• 대한한의학회지
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• 제41권1호
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• pp.93-106
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• 2020

Objectives: The aim of this review is to ascertain whether Bojungikgi-tang and its modifications is more effective than non-specific management in chronic fatigue syndrome (CFS). Methods: We collected clinical trials to investigate the effects of Bojungikgi-tang and non-specific management on general symptoms, fatigue, and sleep quality in CFS patients. The databases used for data retrieval were Pubmed, Central Cochrane, CNKI, VIP, CiNii, OASIS, RISS, and Koreamed. We performed selection/exclusion process from the found records according to prespecified criteria, and assessed the final included trials according to the Cochrane risk of bias tool. The included studies were classified on the basis of interventions in experimental group. Results: Seven randomized controlled trials (476 participants) were eligible and their results were synthesized in the meta-analysis. The synthesis showed a substantial effect of Bojungikgi-tang (relative risk 0.20 [95% CI 0.13 to 0.31], Z=7.44, P<0.00001; I²=0%) and combination of Bojungikgi-tang and Sosiho-tang (relative risk 0.15 [95% CI 0.08 to 0.28], Z=5.85, P<0.00001; I²=0%) compared with non-specific management on improvement of general symptoms. However, we could not find sufficient clinical research records to determine their effects of improvement on fatigue and sleep quality. Conclusions: Bojungikgi-tang and its modifications are more effective than non-specific management for improvement of general symptoms in CFS post-treatment.

• Asian Pacific Journal of Cancer Prevention
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• 제15권1호
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• pp.397-405
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• 2014

Obesity has been considered as an important risk factor for the development of colorectal cancer (CRC), but the association has not been fully elucidated. Obesity is linked significantly to adipose tissue dysfunction and to alteration of adipokines in blood; in particular, obesity-induced inflammation is thought to be an important link between obesity and colorectal cancer. Based on epidemiological studies, we undertook a systematic review to understand the association of circulating levels of selected adipokines, including adiponectin, leptin, resistin, IL-6 and TNF-${\alpha}$, with the level of CRC risk. Most prospective studies suggested protective effects of adiponectin, but these were attenuated by body mass index (BMI) and waist circumference (WC) data in our meta-analysis. On the other hand, meta-analyses for leptin and CRC did not demonstrate any association, similar to the results of systematic review. Although it proved difficult to determine whether other selected adipokines (resistin, IL-6 and TNF-${\alpha}$) were related to CRC risk due to small number of reports, the present systematic review suggested a positive association with elevated resistin levels but null associations with IL-6 and TNF-${\alpha}$.

• 여성건강간호학회지
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• 제21권4호
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• pp.342-354
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• 2015

Purpose: The purpose of this study was to test the effect size of intervention programs for married immigrant women as well as to suggest the basic data for health care practices for married migrant women. Methods: Meta-analysis was conducted with 27 articles from domestic Korea master's and doctorate degree dissertations and Korea academic journals from 2007 to 2014. Results: Overall average effect size was 1.17 and 'parental education' of Intervention Variables was the biggest effect size. Intervention Variables were also identified to be the most desirable in cases when total sessions were applied with 10-18 sessions, 1 session per week, 90-120 minutes per session activity time and with less than 10 subjects in group size. Regarding effect variables, psychological variable group was identified to show the biggest effect size and in sub-variables, self-efficacy was identified to show the biggest effect size. Conclusion: If intervention programs for married immigrant women is expanded and conducted based on the results of this study, the program would have significant affect psychological, social and physical health of the married migrant women who currently occupy the important status in our society.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1145-1149
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• 2012

Aim: To clarify any association between the hOGG1 Ser326Cys polymorphism and susceptibility to gastric cancer. Methods: A meta-analysis based on 11 eligible case-control studies involving 5,107 subjects was carried out to summarize the data on the association between hOGG1 Ser326Cys polymorphism and gastric cancer risk. Results: No association was found between hOGG1 Ser326Cys polymorphism and gastric cancer risk (dominant model: OR = 0.95, 95% CI: 0.83-1.09, p = 0.486, ph (p values for heterogeneity) = 0.419; additive model: OR = 1.02, 95% CI: 0.81-1.30, p = 0.850, ph = 0.181; recessive model: OR = 1.09, 95% CI: 0.80-1.48, p = 0.586, ph = 0.053). Subgroup analysis based on ethnicity (Asian and Caucasian) and smoking status (ever smoker and never smoker) did did notpresent any significant association. Sensitivity analysis did not perturb the results. Conclusions: This study strongly suggested there might be no association between the hOGG1 Ser326Cys polymorphism and gastric cancer risk. However, larger scale studies are needed for confirmation.

• 가족자원경영과 정책
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• 제15권3호
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• pp.43-62
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• 2011

The purpose of this study was to propose a framework and system for an advanced evaluation scale for the Multicultural Family Support Center and its services. For this study, we used the Meta-Evaluation method, which is also known as an 'evaluation of the evaluation.' The data were collected from 134 surveys of individuals working in the Multicultural Family Support Center. The questionnaire consisted of two parts: a) general opinions regarding the present evaluation scale; and b) concrete opinions about the details of the scale. The results indicated several problems and issues for improvement. In light of these results, we suggest that not only do the detailed scales have to be modified to incorporate workers' opinions, but also that the management of the evaluation system itself has to be improved in order to achieve more effective evaluation procedures.

• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2297-2302
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• 2014

Objective: To evaluate early treatment for extranodal natural killer/T cell lymphoma (ENK/TCL) in China and provide reference for clinical treatment of these patients. Methods: Computer-based retrieval was performed in PubMed, CNKI, CBM, VIP and WanFang Data to search for randomized controlled trials (RCTs) of treatment for early ENK/TCL, and a meta-analysis was conducted with RevMan 5.0 software. Results: A total of 11 RCTs, including 871 patients, were selected, of which the first radiotherapy had a higher complete response (CR) than the first chemotherapy [OR=14.16, 95%CI (8.68, 23.10), P<0.00001] and CR was not different between combined treatment group and radiotherapy group [OR=1.86, 95%CI (0.47, 3.58), P=0.61], but long-term survival rate was higher with combined treatment[OR=1.88, 95%CI (1.09, 3.19), P=0.02]. No difference in survival rate was observed between radio-chemotherapy and chemo-radiotherapy groups [OR=1.11, 95%CI (0.73, 1.69), P=0.63]. Conclusions: Radiotherapy is of great significance in the treatment of early ENK/TCL, but combined therapy could further enhance long-term survival rate of patients. This conclusion still requires further confirmation using RCTs with high quality and large sample size.

• 성인간호학회지
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• 제28권2호
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• pp.213-225
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• 2016

Purpose: The purpose of this study was to provide basic data about agitation in patients with dementia by surveying the literature. Method: Key words used for search through hand-search and electronic database (CINHAL, Pubmed, Google scholar, Riss, Kiss, DBpia) included 'dementia', 'Alzheimer disease', 'agitation', 'aggression or aggressive behavior', 'problem or disruptive behavior', and 'abnormal behavior.' Seventeen studies met the inclusion criteria for the Meta-analysis and 'R' version 3.2.2 was used to analyze the correlated effect size. Results: Study results showed that variables related to agitation were identified as the demographic (age, gender), dementia-related (cognition, medication uses), physical (Activity of Daily Living [ADL], pain), psychological (depression, psychotic symptom, caregiver burden) and environmental (psychosocial environment) factors. The effect size between the correlated variables and agitation were low to moderate (caregiver burden .36; ADL -.24; psychotic symptom and depression .21; pain .19; cognition -.15; medication uses .12; and psychosocial environment -.12). Conclusion: Based on the findings of this study, strategies to improve patients' depressive and psychotic symptoms and ADL and to reduce caregivers' burden are needed for prevention and management of agitation in patients with dementia.

• 성인간호학회지
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• 제28권2호
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• pp.156-168
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• 2016

Purpose: The purpose of this study was to provide basic data by surveying the literature for the past fifteen years (2001-2015). The focus of the search was death anxiety among the elderly. Methods: Sixty-two published works including graduate theses were selected for the Meta-analysis. Results: Study results showed that variables related to familial factors were the most often cited in the review of the manuscripts as relevant to death anxiety among the elderly. Specifically family support was most important. The other variables reported in the literature review were classified into four other groupings: social, physical, psychological, and demographics. The significant variable in the social grouping was religious activities, health promotion in the physical grouping and ego integrity in the psychological group. Conclusion: This study could provide effect sizes of variables based on materials, which are needed to make an intervention program that is related to death anxiety of the elderly. Since this study identified major variables as significant to death anxiety, several distinctions within these variables can be further studied as these relate to death anxiety.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2003-2007
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• 2012

Purpose: E-cadherin is a transmemberane protein which is responsible for adhesion of endothelial cells. The aim of our study was to assess existing evidence of associations between reduced expression of E-cadherin and prognosis of ovarian cancer with a discussion of potential approaches to exploiting any prognostic value for improved clinical management. Methods: We conducted a meta-analysis of 9 studies (n=915 patients) focusing on the correlation of reduced expression of E-cadherin with overall survival. Data were synthesized with random or fixed effect hazard ratios. Results: The studies were categorized by author/year, number of patients, FIGO stage, histology, cutoff value for E-cadherin positivity, and methods of hazard rations (HR) estimation, HR and its 95% confidence interval (CI). Combined hazard ratios suggested that reduced expression of E-cadherin positivity was associated with poor overall survival (OS), HR= 2.10, 95% CI:1.13-3.06. Conclusion: The overall survival of the E-cadherin negative group with ovarian cancer was significant poorer than the E-cadherin positive group. Upregulation of E-cadherin is an attractive therapeutic approach that could exert significant effects on clinical outcome of ovarian cancer.

• 한국생활과학회지
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• 제19권5호
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• pp.835-844
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• 2010

This study used meta-analysis to compare analyze data regarding the effects of music therapy on children and adolescent. The study examined 96 ESs using means and standard deviations from 77 Korean degree dissertations conducted between2000 and 2010. Results were as follows: The overall effect size (ES) of the therapy program was found to be 0.14, which, according to Cohen's ES interpretation criteria, is small. The mean ES was influenced by the subjects (children/ adolescents), ES of children(0.50) was bigger than ES of adolescents(-0.23). When results were sorted by the variables of therapy part: social, emotional and behavior development), the ES of social development was the biggest (1.11), followed by behavior development (-1.07) and emotional development (-0.01). However, other variables (total number of procedures, number of treatments per week, the average treatment time, therapist characteristics) made no statistically significant differences to the efficacy of the therapy. Finally, limitations of this study and potential future research are discussed.