• Journal of Periodontal and Implant Science
• /
• 제51권1호
• /
• pp.18-29
• /
• 2021

Purpose: The aim of this study was to compare the characteristic expression patterns of advanced periodontitis in 2 cohort data sets analyzed using different microarray platforms, and to identify differentially expressed genes (DEGs) through a meta-analysis of both data sets. Methods: Twenty-two patients for cohort 1 and 40 patients for cohort 2 were recruited with the same inclusion criteria. The 2 cohort groups were analyzed using different platforms: Illumina and Agilent. A meta-analysis was performed to increase reliability by removing statistical differences between platforms. An integrative meta-analysis based on an empirical Bayesian methodology (ComBat) was conducted. DEGs for the integrated data sets were identified using the limma package to adjust for age, sex, and platform and compared with the results for cohorts 1 and 2. Clustering and pathway analyses were also performed. Results: This study detected 557 and 246 DEGs in cohorts 1 and 2, respectively, with 146 and 42 significantly enriched gene ontology (GO) terms. Overlapping between cohorts 1 and 2 was present in 59 DEGs and 18 GO terms. However, only 6 genes from the top 30 enriched DEGs overlapped, and there were no overlapping GO terms in the top 30 enriched pathways. The integrative meta-analysis detected 34 DEGs, of which 10 overlapped in all the integrated data sets of cohorts 1 and 2. Conclusions: The characteristic expression pattern differed between periodontitis and the healthy periodontium, but the consistency between the data sets from different cohorts and metadata was too low to suggest specific biomarkers for identifying periodontitis.

• 한국정보통신학회:학술대회논문집
• /
• 한국정보통신학회 2021년도 춘계학술대회
• /
• pp.52-54
• /
• 2021

인공 지능 시대가 도래함에 따라, 로봇 교육과 그 역량 강화에 대한 교육은 전 세계적으로 널리 적용되고 적용되었습니다. 본 연구의 목적 : 학생 교육 및 교육에서 AI 교육 로봇의 응용 효과를 체계적으로 평가; 본 연구의 방법 : 컴퓨터를 사용하여 "Web of Science", "CNKI", "ERIC", "IEEE"와 같은 검색 도구에서 관련 교육을 검색하십시오. 로봇 티칭과 전통적인 티칭의 효과에 대한 비교 연구 검색 시간은 2000 년 1 월부터 2020 년 1 월까지입니다. 포괄적인 MetaAnalysis 2.0을 메타 분석에 사용했습니다. 본 연구 결과 : 31 개의 유효한 연구 문헌에 대한 정량 분석과 메타 분석이 AI 교육 로봇에 미치는 영향에 대한 객관적인 평가 분석 결과 AI 교육 로봇이 학생 학습 효과에 미치는 효과는 0.465임 이는 교육용 로봇이 학생의 학습 효과에 어느 정도 긍정적인 영향을 미침을 나타냅니다. 이 연구의 결론 : 학생 교육 및 교육에서 AI 교육 로봇의 적용 효과는 전통적인 교육 방법보다 우수하며 학생 학습을보다 효과적으로 홍보 할 수 있습니다.

• Journal of the Korean Data and Information Science Society
• /
• 제11권2호
• /
• pp.313-318
• /
• 2000

This article addresses aspects of combining information, with special attention to meta-analysis. In specific, we consider hierarchical Bayesian models for meta-analysis under priors which are scale mixtures of normal, and thus have tail heavier than that of the normal. Numerical methods of finding Bayes estimators under these heavy tailed prior are given, and are illustrated with an actual example.

• 대한통합의학회지
• /
• 제9권1호
• /
• pp.203-217
• /
• 2021

Purpose: The purpose of this meta-analysis was to examine the high-level evidence of the effects of manual therapy on musculoskeletal diseases. Methods: Domestic databases were searched for studies that conducted clinical trials associated with manual therapy on chronic musculoskeletal diseases. A total of 591 studies published between 2005 and 2018 were identified, with 18 studies satisfying the inclusion data. The studies were classified according to patient, intervention, comparison, and outcome (PICO). The search outcomes were items associated with pain and physical function. The 18 studies included in the study were evaluated by using the R meta-analysis (version 4.0). The quality of 18 randomized control trials was evaluated by using the Cochrane risk of bias (ROB). The effect sizes were computed as the corrected standardized mean difference (SMD). Subgroup and meta-regression analyses were also used. Egger's regression test was carried out in order to analyze the publication bias. Cumulative meta-analysis and sensitivity analysis were also conducted in order to analyze the data error. Results: The following factors showed the large effect size of manual therapy on chronic musculoskeletal diseases: pain (Hedges's g = 2.66; 95% CI = 1.47 ~ 3.85), and physical function (Hedges's g = 2.15; 95% CI: 1.22 ~ 3.08). The subgroup analysis only showed a statistical difference in the type of manual therapy (pain) and outcome (physical function). No statistically significant difference was found in the meta-regression analysis. Publication bias was found in the data, but the results of the trim-and-fill method showed that such bias did not largely affect the obtained data. Furthermore, there were no data errors in the cumulative meta-analysis and sensitivity analysis. Conclusion: This study provides evidence for the effectiveness of manual therapy on chronic musculoskeletal diseases in pain and physical function. Subgroup analysis suggests that only the type of manual therapy for pain and the type of outcome for physical function differed in effect size.

• 응용통계연구
• /
• 제26권5호
• /
• pp.797-806
• /
• 2013

메타분석은 이전의 연구들의 결과를 결합하기 위해 많은 분야에서 널리 사용된다. 메타분석 방법들 중에 p-value의 통합은 가장 단순한 방법이며 Tippett (1931), Fisher (1932) Stouffer 등 (1949) 등이 p-value를 통합하는 다양한 방법들을 제안하였다. 이 논문에서 우리는 지수분포에 기초한 새로운 p-value의 통합 방법을 제안하였다. 또한, 몬테카를로 모의시험 연구를 통해 제안된 방법과 이전의 방법들의 검정력을 비교하였다.

• Asian-Australasian Journal of Animal Sciences
• /
• 제24권12호
• /
• pp.1757-1762
• /
• 2011

Aflatoxins are natural contaminants of poultry feeds and feed ingredients and cause liver damage, immunosuppression, reduction in performance and mortality in broilers. A number of studies have been carried out to study the effects of aflatoxin on feed conversion ratio in broilers. The results on feed conversion ratio of 10 research articles in broilers fed with aflatoxin from first day of age to six weeks of age were compiled and were subjected to meta-analysis. Chi-square test and $Tau^2$ (heterogeneity co-efficient) were applied to test for significance of heterogeneity of studies. To integrate results, fixed effect model by Inverse Variance method (IV method) was used when heterogeneity was insignificant and otherwise random effect model by DerSimonian and Laird Method (DL method) was used. The results of meta-analysis showed that the adverse effect of aflatoxin on feed conversion ratio at the end of first week was negligible, second week was medium and third to six weeks was very large.

• 한국컴퓨터정보학회논문지
• /
• 제23권6호
• /
• pp.81-89
• /
• 2018

In this paper, we propose to investigate the existing EPL education related studies and to collect the total effect size for the improvement of high-level thinking through meta-analysis and to confirm the effect size according to various variables. So, we have objectively identified and generalized the practical effects of EPL education on the various elements of high-level thinking and high-level thinking. The results of the meta-analysis showed that 1) EPL is a teaching-learning tool that greatly improves students' high-level thinking. 2) Education based EPL has greatly contributed to the enhancement of creative thinking and logical thinking among high-level thinking. 3) Kodu, App Inventor, Scratch, and Dolittle was confirmed that the effect on the improvement of high-level thinking was great.

• 한국컴퓨터정보학회논문지
• /
• 제23권11호
• /
• pp.239-246
• /
• 2018

In this paper, we propose to investigate the existing SW education related studies and to collect the total effect size for the improvement of computational thinking(CT) through meta-analysis and to confirm the effect size according to various variables. So, we have objectively identified and generalized the practical effects of SW education on the various variable. The results of the meta-analysis showed that 1) the overall effect of SW educational activities on CT improvement was 'Hedges' g=0.643', so SW educational activity can get a CT improvement of about 24% over other educational activities. 2) EPL is a SW teaching-learning method that greatly improves students' CT. 3) Since SW education can be guaranteed to improve CT among elementary school students and university students, essential SW education for these should be further promoted. And it was found that SW education activity were more effective for CT improvement in small cities & rural areas than big cities, but the cause was not identified, so further study will be required.

• Journal of Preventive Medicine and Public Health
• /
• 제55권5호
• /
• pp.424-427
• /
• 2022

A retrospective record-linkage study (RLS) based on medical records containing drug prescription histories involves immortal time bias (ITB). Thus, it is necessary to control for this bias in the research planning and analysis stages. Furthermore, a summary of a meta-analysis including RLSs that did not control for ITB showed that specific drugs had a preventive effect on the occurrence of the disease. Previous meta-analytic results of three systematic reviews evaluating the association between statin intake and gastric cancer risk showed that the summary hazard ratio (sHR) of the RLSs was lower than 1 and was statistically significant. We should consider the possibility of ITB in the sHR of RLSs and interpret the results carefully.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권9호
• /
• pp.4071-4077
• /
• 2014

Background: The effects of CYP1A1 gene polymorphisms on the risk of bladder cancer (BC) remain controversial. We carried out a meta-analysis to clarify the role of CYP1A1 gene polymorphisms in BC. Material and Methods: A comprehensive literature search was conducted up to November 20, 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of the association. Meta-regression, subgroup analysis, sensitivity analysis and publication bias were also performed. Results: Eight studies involving 1,059 BC cases and 1,061 controls were included. The meta-analysis showed that there was no significant association between the two common mutations of CYP1A1 and BC risk. For the I1e462Val A/G polymorphism with GG vs. AA the OR was 1.47 (95 % CI= 0.70-3.07, P =0.308). For the MspI T/C polymorphism, though a slight trend was found this was not statistically nonsignificant (CC vs.TT, OR = 1.24, 95 % CI= 0.98-1.58, P =0.078). Subgroup analyses by ethnicity also found no obvious association between CYP1A1 and BC risk. Conclusion: The present meta-analysis suggests that CYP1A1 polymorphism is not associated with bladder cancer risk.