• 생물정신의학
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• 제16권4호
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• pp.229-237
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• 2009

Recent Korean statistics show that a Korean woman can now expect to live until her mid-80s, which implies living at least one-third of her life after menopause. The menopausal transition is typically marked by intense hormonal fluctuations, accompanied by sleep disturbance, vasomotor symptoms(e.g., hot flashes, night sweats), increased risk for osteoporosis, cardiovascular disease, and developing depression as well as mood disturbances. These symptoms can affect a woman's quality of life negatively. Therefore, a comprehensive understanding of the accurate detection and appropriate treatment of various menopause-related symptoms including depression in the menopausal transitions and postmenopause is mandatory. This review primarily focused on the current knowledge about the treatment of menopause-related depression.

• 한국산학기술학회논문지
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• 제21권5호
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• pp.150-166
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• 2020

본 연구는 인지예비능 이론에 입각하여 인지기능감퇴를 호소하는 갱년기 여성들을 위해 인지기능훈련 프로그램을 개발하고자 하였다. Jung의 웹기반 교수-학습 체제 설계의 절차적 모형에 근거하여 분석, 설계 및 개발 단계를 거쳐 개발하였다. 인지기능훈련 프로그램은 8주간의 프로그램으로 모바일 애플리케이션을 활용한 인지훈련과 동영상 교육이며 총 24회기로 매 회기는 20~30분이 소요되며 3회/주 하도록 구성되었다. 인지기능훈련은 갱년기 여성들에 있어서 가장 취약한 인지영역으로 확인된 기억력, 주의집중력, 언어기능과 통합적 집행기능을 위한 시나리오기반 문제해결 등으로 내용을 구성하였다. 각 주차별 교육내용은 갱년기의 정의, 원인 및 증상, 갱년기와 뇌기능 등 총 8가지 주제로 개발되었다. 프로그램 시범운영을 위해 인지기능감퇴를 호소하는 10명의 갱년기 여성을 대상으로 인지기능훈련 프로그램을 적용하여 훈련 전과 훈련 8주후 인지기능의 효과를 측정한 결과 전반적 인지기능이 증가되었고 통계적으로 유의하였다(t=-3.04, p=.014). 모바일 앱 기반 인지기능훈련 프로그램은 기억력 향상뿐만 아니라 잠재적 치매 유병율을 감소시키는 효과도 기대할 수 있을 것이라 기대된다.

• 대한간호학회지
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• 제29권6호
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• pp.1336-1354
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• 1999

Researchers have rarely explored menopausal experience in the context of the totality of women's lives, subsequently making the picture of menopause incomplete, discrete and fragmented. Respecting the totality of women's lives, this study addressed how a vulnerable group of women-low income Korean immigrant women-experience menopause within a context of multiple transitions. This is a cross-sectional study using methodological triangulation. A sample of 119 first-generation Korean immigrant women aged 40 to 60 years, who were in low-income jobs, was recruited using convenience sampling methods. From the total sample, 21 peri-or post-menopausal women were recruited for in-depth interviews following the collection of the survey data. Questionnaires, short interviews, and in- depth interviews were used to collect data. The quantitative data were analyzed using descriptive and inferential statistics. Thematic analysis was used to interpret interview data. The findings indicate that menopause was given the lowest priority amidst women's multiple and demanding roles within a gendered multiple transitional (immigration, work and menopause) context. The lack of language clarity to describe women's experience, cultural background, inadequate knowledge, and lack of social supports made menopause hidden, invisible, and inaudible. Conclusions and implications for nursing practice are guided by the goal of understanding women's experiences and meanings of menopause and supporting women through reflecting these experiences into their health care.

• 지역사회간호학회지
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• 제33권2호
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• pp.188-195
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• 2022

Purpose: With the first generation of marriage-based immigrant women in East Asia now reaching their middle or old age, the need to focus investigations on their health-related quality of life has arisen. This study aimed to examine the extent to which physical and mental health, and psychosocial variables can predict health-related quality of life among Japanese middle-aged immigrant women. Methods: This study has a descriptive cross-sectional design. A convenience sample of 197 Japanese middle-aged marriage-based immigrant women from two regions of South Korea were recruited between December 2017 and March 2018. Participants completed self-administered questionnaires on health-related quality of life, menopausal symptoms, depression, perceived health status, disease morbidity, social support, and acculturation. The data were analyzed using hierarchical multiple regression. Results: Depression was the strongest predictor of health-related quality of life, followed by perceived health status, social support, and household income. Menopausal symptoms, presence of disease, and acculturation appeared to have no additional impact on participant's health-related quality of life. Conclusion: In times of rapid growth of global migration and the aging of immigrants in new destination countries, nursing interventions and public health policies for aging marriage-based immigrant women should be prioritized to improve their mental health by facilitating social support and disease management. In addition, social and employment policies that can help immigrant women transition to a healthy midlife are needed.

• 한국산학기술학회논문지
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• 제13권6호
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• pp.2579-2588
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• 2012

본 연구의 목적은 폐경기 중년여성의 피로, 가족기능과 자아존중감의 정도를 파악하고, 이들 변수 간의 관계를 파악하는 것이다. 본 연구는 폐경이행기를 포함하여 폐경기에 해당하는 중년여성 133명을 대상으로 구조화된 설문지를 이용하여 자가보고방식으로 설문조사가 시행되었다. 본 연구를 위한 자료수집 기간은 2012년 3월 2일부터 4월 10일 까지였다. 연구결과, 대상자의 피로정도는 교육수준(F=5.61, p=.005)과 월경상태(F=3.61, p=.030)에 따라 유의한 차이가 있었으며, 가족기능은 교육수준(F=4.49, p=.013), 결혼상태(t=2.25, p=.026)에 따라 유의한 차이가 있었다. 자아존중감은 교육수준(F=5.60, p=.005), 결혼상태(t=2.68, p=.008), 월 소득수준(F=3.51, p=.009)에 있어서 유의한 차이를 나타났다. 대상자의 피로정도는 가족기능(r=-.20, p=.020) 및 자아존중감(r=-.31, p=<.001)과 음의 상관관계가 있었으며, 가족기능과 자아존중감은 양의 상관관계가 있는 것으로 나타났다(r=.45, p<.001). 그러므로 폐경기 중년여성의 피로 및 건강관리를 위한 방안으로 가족기능을 강화하고, 자아존중감을 향상시키는 전략이 도움이 될 것으로 사료된다. 특히, 폐경기 이행기에 해당하는 중년여성의 피로 관리 및 소득과 교육수준이 낮고, 혼자 사는 폐경기 중년여성의 가족기능과 자아존중감의 향상을 위해 가족적, 사회적, 간호학적 지지자원 마련이 필요하다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1277-1280
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• 2015

Aim: To report epidemiologic and anatomoclinical transitions of inflammatory breast cancer (IBC) in Tunisia. Materials and Methods: Data including clinico-pathological data for 208 cases of T4d or PEV 3 non-metastatic breast cancer diagnosed between 2005 and 2010 were collected from patient records. Chi2 and Z tests were used to compare variables with two Tunisian historical series and a series about Arab-American patients. Results: Thirty three percent of our patients had their first child before 23 years of age and 56% had their menarche before 12 years, 75% never receiving oral contraception. Obesity was observed in 42% of women and IBC occurred during pregnancy in 13% of cases. Tumor grade was II-III in 90% of cases, HR was negative in 52%, HER2 was over expressed in 31% and invasion of more than 3 axillary nodes occurred in 18% of patients. We observed a pCR rate of 19% after neoadjuvant treatment (anthracyline-taxane used in 79%, trastuzumab in 27% ). Compared to historical Tunisian series (since 1996), IBC epidemiology remained stable in terms of median age, menopausal status and obesity. However we observed a significant decrease in median clinical tumor size and number of positive axillary lymph nodes. Comparison to IBC in Arab-Americans showed a significant difference in terms of median age, menopausal status, positivity of hormonal receptors and educational level. Conclusions: Our assessment of epidemiologic transition showed a reduction of clinco-pathological stage of IBC, keeping the same characteristics as compared to Tunisian historical series over a period of 14 years. Features seem to be different in Arab-American patients, probably related to migration, "occidentalization" of life style and improvement in socio-economic level.

• Nutritional Sciences
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• 제5권1호
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• pp.13-19
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• 2002

A mutation in the promoter region of uncoupling protein 3 (UCF3), specifically the -55C longrightarrow T transition, may influence an individual's energy metabolism and body weight. The objective of this study was to investigate the effect of a weight reduction program on endocrine functions and body fat distribution, related to UCP3 promoter genotype. Ninety overweight pre-menopausal female subjects participated in the weight reduction program at Yonsei University Hospital, and were placed on a calorie-restricted diet (300 kcal less than their daily requirements) for 12 weeks. After 12 weeks, all subjects on the program lost approximately 5% of their initial body weights and had lower Body Mass Index (BMI) values. Among the 90 women, 56 had a normal (without mutation) UCP3 genotype, while 34 women had mutations in the promoter region of UCP3. Despite similar weight reductions in both groups, a significantly higher decrease in abdominal adipose tissue was observed in the normal UCP3 genotype group, compared to the group with mutations. In particular, there was a significant reduction of fat at the lumbar 1 (Ll) level in the without-mutation group. Serum levels of total cholesterol, apolipoprotein Al were significantly decreased in the without-mutation group, by 4.4% and 5.7% respectively. Serum levels of hormones were not significantly changed in both groups artier the intervention. However, in the group without the mutations, the leptin level significantly reduced by 23.4% (p<0.001). Serum free fatty acid (FFA) concentration was significantly increased in the group with mutation following the weight reduction program. On the other hand, FFA responses were shown similar increases in both groups. In conclusion, although no difference was found in the magnitude of weight reduction in both groups, there were significant differences in body fat distribution and in endocrine function between the groups.

• 여성건강간호학회지
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• 제29권2호
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• pp.128-136
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• 2023

Purpose: Topic modeling is a text mining technique that extracts concepts from textual data and uncovers semantic structures and potential knowledge frameworks within context. This study aimed to identify major keywords and network structures for each major topic to discern research trends in women's health nursing published in the Korean Journal of Women Health Nursing (KJWHN) using text network analysis and topic modeling. Methods: The study targeted papers with English abstracts among 373 articles published in KJWHN from January 2011 to December 2021. Text network analysis and topic modeling were employed, and the analysis consisted of five steps: (1) data collection, (2) word extraction and refinement, (3) extraction of keywords and creation of networks, (4) network centrality analysis and key topic selection, and (5) topic modeling. Results: Six major keywords, each corresponding to a topic, were extracted through topic modeling analysis: "gynecologic neoplasms," "menopausal health," "health behavior," "infertility," "women's health in transition," and "nursing education for women." Conclusion: The latent topics from the target studies primarily focused on the health of women across all age groups. Research related to women's health is evolving with changing times and warrants further progress in the future. Future research on women's health nursing should explore various topics that reflect changes in social trends, and research methods should be diversified accordingly.

• 한국식품과학회지
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• 제51권2호
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• pp.182-187
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• 2019

본 연구는 슈퍼홍미 미강 추출물이 폐경 후 갱년기 증상에 및 대사 개선 효과를 확인하고자 수행되었다. 무월경이 지속된 지 5년 미만의 여성을 대상으로 12주동안 진행되었으며 위약대조군 15명, 실험군 15명으로 배정하였고, 1일 2개의 캡슐을 섭취하도록 하였다(슈퍼홍미 미강추출물 700 mg/day). 시험 종료 후 슈퍼홍미 미강 추출물 섭취군의 체중과 BMI 그리고 중성지질과 및 총콜레스테롤은 수준이 유의하게 감소하였다. 혈중 HDL 콜레스테롤과 ApoA1 농도는 약 10% 증가하여 지질대사 개선에 효과를 기대할 수 있었다. 항당뇨과 관련된 지표 중 혈중 glucose와 인슐린이 유의하게 감소하여 인슐린 저항성 지표인 HOMA-IR이 감소한 것을 확인할 수 있었고, 아디포넥틴 수준이 유의하게 증가하였으며, $TNF-{\alpha}$는 슈퍼홍미 미강 추출물 섭취군에서 투여 전보다 유의하게 감소하여 폐경 이후 당질대사 개선에 도움을 줄 수 있을 것으로 보인다. 항산화활성 분석 결과 SOD1, GSH 그리고 TBARS 수준이 실험군에서 감소하였으며, AOPP 는 유의적인 차이를 보이지 않았다. 여성호르몬 중 $17{\beta}-estradiol$과 progesterone 농도는 위약대조군에서 유의하게 감소하였으나 실험군은 섭취기간동안 호로몬 농도를 유지한 것으로 나타나 대조군에 비해 높은 수준을 나타났다. 폐경을 겪은 여성들은 여성호르몬 저하로 인해 갱년기 증상 및 대사증후군 발병 가능성이 증가하는데 슈퍼홍미 미강과 같은 기능성 식품 섭취로 대사증후군 위험인자들에 대한 호전이 높을 것이라 보고 이러한 연구 결과는 갱년기 여성 건강에 시사하는 바가 크다고 생각된다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7533-7537
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• 2014

Background: Breast cancer (BC) is the most frequent cancer type, and the leading cause of death from cancer among women in Israel. The Bedouin-Arab (BA) population in southern Israel is characterized by a high rate of consanguinity, common hereditary disorders, and transition from a semi-nomadic, traditional society to a more sedentary and urbanized society. In this hospital-based study, the demographic and the clinicopathological characteristics of BC in BA were compared with Jewish patients. Materials and Methods: 85 BA patients treated at the Soroka Medical Center, Beer Sheba, during the years 2004-2012, were studied and compared with 180 consecutive Jewish patients treated during the year 2007. Clinicopathological features compared included age, menopausal state, number of births, a history of BC in first-degree relatives, tumor size (T), extent of lymph-node involvement (N), distant metastases (M), stage, grade, estrogen and progesterone receptor (ER/PR), and Her2 status. Types of treatment, relapse rate and site, as well as outcome were also studied. Cox's regression models were applied for studying disease-free, and overall survival. Results: Compared with Jewish patients, BA patients were younger (average age $49{\pm}12$ yrs vs $59{\pm}13$, p<0.001), had a lower rate of BC in first-degree relatives (p<0.001), and a larger number of births ($6{\pm}4.2$ vs $2.5{\pm}1.9$, p<0.001). BA patients had larger tumors (p=0.02), more extensive lymph-node involvement (p=0.002), and more advanced stage (p=0.003). Grade, ER, PR, and Her2 status were similar in the two ethnic groups. Relapse type was most commonly systemic in BA patients (p=0.05), and loco-regional in Jewish patients (p=0.02). Median survival was 63, and 35 months for Jewish and BA patients, respectively (log-rank test, p=0.02). In Cox multivariate analysis, stage and PR status (HR-0.14, p<0.0001; HR-3.11, p=0.046), but not ethnicity, influenced overall survival. Conclusions: BC presents a decade earlier, and with more advanced disease in BA compared with Jewish patients. Biologic parameters including grade, ER, PR, and Her2 status were similar in both groups. Although prognosis was worse in BA than in Jewish patients, it was affected only by stage and PR status, but not by ethnicity.