of diagnosed diabetess(F=4.13, p=0.007) and complication (t=2.47, p=0.014). These results suggest that for improvement in sick-role behavior nursing intervention needs to be directed at promoting self-efficacy.

• Journal of Chest Surgery
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• 제38권3호
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• pp.237-240
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• 2005

Todd 마비는 경련발작 후에 발생하는 일시적인 신경학적 결손으로 국소적 혹은 전신발작 후에 발생 할 수 있는 합병증으로, 명확한 병태생리가 밝혀지지 않았으나 경련발작 후 신경세포의 피로(ex-haustion) 혹은 소실에 의해 초래된다고 알려져 있다. 저자들은 개심술 후 우측 중대뇌동맥 뇌경색과 유사한 임상양상을 보인 Todd 마비 환자를 경험하였기에 문헌고찰과 함께 보고한다.

• 대한핵의학회지
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• 제16권2호
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• pp.97-102
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• 1982

Avascular necrosis of bone has become a well-recognized complication of renal transplantation. While preexisting metabolic bone disease, especially hyperparathyroidism, and metabolic disturbances induced by steroids have been implicated as etiological factors, the pathogenesis is controversial. The diagnosis of avascular necrosis of bone had been based on a history of joint pain and radiographic demonstration of bone necrosis. Recently the bone scan using 99mTc-methylene diphosphonate is helpful in determining the early stage of bone necrosis. We report two cases of avascular necrosis of femur head, of which diagnosis was made by the bone scan using 99mTc-methylene diphosphonate.

• 대한유전성대사질환학회지
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• 제14권1호
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• pp.42-47
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• 2014

Gaucher disease is a multisystemic disorder arising from a deficient activity of the lysosomal enzyme glucocerebrosidase, which leads to accumulation of glycosylceraide and other glycolipids in the regiculoendothelial system. The characteristics of Gaucher disease are anemia, thrombocytopenia, hepatosplenomegaly, and skeletal disease. Enzyme replacement therapy (ERT) has been proven to prevent progressive manifestations of Gaucher disease and effective in improving anemia, thrombocytopenia, bone markers and biomarkers. However, some patient needs still remain unmet because of the inaccessibility of certain sites including brain, bone and various organs. ERT could not Improve the irreversible lesion such as liver fibrosis, hepatopulmonary syndrome, and necrosis or infarction of bone and other organs. Adult patients with Gaucher disease should be screened for longterm complication such as bone disease, pulmonary hypertension, gallstone, and cancer, especially in patients with splenectomy. Parkinsonism and polyneuropathy was also reported among patients with type 1 Gaucher disease, but ERT does not improve neurological function. We need to review the benefits and unmet needs of ERT in Gaucher disease.

• 대한유전성대사질환학회지
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• 제20권1호
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• pp.14-23
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• 2020

고전적 갈락토스 혈증은 한국에서 드물게 발생하는 유전 대사 질환이다. 또한 한국인의 돌연변이 스펙트럼은 코카시안과 비코카시안의 돌연변이 스펙트럼이 다르다. 한국에서 고전적 갈락토스 혈증은 임상적으로 서방국가와 유사하지만 분자적 연구에 따르면 백인, 아프리카인, 미국인, 일본인 및 한국인에게 고유한 돌연변이가 나타났다. 고전적인 갈락토스 혈증은 신생아 스크리닝 검사로 조기 발견하여 식이요법을 할 경우 대사질환으로 인한 합병증이 예방될 수 있다고 생각되어 왔다. 한국의 고전적 갈락토스 혈증의 가장 최근의 사례에서 신생아 시기에 임상 증상이 시작되었다. 식이 치료를 통하여 합병증이 교정되어 정상화 되었다. 추가로 저자들은 25명의 고전적 갈락토스 혈증을 가진 돌연변이의 특징을 리뷰했다.

• 한국생활과학회지
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• 제17권1호
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• pp.159-170
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• 2008

This study was carried out for the prevalence of metabolic syndrome in obese middle school students. The subjects were 104 obese adolescents of 4 middle schools in Namwon city, Jeonbuk. Average age of the subjects was 12.2 years old, BMI of mild obesity group, moderate obesity group and severe obesity group were 24.6kg/m2, 27.5kg/m2, and 31.8 kg/m2, respectively. Prevalence of metabolic syndrome in obese students was 2.9%. And the person who has more than 2 out of 5 symptoms was 22.1%, and more than 1 was 39.4%. The prevalence of each symptoms were abdomen obesity(46.2%), hyper triglyceride(23.1%), high blood pressure(20.2%), high HDLcholesterol(2.9%), but the hyper glycemia had not been found. Nutrient intakes of 3 groups were not significantly different, energy was 1817.9kcal, carbohydrate was 265.7g, protein was 72.2g, and fat was 51.9g. Nutrient adequacy ratio(NAR) of protein, phosphorus, iron, vitamin A, vitamin B1, vitamin B1, niacin, vitamin C was proper, except calcium. Seventy point two percent of the obese students knew 'obesity is a disease', and 49.0% of the subjects didn't know the complication of the obesity. Only 27.9% of the obese adolescents took nutrition education class, but 51.9% of them thought nutrition education was necessary. We suggest that the nation enforce the policy for early detection and treatment of obesity for adolescents. Obese students and their parents should take nutrition education.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제35권5호
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• pp.353-360
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• 2009

Bisphosphonates are compounds widely used in the treatment of various metabolic and malignant bone disease. Recently, an association between bisphosphonate use and a rare dental condition termed 'osteonecrosis of the jaw(ONJ)' has been reported. Bisphosphonate-related osteonecrosis of the jaw(BRONJ) is rare, but serious, side effect of bisphosphonate therapy in affected patients. It is characterized by poor wound healing and spontaneous intra-oral soft tissue break down, which lead to exposure of necrotic maxillary and mandibular bone. We reviewed 11 patients of BRONJ visited Ajou University Hospital Dental clinic from May 2007 to November 2008. The management of the patients included cessation of bisphosphonate therapy and various surgical restorative procedures and conservative care there after. Aggressive debridement is contraindicated. A new complication of bisphosphonate therapy administration, osteonecrosis of jaws, seems to be developing. The improved results after cessation of the medication should make clinicians reconsider the merits of the rampant use of bisphosphonates, while further investigation is needed to completely elucidate this complication.

• Journal of Yeungnam Medical Science
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• 제31권2호
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• pp.99-102
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• 2014

Diabetic ketoacidosis (DKA), a fatal acute diabetic complication, is characterized by severe metabolic decompensation and intravascular volume depletion. These conditions may result in hypercoagulability and prothrombic state. Pulmonary thromboembolism (PTE) could be presented as an uncommon and life-threatening complication of DKA. Reported herein is a case involving a 54-year-old male patient who was admitted with DKA due to chronic alcohol consumption and stopping the intake of oral antidiabetic drugs. After low-molecular-weight heparin and warfarin treatment because of PTE during the DKA treatment, the patient's condition improved over the week that he was discharged on insulin and warfarin.