• 제목/요약/키워드: Mesitol

검색결과 1건 처리시간 0.014초

웅담 성분 Ursodeoxycholic Acid 유도체들의 생물활성 (Biological Activities of Ursi Fel's Component Ursodeoxycholic Acid and Its Derivatives)

  • 차배천
    • 생약학회지
    • /
    • 제48권1호
    • /
    • pp.10-17
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    • 2017
  • Ursi Fel's component ursodeoxycholic acid (UDCA), a traditional medicine, is used for the treatment of hepatic diseases. UDCA derivatives prepared by conjugation with antioxidant moiety such as maltol, sesamol, eugenol, mesitol and 3,4-(methylenedeoxy)aniline were expected to have various biological activity caused by synergistic effect of UDCA. Therefore, in this study, it was conducted the study of the manufacture of the UDCA derivatives and their biological activity. As a result, UDCA derivatives showed weak antioxidant activity in TBA method in vitro compared to original agents. SJ-505, SJ-502 and SJ-504 showed the effect of reducing ALT, AST, sorbitol dehydrogenase and ${\gamma}-glutamyltransferase$ in $CCl_4-induced$ liver injury experiment in vivo, even if the effects are weaker than UDCA and silymarin of the control group.